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The map label for this gene is uvrD [H]

Identifier: 169630592

GI number: 169630592

Start: 3552723

End: 3554792

Strand: Reverse

Name: uvrD [H]

Synonym: MAB_3511c

Alternate gene names: 169630592

Gene position: 3554792-3552723 (Counterclockwise)

Preceding gene: 169630594

Following gene: 169630591

Centisome position: 70.15

GC content: 66.62

Gene sequence:

>2070_bases
GTGGCGCGCTCTCTTCTCGATGGTCTCGATGACGAGCAGCGTGCCGCCGTCACCGCTCCGCGCGGCCCCGTCTGCGTGCT
CGCTGGGGCCGGAACAGGCAAGACGCGCACAATTACCCATCGCATCGCCTATTTGGTCGCATCCGGCCATGTCGCCGCGG
GCCAGATTCTGGCTGTCACCTTCACCCAGCGGGCGGCGGGGGAGATGCGGGGTCGGCTGCGTGACCTGGGTGTCGGATCC
GCGCAGGCCGTCACATTTCACGCGGCCGGTCTACGGCAGCTCCGGTATTTCTGGCCGCAGTTGGTCGGCGATACCCGCTG
GGAGCTGATCGACAGCAAGTTCACCCTCGTCGCGCAGGCCGCGAACCGCGCCAAGGTGAGCACCACCACCGACACCGTGC
GTGACCTCGCCGGTGAAATCGAGTGGGCCAAGGCGTCTTTGATCAGCCCGGAGACATATCCGGCCGCCGCCGCCAAGTTC
GGCAGGGACGCGCCGGTGCCGGCCGAACAGGTGGCCAAGGTCTACGCGGGCTACGAAAAACTCAAGGCCCGGCCCGATGG
GTCCACCCTTCTCGACTTCGACGACCTGCTGCTTCATACCGCGGCCGCCATCGAGAACTCGGCAGCCGTCGCCGAGGAGT
TCCGGGACCGTTATCGCTGTTTCGTCGTCGACGAGTACCAGGACGTGACCCCGCTGCAGCAGCGGGTGCTCGACGCGTGG
CTGGGGCCGCGCGATGACGTGACGGTAGTGGGCGACGCCAACCAGACCATCTACTCGTTCACCGGTGCCACTCCGCAGTA
CCTGCTTGGCTTCTCGCGCAGATTTCCCGATGCGACGGTGGTCCGTCTGGAACGCGACTATCGTTCGACGCCGCAAGTGG
TTTCGCTGGCCAATCGGTTGATCTCGGCCGCGCAGGGCCGGGTGGCCGGCAGCAAGCTGCAACTGATCGGTCAGCGGCCA
CAGGGGCCTGCCCCCAGGTTTTCCGAGCATGACGACGAGGCGGCAGAGGCCAAGTCTGTTGCGAAATCCATTGCGGCACT
GATTGAATCCGGAACCCCCGCCTCCGAGGTCGCGGTGTTGTACCGCATCAACGCACAGTCTGAGGTGTACGAGGAGGCGC
TGACCGAGGCCGGCATCCCGTTTCAAGTGCGTGGCGGCGAAGGGTTCTTCACGCGGCAGGAGGTGCGGCAGGCGTTGGTG
GCGCTGCAACGCGCAGCCGGCCGTGAGGATGCGGGAATGCCTGTGCCAGAACAGGTGCGGGAGATTCTGGAACCGTTGGG
ATTGTCGCAGGAAGAGCCGCACGGAACCCAGGCGCGCGAACGGTGGGAATCGCTGCGGGCACTTGTCGAACTTGCCGACG
AGGAGTGTGCTCGTCAGCCGGAGCTGGATCTGCCCGGGCTCGTGCGCGAGCTGCGGGTACGCGCCGAGGCGCGCCATCCA
CCGACCGTGCAGGGCGTGACGCTGGCGTCGCTGCACGCGGCCAAGGGCCTGGAATGGGACGCGGTGTTCCTGGTGGGGCT
CGCCGACGGCACCCTACCCATCTCGCATGCACTGTCGCGCGCCGGTGATATCGAGCCGGTGGAGGAAGAGCGCCGCCTGC
TGTACGTGGGAATCACTCGCGCCCGTGTGCATTTGAACTTGAGCTGGGCGCTGTCGCGCGCCGCCGGCGGGCGTAAGTCG
CGTAAGCATTCACGATTCCTCAACGGAATCGCCCCGACCGCGCAACTTCCCGCTTCTGCCACGCCCAGGCGCCGCGGCGG
TGGCGCGCGCTGCCGTGTCTGCAATGCGGCGCTGAGCACGCCCGCCGCAGTGCTGCTGCGGCGCTGCGAGAGCTGCCCGT
CCGATATCGACGAGGAACTGCTTGTCGCACTGAAGGATTGGCGGCTCAAGACGGCCAAGGAAATGAAGGTTCCGGCGTTC
GTGGTCTTCACCGACAACACGTTGATCGCCATCGCCGAACTGCTTCCCGGCGACGATGCCGCTCTGGTCGCCATTCCCGG
GATCGGTGCGCGCAAGCTGGAGCAGTACGGCCCCGACGTATTGCGTCTGGTGCGTGCCAGATCCTCGTGA

Upstream 100 bases:

>100_bases
CAACGTCATACCCCGAGGGGGTGTTCCGCCGGGGGTGTGAGATCTGTCAACAGCGGGGTGGGGGCGGTGTGTTGTCGGCC
GTTGCTGAGAGGATGGCTGG

Downstream 100 bases:

>100_bases
TCGCTTGTTGAACACGTGTCTAGCGCGGATCGCGATCTCGTCCTAGGCTCGGCCCATGGCCGATGATGACCTCCGCGATT
TCGAAGCAGGCACCTTCACT

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 689; Mature: 688

Protein sequence:

>689_residues
MARSLLDGLDDEQRAAVTAPRGPVCVLAGAGTGKTRTITHRIAYLVASGHVAAGQILAVTFTQRAAGEMRGRLRDLGVGS
AQAVTFHAAGLRQLRYFWPQLVGDTRWELIDSKFTLVAQAANRAKVSTTTDTVRDLAGEIEWAKASLISPETYPAAAAKF
GRDAPVPAEQVAKVYAGYEKLKARPDGSTLLDFDDLLLHTAAAIENSAAVAEEFRDRYRCFVVDEYQDVTPLQQRVLDAW
LGPRDDVTVVGDANQTIYSFTGATPQYLLGFSRRFPDATVVRLERDYRSTPQVVSLANRLISAAQGRVAGSKLQLIGQRP
QGPAPRFSEHDDEAAEAKSVAKSIAALIESGTPASEVAVLYRINAQSEVYEEALTEAGIPFQVRGGEGFFTRQEVRQALV
ALQRAAGREDAGMPVPEQVREILEPLGLSQEEPHGTQARERWESLRALVELADEECARQPELDLPGLVRELRVRAEARHP
PTVQGVTLASLHAAKGLEWDAVFLVGLADGTLPISHALSRAGDIEPVEEERRLLYVGITRARVHLNLSWALSRAAGGRKS
RKHSRFLNGIAPTAQLPASATPRRRGGGARCRVCNAALSTPAAVLLRRCESCPSDIDEELLVALKDWRLKTAKEMKVPAF
VVFTDNTLIAIAELLPGDDAALVAIPGIGARKLEQYGPDVLRLVRARSS

Sequences:

>Translated_689_residues
MARSLLDGLDDEQRAAVTAPRGPVCVLAGAGTGKTRTITHRIAYLVASGHVAAGQILAVTFTQRAAGEMRGRLRDLGVGS
AQAVTFHAAGLRQLRYFWPQLVGDTRWELIDSKFTLVAQAANRAKVSTTTDTVRDLAGEIEWAKASLISPETYPAAAAKF
GRDAPVPAEQVAKVYAGYEKLKARPDGSTLLDFDDLLLHTAAAIENSAAVAEEFRDRYRCFVVDEYQDVTPLQQRVLDAW
LGPRDDVTVVGDANQTIYSFTGATPQYLLGFSRRFPDATVVRLERDYRSTPQVVSLANRLISAAQGRVAGSKLQLIGQRP
QGPAPRFSEHDDEAAEAKSVAKSIAALIESGTPASEVAVLYRINAQSEVYEEALTEAGIPFQVRGGEGFFTRQEVRQALV
ALQRAAGREDAGMPVPEQVREILEPLGLSQEEPHGTQARERWESLRALVELADEECARQPELDLPGLVRELRVRAEARHP
PTVQGVTLASLHAAKGLEWDAVFLVGLADGTLPISHALSRAGDIEPVEEERRLLYVGITRARVHLNLSWALSRAAGGRKS
RKHSRFLNGIAPTAQLPASATPRRRGGGARCRVCNAALSTPAAVLLRRCESCPSDIDEELLVALKDWRLKTAKEMKVPAF
VVFTDNTLIAIAELLPGDDAALVAIPGIGARKLEQYGPDVLRLVRARSS
>Mature_688_residues
ARSLLDGLDDEQRAAVTAPRGPVCVLAGAGTGKTRTITHRIAYLVASGHVAAGQILAVTFTQRAAGEMRGRLRDLGVGSA
QAVTFHAAGLRQLRYFWPQLVGDTRWELIDSKFTLVAQAANRAKVSTTTDTVRDLAGEIEWAKASLISPETYPAAAAKFG
RDAPVPAEQVAKVYAGYEKLKARPDGSTLLDFDDLLLHTAAAIENSAAVAEEFRDRYRCFVVDEYQDVTPLQQRVLDAWL
GPRDDVTVVGDANQTIYSFTGATPQYLLGFSRRFPDATVVRLERDYRSTPQVVSLANRLISAAQGRVAGSKLQLIGQRPQ
GPAPRFSEHDDEAAEAKSVAKSIAALIESGTPASEVAVLYRINAQSEVYEEALTEAGIPFQVRGGEGFFTRQEVRQALVA
LQRAAGREDAGMPVPEQVREILEPLGLSQEEPHGTQARERWESLRALVELADEECARQPELDLPGLVRELRVRAEARHPP
TVQGVTLASLHAAKGLEWDAVFLVGLADGTLPISHALSRAGDIEPVEEERRLLYVGITRARVHLNLSWALSRAAGGRKSR
KHSRFLNGIAPTAQLPASATPRRRGGGARCRVCNAALSTPAAVLLRRCESCPSDIDEELLVALKDWRLKTAKEMKVPAFV
VFTDNTLIAIAELLPGDDAALVAIPGIGARKLEQYGPDVLRLVRARSS

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=413, Percent_Identity=36.319612590799, Blast_Score=218, Evalue=1e-57,
Organism=Escherichia coli, GI48994965, Length=408, Percent_Identity=33.0882352941176, Blast_Score=179, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6322369, Length=436, Percent_Identity=27.2935779816514, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324477, Length=387, Percent_Identity=23.7726098191214, Blast_Score=110, Evalue=7e-25,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR002121
- InterPro:   IPR014016
- InterPro:   IPR010997 [H]

Pfam domain/function: PF00570 HRDC; PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 74773; Mature: 74642

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARSLLDGLDDEQRAAVTAPRGPVCVLAGAGTGKTRTITHRIAYLVASGHVAAGQILAVT
CCCCHHCCCCCCCHHEEECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEE
FTQRAAGEMRGRLRDLGVGSAQAVTFHAAGLRQLRYFWPQLVGDTRWELIDSKFTLVAQA
EHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHH
ANRAKVSTTTDTVRDLAGEIEWAKASLISPETYPAAAAKFGRDAPVPAEQVAKVYAGYEK
CCCCCCCCHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHH
LKARPDGSTLLDFDDLLLHTAAAIENSAAVAEEFRDRYRCFVVDEYQDVTPLQQRVLDAW
HHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHH
LGPRDDVTVVGDANQTIYSFTGATPQYLLGFSRRFPDATVVRLERDYRSTPQVVSLANRL
CCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEEHHCCCCHHHHHHHHHH
ISAAQGRVAGSKLQLIGQRPQGPAPRFSEHDDEAAEAKSVAKSIAALIESGTPASEVAVL
HHHHCCCCCCCHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHEEEE
YRINAQSEVYEEALTEAGIPFQVRGGEGFFTRQEVRQALVALQRAAGREDAGMPVPEQVR
EEECCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
EILEPLGLSQEEPHGTQARERWESLRALVELADEECARQPELDLPGLVRELRVRAEARHP
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCC
PTVQGVTLASLHAAKGLEWDAVFLVGLADGTLPISHALSRAGDIEPVEEERRLLYVGITR
CCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCHHCCEEEEEEEEE
ARVHLNLSWALSRAAGGRKSRKHSRFLNGIAPTAQLPASATPRRRGGGARCRVCNAALST
EEEEEEEHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHCC
PAAVLLRRCESCPSDIDEELLVALKDWRLKTAKEMKVPAFVVFTDNTLIAIAELLPGDDA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCCCC
ALVAIPGIGARKLEQYGPDVLRLVRARSS
EEEEECCCCHHHHHHHCHHHHHHHHHCCC
>Mature Secondary Structure 
ARSLLDGLDDEQRAAVTAPRGPVCVLAGAGTGKTRTITHRIAYLVASGHVAAGQILAVT
CCCHHCCCCCCCHHEEECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEE
FTQRAAGEMRGRLRDLGVGSAQAVTFHAAGLRQLRYFWPQLVGDTRWELIDSKFTLVAQA
EHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHH
ANRAKVSTTTDTVRDLAGEIEWAKASLISPETYPAAAAKFGRDAPVPAEQVAKVYAGYEK
CCCCCCCCHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHH
LKARPDGSTLLDFDDLLLHTAAAIENSAAVAEEFRDRYRCFVVDEYQDVTPLQQRVLDAW
HHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHH
LGPRDDVTVVGDANQTIYSFTGATPQYLLGFSRRFPDATVVRLERDYRSTPQVVSLANRL
CCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEEHHCCCCHHHHHHHHHH
ISAAQGRVAGSKLQLIGQRPQGPAPRFSEHDDEAAEAKSVAKSIAALIESGTPASEVAVL
HHHHCCCCCCCHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHEEEE
YRINAQSEVYEEALTEAGIPFQVRGGEGFFTRQEVRQALVALQRAAGREDAGMPVPEQVR
EEECCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
EILEPLGLSQEEPHGTQARERWESLRALVELADEECARQPELDLPGLVRELRVRAEARHP
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCC
PTVQGVTLASLHAAKGLEWDAVFLVGLADGTLPISHALSRAGDIEPVEEERRLLYVGITR
CCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCHHCCEEEEEEEEE
ARVHLNLSWALSRAAGGRKSRKHSRFLNGIAPTAQLPASATPRRRGGGARCRVCNAALST
EEEEEEEHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHCC
PAAVLLRRCESCPSDIDEELLVALKDWRLKTAKEMKVPAFVVFTDNTLIAIAELLPGDDA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCCCC
ALVAIPGIGARKLEQYGPDVLRLVRARSS
EEEEECCCCHHHHHHHCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]