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The map label for this gene is pyrC [H]

Identifier: 169629914

GI number: 169629914

Start: 2881698

End: 2883032

Strand: Reverse

Name: pyrC [H]

Synonym: MAB_2830c

Alternate gene names: 169629914

Gene position: 2883032-2881698 (Counterclockwise)

Preceding gene: 169629915

Following gene: 169629913

Centisome position: 56.9

GC content: 65.47

Gene sequence:

>1335_bases
ATGAGCGTGTTGATCAAGGGCGTACTGCTGTACGGCGAGGGTGACCAGGTCGACGTCCTCATCGAGGACGGTCAGATCAC
CCGCATCGAGGCCGGCATCGGCGCAGGCATCGAGACCGAGGTCGATACGGCCATCGAGGCGCCCGGTCAGATATTGCTGC
CCGGGTTCGTGGACCTGCATACACATCTGCGTGAGCCGGGACGTGAAGACACCGAGACCATCGATTCCGGTTCGGCCGCG
GCCGCGCTCGGCGGCTACACCGCGGTGTTCGCGATGGCCAATACCAACCCCGTCGCCGACAGCCCCGTGGTGACCGACCA
TGTGTGGCAACGTGGTCAGCAGGTAGGCATCGTCGACGTTCATCCGGTCGGTGCGGTCACTGTCGGGCTCGAAGGCAAGC
AACTCACCGAAATGGCGATGATGGCACGCGGTGCGGGCCGGGTGCGGATGTTCTCCGATGACGGCAAGTGCGTGCACGAT
CCGTTGGTGATGCGCCGTGCCCTGGAATACGCCAAGGGACTGGGCGTGCTGATTGCCCAGCATGCCGAGGAACCGCGGCT
CACCGTCGGCTCGGTGGCGCACGAGGGTGCCAACGCGGCTCGGCTGGGCCTGACCGGATGGCCACGCGCCGCCGAAGAAT
CCATCGTCGCGCGCGACGCGATCCTTTCCCGCGACACGGGTGCACCGGTGCACATCTGCCACGCCTCCACTGCCGGGACC
GTTGAACTACTCAAATGGGCCAAGGGGCAAGGGATTTCTATTACCGCCGAGGTGACGCCGCACCATCTGTTGCTCGATGA
TGGCCGATTGTCTTCCTACGACGGTGTGTACCGGGTGAACCCGCCGCTCCGTGAGTCCAGCGACGCCGCGGCGCTGCGCC
AGGCTCTCGCTGACGGAGTGATCGACTGCGTGGCAACCGATCACGCGCCACACGCCGATCACGAGAAATGCTGTGAGTTC
GCCGCGGCCCGCCCGGGAATGCTCGGATTGCAGACCGCGCTATCGGTGGTCGTGCAGACCATGGTGAGACCGGGGTTGCT
CACCTGGCGCGATATCGCCAGGGTGATGAGTGAGCGCCCGGCGCAGATCGTGGGCCTGCCCGACCAAGGGCGCCCGATTG
CCGTCGGTGAGCCCGCCAACCTGACCATCGTGGACCCCGATGCGTCCTGGACTGTCAGTGGCGATGGTTTGGCCAGTAAG
TCGGCCAACACCCCGTTCGAATCAATGACCTTGCCCGCCACGGTGACCGCCACGCTACTGCGTGGCCGCATCACCGCGCG
GGACGGGAGGGTGGCGTCGATGAGTCATCTGTGCGACGAGGATTTGGCACAGTGA

Upstream 100 bases:

>100_bases
CCGGTGTTCTGCAACAGGTATCGAATGGAGTGCATATCCGCATGGCCGTGCTGTTCCACCTGCTGGTCGGGTCCTCCGAT
AGCCCCGAGGCGGTTCCGGC

Downstream 100 bases:

>100_bases
ACCACGGCGACTTCATTGGTGCGCTCATCATGGCGGGCGCCTCACTGACGTTGGCGGTCTTACTCTTCCGCCTGATGTGG
CGCGGTTGGCGCGCCCGCGC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSVLIKGVLLYGEGDQVDVLIEDGQITRIEAGIGAGIETEVDTAIEAPGQILLPGFVDLHTHLREPGREDTETIDSGSAA
AALGGYTAVFAMANTNPVADSPVVTDHVWQRGQQVGIVDVHPVGAVTVGLEGKQLTEMAMMARGAGRVRMFSDDGKCVHD
PLVMRRALEYAKGLGVLIAQHAEEPRLTVGSVAHEGANAARLGLTGWPRAAEESIVARDAILSRDTGAPVHICHASTAGT
VELLKWAKGQGISITAEVTPHHLLLDDGRLSSYDGVYRVNPPLRESSDAAALRQALADGVIDCVATDHAPHADHEKCCEF
AAARPGMLGLQTALSVVVQTMVRPGLLTWRDIARVMSERPAQIVGLPDQGRPIAVGEPANLTIVDPDASWTVSGDGLASK
SANTPFESMTLPATVTATLLRGRITARDGRVASMSHLCDEDLAQ

Sequences:

>Translated_444_residues
MSVLIKGVLLYGEGDQVDVLIEDGQITRIEAGIGAGIETEVDTAIEAPGQILLPGFVDLHTHLREPGREDTETIDSGSAA
AALGGYTAVFAMANTNPVADSPVVTDHVWQRGQQVGIVDVHPVGAVTVGLEGKQLTEMAMMARGAGRVRMFSDDGKCVHD
PLVMRRALEYAKGLGVLIAQHAEEPRLTVGSVAHEGANAARLGLTGWPRAAEESIVARDAILSRDTGAPVHICHASTAGT
VELLKWAKGQGISITAEVTPHHLLLDDGRLSSYDGVYRVNPPLRESSDAAALRQALADGVIDCVATDHAPHADHEKCCEF
AAARPGMLGLQTALSVVVQTMVRPGLLTWRDIARVMSERPAQIVGLPDQGRPIAVGEPANLTIVDPDASWTVSGDGLASK
SANTPFESMTLPATVTATLLRGRITARDGRVASMSHLCDEDLAQ
>Mature_443_residues
SVLIKGVLLYGEGDQVDVLIEDGQITRIEAGIGAGIETEVDTAIEAPGQILLPGFVDLHTHLREPGREDTETIDSGSAAA
ALGGYTAVFAMANTNPVADSPVVTDHVWQRGQQVGIVDVHPVGAVTVGLEGKQLTEMAMMARGAGRVRMFSDDGKCVHDP
LVMRRALEYAKGLGVLIAQHAEEPRLTVGSVAHEGANAARLGLTGWPRAAEESIVARDAILSRDTGAPVHICHASTAGTV
ELLKWAKGQGISITAEVTPHHLLLDDGRLSSYDGVYRVNPPLRESSDAAALRQALADGVIDCVATDHAPHADHEKCCEFA
AARPGMLGLQTALSVVVQTMVRPGLLTWRDIARVMSERPAQIVGLPDQGRPIAVGEPANLTIVDPDASWTVSGDGLASKS
ANTPFESMTLPATVTATLLRGRITARDGRVASMSHLCDEDLAQ

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=382, Percent_Identity=30.6282722513089, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI19923821, Length=471, Percent_Identity=26.1146496815287, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI4503051, Length=455, Percent_Identity=25.0549450549451, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI62422571, Length=455, Percent_Identity=25.0549450549451, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI4503379, Length=457, Percent_Identity=24.2888402625821, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4503375, Length=441, Percent_Identity=24.7165532879819, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1786722, Length=441, Percent_Identity=26.530612244898, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI87082175, Length=443, Percent_Identity=25.9593679458239, Blast_Score=112, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI193204318, Length=387, Percent_Identity=31.7829457364341, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71989490, Length=444, Percent_Identity=24.7747747747748, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI86575075, Length=428, Percent_Identity=25, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17539558, Length=466, Percent_Identity=23.6051502145923, Blast_Score=81, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6322218, Length=449, Percent_Identity=25.6124721603563, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24642586, Length=390, Percent_Identity=31.7948717948718, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI17137462, Length=456, Percent_Identity=25.4385964912281, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18859883, Length=413, Percent_Identity=28.3292978208232, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221377917, Length=467, Percent_Identity=24.8394004282655, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46806; Mature: 46674

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLIKGVLLYGEGDQVDVLIEDGQITRIEAGIGAGIETEVDTAIEAPGQILLPGFVDLH
CCEEEEEEEEECCCCEEEEEEECCCEEEEECCCCCCCCCCHHHHHCCCCCEECCCHHHHH
THLREPGREDTETIDSGSAAAALGGYTAVFAMANTNPVADSPVVTDHVWQRGQQVGIVDV
HHHCCCCCCCHHHHCCCCCHHHHCCEEEEEEEECCCCCCCCCCCHHHHHHCCCEECEEEE
HPVGAVTVGLEGKQLTEMAMMARGAGRVRMFSDDGKCVHDPLVMRRALEYAKGLGVLIAQ
CCCCEEEECCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEC
HAEEPRLTVGSVAHEGANAARLGLTGWPRAAEESIVARDAILSRDTGAPVHICHASTAGT
CCCCCCEEEHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCH
VELLKWAKGQGISITAEVTPHHLLLDDGRLSSYDGVYRVNPPLRESSDAAALRQALADGV
HHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHH
IDCVATDHAPHADHEKCCEFAAARPGMLGLQTALSVVVQTMVRPGLLTWRDIARVMSERP
EEEHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
AQIVGLPDQGRPIAVGEPANLTIVDPDASWTVSGDGLASKSANTPFESMTLPATVTATLL
CEEEECCCCCCEEEECCCCEEEEECCCCCEEECCCCCCCCCCCCCHHHEECCHHHHHHHH
RGRITARDGRVASMSHLCDEDLAQ
HCEEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SVLIKGVLLYGEGDQVDVLIEDGQITRIEAGIGAGIETEVDTAIEAPGQILLPGFVDLH
CEEEEEEEEECCCCEEEEEEECCCEEEEECCCCCCCCCCHHHHHCCCCCEECCCHHHHH
THLREPGREDTETIDSGSAAAALGGYTAVFAMANTNPVADSPVVTDHVWQRGQQVGIVDV
HHHCCCCCCCHHHHCCCCCHHHHCCEEEEEEEECCCCCCCCCCCHHHHHHCCCEECEEEE
HPVGAVTVGLEGKQLTEMAMMARGAGRVRMFSDDGKCVHDPLVMRRALEYAKGLGVLIAQ
CCCCEEEECCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEC
HAEEPRLTVGSVAHEGANAARLGLTGWPRAAEESIVARDAILSRDTGAPVHICHASTAGT
CCCCCCEEEHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCH
VELLKWAKGQGISITAEVTPHHLLLDDGRLSSYDGVYRVNPPLRESSDAAALRQALADGV
HHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHH
IDCVATDHAPHADHEKCCEFAAARPGMLGLQTALSVVVQTMVRPGLLTWRDIARVMSERP
EEEHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
AQIVGLPDQGRPIAVGEPANLTIVDPDASWTVSGDGLASKSANTPFESMTLPATVTATLL
CEEEECCCCCCEEEECCCCEEEEECCCCCEEECCCCCCCCCCCCCHHHEECCHHHHHHHH
RGRITARDGRVASMSHLCDEDLAQ
HCEEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]