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The map label for this gene is gltC [H]

Identifier: 169630389

GI number: 169630389

Start: 3347355

End: 3348263

Strand: Direct

Name: gltC [H]

Synonym: MAB_3308

Alternate gene names: 169630389

Gene position: 3347355-3348263 (Clockwise)

Preceding gene: 169630383

Following gene: 169630393

Centisome position: 66.06

GC content: 59.74

Gene sequence:

>909_bases
ATGGAACTTCGACAGTTGGAGCATTTCGTGGCCGTTGCTGGCGAGATGAGCTTCTCTCGAGCCGTGCAGCGCGCCCACGT
TGTTCAGTCCGCGCTGTCCACGTCGGTGGGCAAGTTGGAGAAAGAGCTCGGAGTCGAATTGTTCGACCGAACGCGGCAAC
AGATCCGATTGACTCCAGCCGGAGAGCTTTTCCACACTCATGCGACCCGGGTGATTCAGGCCGCTCGGTACGCCAAAGAT
TCCATCGGCAACTTCCGTGGCGAGCTGACCGGCACTGTCGATCTCGGCGCACTTATTACCTTCGGCCCGTTAGATGTACC
CAAAATGCTGGGCCAATTCCACCGCGAATACCCGCTGGTTCAAATCAGGCTGCGCCAAAGCCAGAGCGGCTCGAACGCAT
ATCTTTCGGCCATCGCCGACGGAACCCTTGATCTGGCTCTCGTCTCAGCACCCGATCGGTTTCCAGCAGGCATCCAGATG
CGGCTGCTGTGCCAAGAGCCCATGATGTTTGTCTGCCGACCCGACCATCGGCTGGCGCAACGACGTCACGTCACCGTCAC
CGAACTCGTCGACGAGCACCTTATTGGTTTTCCGCCTCAATTCAGCTTGCGCCGCATAGTGGAGGACGCCTTCACTGCTG
CAGGCGTTACGGCATTCACACCGCACGAAGTCGCCCTCGAATACGCGATCGCCGCCAGTTTGGTCCATCACGGGCTGGGC
ACTATCTTCATGCCCGCCAGCGAAGCGGCCCAATTCCCACACCTGCGCGCGCTAGCCGTACGCCCAGCCATCATATGGAA
GATCTACCTGGCCTCCGCCGAACAATCCCAGCTCGGACCAGCCAGCGCCCAACTTGCAGAACACCTCGTCGCATCGGCCC
ACGCTCAAACGAACTCACCCAAGACATAG

Upstream 100 bases:

>100_bases
CCTTTCGTCCGTGTTGTCCTTCCATCACAGCCGCCGGGAGTCATCTAGTCCAACAGATCTTTTTGATAGATTCCATCTAC
AAAACAGATGAGGGTGGCGG

Downstream 100 bases:

>100_bases
GCGCTCCACTCAAGGCGAGCGAAAGCGGATGGCGACGAATGCCGCGCCGCCTCTGCCGTACGCGCAGAGGCGGCGCAGTC
GATGAGACCCTGCTATTCAG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MELRQLEHFVAVAGEMSFSRAVQRAHVVQSALSTSVGKLEKELGVELFDRTRQQIRLTPAGELFHTHATRVIQAARYAKD
SIGNFRGELTGTVDLGALITFGPLDVPKMLGQFHREYPLVQIRLRQSQSGSNAYLSAIADGTLDLALVSAPDRFPAGIQM
RLLCQEPMMFVCRPDHRLAQRRHVTVTELVDEHLIGFPPQFSLRRIVEDAFTAAGVTAFTPHEVALEYAIAASLVHHGLG
TIFMPASEAAQFPHLRALAVRPAIIWKIYLASAEQSQLGPASAQLAEHLVASAHAQTNSPKT

Sequences:

>Translated_302_residues
MELRQLEHFVAVAGEMSFSRAVQRAHVVQSALSTSVGKLEKELGVELFDRTRQQIRLTPAGELFHTHATRVIQAARYAKD
SIGNFRGELTGTVDLGALITFGPLDVPKMLGQFHREYPLVQIRLRQSQSGSNAYLSAIADGTLDLALVSAPDRFPAGIQM
RLLCQEPMMFVCRPDHRLAQRRHVTVTELVDEHLIGFPPQFSLRRIVEDAFTAAGVTAFTPHEVALEYAIAASLVHHGLG
TIFMPASEAAQFPHLRALAVRPAIIWKIYLASAEQSQLGPASAQLAEHLVASAHAQTNSPKT
>Mature_302_residues
MELRQLEHFVAVAGEMSFSRAVQRAHVVQSALSTSVGKLEKELGVELFDRTRQQIRLTPAGELFHTHATRVIQAARYAKD
SIGNFRGELTGTVDLGALITFGPLDVPKMLGQFHREYPLVQIRLRQSQSGSNAYLSAIADGTLDLALVSAPDRFPAGIQM
RLLCQEPMMFVCRPDHRLAQRRHVTVTELVDEHLIGFPPQFSLRRIVEDAFTAAGVTAFTPHEVALEYAIAASLVHHGLG
TIFMPASEAAQFPHLRALAVRPAIIWKIYLASAEQSQLGPASAQLAEHLVASAHAQTNSPKT

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787806, Length=253, Percent_Identity=30.0395256916996, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI157672245, Length=265, Percent_Identity=29.811320754717, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790399, Length=246, Percent_Identity=29.2682926829268, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1787879, Length=300, Percent_Identity=28.6666666666667, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081904, Length=199, Percent_Identity=32.1608040201005, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788748, Length=245, Percent_Identity=30.2040816326531, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI145693105, Length=297, Percent_Identity=24.9158249158249, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788887, Length=252, Percent_Identity=30.952380952381, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787601, Length=177, Percent_Identity=27.683615819209, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI2367136, Length=289, Percent_Identity=25.9515570934256, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788297, Length=258, Percent_Identity=27.5193798449612, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790208, Length=247, Percent_Identity=25.1012145748988, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787530, Length=249, Percent_Identity=26.1044176706827, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1790262, Length=219, Percent_Identity=26.9406392694064, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33140; Mature: 33140

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRQLEHFVAVAGEMSFSRAVQRAHVVQSALSTSVGKLEKELGVELFDRTRQQIRLTPA
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
GELFHTHATRVIQAARYAKDSIGNFRGELTGTVDLGALITFGPLDVPKMLGQFHREYPLV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCHHHHHHHHHHCCCEE
QIRLRQSQSGSNAYLSAIADGTLDLALVSAPDRFPAGIQMRLLCQEPMMFVCRPDHRLAQ
EEEEECCCCCCCHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEECCCEEEEECCCHHHHH
RRHVTVTELVDEHLIGFPPQFSLRRIVEDAFTAAGVTAFTPHEVALEYAIAASLVHHGLG
HCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCC
TIFMPASEAAQFPHLRALAVRPAIIWKIYLASAEQSQLGPASAQLAEHLVASAHAQTNSP
EEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHCCCCC
KT
CC
>Mature Secondary Structure
MELRQLEHFVAVAGEMSFSRAVQRAHVVQSALSTSVGKLEKELGVELFDRTRQQIRLTPA
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
GELFHTHATRVIQAARYAKDSIGNFRGELTGTVDLGALITFGPLDVPKMLGQFHREYPLV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCHHHHHHHHHHCCCEE
QIRLRQSQSGSNAYLSAIADGTLDLALVSAPDRFPAGIQMRLLCQEPMMFVCRPDHRLAQ
EEEEECCCCCCCHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEECCCEEEEECCCHHHHH
RRHVTVTELVDEHLIGFPPQFSLRRIVEDAFTAAGVTAFTPHEVALEYAIAASLVHHGLG
HCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCC
TIFMPASEAAQFPHLRALAVRPAIIWKIYLASAEQSQLGPASAQLAEHLVASAHAQTNSP
EEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHCCCCC
KT
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]