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The map label for this gene is thrS

Identifier: 169629982

GI number: 169629982

Start: 2949359

End: 2951413

Strand: Reverse

Name: thrS

Synonym: MAB_2898c

Alternate gene names: 169629982

Gene position: 2951413-2949359 (Counterclockwise)

Preceding gene: 169629983

Following gene: 169629981

Centisome position: 58.25

GC content: 62.92

Gene sequence:

>2055_bases
ATGACTGCGCCCAACCCGTCTTCCCTTGTGGCCCCAATCCGGGTGCCGGCCGGGACGACGGCGGGGACCGCGGTGCGGGA
GGCCGGCCTGCCCGGCAAGGGCGAGGACGCCATCGTCGTCGTGCGTGTGGATGGTGCGCTCAAGGATTTGTCCTGGACCC
CGGAATCCGACACCGAGGTCGAGCCGGTTGCGGCCAATACCGAGGACGGCCGCAGCGTCATCCGGCACTCGGCCGCCCAT
GTGCTGGCGCAGGCCGTGCAGGAGCTGTTCCCGCAGGCAAAGCTCGGCATCGGCCCGCCGATCACCGACGGCTTCTACTA
TGACTTCGGGATTGATCACGCCTTCACTCCCGAGGACTTGACCGCCCTCGAAAAGAAGATGAAGCAGATCATCAAAGAAG
GGCAACGTTTTTCGCGCCGGGTTTACGAATCGGTAGAAGAGGCCCAGGCCGAGCTCGCCAACGAGCCATTCAAGCTGGAA
TTGGTGTCGGACAAGTCCGGAGCCGATGACCCGGAGGTCATGGAGGTCGGCGGCGACGAGTTATCCGCCTACGACAACCT
GAATCCCCGCACCGGGGAACGGGAATGGTTCGACTTGTGCCGCGGCCCGCATATCCCCACCACCAAGCACATTCCGGCCT
TCCGGCTCACCCGTAGCTCGGCCGCCTACTGGCGTGGTAATCAGGCGAACGCCAGCATGCAGCGTGTCTACGGCACCGCC
TGGGAGTCGCAGGAAGCCCTCGACAAGCATCTCGAGCTGTTGGAAGAGGCGCAGCGGCGCGATCACCGCAAGCTCGGTGT
GGAGCTGGATCTGTTCAGCTTCCCCGATGAAATTGGTTCCGGCCTACCGGTTTTCCATCCGAAGGGTGGCATCGTGCGCA
AGGAGCTGGAGGACTATTCGCGCGCCAAGCACACTGCCGCCGGCTACGAGTTCGTCAACACCCCGCACATCACCAAGGAG
AACCTTTACCAAACCTCGGGTCACCTGGACTGGTACTCCGACGGCATGTTTCCCCCGATGCATATCGACGCCGAACTCAA
TGAGGACGGCACGGTACGCAAGCCGGGCCAGAATTACTACCTCAAGCCCATGAACTGCCCGATGCACCACCTGATCTACC
GGGCACGGGGCCGCTCGTACCGTGAATTGCCCTTGCGGCTCTTCGAATTCGGATCGGTCTACCGATATGAGAAATCCGGT
GTGGTGCACGGATTGACCCGGGTGCGCGGCATGACGCAGGACGACGCGCACATCTACACCACCCGCGAGCAGATGCATGA
GGAGCTGACCTCGCTGCTGCGATTCGTGCTGGACCTGCTGTCCGACTACGGGCTTGATGACTTCTACCTAGAACTGTCGA
CCAAGGACGAGGCGAAATTCGTTGGGTCCGACGAGGTCTGGGAGGAAGCGACCAAGACGCTGGAGCAGGTGGCGCTCGAT
TCAGGGCTGCAGCTGGTGCCGGATCCTGGCGGTGCGGCCTTCTACGGCCCCAAGATCTCGGTGCAGGCCAAGGATGCGCT
GGGACGGTCGTGGCAGATGTCGACCATTCAGCTCGACTTCAACATGCCCGAGCGCTTCAACCTCGAGTACACCGCCGCCG
ACGGCACCCGTAAGCAGCCGGTGCTGATCCACCGTGCTCTCTTCGGATCCATCGAACGGTTCTTCGGTGTGCTCACCGAG
CACTACGCGGGAGCCTTCCCGGCCTGGTTGTCGCCGGTGCAGGCGGTGGGTATCCCGATCGCCGATGCGCACGCGCCATA
TCTGAACGACATTGTTTCGCAGCTCAAAGCGCAGGGCATCCGGGCCGAGGTAGACAGCAGCGATGACCGCATGAACAAGA
AGATCGTCAATCACACCAACCAGCGGGTGCCGTTCTTGCTGCTGGCCGGCGATCGCGATGTCGAGGCGGGCGCCGTCAGC
TTCCGGTTCCGCGACCGTACCCAGGTGAATGGGGTGCCCCGGGACGAGGCTGTCGCCGCCATCGTCGACTGGGTGAACAG
ACGTGAAAACGTCTCGCCGACTGCCGAACTCCTGAAGCTGGGTGCCAGTGACTGA

Upstream 100 bases:

>100_bases
CGGCCTGAGTGCGCATGGCACCCATCGGGCTGGGAAGTGGCTGGTGCGGACCGATAGCATGAGTTCGCAAACCCCCCGTC
TCTGAATTGGAGAACTGCCG

Downstream 100 bases:

>100_bases
CCAGGACTCGACCATCATCGACCGCGGCGTGGGCGACCCGGATCATCTGCAGCGGCTGTGGAGCCCCCACCGGATGAGTT
ACATCGCCGAGGCCGTGAAG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 684; Mature: 683

Protein sequence:

>684_residues
MTAPNPSSLVAPIRVPAGTTAGTAVREAGLPGKGEDAIVVVRVDGALKDLSWTPESDTEVEPVAANTEDGRSVIRHSAAH
VLAQAVQELFPQAKLGIGPPITDGFYYDFGIDHAFTPEDLTALEKKMKQIIKEGQRFSRRVYESVEEAQAELANEPFKLE
LVSDKSGADDPEVMEVGGDELSAYDNLNPRTGEREWFDLCRGPHIPTTKHIPAFRLTRSSAAYWRGNQANASMQRVYGTA
WESQEALDKHLELLEEAQRRDHRKLGVELDLFSFPDEIGSGLPVFHPKGGIVRKELEDYSRAKHTAAGYEFVNTPHITKE
NLYQTSGHLDWYSDGMFPPMHIDAELNEDGTVRKPGQNYYLKPMNCPMHHLIYRARGRSYRELPLRLFEFGSVYRYEKSG
VVHGLTRVRGMTQDDAHIYTTREQMHEELTSLLRFVLDLLSDYGLDDFYLELSTKDEAKFVGSDEVWEEATKTLEQVALD
SGLQLVPDPGGAAFYGPKISVQAKDALGRSWQMSTIQLDFNMPERFNLEYTAADGTRKQPVLIHRALFGSIERFFGVLTE
HYAGAFPAWLSPVQAVGIPIADAHAPYLNDIVSQLKAQGIRAEVDSSDDRMNKKIVNHTNQRVPFLLLAGDRDVEAGAVS
FRFRDRTQVNGVPRDEAVAAIVDWVNRRENVSPTAELLKLGASD

Sequences:

>Translated_684_residues
MTAPNPSSLVAPIRVPAGTTAGTAVREAGLPGKGEDAIVVVRVDGALKDLSWTPESDTEVEPVAANTEDGRSVIRHSAAH
VLAQAVQELFPQAKLGIGPPITDGFYYDFGIDHAFTPEDLTALEKKMKQIIKEGQRFSRRVYESVEEAQAELANEPFKLE
LVSDKSGADDPEVMEVGGDELSAYDNLNPRTGEREWFDLCRGPHIPTTKHIPAFRLTRSSAAYWRGNQANASMQRVYGTA
WESQEALDKHLELLEEAQRRDHRKLGVELDLFSFPDEIGSGLPVFHPKGGIVRKELEDYSRAKHTAAGYEFVNTPHITKE
NLYQTSGHLDWYSDGMFPPMHIDAELNEDGTVRKPGQNYYLKPMNCPMHHLIYRARGRSYRELPLRLFEFGSVYRYEKSG
VVHGLTRVRGMTQDDAHIYTTREQMHEELTSLLRFVLDLLSDYGLDDFYLELSTKDEAKFVGSDEVWEEATKTLEQVALD
SGLQLVPDPGGAAFYGPKISVQAKDALGRSWQMSTIQLDFNMPERFNLEYTAADGTRKQPVLIHRALFGSIERFFGVLTE
HYAGAFPAWLSPVQAVGIPIADAHAPYLNDIVSQLKAQGIRAEVDSSDDRMNKKIVNHTNQRVPFLLLAGDRDVEAGAVS
FRFRDRTQVNGVPRDEAVAAIVDWVNRRENVSPTAELLKLGASD
>Mature_683_residues
TAPNPSSLVAPIRVPAGTTAGTAVREAGLPGKGEDAIVVVRVDGALKDLSWTPESDTEVEPVAANTEDGRSVIRHSAAHV
LAQAVQELFPQAKLGIGPPITDGFYYDFGIDHAFTPEDLTALEKKMKQIIKEGQRFSRRVYESVEEAQAELANEPFKLEL
VSDKSGADDPEVMEVGGDELSAYDNLNPRTGEREWFDLCRGPHIPTTKHIPAFRLTRSSAAYWRGNQANASMQRVYGTAW
ESQEALDKHLELLEEAQRRDHRKLGVELDLFSFPDEIGSGLPVFHPKGGIVRKELEDYSRAKHTAAGYEFVNTPHITKEN
LYQTSGHLDWYSDGMFPPMHIDAELNEDGTVRKPGQNYYLKPMNCPMHHLIYRARGRSYRELPLRLFEFGSVYRYEKSGV
VHGLTRVRGMTQDDAHIYTTREQMHEELTSLLRFVLDLLSDYGLDDFYLELSTKDEAKFVGSDEVWEEATKTLEQVALDS
GLQLVPDPGGAAFYGPKISVQAKDALGRSWQMSTIQLDFNMPERFNLEYTAADGTRKQPVLIHRALFGSIERFFGVLTEH
YAGAFPAWLSPVQAVGIPIADAHAPYLNDIVSQLKAQGIRAEVDSSDDRMNKKIVNHTNQRVPFLLLAGDRDVEAGAVSF
RFRDRTQVNGVPRDEAVAAIVDWVNRRENVSPTAELLKLGASD

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=650, Percent_Identity=36.7692307692308, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI38202255, Length=645, Percent_Identity=35.968992248062, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI20070344, Length=648, Percent_Identity=35.0308641975309, Blast_Score=343, Evalue=4e-94,
Organism=Escherichia coli, GI1788013, Length=634, Percent_Identity=38.801261829653, Blast_Score=486, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI71984184, Length=629, Percent_Identity=35.4531001589825, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI71984192, Length=627, Percent_Identity=35.5661881977671, Blast_Score=382, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6322112, Length=641, Percent_Identity=36.3494539781591, Blast_Score=391, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6322654, Length=406, Percent_Identity=33.9901477832512, Blast_Score=228, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24583842, Length=655, Percent_Identity=35.8778625954198, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI28574141, Length=655, Percent_Identity=35.8778625954198, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24583839, Length=655, Percent_Identity=35.8778625954198, Blast_Score=408, Evalue=1e-114,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_MYCA9 (B1MCK6)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001703631.1
- ProteinModelPortal:   B1MCK6
- SMR:   B1MCK6
- EnsemblBacteria:   EBMYCT00000008482
- GeneID:   5965406
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_2898c
- GeneTree:   EBGT00070000032298
- HOGENOM:   HBG352811
- OMA:   NDETMST
- ProtClustDB:   PRK12305
- BioCyc:   MABS561007:MAB_2898C-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 76413; Mature: 76281

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPNPSSLVAPIRVPAGTTAGTAVREAGLPGKGEDAIVVVRVDGALKDLSWTPESDTEV
CCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCHHCCCCCCCCCCCC
EPVAANTEDGRSVIRHSAAHVLAQAVQELFPQAKLGIGPPITDGFYYDFGIDHAFTPEDL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCEEEECCCCCCCCHHHH
TALEKKMKQIIKEGQRFSRRVYESVEEAQAELANEPFKLELVSDKSGADDPEVMEVGGDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHCCCCH
LSAYDNLNPRTGEREWFDLCRGPHIPTTKHIPAFRLTRSSAAYWRGNQANASMQRVYGTA
HHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCEEEECCCCHHCCCCCCCHHHHHHHHCC
WESQEALDKHLELLEEAQRRDHRKLGVELDLFSFPDEIGSGLPVFHPKGGIVRKELEDYS
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHCCCCCEECCCCCCHHHHHHHHH
RAKHTAAGYEFVNTPHITKENLYQTSGHLDWYSDGMFPPMHIDAELNEDGTVRKPGQNYY
HHHHHHCCCEECCCCCCCHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCEECCCCCCE
LKPMNCPMHHLIYRARGRSYRELPLRLFEFGSVYRYEKSGVVHGLTRVRGMTQDDAHIYT
EECCCCCHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCCCCEEEE
TREQMHEELTSLLRFVLDLLSDYGLDDFYLELSTKDEAKFVGSDEVWEEATKTLEQVALD
CHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHCCCCHHHHHHHHHHHHHHHHH
SGLQLVPDPGGAAFYGPKISVQAKDALGRSWQMSTIQLDFNMPERFNLEYTAADGTRKQP
CCCEEEECCCCCEEECCEEEEEEHHHCCCCEEEEEEEEECCCCCCCCEEEEECCCCCCCC
VLIHRALFGSIERFFGVLTEHYAGAFPAWLSPVQAVGIPIADAHAPYLNDIVSQLKAQGI
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
RAEVDSSDDRMNKKIVNHTNQRVPFLLLAGDRDVEAGAVSFRFRDRTQVNGVPRDEAVAA
EEECCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCHHHHHH
IVDWVNRRENVSPTAELLKLGASD
HHHHHHCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure 
TAPNPSSLVAPIRVPAGTTAGTAVREAGLPGKGEDAIVVVRVDGALKDLSWTPESDTEV
CCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCHHCCCCCCCCCCCC
EPVAANTEDGRSVIRHSAAHVLAQAVQELFPQAKLGIGPPITDGFYYDFGIDHAFTPEDL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCEEEECCCCCCCCHHHH
TALEKKMKQIIKEGQRFSRRVYESVEEAQAELANEPFKLELVSDKSGADDPEVMEVGGDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHCCCCH
LSAYDNLNPRTGEREWFDLCRGPHIPTTKHIPAFRLTRSSAAYWRGNQANASMQRVYGTA
HHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCEEEECCCCHHCCCCCCCHHHHHHHHCC
WESQEALDKHLELLEEAQRRDHRKLGVELDLFSFPDEIGSGLPVFHPKGGIVRKELEDYS
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHCCCCCEECCCCCCHHHHHHHHH
RAKHTAAGYEFVNTPHITKENLYQTSGHLDWYSDGMFPPMHIDAELNEDGTVRKPGQNYY
HHHHHHCCCEECCCCCCCHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCEECCCCCCE
LKPMNCPMHHLIYRARGRSYRELPLRLFEFGSVYRYEKSGVVHGLTRVRGMTQDDAHIYT
EECCCCCHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCCCCEEEE
TREQMHEELTSLLRFVLDLLSDYGLDDFYLELSTKDEAKFVGSDEVWEEATKTLEQVALD
CHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHCCCCHHHHHHHHHHHHHHHHH
SGLQLVPDPGGAAFYGPKISVQAKDALGRSWQMSTIQLDFNMPERFNLEYTAADGTRKQP
CCCEEEECCCCCEEECCEEEEEEHHHCCCCEEEEEEEEECCCCCCCCEEEEECCCCCCCC
VLIHRALFGSIERFFGVLTEHYAGAFPAWLSPVQAVGIPIADAHAPYLNDIVSQLKAQGI
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
RAEVDSSDDRMNKKIVNHTNQRVPFLLLAGDRDVEAGAVSFRFRDRTQVNGVPRDEAVAA
EEECCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCHHHHHH
IVDWVNRRENVSPTAELLKLGASD
HHHHHHCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA