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The map label for this gene is adk

Identifier: 169630863

GI number: 169630863

Start: 3838223

End: 3838768

Strand: Reverse

Name: adk

Synonym: MAB_3783c

Alternate gene names: 169630863

Gene position: 3838768-3838223 (Counterclockwise)

Preceding gene: 169630864

Following gene: 169630862

Centisome position: 75.76

GC content: 66.67

Gene sequence:

>546_bases
GTGAGAGTGGTGTTACTCGGCCCGCCCGGGGCAGGCAAAGGTACGCAGGCGCAGCTGATTTCGGAGAAGTTCGGTATTCC
GCAGATCTCCACCGGCGACCTGTTCCGCTCGAACATCAGCGAGGGCACCGAGCTGGGCCTGCAGGCCAAGCAGTACCTGG
ATGCCGGCGACCTGGTGCCCAGCGAGGTGACCAACAAGATGGTCGAGGCGCGTCTCGATGAGCCCGACGCCGCGGCCGGG
TTCATTCTCGACGGCTTCCCGCGCACCGTGGACCAAGCCGATGCGTTGGCTGCCATGGAGGAGGCCCGTGGCGTCACGAT
CGATGCCGTGCTGGAGTTCCGGGTGCCGGTGGAGGAACTCGTGCAGCGCCTGCTGGGCCGTGGCCGCGCCGATGACACCG
AGGACATCATCCGCAACCGGCTCAACGTCTACCGCGATGAGACCGCGCCGCTGCTGGAGTACTACCAGAACGTGCTGCAG
ACCATCGATGCCGTCGGCACGGTGGACGAGGTGTTCGCGCGCACCTCGCAGGCACTGGGCCGGTAG

Upstream 100 bases:

>100_bases
TCGGCGGAACTGCGGTACTCATCATGATCGGCGTGGGCCTCGATACCGTGAAGCAGATTGAAAGCCAGTTGATGCAGCGT
AACTACGAAGGGTTCCTGAA

Downstream 100 bases:

>100_bases
TAGCGAGTTCGTTAGTGGGTCTCTTCGGCCGTAAGAAGACGGTGGAACAGCGCACGCCCGGTGAGCTCGACGCCATGGCT
GCTGCCGGCTCCATCGTGGG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MRVVLLGPPGAGKGTQAQLISEKFGIPQISTGDLFRSNISEGTELGLQAKQYLDAGDLVPSEVTNKMVEARLDEPDAAAG
FILDGFPRTVDQADALAAMEEARGVTIDAVLEFRVPVEELVQRLLGRGRADDTEDIIRNRLNVYRDETAPLLEYYQNVLQ
TIDAVGTVDEVFARTSQALGR

Sequences:

>Translated_181_residues
MRVVLLGPPGAGKGTQAQLISEKFGIPQISTGDLFRSNISEGTELGLQAKQYLDAGDLVPSEVTNKMVEARLDEPDAAAG
FILDGFPRTVDQADALAAMEEARGVTIDAVLEFRVPVEELVQRLLGRGRADDTEDIIRNRLNVYRDETAPLLEYYQNVLQ
TIDAVGTVDEVFARTSQALGR
>Mature_181_residues
MRVVLLGPPGAGKGTQAQLISEKFGIPQISTGDLFRSNISEGTELGLQAKQYLDAGDLVPSEVTNKMVEARLDEPDAAAG
FILDGFPRTVDQADALAAMEEARGVTIDAVLEFRVPVEELVQRLLGRGRADDTEDIIRNRLNVYRDETAPLLEYYQNVLQ
TIDAVGTVDEVFARTSQALGR

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=37.8504672897196, Blast_Score=147, Evalue=5e-36,
Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=37.8504672897196, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI4502011, Length=184, Percent_Identity=34.7826086956522, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI19923437, Length=200, Percent_Identity=34.5, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI310110345, Length=188, Percent_Identity=34.0425531914894, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI53832003, Length=188, Percent_Identity=34.0425531914894, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI8051579, Length=188, Percent_Identity=34.0425531914894, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI53832001, Length=188, Percent_Identity=34.0425531914894, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI7706497, Length=190, Percent_Identity=32.1052631578947, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI28144899, Length=184, Percent_Identity=31.5217391304348, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI28144897, Length=184, Percent_Identity=31.5217391304348, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI22749187, Length=127, Percent_Identity=31.496062992126, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI237858799, Length=167, Percent_Identity=29.3413173652695, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=43.1192660550459, Blast_Score=157, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17552384, Length=221, Percent_Identity=35.2941176470588, Blast_Score=139, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17567503, Length=178, Percent_Identity=40.4494382022472, Blast_Score=116, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17533833, Length=176, Percent_Identity=32.3863636363636, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17550688, Length=175, Percent_Identity=32.5714285714286, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17537943, Length=215, Percent_Identity=27.906976744186, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25147457, Length=190, Percent_Identity=24.2105263157895, Blast_Score=66, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=34.8837209302326, Blast_Score=132, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322828, Length=161, Percent_Identity=32.2981366459627, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321018, Length=186, Percent_Identity=28.494623655914, Blast_Score=85, Evalue=6e-18,
Organism=Drosophila melanogaster, GI22026816, Length=218, Percent_Identity=35.3211009174312, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17737899, Length=187, Percent_Identity=35.2941176470588, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24645822, Length=187, Percent_Identity=35.2941176470588, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24663208, Length=184, Percent_Identity=34.7826086956522, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17647141, Length=184, Percent_Identity=34.7826086956522, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI221459597, Length=179, Percent_Identity=35.195530726257, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI21356893, Length=179, Percent_Identity=35.195530726257, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24582962, Length=170, Percent_Identity=30.5882352941176, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_MYCA9 (B1MGB3)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001704512.1
- ProteinModelPortal:   B1MGB3
- SMR:   B1MGB3
- EnsemblBacteria:   EBMYCT00000004898
- GeneID:   5966275
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_3783c
- GeneTree:   EBGT00050000015504
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- BioCyc:   MABS561007:MAB_3783C-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 19704; Mature: 19704

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVLLGPPGAGKGTQAQLISEKFGIPQISTGDLFRSNISEGTELGLQAKQYLDAGDLVP
CEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCH
SEVTNKMVEARLDEPDAAAGFILDGFPRTVDQADALAAMEEARGVTIDAVLEFRVPVEEL
HHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHH
VQRLLGRGRADDTEDIIRNRLNVYRDETAPLLEYYQNVLQTIDAVGTVDEVFARTSQALG
HHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
R
C
>Mature Secondary Structure
MRVVLLGPPGAGKGTQAQLISEKFGIPQISTGDLFRSNISEGTELGLQAKQYLDAGDLVP
CEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCH
SEVTNKMVEARLDEPDAAAGFILDGFPRTVDQADALAAMEEARGVTIDAVLEFRVPVEEL
HHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHH
VQRLLGRGRADDTEDIIRNRLNVYRDETAPLLEYYQNVLQTIDAVGTVDEVFARTSQALG
HHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA