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The map label for this gene is thrS

Identifier: 169824388

GI number: 169824388

Start: 753487

End: 755391

Strand: Direct

Name: thrS

Synonym: FMG_0691

Alternate gene names: 169824388

Gene position: 753487-755391 (Clockwise)

Preceding gene: 169824387

Following gene: 169824389

Centisome position: 41.92

GC content: 31.34

Gene sequence:

>1905_bases
ATGTTTGAAGTAAAATTAAAAGATGGATCCGCAAAAGAATTTGATGGAGAAATAAGTTTATTAGATGTTTGCAAATCAAT
ATCTGAAGGATTAGCAAGAGACTGCGTTGGAGCAGTTGTAGATGGTAAAATAATGGGATTAATGGAAACTATTGATTCTG
ATTGTGAAGTTCAATTCGTAAAATTTGATGATGATGAAGGAAAACAAGTTTTCTGGCATACTTCATCACACTTAATGGCC
TATGCTATTCAAAGATTGTATCCGGGTACAAAATTTGCAATTGGTCCTTCAATTGATTCTGGATTCTATTATGATTTAGA
TACAGATCATAAATTTGTACCAGAAGATTTAGAAAAAATCGAAGCTGAAATGAAAAAAATAGTTAAAGAAAATCCTAAAC
TAGTAAGAGTTGAAATTTCTAGAAAAGAAGCATTGGAAAGATTCAAAAATGAAGGACAAGACTATAAAGTAGATTTAATA
GAAAATTTTGATGAGGATGCTACAATTACTTTATATGAAATGGGAGACTTTGTGGATTTATGTAGAGGACCTCATTTATT
GGATGTAAAAAATATTAAAGCATTTAAATTATTATCAATCGCAGGTGCATACTGGAGAGGCGACGAAAATAATAAGATGC
TTCAAAGAATTTACGGTATTTCATTCCCTAAGAAAAAACTATTAGATGAATATTTGGATAGAATGGAAGAAGCTAAGAAA
AGAGACCATAGAAAAATTGGTAAAGAAATGGGATTATTCTCAATTCAAGAAGAAGGACCAGGTTTTCCATTCTTCCATCC
AAATGGGATGGTTGTTTTAAACGAATTAGAAAAATTCCTAAAAGAACAACTTTTAGAAAGAGGATATGGCCAAATTAAAA
CTCCTTTAATATTAAATGAACATTTATGGCATCAATCAGGACACTGGGACCATTACAAAGAAAATATGTATTTTACTAAA
ATAGATGGTGAAGATTATGCAATCAAACCAATGAACTGCCCAGGATCAATTTTAGTTTATAAAGATGAATTGCACAGCTA
TAGAGAGCTTCCAATTAAAGTAGCAGAATTAGGTCAAGTTCACCGTCATGAGTTATCAGGTGCATTACACGGTCTATTTA
GAGTAAGAACTTTCGTGCAAGATGATGCTCACGTATTCTGCTTACCTGAACAAATAGAAGAAGAAGTTAGTAAGACAATT
GATTTCTGTGATTACATTTATTCTAAATTTGGTTTTAAATATGAAGTTGAATTATCAACACGTCCTGAAGATTCAATGGG
CTCAGACGAAGATTGGGACTTGGCAATAAGTTCTCTTAAGAATGCATTAGAACATAAAGGTCTCCCATACAAGATTAATG
AAGGAGACGGTGCTTTCTACGGACCTAAAATAGATTTCCATTTGGAAGATGCAATTGGTAGAACTTGGCAATGTGGAACT
ATTCAATTAGATTTCCAAATGCCAGAAAGATTTGATATGACATACATTGCAAGTGACGGATCTAAAAAACGACCAGCAAT
GATTCATAGAGCTATTTTAGGTAGTGAAGAAAGATTTATGGGAATATTGATTGAACATTATGCAGGAAAATTCCCACTAT
GGTTGTCACCAGTTCAAGTAGAAATACTTCCTATTAGTGATAAATTTAATGATTATGCTTATGAATTACAACAAAAAATG
AAAGCCCGTGGATTGAGAGTAAAAGTCGATGATAGAAGTGAAAAAATCGGACTTAAAATTAGAGAATCTCAATTGAAGAA
AGTAAATTATTCATTAATAATTGGACAAAATGAAATTGATAATAATGAAGTATCAGTAAGAAAAAGAGATATTGGCGATG
TAGGATCTAAAAACACTGATGAATTTATTAATGAATTAGTAGATGAATATCAAAATAGAAAATAA

Upstream 100 bases:

>100_bases
ATTTGGAGCCGATTATTTAAATGAGAAAAAATTAGGGTGGAACCACGAGACACTTGTCCCTATCAGGGGATGAGGGTCTC
TTTTTTATTAGGAGGTATTT

Downstream 100 bases:

>100_bases
TATTTAAAAATTTATTTTCAAATAAAAAATTTGCTCTGAGTTTTTCAGAGCAAATTTTTAATAGAAGGAGACAAAATGTA
CAAGAAATTTTATTGGTTTC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MFEVKLKDGSAKEFDGEISLLDVCKSISEGLARDCVGAVVDGKIMGLMETIDSDCEVQFVKFDDDEGKQVFWHTSSHLMA
YAIQRLYPGTKFAIGPSIDSGFYYDLDTDHKFVPEDLEKIEAEMKKIVKENPKLVRVEISRKEALERFKNEGQDYKVDLI
ENFDEDATITLYEMGDFVDLCRGPHLLDVKNIKAFKLLSIAGAYWRGDENNKMLQRIYGISFPKKKLLDEYLDRMEEAKK
RDHRKIGKEMGLFSIQEEGPGFPFFHPNGMVVLNELEKFLKEQLLERGYGQIKTPLILNEHLWHQSGHWDHYKENMYFTK
IDGEDYAIKPMNCPGSILVYKDELHSYRELPIKVAELGQVHRHELSGALHGLFRVRTFVQDDAHVFCLPEQIEEEVSKTI
DFCDYIYSKFGFKYEVELSTRPEDSMGSDEDWDLAISSLKNALEHKGLPYKINEGDGAFYGPKIDFHLEDAIGRTWQCGT
IQLDFQMPERFDMTYIASDGSKKRPAMIHRAILGSEERFMGILIEHYAGKFPLWLSPVQVEILPISDKFNDYAYELQQKM
KARGLRVKVDDRSEKIGLKIRESQLKKVNYSLIIGQNEIDNNEVSVRKRDIGDVGSKNTDEFINELVDEYQNRK

Sequences:

>Translated_634_residues
MFEVKLKDGSAKEFDGEISLLDVCKSISEGLARDCVGAVVDGKIMGLMETIDSDCEVQFVKFDDDEGKQVFWHTSSHLMA
YAIQRLYPGTKFAIGPSIDSGFYYDLDTDHKFVPEDLEKIEAEMKKIVKENPKLVRVEISRKEALERFKNEGQDYKVDLI
ENFDEDATITLYEMGDFVDLCRGPHLLDVKNIKAFKLLSIAGAYWRGDENNKMLQRIYGISFPKKKLLDEYLDRMEEAKK
RDHRKIGKEMGLFSIQEEGPGFPFFHPNGMVVLNELEKFLKEQLLERGYGQIKTPLILNEHLWHQSGHWDHYKENMYFTK
IDGEDYAIKPMNCPGSILVYKDELHSYRELPIKVAELGQVHRHELSGALHGLFRVRTFVQDDAHVFCLPEQIEEEVSKTI
DFCDYIYSKFGFKYEVELSTRPEDSMGSDEDWDLAISSLKNALEHKGLPYKINEGDGAFYGPKIDFHLEDAIGRTWQCGT
IQLDFQMPERFDMTYIASDGSKKRPAMIHRAILGSEERFMGILIEHYAGKFPLWLSPVQVEILPISDKFNDYAYELQQKM
KARGLRVKVDDRSEKIGLKIRESQLKKVNYSLIIGQNEIDNNEVSVRKRDIGDVGSKNTDEFINELVDEYQNRK
>Mature_634_residues
MFEVKLKDGSAKEFDGEISLLDVCKSISEGLARDCVGAVVDGKIMGLMETIDSDCEVQFVKFDDDEGKQVFWHTSSHLMA
YAIQRLYPGTKFAIGPSIDSGFYYDLDTDHKFVPEDLEKIEAEMKKIVKENPKLVRVEISRKEALERFKNEGQDYKVDLI
ENFDEDATITLYEMGDFVDLCRGPHLLDVKNIKAFKLLSIAGAYWRGDENNKMLQRIYGISFPKKKLLDEYLDRMEEAKK
RDHRKIGKEMGLFSIQEEGPGFPFFHPNGMVVLNELEKFLKEQLLERGYGQIKTPLILNEHLWHQSGHWDHYKENMYFTK
IDGEDYAIKPMNCPGSILVYKDELHSYRELPIKVAELGQVHRHELSGALHGLFRVRTFVQDDAHVFCLPEQIEEEVSKTI
DFCDYIYSKFGFKYEVELSTRPEDSMGSDEDWDLAISSLKNALEHKGLPYKINEGDGAFYGPKIDFHLEDAIGRTWQCGT
IQLDFQMPERFDMTYIASDGSKKRPAMIHRAILGSEERFMGILIEHYAGKFPLWLSPVQVEILPISDKFNDYAYELQQKM
KARGLRVKVDDRSEKIGLKIRESQLKKVNYSLIIGQNEIDNNEVSVRKRDIGDVGSKNTDEFINELVDEYQNRK

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=630, Percent_Identity=43.1746031746032, Blast_Score=537, Evalue=1e-152,
Organism=Homo sapiens, GI38570111, Length=616, Percent_Identity=43.1818181818182, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI20070344, Length=632, Percent_Identity=40.9810126582278, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI27886582, Length=245, Percent_Identity=23.6734693877551, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788013, Length=632, Percent_Identity=47.4683544303797, Blast_Score=638, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=635, Percent_Identity=41.7322834645669, Blast_Score=538, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI71984192, Length=635, Percent_Identity=41.7322834645669, Blast_Score=538, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6322112, Length=653, Percent_Identity=41.6539050535988, Blast_Score=525, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6322654, Length=396, Percent_Identity=39.3939393939394, Blast_Score=305, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24583842, Length=629, Percent_Identity=43.5612082670906, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI28574141, Length=629, Percent_Identity=43.5612082670906, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24583839, Length=629, Percent_Identity=43.5612082670906, Blast_Score=555, Evalue=1e-158,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_FINM2 (B0S169)

Other databases:

- EMBL:   AP008971
- RefSeq:   YP_001691999.1
- ProteinModelPortal:   B0S169
- SMR:   B0S169
- GeneID:   6019841
- GenomeReviews:   AP008971_GR
- KEGG:   fma:FMG_0691
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- ProtClustDB:   PRK00413
- BioCyc:   FMAG334413:FMG_0691-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73295; Mature: 73295

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEVKLKDGSAKEFDGEISLLDVCKSISEGLARDCVGAVVDGKIMGLMETIDSDCEVQFV
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEEEE
KFDDDEGKQVFWHTSSHLMAYAIQRLYPGTKFAIGPSIDSGFYYDLDTDHKFVPEDLEKI
EECCCCCCEEEEECCHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCCCCCCCHHHHHHH
EAEMKKIVKENPKLVRVEISRKEALERFKNEGQDYKVDLIENFDEDATITLYEMGDFVDL
HHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCCEEEEHCCCCCCCCEEEEEECCCHHHH
CRGPHLLDVKNIKAFKLLSIAGAYWRGDENNKMLQRIYGISFPKKKLLDEYLDRMEEAKK
HCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RDHRKIGKEMGLFSIQEEGPGFPFFHPNGMVVLNELEKFLKEQLLERGYGQIKTPLILNE
HHHHHHHHHCCCEEEECCCCCCCEECCCCEEEHHHHHHHHHHHHHHCCCCCCCCCEEECH
HLWHQSGHWDHYKENMYFTKIDGEDYAIKPMNCPGSILVYKDELHSYRELPIKVAELGQV
HHHCCCCCCCCHHCCEEEEEECCCCEEEEECCCCCCEEEEHHHHHHHHHCCEEHHHHHHH
HRHELSGALHGLFRVRTFVQDDAHVFCLPEQIEEEVSKTIDFCDYIYSKFGFKYEVELST
HHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
RPEDSMGSDEDWDLAISSLKNALEHKGLPYKINEGDGAFYGPKIDFHLEDAIGRTWQCGT
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEECCEEEEEEHHHCCCEEECCE
IQLDFQMPERFDMTYIASDGSKKRPAMIHRAILGSEERFMGILIEHYAGKFPLWLSPVQV
EEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCEEE
EILPISDKFNDYAYELQQKMKARGLRVKVDDRSEKIGLKIRESQLKKVNYSLIIGQNEID
EEEECCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEHHHHHHCCEEEEEECCCCC
NNEVSVRKRDIGDVGSKNTDEFINELVDEYQNRK
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFEVKLKDGSAKEFDGEISLLDVCKSISEGLARDCVGAVVDGKIMGLMETIDSDCEVQFV
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEEEE
KFDDDEGKQVFWHTSSHLMAYAIQRLYPGTKFAIGPSIDSGFYYDLDTDHKFVPEDLEKI
EECCCCCCEEEEECCHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCCCCCCCHHHHHHH
EAEMKKIVKENPKLVRVEISRKEALERFKNEGQDYKVDLIENFDEDATITLYEMGDFVDL
HHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCCEEEEHCCCCCCCCEEEEEECCCHHHH
CRGPHLLDVKNIKAFKLLSIAGAYWRGDENNKMLQRIYGISFPKKKLLDEYLDRMEEAKK
HCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RDHRKIGKEMGLFSIQEEGPGFPFFHPNGMVVLNELEKFLKEQLLERGYGQIKTPLILNE
HHHHHHHHHCCCEEEECCCCCCCEECCCCEEEHHHHHHHHHHHHHHCCCCCCCCCEEECH
HLWHQSGHWDHYKENMYFTKIDGEDYAIKPMNCPGSILVYKDELHSYRELPIKVAELGQV
HHHCCCCCCCCHHCCEEEEEECCCCEEEEECCCCCCEEEEHHHHHHHHHCCEEHHHHHHH
HRHELSGALHGLFRVRTFVQDDAHVFCLPEQIEEEVSKTIDFCDYIYSKFGFKYEVELST
HHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
RPEDSMGSDEDWDLAISSLKNALEHKGLPYKINEGDGAFYGPKIDFHLEDAIGRTWQCGT
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEECCEEEEEEHHHCCCEEECCE
IQLDFQMPERFDMTYIASDGSKKRPAMIHRAILGSEERFMGILIEHYAGKFPLWLSPVQV
EEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCEEE
EILPISDKFNDYAYELQQKMKARGLRVKVDDRSEKIGLKIRESQLKKVNYSLIIGQNEID
EEEECCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEHHHHHHCCEEEEEECCCCC
NNEVSVRKRDIGDVGSKNTDEFINELVDEYQNRK
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA