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The map label for this gene is hisS

Identifier: 169824387

GI number: 169824387

Start: 751996

End: 753291

Strand: Direct

Name: hisS

Synonym: FMG_0690

Alternate gene names: 169824387

Gene position: 751996-753291 (Clockwise)

Preceding gene: 169824386

Following gene: 169824388

Centisome position: 41.83

GC content: 27.62

Gene sequence:

>1296_bases
ATGATTCAACCATCTACATTACCTGGAATGATGGAACTTCTTCCTGAAGACCAATTGGTATTTGATACAATTAAAAGAAA
AATAGAAGATGTTTTTATTAAAAATGCATTTTTCTCTATTGATACACCAGCTATAGAAAAACTTGACGTTTTACTATCTA
AAGGTGGAGGAGAAACTAGTAAGCAAGTTTTCAGAATTGACAATAGCAAAAAAAATCAAGGATTAAGATTTGACTTAACT
GTGCCACTTGCAAAATATGTTTCAATGTACATGCAAGATTTAGCGTTCCCATTCAGAAGATATCAAATAGCAAAAGTTTA
CAGGGGAGAGAGAAATCAAAAGGGTCGCTACAAAGAATTTTATCAATGTGATATAGACATAATTGGAAATGAAAAATTAA
GCTTATATAATGATGCAGAAATAGTAAAATGCATGTATGAAGCTTTAAAATCTATTGATGTTCCAGAGTTTGAATTTCAA
TTTAATAATAGAAAAATATTAAATGGATATTTTTCATACCTAGGCATCGATGATTTTGAATCATGTTTGCGAGTAATCGA
CAAGCTAGATAAAATCGGAATAGATAATGTAAAAGAAGAACTATCTAAAATAAATTTGGATGCATCAAAAATTGATACTT
TATTAAAATTTTTAGAAATCGATGGAACTAACCAAGAAATAATTGAAAAACTTGAATCATTAAATATCGATAACGAGTTA
TTTACATGTGGAGTTAATGAATTAAAATTTGTGTATCAAGATATTTTATCATTGGGTGTAAATCCAGAAAATATTAAAAT
AAATTTATCTATAACAAGAGGACTTGATTACTATACGGGTTCTGTATTTGAAACATTTTTTAAAGATTACCGTGAGATAG
GATCTATATGTTCTGGCGGAAGATATGATAGTTTAGCTAATAATTTTACTAAGAGTAAGTTGCCGGGAGTGGGCATGAGT
ATTGGATTGACTCGATTATTTTATCAACTTCAAGAATTAAATTTAGTAAAAGGAAAACAAACTAATTTTGATTGCATTAT
AATCCCTATGAAAGGTTACGAAAAAAACGCAGTAAAACTTATGAATGATTTGAGAAACTCTTCTGTAAAATGCATGAGTT
ATCTTGAAGATGATAAATTAAAAAAGAAATTTAATTATGCTGACAAATTATCTGTAAAATATGTTATAATAATAGGACAG
GATGAAGTTGAGCAAAATAAATTCACTTTACGAAACATGGAAAATGGTAATCAAGAATTATTAGAACTTAACGAAATTAT
AGAAAAGTTAAAATAA

Upstream 100 bases:

>100_bases
ATTGATATTTTAAATAAAGAAAAGATAAAATATTATTATCCAAAAGATGATGATTTTATAGATCGTGGATCTATAATCTT
TAATTAATAGGAGGTTAATT

Downstream 100 bases:

>100_bases
AGGCTATGAAAAATCCCAGTAGGCATATAAGAACTTTCAGAGAGAGTAGAACTTAGGCTGAAATTCTATTTAAGAGATCA
GTATGCTGAATACTAATTTG

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MIQPSTLPGMMELLPEDQLVFDTIKRKIEDVFIKNAFFSIDTPAIEKLDVLLSKGGGETSKQVFRIDNSKKNQGLRFDLT
VPLAKYVSMYMQDLAFPFRRYQIAKVYRGERNQKGRYKEFYQCDIDIIGNEKLSLYNDAEIVKCMYEALKSIDVPEFEFQ
FNNRKILNGYFSYLGIDDFESCLRVIDKLDKIGIDNVKEELSKINLDASKIDTLLKFLEIDGTNQEIIEKLESLNIDNEL
FTCGVNELKFVYQDILSLGVNPENIKINLSITRGLDYYTGSVFETFFKDYREIGSICSGGRYDSLANNFTKSKLPGVGMS
IGLTRLFYQLQELNLVKGKQTNFDCIIIPMKGYEKNAVKLMNDLRNSSVKCMSYLEDDKLKKKFNYADKLSVKYVIIIGQ
DEVEQNKFTLRNMENGNQELLELNEIIEKLK

Sequences:

>Translated_431_residues
MIQPSTLPGMMELLPEDQLVFDTIKRKIEDVFIKNAFFSIDTPAIEKLDVLLSKGGGETSKQVFRIDNSKKNQGLRFDLT
VPLAKYVSMYMQDLAFPFRRYQIAKVYRGERNQKGRYKEFYQCDIDIIGNEKLSLYNDAEIVKCMYEALKSIDVPEFEFQ
FNNRKILNGYFSYLGIDDFESCLRVIDKLDKIGIDNVKEELSKINLDASKIDTLLKFLEIDGTNQEIIEKLESLNIDNEL
FTCGVNELKFVYQDILSLGVNPENIKINLSITRGLDYYTGSVFETFFKDYREIGSICSGGRYDSLANNFTKSKLPGVGMS
IGLTRLFYQLQELNLVKGKQTNFDCIIIPMKGYEKNAVKLMNDLRNSSVKCMSYLEDDKLKKKFNYADKLSVKYVIIIGQ
DEVEQNKFTLRNMENGNQELLELNEIIEKLK
>Mature_431_residues
MIQPSTLPGMMELLPEDQLVFDTIKRKIEDVFIKNAFFSIDTPAIEKLDVLLSKGGGETSKQVFRIDNSKKNQGLRFDLT
VPLAKYVSMYMQDLAFPFRRYQIAKVYRGERNQKGRYKEFYQCDIDIIGNEKLSLYNDAEIVKCMYEALKSIDVPEFEFQ
FNNRKILNGYFSYLGIDDFESCLRVIDKLDKIGIDNVKEELSKINLDASKIDTLLKFLEIDGTNQEIIEKLESLNIDNEL
FTCGVNELKFVYQDILSLGVNPENIKINLSITRGLDYYTGSVFETFFKDYREIGSICSGGRYDSLANNFTKSKLPGVGMS
IGLTRLFYQLQELNLVKGKQTNFDCIIIPMKGYEKNAVKLMNDLRNSSVKCMSYLEDDKLKKKFNYADKLSVKYVIIIGQ
DEVEQNKFTLRNMENGNQELLELNEIIEKLK

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI15029520, Length=431, Percent_Identity=29.2343387470998, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI6996014, Length=434, Percent_Identity=31.1059907834101, Blast_Score=185, Evalue=6e-47,
Organism=Escherichia coli, GI1788861, Length=446, Percent_Identity=22.8699551569507, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71993693, Length=457, Percent_Identity=31.5098468271335, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71993686, Length=460, Percent_Identity=31.5217391304348, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6325290, Length=456, Percent_Identity=28.9473684210526, Blast_Score=168, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24643061, Length=472, Percent_Identity=29.4491525423729, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24643059, Length=491, Percent_Identity=28.3095723014257, Blast_Score=174, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_FINM2 (B0S168)

Other databases:

- EMBL:   AP008971
- RefSeq:   YP_001691998.1
- ProteinModelPortal:   B0S168
- SMR:   B0S168
- GeneID:   6019826
- GenomeReviews:   AP008971_GR
- KEGG:   fma:FMG_0690
- HOGENOM:   HBG616575
- OMA:   YVAEHEH
- ProtClustDB:   PRK00037
- BioCyc:   FMAG334413:FMG_0690-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 49766; Mature: 49766

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQPSTLPGMMELLPEDQLVFDTIKRKIEDVFIKNAFFSIDTPAIEKLDVLLSKGGGETS
CCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCCCC
KQVFRIDNSKKNQGLRFDLTVPLAKYVSMYMQDLAFPFRRYQIAKVYRGERNQKGRYKEF
HHEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
YQCDIDIIGNEKLSLYNDAEIVKCMYEALKSIDVPEFEFQFNNRKILNGYFSYLGIDDFE
HEECEEEECCCCEEECCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCHHHH
SCLRVIDKLDKIGIDNVKEELSKINLDASKIDTLLKFLEIDGTNQEIIEKLESLNIDNEL
HHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHH
FTCGVNELKFVYQDILSLGVNPENIKINLSITRGLDYYTGSVFETFFKDYREIGSICSGG
EECCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
RYDSLANNFTKSKLPGVGMSIGLTRLFYQLQELNLVKGKQTNFDCIIIPMKGYEKNAVKL
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHH
MNDLRNSSVKCMSYLEDDKLKKKFNYADKLSVKYVIIIGQDEVEQNKFTLRNMENGNQEL
HHHHHCCHHHHHHHHHHHHHHHHCCCHHCCCEEEEEEECCCCCCCCHHHCCCCCCCCHHH
LELNEIIEKLK
HHHHHHHHHCC
>Mature Secondary Structure
MIQPSTLPGMMELLPEDQLVFDTIKRKIEDVFIKNAFFSIDTPAIEKLDVLLSKGGGETS
CCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCCCC
KQVFRIDNSKKNQGLRFDLTVPLAKYVSMYMQDLAFPFRRYQIAKVYRGERNQKGRYKEF
HHEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
YQCDIDIIGNEKLSLYNDAEIVKCMYEALKSIDVPEFEFQFNNRKILNGYFSYLGIDDFE
HEECEEEECCCCEEECCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCHHHH
SCLRVIDKLDKIGIDNVKEELSKINLDASKIDTLLKFLEIDGTNQEIIEKLESLNIDNEL
HHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHH
FTCGVNELKFVYQDILSLGVNPENIKINLSITRGLDYYTGSVFETFFKDYREIGSICSGG
EECCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
RYDSLANNFTKSKLPGVGMSIGLTRLFYQLQELNLVKGKQTNFDCIIIPMKGYEKNAVKL
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHH
MNDLRNSSVKCMSYLEDDKLKKKFNYADKLSVKYVIIIGQDEVEQNKFTLRNMENGNQEL
HHHHHCCHHHHHHHHHHHHHHHHCCCHHCCCEEEEEEECCCCCCCCHHHCCCCCCCCHHH
LELNEIIEKLK
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA