| Definition | Mycobacterium abscessus ATCC 19977 chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_010397 |
| Length | 5,067,172 |
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The map label for this gene is coaBC [H]
Identifier: 169629905
GI number: 169629905
Start: 2871386
End: 2872633
Strand: Reverse
Name: coaBC [H]
Synonym: MAB_2821c
Alternate gene names: 169629905
Gene position: 2872633-2871386 (Counterclockwise)
Preceding gene: 169629906
Following gene: 169629904
Centisome position: 56.69
GC content: 66.35
Gene sequence:
>1248_bases ATGTCCCGGATCATCGTCGGAGTGGGTGGAGGAATCGCCGCCTACAAGGCCTGCACCGTGGTGCGCCAGCTCGCCGAGGC CGGGCACAGCGTCCGGGTCGTTCCCACCGAGTCGGCCCTGCAGTTCGTGGGAGCCGCGACCTTTGAGGCGCTCTCCGGTG AGCCGGCCCGTACCGGGGTGTTCGACGATGTTCCCGAGGTTCCGCACGTGCGGCTCGGACAGGATGCCGACCTGGTAGTG GTCGCTCCCGCCACCGCGGACCTGCTGTCGCGTGCCGCCACCGGCCGGGCGGATGACCTGCTGACCGCGACCCTGCTCAC CGCCACGTGTCCAGTGCTGTTCGCCCCCGCGATGCATACGGAGATGTGGCTGCATCCGGCAACCCAGCAGAATGTCGCGA CCCTGCGGAGCCGTGGCGCGGTTGTCCTGGAGCCCGCCTCTGGCCGCCTGACGGGGGCGGACACCGGCCCGGGCCGTCTT CCCGAGGCCGAAGAAATCACCACCCTGGCCCAATTATTGCTGGCACGACCCGACGCGCTGCCGCACGATCTGGCCGGTGT GCGGGTCCTGGTCACCGCCGGCGGCACTCGTGAACCCCTGGACCCGGTGCGCTTTATCGGAAACCGCAGTTCCGGTAAGC AGGGATACGCCATCGCCCGGGTCGCCGCTCAGCGTGGTGCCGAAGTCACGCTCATCGCGGGTCATACCGTCGGCTTACCG GATCCCGCTGGCGTCGAGGTGGTGCATATCAGCTCCGCCGCGCAATTGCAGGACGCTGTCACCAAACACGCTCCTGCGGC CGAAGCGCTGATCATGGCGGCAGCGGTGGCAGATTTCCGGCCGGCCCACGTTGCGACCAGCAAGATCAAAAAGAGCCACG GGGCCGCCGGTGAGAATGACGCGCCCATTGAGTTGCTGCGCAACGCCGATGTGCTGGCCGGTGTGGTTCGTGCGCGTGCA GACGGGCAGCTGCCCAAGATGCGGGCAATCGTCGGGTTTGCCGCGGAAACGGGCGACGCAAACGGCGATGTGCTCTTTCA CGCCCGCGCCAAGTTGAAGCGCAAGGGCTGTGATTTGTTGGTAGTCAACGCTGTTGGCGAGGGACGGGCCTTCGAGGTGG ACAGCAATGACGGGTGGTTGCTCTCGGCGCAGAGTGGTGGTGACATCACCGAAGTTGTCCTTGAACACGGCACCAAAGTT CTGATGGCAAGCCGTATTGTGGATGCCGTTGCCGGGCTTTGTCAGTGA
Upstream 100 bases:
>100_bases GCGCGAGATCCACGGCGACCTGCTCGAGCACACCGAAGGCGAGTAAGAAGCTCTGCGATGAGCCGCTTGCGCGAAGAGCA TCAAGGCTAGGGCGACGTCC
Downstream 100 bases:
>100_bases AGCTGACAACCGGGCATGGCCTCGATCTTGGTTCGTCGGCCATAATGATTAGGACATGTAACGATCTGAAAGGGGCTGCG CTGTGAGCTCAGCTGGACGG
Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 415; Mature: 414
Protein sequence:
>415_residues MSRIIVGVGGGIAAYKACTVVRQLAEAGHSVRVVPTESALQFVGAATFEALSGEPARTGVFDDVPEVPHVRLGQDADLVV VAPATADLLSRAATGRADDLLTATLLTATCPVLFAPAMHTEMWLHPATQQNVATLRSRGAVVLEPASGRLTGADTGPGRL PEAEEITTLAQLLLARPDALPHDLAGVRVLVTAGGTREPLDPVRFIGNRSSGKQGYAIARVAAQRGAEVTLIAGHTVGLP DPAGVEVVHISSAAQLQDAVTKHAPAAEALIMAAAVADFRPAHVATSKIKKSHGAAGENDAPIELLRNADVLAGVVRARA DGQLPKMRAIVGFAAETGDANGDVLFHARAKLKRKGCDLLVVNAVGEGRAFEVDSNDGWLLSAQSGGDITEVVLEHGTKV LMASRIVDAVAGLCQ
Sequences:
>Translated_415_residues MSRIIVGVGGGIAAYKACTVVRQLAEAGHSVRVVPTESALQFVGAATFEALSGEPARTGVFDDVPEVPHVRLGQDADLVV VAPATADLLSRAATGRADDLLTATLLTATCPVLFAPAMHTEMWLHPATQQNVATLRSRGAVVLEPASGRLTGADTGPGRL PEAEEITTLAQLLLARPDALPHDLAGVRVLVTAGGTREPLDPVRFIGNRSSGKQGYAIARVAAQRGAEVTLIAGHTVGLP DPAGVEVVHISSAAQLQDAVTKHAPAAEALIMAAAVADFRPAHVATSKIKKSHGAAGENDAPIELLRNADVLAGVVRARA DGQLPKMRAIVGFAAETGDANGDVLFHARAKLKRKGCDLLVVNAVGEGRAFEVDSNDGWLLSAQSGGDITEVVLEHGTKV LMASRIVDAVAGLCQ >Mature_414_residues SRIIVGVGGGIAAYKACTVVRQLAEAGHSVRVVPTESALQFVGAATFEALSGEPARTGVFDDVPEVPHVRLGQDADLVVV APATADLLSRAATGRADDLLTATLLTATCPVLFAPAMHTEMWLHPATQQNVATLRSRGAVVLEPASGRLTGADTGPGRLP EAEEITTLAQLLLARPDALPHDLAGVRVLVTAGGTREPLDPVRFIGNRSSGKQGYAIARVAAQRGAEVTLIAGHTVGLPD PAGVEVVHISSAAQLQDAVTKHAPAAEALIMAAAVADFRPAHVATSKIKKSHGAAGENDAPIELLRNADVLAGVVRARAD GQLPKMRAIVGFAAETGDANGDVLFHARAKLKRKGCDLLVVNAVGEGRAFEVDSNDGWLLSAQSGGDITEVVLEHGTKVL MASRIVDAVAGLCQ
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Homo sapiens, GI71725351, Length=165, Percent_Identity=34.5454545454545, Blast_Score=80, Evalue=3e-15, Organism=Escherichia coli, GI87082301, Length=378, Percent_Identity=41.5343915343915, Blast_Score=231, Evalue=9e-62, Organism=Drosophila melanogaster, GI24657262, Length=180, Percent_Identity=30.5555555555556, Blast_Score=77, Evalue=2e-14,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 42826; Mature: 42695
Theoretical pI: Translated: 6.38; Mature: 6.38
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSRIIVGVGGGIAAYKACTVVRQLAEAGHSVRVVPTESALQFVGAATFEALSGEPARTGV CCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCC FDDVPEVPHVRLGQDADLVVVAPATADLLSRAATGRADDLLTATLLTATCPVLFAPAMHT CCCCCCCCCEECCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHH EMWLHPATQQNVATLRSRGAVVLEPASGRLTGADTGPGRLPEAEEITTLAQLLLARPDAL HHEECCCCHHHHHHHHHCCCEEEECCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC PHDLAGVRVLVTAGGTREPLDPVRFIGNRSSGKQGYAIARVAAQRGAEVTLIAGHTVGLP CCCCCCEEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCC DPAGVEVVHISSAAQLQDAVTKHAPAAEALIMAAAVADFRPAHVATSKIKKSHGAAGEND CCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC APIELLRNADVLAGVVRARADGQLPKMRAIVGFAAETGDANGDVLFHARAKLKRKGCDLL CCHHHHHCCHHHHHHHHHCCCCCCCHHHHHEEEHHCCCCCCCCEEEEEHHHHHHCCCCEE VVNAVGEGRAFEVDSNDGWLLSAQSGGDITEVVLEHGTKVLMASRIVDAVAGLCQ EEEECCCCEEEEECCCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCC >Mature Secondary Structure SRIIVGVGGGIAAYKACTVVRQLAEAGHSVRVVPTESALQFVGAATFEALSGEPARTGV CEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCC FDDVPEVPHVRLGQDADLVVVAPATADLLSRAATGRADDLLTATLLTATCPVLFAPAMHT CCCCCCCCCEECCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHH EMWLHPATQQNVATLRSRGAVVLEPASGRLTGADTGPGRLPEAEEITTLAQLLLARPDAL HHEECCCCHHHHHHHHHCCCEEEECCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC PHDLAGVRVLVTAGGTREPLDPVRFIGNRSSGKQGYAIARVAAQRGAEVTLIAGHTVGLP CCCCCCEEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCC DPAGVEVVHISSAAQLQDAVTKHAPAAEALIMAAAVADFRPAHVATSKIKKSHGAAGEND CCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC APIELLRNADVLAGVVRARADGQLPKMRAIVGFAAETGDANGDVLFHARAKLKRKGCDLL CCHHHHHCCHHHHHHHHHCCCCCCCHHHHHEEEHHCCCCCCCCEEEEEHHHHHHCCCCEE VVNAVGEGRAFEVDSNDGWLLSAQSGGDITEVVLEHGTKVLMASRIVDAVAGLCQ EEEECCCCEEEEECCCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12788972 [H]