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The map label for this gene is betA [C]

Identifier: 169630910

GI number: 169630910

Start: 3876637

End: 3878031

Strand: Reverse

Name: betA [C]

Synonym: MAB_3830c

Alternate gene names: 169630910

Gene position: 3878031-3876637 (Counterclockwise)

Preceding gene: 169630911

Following gene: 169630909

Centisome position: 76.53

GC content: 65.09

Gene sequence:

>1395_bases
GTGGGCGCAGGAAGCGCGGGTTCGATTCTGGCAGGCCGCCTTTCTGAAGACCCGTCGTTTCGAGTGGTGCTCGTCGAGGC
GGGGCCGGTGTCGTCGGCGGACGAGGCCGGGGTACGGAACGGGTACCGCCTGCCGATTGGGCCCGGCAGTCAGATAGCTA
CCTACTACTGGGCGACATTGACGTCCACCGGCGATCAGGCCGAACTGGTACGCGGATCCGTGGTGGGGGGCTCGGGGGCT
ATCAATGGCGGGTACTTCGTGCGGGGCCGGCCGGCGGACTTCGATGGATGGGCGGTATCGGGATGGTCCTGGGCGGAGGT
GCGCGATCACTTCCGGGCGATAGAAACCGACCACGATTTTCGCGACGATCCGCTGCACGGATCGCAGGGGCCCATACCTG
TTGGCCGTAGGCACGAACAGAGCAGCGCTGGAACAGAATTGATGGACCTTGCCGTCAATCGGGGGTACCCGGTGGTCGCT
GATCTCAACGGCTCGGCCGGTGCCGGAGTGGGATTGGTACCGCTCAACATCGACTCCGGCATCAGGGTCGGGCCCGCACG
CGCCTACCTGGAGAGCGCGGTGTGGCGTCCCAATCTCGCCGTGTATTCCGGCACCCGAGTGCTGCGAGTGCTGTGCAGCG
GCGGAAAGGCAACCGGAGTGCAGGTGGCGGTGGGCAATTCGGTGCGAACCCTCACCGCCGATCGGATCATTCTGAGCGCG
GGGGCTATCGAGAGCGCAAAGCTGCTGTTGCTGTCGGGGCTGGGCCCGGCAGATGAACTGCGTGCGGTGGGGGTGCAGCC
CGTTGTCGATCTGCCGGGCGTGGGCACGCGGGTGATGGACCACGCCGAATGGGTACTCGATACCGGTGAGCAAGGGCAGC
AGGGCCATCCGGTCCTGGACACCGTCTTACATACCGATCACCCGATGTGTCTTGAAATACGGCCCTATACAACAGGATTC
GCCGCGATGGCCGGAGTCGTAGCAGATGGGGCGGACGCCCGGCAGATCGGTGTGGCGTTGATGACGCCACAGTGTCGCGG
CCGTCTCGAGCTGCGATCGACCGATCCGGCAGCGCCGGTCTACATCGATCTGAGGTACGACAGCGAGACCGCCGATATGG
ATCGCTTGCGCGACGGGGTGCACCTGGTGTCTGAACTGTATGGGCGCCGCTTTGGCGGCCCGCGATGGTCGACGTCGCAG
CACCTGTGTGGCACGGCGCCCTTGGGAAATGACCGCGACAAGCATGCTGTTGTCGACAAGTACTGCCGCGTCAGGGGAAT
CGACGGGCTGTTTGTCATCGACGGATCGATCCTGCCAACCATTCCGAGTCGCGGCCCCGCGGCCACCATCGCCATGATCG
GACACCGGGCCGCGCAGTTTGTTGCGTGGTCGTAA

Upstream 100 bases:

>100_bases
GGATTGGGCTGTGGTCCGGAATCGTGCGGGAGCGTGATCTCGGTGCGCTCCGACCGGAACTACGGCCCTGAGTAGGCCGA
TCCACGCCGATGCGCTCATC

Downstream 100 bases:

>100_bases
CGGAATATGAATCTCGTCGTCTAACCCACGCGTGCAGACCATCGGTCGCACAATTGGACGATGTCAACTTCCGATGATGC
CGCCAGCTCGCCCCCGGAAG

Product: dehydrogenase (glucose-methanol-choline oxidoreductase)

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MGAGSAGSILAGRLSEDPSFRVVLVEAGPVSSADEAGVRNGYRLPIGPGSQIATYYWATLTSTGDQAELVRGSVVGGSGA
INGGYFVRGRPADFDGWAVSGWSWAEVRDHFRAIETDHDFRDDPLHGSQGPIPVGRRHEQSSAGTELMDLAVNRGYPVVA
DLNGSAGAGVGLVPLNIDSGIRVGPARAYLESAVWRPNLAVYSGTRVLRVLCSGGKATGVQVAVGNSVRTLTADRIILSA
GAIESAKLLLLSGLGPADELRAVGVQPVVDLPGVGTRVMDHAEWVLDTGEQGQQGHPVLDTVLHTDHPMCLEIRPYTTGF
AAMAGVVADGADARQIGVALMTPQCRGRLELRSTDPAAPVYIDLRYDSETADMDRLRDGVHLVSELYGRRFGGPRWSTSQ
HLCGTAPLGNDRDKHAVVDKYCRVRGIDGLFVIDGSILPTIPSRGPAATIAMIGHRAAQFVAWS

Sequences:

>Translated_464_residues
MGAGSAGSILAGRLSEDPSFRVVLVEAGPVSSADEAGVRNGYRLPIGPGSQIATYYWATLTSTGDQAELVRGSVVGGSGA
INGGYFVRGRPADFDGWAVSGWSWAEVRDHFRAIETDHDFRDDPLHGSQGPIPVGRRHEQSSAGTELMDLAVNRGYPVVA
DLNGSAGAGVGLVPLNIDSGIRVGPARAYLESAVWRPNLAVYSGTRVLRVLCSGGKATGVQVAVGNSVRTLTADRIILSA
GAIESAKLLLLSGLGPADELRAVGVQPVVDLPGVGTRVMDHAEWVLDTGEQGQQGHPVLDTVLHTDHPMCLEIRPYTTGF
AAMAGVVADGADARQIGVALMTPQCRGRLELRSTDPAAPVYIDLRYDSETADMDRLRDGVHLVSELYGRRFGGPRWSTSQ
HLCGTAPLGNDRDKHAVVDKYCRVRGIDGLFVIDGSILPTIPSRGPAATIAMIGHRAAQFVAWS
>Mature_463_residues
GAGSAGSILAGRLSEDPSFRVVLVEAGPVSSADEAGVRNGYRLPIGPGSQIATYYWATLTSTGDQAELVRGSVVGGSGAI
NGGYFVRGRPADFDGWAVSGWSWAEVRDHFRAIETDHDFRDDPLHGSQGPIPVGRRHEQSSAGTELMDLAVNRGYPVVAD
LNGSAGAGVGLVPLNIDSGIRVGPARAYLESAVWRPNLAVYSGTRVLRVLCSGGKATGVQVAVGNSVRTLTADRIILSAG
AIESAKLLLLSGLGPADELRAVGVQPVVDLPGVGTRVMDHAEWVLDTGEQGQQGHPVLDTVLHTDHPMCLEIRPYTTGFA
AMAGVVADGADARQIGVALMTPQCRGRLELRSTDPAAPVYIDLRYDSETADMDRLRDGVHLVSELYGRRFGGPRWSTSQH
LCGTAPLGNDRDKHAVVDKYCRVRGIDGLFVIDGSILPTIPSRGPAATIAMIGHRAAQFVAWS

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=532, Percent_Identity=30.4511278195489, Blast_Score=193, Evalue=4e-49,
Organism=Escherichia coli, GI1786503, Length=533, Percent_Identity=28.7054409005629, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17532301, Length=545, Percent_Identity=28.0733944954128, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI17137792, Length=546, Percent_Identity=29.1208791208791, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24642051, Length=565, Percent_Identity=28.3185840707965, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24642039, Length=563, Percent_Identity=28.0639431616341, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24642055, Length=567, Percent_Identity=28.7477954144621, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24642035, Length=295, Percent_Identity=33.8983050847458, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24642048, Length=299, Percent_Identity=33.4448160535117, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI45551458, Length=561, Percent_Identity=25.8467023172906, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24642037, Length=308, Percent_Identity=33.7662337662338, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI45549471, Length=564, Percent_Identity=26.063829787234, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI18859995, Length=295, Percent_Identity=33.5593220338983, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24642042, Length=299, Percent_Identity=31.7725752508361, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24650267, Length=299, Percent_Identity=31.438127090301, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24642059, Length=299, Percent_Identity=29.0969899665552, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI18859993, Length=303, Percent_Identity=30.3630363036304, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24642057, Length=563, Percent_Identity=26.2877442273535, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 48985; Mature: 48854

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAGSAGSILAGRLSEDPSFRVVLVEAGPVSSADEAGVRNGYRLPIGPGSQIATYYWATL
CCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCHHHCCCCEEECCCCCCCEEEEEEEEE
TSTGDQAELVRGSVVGGSGAINGGYFVRGRPADFDGWAVSGWSWAEVRDHFRAIETDHDF
ECCCCHHHHHEEEEECCCCCCCCCEEEECCCCCCCCEEECCCCHHHHHHHHHHHCCCCCC
RDDPLHGSQGPIPVGRRHEQSSAGTELMDLAVNRGYPVVADLNGSAGAGVGLVPLNIDSG
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCEEEEEEECCCC
IRVGPARAYLESAVWRPNLAVYSGTRVLRVLCSGGKATGVQVAVGNSVRTLTADRIILSA
CEECHHHHHHHHHHCCCCEEEECCHHEEHHHHCCCCCCEEEEEECCCEEEEECCEEEEEC
GAIESAKLLLLSGLGPADELRAVGVQPVVDLPGVGTRVMDHAEWVLDTGEQGQQGHPVLD
CCCCCCEEEEEECCCCHHHHHHCCCCCEECCCCCCHHHHHHHHHEECCCCCCCCCCCHHH
TVLHTDHPMCLEIRPYTTGFAAMAGVVADGADARQIGVALMTPQCRGRLELRSTDPAAPV
HHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCCHHEEEEEECCCCCCEEEEECCCCCCCE
YIDLRYDSETADMDRLRDGVHLVSELYGRRFGGPRWSTSQHLCGTAPLGNDRDKHAVVDK
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCHHHHHHH
YCRVRGIDGLFVIDGSILPTIPSRGPAATIAMIGHRAAQFVAWS
HHHHCCCCEEEEECCCEECCCCCCCCCEEHHHHHHHHHHEEECC
>Mature Secondary Structure 
GAGSAGSILAGRLSEDPSFRVVLVEAGPVSSADEAGVRNGYRLPIGPGSQIATYYWATL
CCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCHHHCCCCEEECCCCCCCEEEEEEEEE
TSTGDQAELVRGSVVGGSGAINGGYFVRGRPADFDGWAVSGWSWAEVRDHFRAIETDHDF
ECCCCHHHHHEEEEECCCCCCCCCEEEECCCCCCCCEEECCCCHHHHHHHHHHHCCCCCC
RDDPLHGSQGPIPVGRRHEQSSAGTELMDLAVNRGYPVVADLNGSAGAGVGLVPLNIDSG
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCEEEEEEECCCC
IRVGPARAYLESAVWRPNLAVYSGTRVLRVLCSGGKATGVQVAVGNSVRTLTADRIILSA
CEECHHHHHHHHHHCCCCEEEECCHHEEHHHHCCCCCCEEEEEECCCEEEEECCEEEEEC
GAIESAKLLLLSGLGPADELRAVGVQPVVDLPGVGTRVMDHAEWVLDTGEQGQQGHPVLD
CCCCCCEEEEEECCCCHHHHHHCCCCCEECCCCCCHHHHHHHHHEECCCCCCCCCCCHHH
TVLHTDHPMCLEIRPYTTGFAAMAGVVADGADARQIGVALMTPQCRGRLELRSTDPAAPV
HHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCCHHEEEEEECCCCCCEEEEECCCCCCCE
YIDLRYDSETADMDRLRDGVHLVSELYGRRFGGPRWSTSQHLCGTAPLGNDRDKHAVVDK
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCHHHHHHH
YCRVRGIDGLFVIDGSILPTIPSRGPAATIAMIGHRAAQFVAWS
HHHHCCCCEEEEECCCEECCCCCCCCCEEHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7836301 [H]