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The map label for this gene is fmt

Identifier: 169629895

GI number: 169629895

Start: 2859561

End: 2860484

Strand: Reverse

Name: fmt

Synonym: MAB_2811c

Alternate gene names: 169629895

Gene position: 2860484-2859561 (Counterclockwise)

Preceding gene: 169629897

Following gene: 169629894

Centisome position: 56.45

GC content: 67.97

Gene sequence:

>924_bases
GTGCGCATAGTGTTCGCCGGTACTCCGGCCCCGGCGTTGCCGTCTCTGGAGAGGTTATTGGCGTCTCGTCATGAGGTGGT
CGCGGTGTTGACCCGGCCCGATGCCCGTGCGGGCAGAGGGAGGGCATCGGCGTCCTCTCCGGTGGCGGCGCTGGCACGTG
AACACGGGGTTGCCGTGCTTACTCCGGCGCGCCCCAACGAACCCGAGTTCGTGCGCGAGTTGGCGCAACTCGACGTCGAC
TGTTGTGCGGTCGTGGCCTACGGCGCCCTGCTCAAACCCGAGCTGCTGGCGGTGCCGCGGCTTGGCTGGGTGAATCTGCA
CTTCTCGCTGCTGCCGGCCTGGCGTGGTGCCGCGCCGGTACAAGCTTCGATCGCGGCTGGAGATGAGATCACGGGCGCTA
CAACATTTCTCATTGAGCCCGCACTGGACAGTGGGCCCGTGTACGGGGTGGTGACCGAACGAATCTCGCCGAATGACACC
GCCGGTGCGTTACTGGGCAGGCTGGCCGAATCCGGCGCGGGCCTGCTCGAATCGACGATGGACGGCATCGAGGACGGCGC
GCTGGTGGCCGTGCCGCAGGCGGTGGACGGGGTGAGCATCGCACCGAAAATCACGGTGGAGCAGGCGCGCATCCGCTGGG
AGCTACCCGCGCACGCTATCGACCGGCATATTCGGGCGATGACTCCGGAACCAGGCGCCTGGACCAATATCGGCGGGACG
CGGGTCAAGGTCGGCCCGGTCGGCGTCGCCACCGACGAGCAGTTACCGCCCGGCGCCGTGGCGGTGCGCAAGCGTGACGT
CCTGGTTGGCACGGGAACCACGGCGATCGCACTCGATGAGGTGCAGCCTCAGGGCAAGAAGGTGATGAAGGCCGCGGATT
GGGCCCGGGGTGCCCGGCTGGATGCGGAGGTTCACGCGCTGTGA

Upstream 100 bases:

>100_bases
GTTTCTCCCGCTACTCTTGGCGAACCCTATCGCATGGTCTGTGTGGTTCCGCGCTCTTCGGGATTCGATGTGGGCGGTGC
ATCCTTCCTAGACTGGCGCG

Downstream 100 bases:

>100_bases
GTACGCGTCCGCCGCGCCGCCGGTCGAATCAGGACTCCCGTCGGAGTGCGGGTCCTGCGGAGCGTGCGCGCCGTAAGCTT
GACCCACCACGTCAGGCCGC

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MRIVFAGTPAPALPSLERLLASRHEVVAVLTRPDARAGRGRASASSPVAALAREHGVAVLTPARPNEPEFVRELAQLDVD
CCAVVAYGALLKPELLAVPRLGWVNLHFSLLPAWRGAAPVQASIAAGDEITGATTFLIEPALDSGPVYGVVTERISPNDT
AGALLGRLAESGAGLLESTMDGIEDGALVAVPQAVDGVSIAPKITVEQARIRWELPAHAIDRHIRAMTPEPGAWTNIGGT
RVKVGPVGVATDEQLPPGAVAVRKRDVLVGTGTTAIALDEVQPQGKKVMKAADWARGARLDAEVHAL

Sequences:

>Translated_307_residues
MRIVFAGTPAPALPSLERLLASRHEVVAVLTRPDARAGRGRASASSPVAALAREHGVAVLTPARPNEPEFVRELAQLDVD
CCAVVAYGALLKPELLAVPRLGWVNLHFSLLPAWRGAAPVQASIAAGDEITGATTFLIEPALDSGPVYGVVTERISPNDT
AGALLGRLAESGAGLLESTMDGIEDGALVAVPQAVDGVSIAPKITVEQARIRWELPAHAIDRHIRAMTPEPGAWTNIGGT
RVKVGPVGVATDEQLPPGAVAVRKRDVLVGTGTTAIALDEVQPQGKKVMKAADWARGARLDAEVHAL
>Mature_307_residues
MRIVFAGTPAPALPSLERLLASRHEVVAVLTRPDARAGRGRASASSPVAALAREHGVAVLTPARPNEPEFVRELAQLDVD
CCAVVAYGALLKPELLAVPRLGWVNLHFSLLPAWRGAAPVQASIAAGDEITGATTFLIEPALDSGPVYGVVTERISPNDT
AGALLGRLAESGAGLLESTMDGIEDGALVAVPQAVDGVSIAPKITVEQARIRWELPAHAIDRHIRAMTPEPGAWTNIGGT
RVKVGPVGVATDEQLPPGAVAVRKRDVLVGTGTTAIALDEVQPQGKKVMKAADWARGARLDAEVHAL

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=316, Percent_Identity=25.3164556962025, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI238814322, Length=288, Percent_Identity=26.0416666666667, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI164663775, Length=152, Percent_Identity=33.5526315789474, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1789683, Length=303, Percent_Identity=41.5841584158416, Blast_Score=197, Evalue=7e-52,
Organism=Escherichia coli, GI1788589, Length=309, Percent_Identity=28.4789644012945, Blast_Score=113, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI133930964, Length=325, Percent_Identity=25.8461538461538, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45550868, Length=305, Percent_Identity=29.8360655737705, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28571984, Length=228, Percent_Identity=31.5789473684211, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_MYCA9 (B1MCB9)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001703544.1
- ProteinModelPortal:   B1MCB9
- SMR:   B1MCB9
- EnsemblBacteria:   EBMYCT00000005712
- GeneID:   5965319
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_2811c
- GeneTree:   EBGT00050000015792
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- BioCyc:   MABS561007:MAB_2811C-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 32008; Mature: 32008

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVFAGTPAPALPSLERLLASRHEVVAVLTRPDARAGRGRASASSPVAALAREHGVAVL
CEEEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCEEEE
TPARPNEPEFVRELAQLDVDCCAVVAYGALLKPELLAVPRLGWVNLHFSLLPAWRGAAPV
ECCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHCCCCCCEEEEEEEEEECCCCCCCC
QASIAAGDEITGATTFLIEPALDSGPVYGVVTERISPNDTAGALLGRLAESGAGLLESTM
EEEEECCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHH
DGIEDGALVAVPQAVDGVSIAPKITVEQARIRWELPAHAIDRHIRAMTPEPGAWTNIGGT
HCCCCCCEEEECCCCCCCCCCCEEEEEEEEEEEECCHHHHHHHHHHCCCCCCCEECCCCC
RVKVGPVGVATDEQLPPGAVAVRKRDVLVGTGTTAIALDEVQPQGKKVMKAADWARGARL
EEEECCCCCCCCCCCCCCEEEEEECEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCC
DAEVHAL
CCEEECC
>Mature Secondary Structure
MRIVFAGTPAPALPSLERLLASRHEVVAVLTRPDARAGRGRASASSPVAALAREHGVAVL
CEEEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCEEEE
TPARPNEPEFVRELAQLDVDCCAVVAYGALLKPELLAVPRLGWVNLHFSLLPAWRGAAPV
ECCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHCCCCCCEEEEEEEEEECCCCCCCC
QASIAAGDEITGATTFLIEPALDSGPVYGVVTERISPNDTAGALLGRLAESGAGLLESTM
EEEEECCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHH
DGIEDGALVAVPQAVDGVSIAPKITVEQARIRWELPAHAIDRHIRAMTPEPGAWTNIGGT
HCCCCCCEEEECCCCCCCCCCCEEEEEEEEEEEECCHHHHHHHHHHCCCCCCCEECCCCC
RVKVGPVGVATDEQLPPGAVAVRKRDVLVGTGTTAIALDEVQPQGKKVMKAADWARGARL
EEEECCCCCCCCCCCCCCEEEEEECEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCC
DAEVHAL
CCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA