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The map label for this gene is lexA

Identifier: 169630121

GI number: 169630121

Start: 3089783

End: 3090457

Strand: Direct

Name: lexA

Synonym: MAB_3038

Alternate gene names: 169630121

Gene position: 3089783-3090457 (Clockwise)

Preceding gene: 169630118

Following gene: 169630124

Centisome position: 60.98

GC content: 65.04

Gene sequence:

>675_bases
ATGAGCGATACACCCAGCAAGGGACCCGCCACCGGTTCACTGACCGAGCGCCAGCGGACCATCCTGGAGGTCATCCGCGC
ATCGGTGAATGAGCGGGGCTATCCCCCGAGCATCCGCGAAATCGGAGACGCCGTCGGGCTCACCTCCACCTCGTCAGTCG
CCCACCAACTACGCACCCTTGAACAGAAGGGCTTTCTGCGGCGTGATCCCAATCGTCCACGCGCCGTTGATGTTCGGGGA
ATCGATGACGCGGGCACTCCATCGGCGACCACCGACGTGATCGGCTCGGGCGACCTGCCGGAGCCGACATTCGTGCCTGT
GCTCGGGCGCATTGCCGCCGGCGGTCCCATCCTCGCCGAGGAGGCCGTCGAAGATGTGTTCCCACTCCCCCGCGAGCTTG
TCGGCGAGGGCTCGTTGTTCCTGCTCAAGGTGGTTGGCGAGTCGATGGTGGACGCCGCGATCTGCGACGGCGACTGGGTG
GTGGTCCGCCAGCAGAACGTGGCCGACAACGGCGACATCGTGGCCGCGATGATCGACGGAGAAGCGACCGTCAAGACGTT
CAAGCGGACATCGGGCCAGGTCTGGCTGATGCCGCACAATCCACTCTTCGAGCCGATTCCCGGCAACGACGCCGCCATTC
TGGGCAAGGTCGTCACCGTTATCCGGAAGGTCTAG

Upstream 100 bases:

>100_bases
CTGCCCCGTTACCCTCCCGGGGCGACCCGGCGCCCCCTATTTGCGACACGCATCGAACACATGTTTGATATATGCCGTCG
ACAGGGCTAGATTCGGGCCC

Downstream 100 bases:

>100_bases
GCCTCCCCGGGCGCCGGCCCCGGCGCGCGGGAATCGCCGGCGGAGGTCAAGAACAGCTGAAAATGCGTGACGTCATGCCA
GCTGCCCAGCTTGTATCCAA

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MSDTPSKGPATGSLTERQRTILEVIRASVNERGYPPSIREIGDAVGLTSTSSVAHQLRTLEQKGFLRRDPNRPRAVDVRG
IDDAGTPSATTDVIGSGDLPEPTFVPVLGRIAAGGPILAEEAVEDVFPLPRELVGEGSLFLLKVVGESMVDAAICDGDWV
VVRQQNVADNGDIVAAMIDGEATVKTFKRTSGQVWLMPHNPLFEPIPGNDAAILGKVVTVIRKV

Sequences:

>Translated_224_residues
MSDTPSKGPATGSLTERQRTILEVIRASVNERGYPPSIREIGDAVGLTSTSSVAHQLRTLEQKGFLRRDPNRPRAVDVRG
IDDAGTPSATTDVIGSGDLPEPTFVPVLGRIAAGGPILAEEAVEDVFPLPRELVGEGSLFLLKVVGESMVDAAICDGDWV
VVRQQNVADNGDIVAAMIDGEATVKTFKRTSGQVWLMPHNPLFEPIPGNDAAILGKVVTVIRKV
>Mature_223_residues
SDTPSKGPATGSLTERQRTILEVIRASVNERGYPPSIREIGDAVGLTSTSSVAHQLRTLEQKGFLRRDPNRPRAVDVRGI
DDAGTPSATTDVIGSGDLPEPTFVPVLGRIAAGGPILAEEAVEDVFPLPRELVGEGSLFLLKVVGESMVDAAICDGDWVV
VRQQNVADNGDIVAAMIDGEATVKTFKRTSGQVWLMPHNPLFEPIPGNDAAILGKVVTVIRKV

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=194, Percent_Identity=31.4432989690722, Blast_Score=103, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA_MYCA9 (B1MCZ5)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001703770.1
- ProteinModelPortal:   B1MCZ5
- SMR:   B1MCZ5
- MEROPS:   S24.001
- EnsemblBacteria:   EBMYCT00000004698
- GeneID:   5965545
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_3038
- GeneTree:   EBGT00050000016631
- HOGENOM:   HBG679610
- OMA:   IAENPDF
- ProtClustDB:   PRK00215
- BioCyc:   MABS561007:MAB_3038-MONOMER
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 23828; Mature: 23697

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: ACT_SITE 148-148 ACT_SITE 185-185

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTPSKGPATGSLTERQRTILEVIRASVNERGYPPSIREIGDAVGLTSTSSVAHQLRTL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHH
EQKGFLRRDPNRPRAVDVRGIDDAGTPSATTDVIGSGDLPEPTFVPVLGRIAAGGPILAE
HHCCCCCCCCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHCCCCHHHH
EAVEDVFPLPRELVGEGSLFLLKVVGESMVDAAICDGDWVVVRQQNVADNGDIVAAMIDG
HHHHHHCCCCHHHHCCCCEEEHHHHHHHHHHHEEECCCEEEEECCCCCCCCCEEEEEECC
EATVKTFKRTSGQVWLMPHNPLFEPIPGNDAAILGKVVTVIRKV
CHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDTPSKGPATGSLTERQRTILEVIRASVNERGYPPSIREIGDAVGLTSTSSVAHQLRTL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHH
EQKGFLRRDPNRPRAVDVRGIDDAGTPSATTDVIGSGDLPEPTFVPVLGRIAAGGPILAE
HHCCCCCCCCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHCCCCHHHH
EAVEDVFPLPRELVGEGSLFLLKVVGESMVDAAICDGDWVVVRQQNVADNGDIVAAMIDG
HHHHHHCCCCHHHHCCCCEEEHHHHHHHHHHHEEECCCEEEEECCCCCCCCCEEEEEECC
EATVKTFKRTSGQVWLMPHNPLFEPIPGNDAAILGKVVTVIRKV
CHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA