Click here to switch to the map view.

The map label for this gene is wecC [H]

Identifier: 169823825

GI number: 169823825

Start: 148208

End: 149434

Strand: Direct

Name: wecC [H]

Synonym: FMG_0128

Alternate gene names: 169823825

Gene position: 148208-149434 (Clockwise)

Preceding gene: 169823824

Following gene: 169823826

Centisome position: 8.24

GC content: 33.82

Gene sequence:

>1227_bases
ATGATTAATGTAATTGGTTTAGGTTACATAGGTCTACCTACAGCTTTGATGCTTGCAACATCAGGTAATAAGGTAGTGGG
AACAGATATTAAAGAAGAAGTAATTGACAAATTAAAGCATAAAAAATTAACTTTTGAAGAAAAAGGAATGGATGAGCTTT
TCGAAAAAGCCTTGAATGCAGACATTACTTTTTCATTAAAACCAGTATCTACTTCTTTCTATATCATTACAGCGCCAACT
CCATACGATCCTGTATCTAAGAAATTGGATTGTTCTTATGTAGTAAAAGCTGTAGAATCAGTATTGGAACCTGCAGAAGA
AGATGCGATTATTGTTGTTGAATCGACAATTTCACCAGGAGCAATCGACACTTACGTTAGACCTGTTGTTAATGAATACA
TGGAAAAATCCGGCAAGAAATTGAATTTGGTTCACGCTCCAGAAAGAATTATTCCTGGTAACATGGTTTACGAATTGGAA
CACAACGCTAGAACAATAGGCGCTGACGATCCAAAATACGGCGAAAAAGTTAAAGAAGTGTACTCATCTTTCTGTAAAGG
TGAAATCAATCTAACTAACATCAAAACTGCTGAAATGACAAAAGTTGTTGAAAATACATTCAGAGATATCAACATTGCAT
TCGCAAACGAATTGGCTAAAATTTGTCGTCAAGGTGGACTTGATGTCAACGAAGTTATCAGAATTTCTAACAAACACCCA
AGAGTTAACATTCTTTCACCAGGACCTGGTGTAGGTGGACATTGTATTTCAGTTGACCCATGGTTTTTAGTTGGAGATTA
TCCACTTCTTACTGAAATAATCTACAAAGCTCGTCAAATCAACGATTCAATGCCAGAATATGTTCTTAGACGTGCCTACA
ATATTATGCAAGAAAACAACTTAAAAGATTTTTCAAGAGTTGGTATTTATGGATTAACTTACAAAGAAAACGTAGACGAT
GTGAGAGAATCACCAACACTTCAATTATTACAACACCAAAAAGAACATTTGGGAGATGGATTAAAAGTTTACGATCCAAT
GGTAAAAAGAGAAGTTGTGGAAAATCAATACCATGATTTGAATAAATTCTTAAATGATGTTGATTTCGTAATCGTAATGA
TTGGTCACGATGAAATCAGACAAAACATGGATGTTTTAAAAGACAAAGTTGTACTTGATACAAGAAACATCGATGCTGAA
AACAAATACAATTTCTACAAATTATAA

Upstream 100 bases:

>100_bases
CAAGAAAACTGCAGAAAAATGCAATCAGAATTGAATCCACAAAAAAACAACGAAAGATTATTAAAAAGAATAGAAAATTT
ATTTTAAAGGAGAGAATATT

Downstream 100 bases:

>100_bases
AATAAATTAAAGGGCGCTAAATTTGCAGCGCCTTTTTTTAAAAAGAGGTAAAAAATGAAAAAAGTAATGGTGGTTTTTGG
GACAAGACCAGAAGCTATTA

Product: UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MINVIGLGYIGLPTALMLATSGNKVVGTDIKEEVIDKLKHKKLTFEEKGMDELFEKALNADITFSLKPVSTSFYIITAPT
PYDPVSKKLDCSYVVKAVESVLEPAEEDAIIVVESTISPGAIDTYVRPVVNEYMEKSGKKLNLVHAPERIIPGNMVYELE
HNARTIGADDPKYGEKVKEVYSSFCKGEINLTNIKTAEMTKVVENTFRDINIAFANELAKICRQGGLDVNEVIRISNKHP
RVNILSPGPGVGGHCISVDPWFLVGDYPLLTEIIYKARQINDSMPEYVLRRAYNIMQENNLKDFSRVGIYGLTYKENVDD
VRESPTLQLLQHQKEHLGDGLKVYDPMVKREVVENQYHDLNKFLNDVDFVIVMIGHDEIRQNMDVLKDKVVLDTRNIDAE
NKYNFYKL

Sequences:

>Translated_408_residues
MINVIGLGYIGLPTALMLATSGNKVVGTDIKEEVIDKLKHKKLTFEEKGMDELFEKALNADITFSLKPVSTSFYIITAPT
PYDPVSKKLDCSYVVKAVESVLEPAEEDAIIVVESTISPGAIDTYVRPVVNEYMEKSGKKLNLVHAPERIIPGNMVYELE
HNARTIGADDPKYGEKVKEVYSSFCKGEINLTNIKTAEMTKVVENTFRDINIAFANELAKICRQGGLDVNEVIRISNKHP
RVNILSPGPGVGGHCISVDPWFLVGDYPLLTEIIYKARQINDSMPEYVLRRAYNIMQENNLKDFSRVGIYGLTYKENVDD
VRESPTLQLLQHQKEHLGDGLKVYDPMVKREVVENQYHDLNKFLNDVDFVIVMIGHDEIRQNMDVLKDKVVLDTRNIDAE
NKYNFYKL
>Mature_408_residues
MINVIGLGYIGLPTALMLATSGNKVVGTDIKEEVIDKLKHKKLTFEEKGMDELFEKALNADITFSLKPVSTSFYIITAPT
PYDPVSKKLDCSYVVKAVESVLEPAEEDAIIVVESTISPGAIDTYVRPVVNEYMEKSGKKLNLVHAPERIIPGNMVYELE
HNARTIGADDPKYGEKVKEVYSSFCKGEINLTNIKTAEMTKVVENTFRDINIAFANELAKICRQGGLDVNEVIRISNKHP
RVNILSPGPGVGGHCISVDPWFLVGDYPLLTEIIYKARQINDSMPEYVLRRAYNIMQENNLKDFSRVGIYGLTYKENVDD
VRESPTLQLLQHQKEHLGDGLKVYDPMVKREVVENQYHDLNKFLNDVDFVIVMIGHDEIRQNMDVLKDKVVLDTRNIDAE
NKYNFYKL

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=380, Percent_Identity=26.0526315789474, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI296040438, Length=285, Percent_Identity=25.9649122807018, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI296040443, Length=231, Percent_Identity=28.1385281385281, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI48994968, Length=416, Percent_Identity=34.375, Blast_Score=258, Evalue=3e-70,
Organism=Escherichia coli, GI1788340, Length=388, Percent_Identity=23.9690721649485, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560350, Length=377, Percent_Identity=24.6684350132626, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI17136908, Length=374, Percent_Identity=28.0748663101604, Blast_Score=115, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46151; Mature: 46151

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVIGLGYIGLPTALMLATSGNKVVGTDIKEEVIDKLKHKKLTFEEKGMDELFEKALNA
CEEEEEECHHHHHHHEEEECCCCEEECCCHHHHHHHHHHHCCCCCHHCCHHHHHHHHCCC
DITFSLKPVSTSFYIITAPTPYDPVSKKLDCSYVVKAVESVLEPAEEDAIIVVESTISPG
CEEEEEEECCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
AIDTYVRPVVNEYMEKSGKKLNLVHAPERIIPGNMVYELEHNARTIGADDPKYGEKVKEV
HHHHHHHHHHHHHHHHCCCEEEEEECCCHHCCCCEEEEEECCCEECCCCCCHHHHHHHHH
YSSFCKGEINLTNIKTAEMTKVVENTFRDINIAFANELAKICRQGGLDVNEVIRISNKHP
HHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCC
RVNILSPGPGVGGHCISVDPWFLVGDYPLLTEIIYKARQINDSMPEYVLRRAYNIMQENN
EEEEECCCCCCCCEEEEECCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
LKDFSRVGIYGLTYKENVDDVRESPTLQLLQHQKEHLGDGLKVYDPMVKREVVENQYHDL
CCHHHHCCEEEEEECCCHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
NKFLNDVDFVIVMIGHDEIRQNMDVLKDKVVLDTRNIDAENKYNFYKL
HHHHCCCCEEEEEECCHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MINVIGLGYIGLPTALMLATSGNKVVGTDIKEEVIDKLKHKKLTFEEKGMDELFEKALNA
CEEEEEECHHHHHHHEEEECCCCEEECCCHHHHHHHHHHHCCCCCHHCCHHHHHHHHCCC
DITFSLKPVSTSFYIITAPTPYDPVSKKLDCSYVVKAVESVLEPAEEDAIIVVESTISPG
CEEEEEEECCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
AIDTYVRPVVNEYMEKSGKKLNLVHAPERIIPGNMVYELEHNARTIGADDPKYGEKVKEV
HHHHHHHHHHHHHHHHCCCEEEEEECCCHHCCCCEEEEEECCCEECCCCCCHHHHHHHHH
YSSFCKGEINLTNIKTAEMTKVVENTFRDINIAFANELAKICRQGGLDVNEVIRISNKHP
HHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCC
RVNILSPGPGVGGHCISVDPWFLVGDYPLLTEIIYKARQINDSMPEYVLRRAYNIMQENN
EEEEECCCCCCCCEEEEECCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
LKDFSRVGIYGLTYKENVDDVRESPTLQLLQHQKEHLGDGLKVYDPMVKREVVENQYHDL
CCHHHHCCEEEEEECCCHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
NKFLNDVDFVIVMIGHDEIRQNMDVLKDKVVLDTRNIDAENKYNFYKL
HHHHCCCCEEEEEECCHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA