Click here to switch to the map view.

The map label for this gene is rmlD [H]

Identifier: 169630693

GI number: 169630693

Start: 3662692

End: 3663540

Strand: Reverse

Name: rmlD [H]

Synonym: MAB_3613c

Alternate gene names: 169630693

Gene position: 3663540-3662692 (Counterclockwise)

Preceding gene: 169630697

Following gene: 169630692

Centisome position: 72.3

GC content: 68.08

Gene sequence:

>849_bases
GTGCTTGTTATCACCGGAGCGGGTGGCCAACTGGGCACCCATCTCATTGCCCGTGCAAAGCTACGCGACCTCCCCGTTCG
CGCCCTGACGTCCTCTGACTGGGATATTACACGCGACGGTACCCCGGACGGAGTAGTTGCTGAGGGTGACATCGTGATCA
ACTGTGCTGCCTATACCGCCGTCGACGCGGCGGAGGAGGACGAGTCCAGGGCGTATGCGGTGAATGCCGAGGGCGCGGAG
CGTGTGGCGCGGGCCTGCCGGGACGTGGGTGCCAGGCTGATCCATATCTCCACCGACTATGTATTCGACGGTGAGTTCGG
CGACGCCGGCCCGCGGCCCTATCGTCCGGGTGACGCCACTGCTCCCCAGGGTGTCTACGCACGTACCAAGGTGGCAGGGG
AGCTCGCGGTTCACGGGGTATTGCCGTCAGCGCAGGTGGTCCGCACCGCCTGGGTCTACACCGGCGTGAACGGCGACTTC
GTCGGTGTCATGCGGCGGTTGGCGGCCGGCGAGGGGCCGGTACGGGTGGTGACCGACCAGACCGGCTCTCCGACGTACGC
GGTCGACCTCGCCGAGGCACTGTTGGACCTGGCGGCCTCGGATGTCCGGGAACCCTTCCTGCATGCCGCCGGCAGCGGCC
ACGTGAACCGGTTCGAATGGGCCAAGGCCGTATTCGAGCTGGTGGGAGCGGACGCCTCCCGGTTGCAGCCCTGCCTGTCC
GTCGACTTCCCGCGGCCGGCGCCGCGGCCGGCGTACACCGCGCTGGACGGTGATCACTGGGCCGATGCCGGGTTGCCGCG
GTTGCGTCCGTGGCGGGACGCGTTGGCTGAGGCGTTGGCCACAAACTAA

Upstream 100 bases:

>100_bases
CGGCCGGGCCTTCGCCCGGCAACAGTCCTAGGCCTGACTCAGGCTACGTCGGGGTGCCGCCCATCCTTCGGAAGCGAACT
CGGCGTGCCAGACTCTAGGT

Downstream 100 bases:

>100_bases
GGATGGGTACCCTCTAGCACCGTGCTGGATCCTCATCGCGTAAGCGACTCCCCGGCGATCGGTCAGGTCGCCGTGGTGAC
GGTGACGTACTCGCCCGGCG

Product: dTDP-rhamnose modification protein RmlD

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MLVITGAGGQLGTHLIARAKLRDLPVRALTSSDWDITRDGTPDGVVAEGDIVINCAAYTAVDAAEEDESRAYAVNAEGAE
RVARACRDVGARLIHISTDYVFDGEFGDAGPRPYRPGDATAPQGVYARTKVAGELAVHGVLPSAQVVRTAWVYTGVNGDF
VGVMRRLAAGEGPVRVVTDQTGSPTYAVDLAEALLDLAASDVREPFLHAAGSGHVNRFEWAKAVFELVGADASRLQPCLS
VDFPRPAPRPAYTALDGDHWADAGLPRLRPWRDALAEALATN

Sequences:

>Translated_282_residues
MLVITGAGGQLGTHLIARAKLRDLPVRALTSSDWDITRDGTPDGVVAEGDIVINCAAYTAVDAAEEDESRAYAVNAEGAE
RVARACRDVGARLIHISTDYVFDGEFGDAGPRPYRPGDATAPQGVYARTKVAGELAVHGVLPSAQVVRTAWVYTGVNGDF
VGVMRRLAAGEGPVRVVTDQTGSPTYAVDLAEALLDLAASDVREPFLHAAGSGHVNRFEWAKAVFELVGADASRLQPCLS
VDFPRPAPRPAYTALDGDHWADAGLPRLRPWRDALAEALATN
>Mature_282_residues
MLVITGAGGQLGTHLIARAKLRDLPVRALTSSDWDITRDGTPDGVVAEGDIVINCAAYTAVDAAEEDESRAYAVNAEGAE
RVARACRDVGARLIHISTDYVFDGEFGDAGPRPYRPGDATAPQGVYARTKVAGELAVHGVLPSAQVVRTAWVYTGVNGDF
VGVMRRLAAGEGPVRVVTDQTGSPTYAVDLAEALLDLAASDVREPFLHAAGSGHVNRFEWAKAVFELVGADASRLQPCLS
VDFPRPAPRPAYTALDGDHWADAGLPRLRPWRDALAEALATN

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galacta

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=238, Percent_Identity=29.8319327731092, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI33519455, Length=238, Percent_Identity=29.8319327731092, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1788352, Length=288, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 29884; Mature: 29884

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVITGAGGQLGTHLIARAKLRDLPVRALTSSDWDITRDGTPDGVVAEGDIVINCAAYTA
CEEEECCCCHHHHHHHHHHHHHCCCHHEECCCCCCEECCCCCCCEEECCCEEEEEEHHHH
VDAAEEDESRAYAVNAEGAERVARACRDVGARLIHISTDYVFDGEFGDAGPRPYRPGDAT
HCCCCCCCCCEEEECCCHHHHHHHHHHHHCCEEEEEEECEEECCCCCCCCCCCCCCCCCC
APQGVYARTKVAGELAVHGVLPSAQVVRTAWVYTGVNGDFVGVMRRLAAGEGPVRVVTDQ
CCCCCHHHHHHHHHHHEECCCCCHHHHHHHHEEECCCCHHHHHHHHHHCCCCCEEEEECC
TGSPTYAVDLAEALLDLAASDVREPFLHAAGSGHVNRFEWAKAVFELVGADASRLQPCLS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHCCHHHC
VDFPRPAPRPAYTALDGDHWADAGLPRLRPWRDALAEALATN
CCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLVITGAGGQLGTHLIARAKLRDLPVRALTSSDWDITRDGTPDGVVAEGDIVINCAAYTA
CEEEECCCCHHHHHHHHHHHHHCCCHHEECCCCCCEECCCCCCCEEECCCEEEEEEHHHH
VDAAEEDESRAYAVNAEGAERVARACRDVGARLIHISTDYVFDGEFGDAGPRPYRPGDAT
HCCCCCCCCCEEEECCCHHHHHHHHHHHHCCEEEEEEECEEECCCCCCCCCCCCCCCCCC
APQGVYARTKVAGELAVHGVLPSAQVVRTAWVYTGVNGDFVGVMRRLAAGEGPVRVVTDQ
CCCCCHHHHHHHHHHHEECCCCCHHHHHHHHEEECCCCHHHHHHHHHHCCCCCEEEEECC
TGSPTYAVDLAEALLDLAASDVREPFLHAAGSGHVNRFEWAKAVFELVGADASRLQPCLS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHCCHHHC
VDFPRPAPRPAYTALDGDHWADAGLPRLRPWRDALAEALATN
CCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]