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The map label for this gene is accD5 [H]

Identifier: 169630710

GI number: 169630710

Start: 3679675

End: 3681324

Strand: Direct

Name: accD5 [H]

Synonym: MAB_3631

Alternate gene names: 169630710

Gene position: 3679675-3681324 (Clockwise)

Preceding gene: 169630702

Following gene: 169630711

Centisome position: 72.62

GC content: 65.88

Gene sequence:

>1650_bases
ATGACGACCACCGAGTCCGACAGCCACACCGCCGCCGACGCCGCGGCTCCCCAGCCCGACATACATACCACCGCGGGCAA
GCTCGCCGATCTGCGTCGGCGCAATGAGGAAGCACTGCACCCGGTAGGTGAGGCCGCCGTCGACAAGATCCACGCCAAGG
GCAAGCTGACCGCCCGCGAGCGCATCTTCGCGCTGTTGGACGAGGGCTCGTTCGTCGAGCTGGATGCGCTGGCCCGCCAC
CGCAGCACCAACTTCGGCCTGGAGTCCAAGCGCCCGCTCGGTGACGGTGTCGTGACCGGTTTCGGCACCATCGACGGCCG
CGACGTCTGCATCTTCAGCCAGGACGTATCGGTCTTCGGCGGCAGCCTCGGTGAGGTCTACGGCGAAAAGATCGTCAAGG
TCATGGACCTGGCCATCAAGACCGGTCGTCCCCTGATCGGCATCAACGAAGGTGCCGGCGCCCGTATTCAAGAGGGCGTC
GTCTCCCTCGGCCTGTACGGCCAGATCTTCCATCGCAACGTCATCGCCTCCGGTGTCATCCCGCAGATCTCGCTGATCAT
GGGTCCCGCGGCCGGTGGCCACGTGTACTCCCCCGCACTGACCGACTTCGTGGTGATGGTCGACCAGACCAGCCAAATGT
TCATCACCGGCCCCGACGTCATCAAGACCGTCACCGGCGAGGACGTCACCATGGAGGAGCTGGGCGGCGCCCACACCCAC
ATGGCCAAGTCCGGCACCGCGCACTACGTGGCCTCCGGCGAGCAGGACGCCTTCGATTACGTCCGCGACATCCTGAGCTA
CCTGCCCTCCAACAATGCCTCCGAGCCCCCGCGCTACCCCGGACCGGAGCCCACCGACGGTGCCATCGAGGACCACCTCA
CCGAGGAAGACCTCGAACTGGACACGCTGATCCCGGACTCCCCGAACCAGCCGTACGACATGCACGAGGTCATCACCCGC
ATCCTCGACGACGACGAATTCCTCGAGGTGCAGGCGGGCTACGCGCAGAACATCATCGTCGGCTTCGGCCGCATCGACGG
CCGCAGCGTGGGCATCGTCGCCAACCAGCCGACCCAGTTCGCCGGCTGCCTGGATATCAACGCGTCCGAGAAGGCCGCAC
GATTCATCCGCACCTGCGACTGCTTCGGCATCCCGATCATCACCCTGGAGGATGTGCCCGGCTTCCTGCCCGGCACCGAG
CAGGAATACAACGGCATCATCCGGCGCGGCGCCAAGCTGCTGTACGCCTACGGTGAGGCCACCGTTCCGAAGATCACCGT
CATCACCCGCAAGGCCTACGGCGGCGCGTACGACGTGATGGGATCCAAGCACATGGGTGCCGACGTCAACGTCGCATGGC
CCACCGCGCAGATCGCCGTCATGGGCGCATCGGGTGCCGTCGGGTTCGTGTACCGCTCGCAGCTGGCCGAGGCCGCCAAG
AACGGTGACGACGTGGATGCCCTGCGCCTTCAGCTGCAGGCGGAGTACGAAGACACCCTGGTGAACCCCTACATCGCCGC
CGAGCGCGGATACGTCGACGCGGTCATCCCGCCGTCGCACACCCGCGGCTACATCGCTACGTCGCTGCGCTTGCTCGATC
GCAAGATCGTGCGGCTCCCACCGAAGAAGCACGGAAACATTCCGCTGTGA

Upstream 100 bases:

>100_bases
TATCTACCGCGATCGGCGGACATCTCTTCGTGAAAATTTCTGAGAACTCTCTAAGGCCCATGCGTGTTCTGCCGGGTGGC
GCGCGATAGCATCGGGACCC

Downstream 100 bases:

>100_bases
CCAATGAAGAAGGTACGTCCGTGACCGACGAGACCGTAGCCGCTGAAGCGAACCCCGGCGGGGAGGGCCGAGTCAAGGCC
GCCGACATCCAAGTGCTCAG

Product: propionyl-CoA carboxylase beta chain 5 AccD5

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MTTTESDSHTAADAAAPQPDIHTTAGKLADLRRRNEEALHPVGEAAVDKIHAKGKLTARERIFALLDEGSFVELDALARH
RSTNFGLESKRPLGDGVVTGFGTIDGRDVCIFSQDVSVFGGSLGEVYGEKIVKVMDLAIKTGRPLIGINEGAGARIQEGV
VSLGLYGQIFHRNVIASGVIPQISLIMGPAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTH
MAKSGTAHYVASGEQDAFDYVRDILSYLPSNNASEPPRYPGPEPTDGAIEDHLTEEDLELDTLIPDSPNQPYDMHEVITR
ILDDDEFLEVQAGYAQNIIVGFGRIDGRSVGIVANQPTQFAGCLDINASEKAARFIRTCDCFGIPIITLEDVPGFLPGTE
QEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYDVMGSKHMGADVNVAWPTAQIAVMGASGAVGFVYRSQLAEAAK
NGDDVDALRLQLQAEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIATSLRLLDRKIVRLPPKKHGNIPL

Sequences:

>Translated_549_residues
MTTTESDSHTAADAAAPQPDIHTTAGKLADLRRRNEEALHPVGEAAVDKIHAKGKLTARERIFALLDEGSFVELDALARH
RSTNFGLESKRPLGDGVVTGFGTIDGRDVCIFSQDVSVFGGSLGEVYGEKIVKVMDLAIKTGRPLIGINEGAGARIQEGV
VSLGLYGQIFHRNVIASGVIPQISLIMGPAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTH
MAKSGTAHYVASGEQDAFDYVRDILSYLPSNNASEPPRYPGPEPTDGAIEDHLTEEDLELDTLIPDSPNQPYDMHEVITR
ILDDDEFLEVQAGYAQNIIVGFGRIDGRSVGIVANQPTQFAGCLDINASEKAARFIRTCDCFGIPIITLEDVPGFLPGTE
QEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYDVMGSKHMGADVNVAWPTAQIAVMGASGAVGFVYRSQLAEAAK
NGDDVDALRLQLQAEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIATSLRLLDRKIVRLPPKKHGNIPL
>Mature_548_residues
TTTESDSHTAADAAAPQPDIHTTAGKLADLRRRNEEALHPVGEAAVDKIHAKGKLTARERIFALLDEGSFVELDALARHR
STNFGLESKRPLGDGVVTGFGTIDGRDVCIFSQDVSVFGGSLGEVYGEKIVKVMDLAIKTGRPLIGINEGAGARIQEGVV
SLGLYGQIFHRNVIASGVIPQISLIMGPAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHM
AKSGTAHYVASGEQDAFDYVRDILSYLPSNNASEPPRYPGPEPTDGAIEDHLTEEDLELDTLIPDSPNQPYDMHEVITRI
LDDDEFLEVQAGYAQNIIVGFGRIDGRSVGIVANQPTQFAGCLDINASEKAARFIRTCDCFGIPIITLEDVPGFLPGTEQ
EYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYDVMGSKHMGADVNVAWPTAQIAVMGASGAVGFVYRSQLAEAAKN
GDDVDALRLQLQAEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIATSLRLLDRKIVRLPPKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=522, Percent_Identity=54.9808429118774, Blast_Score=552, Evalue=1e-157,
Organism=Homo sapiens, GI295821216, Length=542, Percent_Identity=53.1365313653137, Blast_Score=540, Evalue=1e-153,
Organism=Homo sapiens, GI11545863, Length=498, Percent_Identity=31.3253012048193, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI1788655, Length=191, Percent_Identity=28.7958115183246, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25147359, Length=514, Percent_Identity=53.5019455252918, Blast_Score=549, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI25147362, Length=514, Percent_Identity=53.5019455252918, Blast_Score=548, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17552936, Length=532, Percent_Identity=30.6390977443609, Blast_Score=230, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71997163, Length=406, Percent_Identity=23.6453201970443, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24586065, Length=543, Percent_Identity=31.4917127071823, Blast_Score=236, Evalue=4e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 59028; Mature: 58897

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTESDSHTAADAAAPQPDIHTTAGKLADLRRRNEEALHPVGEAAVDKIHAKGKLTARE
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCHHHHHHHHHHHCCCCCHHHH
RIFALLDEGSFVELDALARHRSTNFGLESKRPLGDGVVTGFGTIDGRDVCIFSQDVSVFG
HHHHEECCCCEEEHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCHHHHC
GSLGEVYGEKIVKVMDLAIKTGRPLIGINEGAGARIQEGVVSLGLYGQIFHRNVIASGVI
CCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PQISLIMGPAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTH
CEEEEEECCCCCCCCCCCHHHEEEEEEECCCEEEEECCHHHEECCCCCEEHHHHCCCHHH
MAKSGTAHYVASGEQDAFDYVRDILSYLPSNNASEPPRYPGPEPTDGAIEDHLTEEDLEL
HHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCE
DTLIPDSPNQPYDMHEVITRILDDDEFLEVQAGYAQNIIVGFGRIDGRSVGIVANQPTQF
EEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCEEEEEECCCCCE
AGCLDINASEKAARFIRTCDCFGIPIITLEDVPGFLPGTEQEYNGIIRRGAKLLYAYGEA
EEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHCCEEEEEECCC
TVPKITVITRKAYGGAYDVMGSKHMGADVNVAWPTAQIAVMGASGAVGFVYRSQLAEAAK
CCCEEEEEEEECCCCEEECCCCCCCCCCCEEECCCEEEEEEECCCCCHHHHHHHHHHHHC
NGDDVDALRLQLQAEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIATSLRLLDRKIVRLP
CCCCCEEEEEEEEECHHHHHCCCEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCC
PKKHGNIPL
CCCCCCCCC
>Mature Secondary Structure 
TTTESDSHTAADAAAPQPDIHTTAGKLADLRRRNEEALHPVGEAAVDKIHAKGKLTARE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCHHHHHHHHHHHCCCCCHHHH
RIFALLDEGSFVELDALARHRSTNFGLESKRPLGDGVVTGFGTIDGRDVCIFSQDVSVFG
HHHHEECCCCEEEHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCHHHHC
GSLGEVYGEKIVKVMDLAIKTGRPLIGINEGAGARIQEGVVSLGLYGQIFHRNVIASGVI
CCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PQISLIMGPAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTH
CEEEEEECCCCCCCCCCCHHHEEEEEEECCCEEEEECCHHHEECCCCCEEHHHHCCCHHH
MAKSGTAHYVASGEQDAFDYVRDILSYLPSNNASEPPRYPGPEPTDGAIEDHLTEEDLEL
HHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCE
DTLIPDSPNQPYDMHEVITRILDDDEFLEVQAGYAQNIIVGFGRIDGRSVGIVANQPTQF
EEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCEEEEEECCCCCE
AGCLDINASEKAARFIRTCDCFGIPIITLEDVPGFLPGTEQEYNGIIRRGAKLLYAYGEA
EEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHCCEEEEEECCC
TVPKITVITRKAYGGAYDVMGSKHMGADVNVAWPTAQIAVMGASGAVGFVYRSQLAEAAK
CCCEEEEEEEECCCCEEECCCCCCCCCCCEEECCCEEEEEEECCCCCHHHHHHHHHHHHC
NGDDVDALRLQLQAEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIATSLRLLDRKIVRLP
CCCCCEEEEEEEEECHHHHHCCCEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCC
PKKHGNIPL
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]