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The map label for this gene is lspA [H]

Identifier: 169824336

GI number: 169824336

Start: 703571

End: 704017

Strand: Direct

Name: lspA [H]

Synonym: FMG_0639

Alternate gene names: 169824336

Gene position: 703571-704017 (Clockwise)

Preceding gene: 169824335

Following gene: 169824337

Centisome position: 39.14

GC content: 27.07

Gene sequence:

>447_bases
ATGGTAACTATTTTAATGATGATTTTGGTAATTGGCTTAGATCATTTAACAAAATACATGGCAATTTCTCTCAAAGAAGG
AGATATTGTAATTTTTGATAAATTTTTAAAGCTTACTTACCTTGAAAATAGAGGAGCGGCATTTGGAATTCTTGAAAACA
AGAAAATATTCTTACTTATAATAACATTACTAATAATTGGATTTGTAATATTGTATATTTTTAAGAATTACAAAAGCTTG
ATGAATTTTGAAAAAGTAATATATGGGCTACTTTTAGGAGGAGCATTAGGAAATCTGATTGACAGAATTTTCAGAGGTTA
TGTCATTGATTTTATTTCTGTAAGACTTCCATTTAATTACGATTTTCCTGTGTTTAACGTGGCGGATATAGCTGTTGTTG
TATCGTGTATTTTACTTGTTATATTTAGCTTAAAAGGACATAAATAA

Upstream 100 bases:

>100_bases
CAATTAGAGGTTATGGTAGGTACAGACTTATAGAATACTTGGGAAACACAAAAAAAGACAAATTGAGAATAAAATATATT
AAATACATTTAGGAGTAAAA

Downstream 100 bases:

>100_bases
TGAGTGTTAATATAGGAAATAGTTGGGATGAATTGCTAAAGGATGAATGGAACAAAGATTATTATAAAAAAATCAGACAA
GTTTTAATTCATGATTATAA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MVTILMMILVIGLDHLTKYMAISLKEGDIVIFDKFLKLTYLENRGAAFGILENKKIFLLIITLLIIGFVILYIFKNYKSL
MNFEKVIYGLLLGGALGNLIDRIFRGYVIDFISVRLPFNYDFPVFNVADIAVVVSCILLVIFSLKGHK

Sequences:

>Translated_148_residues
MVTILMMILVIGLDHLTKYMAISLKEGDIVIFDKFLKLTYLENRGAAFGILENKKIFLLIITLLIIGFVILYIFKNYKSL
MNFEKVIYGLLLGGALGNLIDRIFRGYVIDFISVRLPFNYDFPVFNVADIAVVVSCILLVIFSLKGHK
>Mature_148_residues
MVTILMMILVIGLDHLTKYMAISLKEGDIVIFDKFLKLTYLENRGAAFGILENKKIFLLIITLLIIGFVILYIFKNYKSL
MNFEKVIYGLLLGGALGNLIDRIFRGYVIDFISVRLPFNYDFPVFNVADIAVVVSCILLVIFSLKGHK

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=145, Percent_Identity=33.1034482758621, Blast_Score=66, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 16845; Mature: 16845

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTILMMILVIGLDHLTKYMAISLKEGDIVIFDKFLKLTYLENRGAAFGILENKKIFLLI
CHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCEEEEECCCHHHHHH
ITLLIIGFVILYIFKNYKSLMNFEKVIYGLLLGGALGNLIDRIFRGYVIDFISVRLPFNY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DFPVFNVADIAVVVSCILLVIFSLKGHK
CCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVTILMMILVIGLDHLTKYMAISLKEGDIVIFDKFLKLTYLENRGAAFGILENKKIFLLI
CHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCEEEEECCCHHHHHH
ITLLIIGFVILYIFKNYKSLMNFEKVIYGLLLGGALGNLIDRIFRGYVIDFISVRLPFNY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DFPVFNVADIAVVVSCILLVIFSLKGHK
CCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]