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The map label for this gene is ung

Identifier: 169630364

GI number: 169630364

Start: 3321845

End: 3322525

Strand: Reverse

Name: ung

Synonym: MAB_3283c

Alternate gene names: 169630364

Gene position: 3322525-3321845 (Counterclockwise)

Preceding gene: 169630365

Following gene: 169630363

Centisome position: 65.57

GC content: 66.08

Gene sequence:

>681_bases
GTGACTGCCCGACCTCTTGCCGAGTTGGTTGACCCCGGCTGGGCCGATGCGCTGGGGCCCGTCGCCGACCAGGTGACCAA
GATGGGAGAGTTCCTCCGCGAGGAGAACTCCTCGGGCCGCGGATACCTGCCCTCCGGGGCAAACGTGCTGCGCGCCTTCA
CCTATCCGTTGGCCGACGTCCGCGTGCTCATCGTGGGGCAAGACCCCTACCCGACACCCGGACATGCCATGGGGCTGAGC
TTCTCGGTGGCGGCCGATGTACGGCCGGTGCCGCGCAGCCTGGGCAACATCTTCGACGAGTACCAGAGTGATCTTGGCCT
ACCCAAGCCGGCCAATGGAGATCTGACACCGTGGTCGGAGCAGGGGGTAATGCTGTTGAACAGGGTGTTGACGGTACGGC
CCGGCAACCCGGCGTCCCATCGCGGTAAGGGTTGGGAGATCGTCACCGAATGCGCGATCCGGGCGCTTGTCGCGCGCGAC
GCACCCTTGGTCGCCATTCTGTGGGGTCGCGACGCGGCGACACTCAAGCCGATGCTGGGCCCGAGCGTACCCACCATCGA
ATCTGTGCACCCGTCCCCATTGTCGGCCTCGCGCGGCTTCTTTGGTTCCAAACCCTTCAGCCGGGCGAATGAGCTGCTGG
TCGGTTTGGGCGCACAGCCGGTCGACTGGCGGTTGCCGTAA

Upstream 100 bases:

>100_bases
GATCGGCCGGGTAACGGTGGGGGAACCCGGAGTGACGGTTGACGGGGCAGCATGGACTCGGGCAACCGGTTGGGACTCGT
TTCGGCTAAGTTGACTCTTC

Downstream 100 bases:

>100_bases
TGCGTTGGTCGACGGGAGCGTTCGCGGCGCTCGGCGGTATCACGGCGGCGGTGGCGACCGGTGGCACCGCGCTGCGCAGC
CCCGTGGTGGTTGATCGACT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MTARPLAELVDPGWADALGPVADQVTKMGEFLREENSSGRGYLPSGANVLRAFTYPLADVRVLIVGQDPYPTPGHAMGLS
FSVAADVRPVPRSLGNIFDEYQSDLGLPKPANGDLTPWSEQGVMLLNRVLTVRPGNPASHRGKGWEIVTECAIRALVARD
APLVAILWGRDAATLKPMLGPSVPTIESVHPSPLSASRGFFGSKPFSRANELLVGLGAQPVDWRLP

Sequences:

>Translated_226_residues
MTARPLAELVDPGWADALGPVADQVTKMGEFLREENSSGRGYLPSGANVLRAFTYPLADVRVLIVGQDPYPTPGHAMGLS
FSVAADVRPVPRSLGNIFDEYQSDLGLPKPANGDLTPWSEQGVMLLNRVLTVRPGNPASHRGKGWEIVTECAIRALVARD
APLVAILWGRDAATLKPMLGPSVPTIESVHPSPLSASRGFFGSKPFSRANELLVGLGAQPVDWRLP
>Mature_225_residues
TARPLAELVDPGWADALGPVADQVTKMGEFLREENSSGRGYLPSGANVLRAFTYPLADVRVLIVGQDPYPTPGHAMGLSF
SVAADVRPVPRSLGNIFDEYQSDLGLPKPANGDLTPWSEQGVMLLNRVLTVRPGNPASHRGKGWEIVTECAIRALVARDA
PLVAILWGRDAATLKPMLGPSVPTIESVHPSPLSASRGFFGSKPFSRANELLVGLGAQPVDWRLP

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=200, Percent_Identity=40.5, Blast_Score=140, Evalue=8e-34,
Organism=Homo sapiens, GI6224979, Length=200, Percent_Identity=40.5, Blast_Score=140, Evalue=9e-34,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=38.6046511627907, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17556304, Length=203, Percent_Identity=37.9310344827586, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323620, Length=238, Percent_Identity=36.1344537815126, Blast_Score=130, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_MYCA9 (B1MDP0)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001704013.1
- ProteinModelPortal:   B1MDP0
- SMR:   B1MDP0
- EnsemblBacteria:   EBMYCT00000007604
- GeneID:   5965783
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_3283c
- GeneTree:   EBGT00050000017143
- HOGENOM:   HBG605450
- OMA:   VMLLNRV
- BioCyc:   MABS561007:MAB_3283C-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 24182; Mature: 24051

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 68-68

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARPLAELVDPGWADALGPVADQVTKMGEFLREENSSGRGYLPSGANVLRAFTYPLADV
CCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHCCCCCE
RVLIVGQDPYPTPGHAMGLSFSVAADVRPVPRSLGNIFDEYQSDLGLPKPANGDLTPWSE
EEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
QGVMLLNRVLTVRPGNPASHRGKGWEIVTECAIRALVARDAPLVAILWGRDAATLKPMLG
CCHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCC
PSVPTIESVHPSPLSASRGFFGSKPFSRANELLVGLGAQPVDWRLP
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHEEECCCCCCCCCCC
>Mature Secondary Structure 
TARPLAELVDPGWADALGPVADQVTKMGEFLREENSSGRGYLPSGANVLRAFTYPLADV
CCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHCCCCCE
RVLIVGQDPYPTPGHAMGLSFSVAADVRPVPRSLGNIFDEYQSDLGLPKPANGDLTPWSE
EEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
QGVMLLNRVLTVRPGNPASHRGKGWEIVTECAIRALVARDAPLVAILWGRDAATLKPMLG
CCHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCC
PSVPTIESVHPSPLSASRGFFGSKPFSRANELLVGLGAQPVDWRLP
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA