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The map label for this gene is panE [C]

Identifier: 169629992

GI number: 169629992

Start: 2958699

End: 2959724

Strand: Reverse

Name: panE [C]

Synonym: MAB_2908c

Alternate gene names: 169629992

Gene position: 2959724-2958699 (Counterclockwise)

Preceding gene: 169629993

Following gene: 169629990

Centisome position: 58.41

GC content: 63.65

Gene sequence:

>1026_bases
ATGAGAATCGCCGTCGCCGGAGCCGGCAGTATCGGTTGCTACGTGGGCGGCAGGCTGCAGGCCGCGGGGCACCAGGTCGT
GTACATCGGCCGCCCGAGCCTCGGTCGGGCGATCGCGGAGCACGGTCTGAGCCTGTCGGACTACCTTGGATGGTCGGCCG
CCATCCCGGCATCGGAGTGCGCATTCTCCGAGGACATTGACACCGTCCGCTCAGCGGACATCGTGTTGGTGACCGTGAAG
TCGGCCGCGACCGCGCAGATGGCGGAATCGCTGGCAGGCAGGCTAGAGCCCGGTGCCGTGGTGGTGAGCCTGCAGAATGG
GATCCGCAATCCAGCGCAGCTGTCGCGATACATAAAGCAGCACAATGTGATTACTGGAATTGTCGGCTTCAATGTTGCTC
AGGTAGGGGCGGCACACTTTCATCAGGGCACGCAGGGAAAACTGTCACTCTCCACGGGAGCCGAGTCGCTTGCCGGGGCT
CTCACGCACGGAGGATTGCTCACCACGGTGCGTGACGACATGGCCGCGGTGCAGTGGGGAAAGCTCGTGGTGAACCTCAA
CAACTCGGTCAATGCGTTATCGGGGCTACCGCTGAAAGCCGAACTGGGGGATCGCGACTACCGGCTGGTACTCGCCGCAG
CTCAGCGTGAGGCGCTCGGACTCCTGCGCCGTGCCGGCCAGCCAGTGGTCAGCCCTCTTGCGGCACCGCTTTCGCTCATG
CCCTGGGTGCTCACGATGCCTAACCCCATCTTTACCCGGGCCGCGCGACAGATGGTTGCGATGGACCCACAGGCACGCTC
ATCCATGCTTGACGACATCACCCTCGGCAGACCGACCGAAATCGACTACATCAACGGCGAAGTCGTCGAACTTGCCAAGA
GGCTTGGCGCCAAGGCACCCGTTAACGCCGCGCTGGTCAGTCTCATCCGCGACGTGACCTCCTCCCACGAGATAACGAGA
TGGCCGGGCCCAAAACTGCGCCGCGAGATCAACCATCGCGCCGCGGCGAGCCACATGCTCAGTTGA

Upstream 100 bases:

>100_bases
GCAAAGATTTCTGCGGCCAGGCAGTGATCGTGGGAATTCATCGTCTGGACTATGGGTGTCATTCATTGGTAGTCAGGTGG
AGCGGTCGGGCTGGAGCACA

Downstream 100 bases:

>100_bases
AGACGCCGGACATCTTCATGATCAGCAAGACCGCGGTCGCTAGAAACAAGCCCAGAAGCACGGCAAGCGCAATCATCGAC
ACCATCGCAGGTACCGAAGT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MRIAVAGAGSIGCYVGGRLQAAGHQVVYIGRPSLGRAIAEHGLSLSDYLGWSAAIPASECAFSEDIDTVRSADIVLVTVK
SAATAQMAESLAGRLEPGAVVVSLQNGIRNPAQLSRYIKQHNVITGIVGFNVAQVGAAHFHQGTQGKLSLSTGAESLAGA
LTHGGLLTTVRDDMAAVQWGKLVVNLNNSVNALSGLPLKAELGDRDYRLVLAAAQREALGLLRRAGQPVVSPLAAPLSLM
PWVLTMPNPIFTRAARQMVAMDPQARSSMLDDITLGRPTEIDYINGEVVELAKRLGAKAPVNAALVSLIRDVTSSHEITR
WPGPKLRREINHRAAASHMLS

Sequences:

>Translated_341_residues
MRIAVAGAGSIGCYVGGRLQAAGHQVVYIGRPSLGRAIAEHGLSLSDYLGWSAAIPASECAFSEDIDTVRSADIVLVTVK
SAATAQMAESLAGRLEPGAVVVSLQNGIRNPAQLSRYIKQHNVITGIVGFNVAQVGAAHFHQGTQGKLSLSTGAESLAGA
LTHGGLLTTVRDDMAAVQWGKLVVNLNNSVNALSGLPLKAELGDRDYRLVLAAAQREALGLLRRAGQPVVSPLAAPLSLM
PWVLTMPNPIFTRAARQMVAMDPQARSSMLDDITLGRPTEIDYINGEVVELAKRLGAKAPVNAALVSLIRDVTSSHEITR
WPGPKLRREINHRAAASHMLS
>Mature_341_residues
MRIAVAGAGSIGCYVGGRLQAAGHQVVYIGRPSLGRAIAEHGLSLSDYLGWSAAIPASECAFSEDIDTVRSADIVLVTVK
SAATAQMAESLAGRLEPGAVVVSLQNGIRNPAQLSRYIKQHNVITGIVGFNVAQVGAAHFHQGTQGKLSLSTGAESLAGA
LTHGGLLTTVRDDMAAVQWGKLVVNLNNSVNALSGLPLKAELGDRDYRLVLAAAQREALGLLRRAGQPVVSPLAAPLSLM
PWVLTMPNPIFTRAARQMVAMDPQARSSMLDDITLGRPTEIDYINGEVVELAKRLGAKAPVNAALVSLIRDVTSSHEITR
WPGPKLRREINHRAAASHMLS

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 36003; Mature: 36003

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAVAGAGSIGCYVGGRLQAAGHQVVYIGRPSLGRAIAEHGLSLSDYLGWSAAIPASEC
CEEEEECCCCEEEEECCEEECCCCEEEEECCCCHHHHHHHHCCCHHHHCCCCCCCCHHHH
AFSEDIDTVRSADIVLVTVKSAATAQMAESLAGRLEPGAVVVSLQNGIRNPAQLSRYIKQ
CCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHH
HNVITGIVGFNVAQVGAAHFHQGTQGKLSLSTGAESLAGALTHGGLLTTVRDDMAAVQWG
CCCEEEEHHCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCEEEHHHHHHHHHHHC
KLVVNLNNSVNALSGLPLKAELGDRDYRLVLAAAQREALGLLRRAGQPVVSPLAAPLSLM
EEEEEECCCCHHHCCCCEEECCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHC
PWVLTMPNPIFTRAARQMVAMDPQARSSMLDDITLGRPTEIDYINGEVVELAKRLGAKAP
CHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCC
VNAALVSLIRDVTSSHEITRWPGPKLRREINHRAAASHMLS
HHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIAVAGAGSIGCYVGGRLQAAGHQVVYIGRPSLGRAIAEHGLSLSDYLGWSAAIPASEC
CEEEEECCCCEEEEECCEEECCCCEEEEECCCCHHHHHHHHCCCHHHHCCCCCCCCHHHH
AFSEDIDTVRSADIVLVTVKSAATAQMAESLAGRLEPGAVVVSLQNGIRNPAQLSRYIKQ
CCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHH
HNVITGIVGFNVAQVGAAHFHQGTQGKLSLSTGAESLAGALTHGGLLTTVRDDMAAVQWG
CCCEEEEHHCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCEEEHHHHHHHHHHHC
KLVVNLNNSVNALSGLPLKAELGDRDYRLVLAAAQREALGLLRRAGQPVVSPLAAPLSLM
EEEEEECCCCHHHCCCCEEECCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHC
PWVLTMPNPIFTRAARQMVAMDPQARSSMLDDITLGRPTEIDYINGEVVELAKRLGAKAP
CHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCC
VNAALVSLIRDVTSSHEITRWPGPKLRREINHRAAASHMLS
HHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]