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The map label for this gene is dctA1 [H]

Identifier: 169630021

GI number: 169630021

Start: 2993475

End: 2994836

Strand: Direct

Name: dctA1 [H]

Synonym: MAB_2938

Alternate gene names: 169630021

Gene position: 2993475-2994836 (Clockwise)

Preceding gene: 169630019

Following gene: 169630022

Centisome position: 59.08

GC content: 64.17

Gene sequence:

>1362_bases
ATGCCGACCGCGATCGAGGTACCCGCCAGCGAGATGGTGCGTCTGGCGAACAAGCCGCCCTGGTATCGCTCGCTATTCGT
CCAGCTTCTGGTGGCGATCGTCGCAGGTGTGGTCATCGGCTGGCTGTGGCCGGGCCTGGGCGCCGACCTGCGCCCCTTGG
CCGACGGTTTCATCAAGCTGATCAAGATGCTGATCGCCCCGATCATCTTCTGCACGGTGGTGCTCGGCATCGCCCATGTC
GGCGACCTCAAGTCCGTCGGCCGCATCGGCGTCAAGGCGCTCATCTACTTCGAGGCGGTAACCACCTTCGCGCTGCTCTT
CGGCCTGCTGGTGGGAAATCTCGCCAAGCCGGGAGCGGGCTTTCACATCGACGCCGGGACGCTGGCGACCGGGGCCGACG
CCATCGCGAAGAAGACCAACAACGGGGAGCTACCCCACACCGTCGAGTTCCTGCTCGGCATCATCCCCTCATCCATCGTC
TCGGCCTTCGCCGAAAACGCCTTGCTTCAGGTGCTGTTCTTCGCGGTGCTGTTCGGCCTGGCGCTGGCCAAGTTCGGCGA
ATCAGGTCCGCCAGTGGTACTCGAATTCATCGACCACCTCAGCCACATCTTCTTCACCATCATCGGGTGGATCATGCGGC
TGGCGCCGGTGGGAGCGCTTGGCGCGATGGCCTACATCGTGGGCCAGTACGGCATCGGCTCGTTGAGCAGCTACGGCAAG
CTCATCGCCGCCTGCTATGCCGCCGCGCTGCTGTTCATCGGCGTTCTGGCGGTGATCGCCCGGCTCTTCGCGGGGGTGAA
CCTCTGGAGGTTCGTCGTCTACATCAAGGACGAATTGTTCCTGGCTCTCGGCACCGCCTCCACCGAGGTGGTATTGCCGC
GCATCATGACCAAGCTCAACCACGCGGGGTGCTCCAAGACCACCACCGGGCTGGTCATCCCCACCGGGTACTCCTTCAAT
CTCGACGGAGCCACCTTGTATCTGTCGATCTGCGTGCTCTTCCTTGCCCAGGCCCTGGGGGTCAACCTGACCCTCGGCGA
ACAGATCACCGCGGTGCTGGTGCTGATGTTGACCTCGAAAGGCATGGCGGGCGTGCCGGGTTCGTCATTCCTCGCACTCT
CGGCGACCGTGGCCGCCATAGGCCACGGCGCCATCCCGGTGGCAGCCGTTGCGCTGCTGCTGGGCGCCGATCGCATCATG
GACTCGATGCGCGTCTCGGTGAACCTACTGGGCAATTGCGTGGCGACGCTGGTGGTGGCCCAGTGGGAAGGCCAGCTCGA
TAAGGACCGCATGTGCAAGGTTCTCGCTGGTCAACAGGTCGTGAACGAGCCCGAGGGGGAATCGGCAGCTGCACACCCCT
GA

Upstream 100 bases:

>100_bases
GGTTCCATCTCCCTATCGAACCGCACACCCATGTCGTGCGTAATACGGGCTGAATCCGGTGTTCACATCCAATAAACAGG
CCGTGGTTACGGTCGCGCCC

Downstream 100 bases:

>100_bases
GCACCGCACCCACGAGTCTGCGAACATGGGACCCGTGGCAGCGGCATCCTCATCGAACCCAGTAGATGCCGGCAGCCCCG
GCTGGCTGACTCCGATCGCG

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MPTAIEVPASEMVRLANKPPWYRSLFVQLLVAIVAGVVIGWLWPGLGADLRPLADGFIKLIKMLIAPIIFCTVVLGIAHV
GDLKSVGRIGVKALIYFEAVTTFALLFGLLVGNLAKPGAGFHIDAGTLATGADAIAKKTNNGELPHTVEFLLGIIPSSIV
SAFAENALLQVLFFAVLFGLALAKFGESGPPVVLEFIDHLSHIFFTIIGWIMRLAPVGALGAMAYIVGQYGIGSLSSYGK
LIAACYAAALLFIGVLAVIARLFAGVNLWRFVVYIKDELFLALGTASTEVVLPRIMTKLNHAGCSKTTTGLVIPTGYSFN
LDGATLYLSICVLFLAQALGVNLTLGEQITAVLVLMLTSKGMAGVPGSSFLALSATVAAIGHGAIPVAAVALLLGADRIM
DSMRVSVNLLGNCVATLVVAQWEGQLDKDRMCKVLAGQQVVNEPEGESAAAHP

Sequences:

>Translated_453_residues
MPTAIEVPASEMVRLANKPPWYRSLFVQLLVAIVAGVVIGWLWPGLGADLRPLADGFIKLIKMLIAPIIFCTVVLGIAHV
GDLKSVGRIGVKALIYFEAVTTFALLFGLLVGNLAKPGAGFHIDAGTLATGADAIAKKTNNGELPHTVEFLLGIIPSSIV
SAFAENALLQVLFFAVLFGLALAKFGESGPPVVLEFIDHLSHIFFTIIGWIMRLAPVGALGAMAYIVGQYGIGSLSSYGK
LIAACYAAALLFIGVLAVIARLFAGVNLWRFVVYIKDELFLALGTASTEVVLPRIMTKLNHAGCSKTTTGLVIPTGYSFN
LDGATLYLSICVLFLAQALGVNLTLGEQITAVLVLMLTSKGMAGVPGSSFLALSATVAAIGHGAIPVAAVALLLGADRIM
DSMRVSVNLLGNCVATLVVAQWEGQLDKDRMCKVLAGQQVVNEPEGESAAAHP
>Mature_452_residues
PTAIEVPASEMVRLANKPPWYRSLFVQLLVAIVAGVVIGWLWPGLGADLRPLADGFIKLIKMLIAPIIFCTVVLGIAHVG
DLKSVGRIGVKALIYFEAVTTFALLFGLLVGNLAKPGAGFHIDAGTLATGADAIAKKTNNGELPHTVEFLLGIIPSSIVS
AFAENALLQVLFFAVLFGLALAKFGESGPPVVLEFIDHLSHIFFTIIGWIMRLAPVGALGAMAYIVGQYGIGSLSSYGKL
IAACYAAALLFIGVLAVIARLFAGVNLWRFVVYIKDELFLALGTASTEVVLPRIMTKLNHAGCSKTTTGLVIPTGYSFNL
DGATLYLSICVLFLAQALGVNLTLGEQITAVLVLMLTSKGMAGVPGSSFLALSATVAAIGHGAIPVAAVALLLGADRIMD
SMRVSVNLLGNCVATLVVAQWEGQLDKDRMCKVLAGQQVVNEPEGESAAAHP

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=485, Percent_Identity=25.1546391752577, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI21314632, Length=399, Percent_Identity=26.0651629072682, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI4827012, Length=449, Percent_Identity=24.4988864142539, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI5032093, Length=379, Percent_Identity=27.4406332453826, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI223468566, Length=249, Percent_Identity=30.5220883534137, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI223468564, Length=249, Percent_Identity=30.5220883534137, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI66773030, Length=402, Percent_Identity=24.6268656716418, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI194239697, Length=427, Percent_Identity=21.5456674473068, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI40254478, Length=250, Percent_Identity=27.2, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI262359914, Length=390, Percent_Identity=25.6410256410256, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1789947, Length=432, Percent_Identity=46.5277777777778, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1790514, Length=424, Percent_Identity=41.0377358490566, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1788024, Length=383, Percent_Identity=22.4543080939948, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71996953, Length=464, Percent_Identity=27.5862068965517, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17537407, Length=428, Percent_Identity=23.5981308411215, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71983099, Length=501, Percent_Identity=22.9540918163673, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71983106, Length=501, Percent_Identity=22.9540918163673, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI193206505, Length=468, Percent_Identity=23.5042735042735, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17541374, Length=437, Percent_Identity=21.9679633867277, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI193206654, Length=413, Percent_Identity=22.0338983050847, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24583025, Length=410, Percent_Identity=23.6585365853659, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI17137668, Length=410, Percent_Identity=23.6585365853659, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24583023, Length=410, Percent_Identity=23.6585365853659, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI281360481, Length=488, Percent_Identity=23.3606557377049, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281360483, Length=488, Percent_Identity=23.3606557377049, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17137666, Length=488, Percent_Identity=23.3606557377049, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47508; Mature: 47377

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PTAIEVPASEMVRLANKPPWYRSLFVQLLVAIVAGVVIGWLWPGLGADLRPLADGFIKL
CCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
IKMLIAPIIFCTVVLGIAHVGDLKSVGRIGVKALIYFEAVTTFALLFGLLVGNLAKPGAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FHIDAGTLATGADAIAKKTNNGELPHTVEFLLGIIPSSIVSAFAENALLQVLFFAVLFGL
CEECCCCHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAKFGESGPPVVLEFIDHLSHIFFTIIGWIMRLAPVGALGAMAYIVGQYGIGSLSSYGK
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHH
LIAACYAAALLFIGVLAVIARLFAGVNLWRFVVYIKDELFLALGTASTEVVLPRIMTKLN
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHH
HAGCSKTTTGLVIPTGYSFNLDGATLYLSICVLFLAQALGVNLTLGEQITAVLVLMLTSK
HCCCCCCCCCEEEECCCEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
GMAGVPGSSFLALSATVAAIGHGAIPVAAVALLLGADRIMDSMRVSVNLLGNCVATLVVA
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QWEGQLDKDRMCKVLAGQQVVNEPEGESAAAHP
HHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA