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The map label for this gene is ribBA

Identifier: 169629880

GI number: 169629880

Start: 2845189

End: 2846442

Strand: Reverse

Name: ribBA

Synonym: MAB_2796c

Alternate gene names: 169629880

Gene position: 2846442-2845189 (Counterclockwise)

Preceding gene: 169629881

Following gene: 169629879

Centisome position: 56.17

GC content: 64.11

Gene sequence:

>1254_bases
ATGACCAGGTTGGACAGCATCGAACGCGCTGTCGCCGATATCGCCGCCGGTAAGGCCGTCGTCGTCGTCGACGATGAGGA
TCGGGAAAACGAAGGCGATCTGATTTTCGCCGCGGAGAAGGCCACCCCGGAATTGGTGGCCTTCATGGTGCGGTACACAT
CGGGTTACTTGTGCGTACCGCTGGCCGGGGAGGACTGTGACCGTCTGGGGCTGCTGCCTCAGTATGCGGTGAACCAGGAC
AAACACGGCACCGCCTACACCGTCACGGTGGATGCGAAAAACGGTATCGGCACAGGGATTTCGGCTTCGGATCGCGCGGC
GACGATGCGCCTGCTGGCCGACGCCGCGAGCACTGCCGACGACTTCACCAAGCCTGGGCATGTGGTTCCGTTGCGCGCCA
AAGACGGTGGGGTGCTGCGCCGTCCCGGTCATACCGAGGCGTCGGTCGACCTCGCCAAACTCGCCGGGCTGCGCCCCGCG
GCGGTCATCTGCGAGATCGTCAGCCAAAAAGACGAGGGCGCCATGGCGCAAACCGAGGAACTCCGGGTCTTCGCCGACGA
GCACAATCTGGCGCTGGTGTCGATCGCCGACCTGATCGAGTGGCGGCGCAAGCACGAGAAGCATGTGCAGCGGATAGCCG
AGGCCCGTATCCCCACGCAACACGGCGAGTTCCGTGCGGTGGGTTACACCAGCATCTACGACGACGTAGAACACGTGGCA
CTGGTCCTGGGCGATATCTCCGGCCCCGACGGCGACGGAAATGACGTGCTGGTGCGCGTGCACTCCGAGTGTTTGACAGG
TGACGTATTCGGTTCGCGCCGTTGCGATTGCGGTCCGCAATTGGACGCGGCGATGGAGATGGTGGCCAAGGAGGGGCGCG
GCATTGTGCTGTACATGCGCGGCCACGAGGGCCGCGGTATCGGCCTCATGCACAAGCTGCAGGCCTACCAGTTGCAGGAC
GCCGGCGAGGACACGGTGGATGCGAACCTGAAGCTCGGTCTGCCCGCCGATGCGCGCGATTACGGTTTGGGCGCACAGAT
TCTGGTCGACCTGGGCGTCAAGTCGATGAGGCTGCTGACCAACAACCCGGCCAAGAGGGTGGGGCTGGACGGCTATGGAT
TGCACATCATCGAGAGAGTGCCGCTGCCGGTGCGCGCCAACTCGGAGAACATCCGCTATCTGCGCACCAAGCGGGACCGA
ATGGGTCATGACCTCGCCGACCTGGACGATCATCCCGAGGCTGATGGCGCGTGA

Upstream 100 bases:

>100_bases
ATAGCGCGGCTCGTTCCATTGAGTGAACAGCGCGCGAATCGACGAATCGGCGGTGGTTCATAATTGATATGCCCACACGC
CCCTAACGAGAGTGGTCCCC

Downstream 100 bases:

>100_bases
GCGGCGATGGGATCCCGTCACTGAGTGTCGGTGACGCATCAGGCATCAGCCTGGCGATCGTGGCCAGCACCTGGCATGAC
CAGATCTGCACGGCGCTGCT

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTRLDSIERAVADIAAGKAVVVVDDEDRENEGDLIFAAEKATPELVAFMVRYTSGYLCVPLAGEDCDRLGLLPQYAVNQD
KHGTAYTVTVDAKNGIGTGISASDRAATMRLLADAASTADDFTKPGHVVPLRAKDGGVLRRPGHTEASVDLAKLAGLRPA
AVICEIVSQKDEGAMAQTEELRVFADEHNLALVSIADLIEWRRKHEKHVQRIAEARIPTQHGEFRAVGYTSIYDDVEHVA
LVLGDISGPDGDGNDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMEMVAKEGRGIVLYMRGHEGRGIGLMHKLQAYQLQD
AGEDTVDANLKLGLPADARDYGLGAQILVDLGVKSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANSENIRYLRTKRDR
MGHDLADLDDHPEADGA

Sequences:

>Translated_417_residues
MTRLDSIERAVADIAAGKAVVVVDDEDRENEGDLIFAAEKATPELVAFMVRYTSGYLCVPLAGEDCDRLGLLPQYAVNQD
KHGTAYTVTVDAKNGIGTGISASDRAATMRLLADAASTADDFTKPGHVVPLRAKDGGVLRRPGHTEASVDLAKLAGLRPA
AVICEIVSQKDEGAMAQTEELRVFADEHNLALVSIADLIEWRRKHEKHVQRIAEARIPTQHGEFRAVGYTSIYDDVEHVA
LVLGDISGPDGDGNDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMEMVAKEGRGIVLYMRGHEGRGIGLMHKLQAYQLQD
AGEDTVDANLKLGLPADARDYGLGAQILVDLGVKSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANSENIRYLRTKRDR
MGHDLADLDDHPEADGA
>Mature_416_residues
TRLDSIERAVADIAAGKAVVVVDDEDRENEGDLIFAAEKATPELVAFMVRYTSGYLCVPLAGEDCDRLGLLPQYAVNQDK
HGTAYTVTVDAKNGIGTGISASDRAATMRLLADAASTADDFTKPGHVVPLRAKDGGVLRRPGHTEASVDLAKLAGLRPAA
VICEIVSQKDEGAMAQTEELRVFADEHNLALVSIADLIEWRRKHEKHVQRIAEARIPTQHGEFRAVGYTSIYDDVEHVAL
VLGDISGPDGDGNDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMEMVAKEGRGIVLYMRGHEGRGIGLMHKLQAYQLQDA
GEDTVDANLKLGLPADARDYGLGAQILVDLGVKSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANSENIRYLRTKRDRM
GHDLADLDDHPEADGA

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=198, Percent_Identity=54.040404040404, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI1789420, Length=206, Percent_Identity=45.1456310679612, Blast_Score=187, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=48.0392156862745, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6319438, Length=175, Percent_Identity=49.7142857142857, Blast_Score=145, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBBA_MYCA9 (B1MCA4)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001703529.1
- ProteinModelPortal:   B1MCA4
- EnsemblBacteria:   EBMYCT00000008421
- GeneID:   5965304
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_2796c
- GeneTree:   EBGT00050000015301
- HOGENOM:   HBG735778
- OMA:   RCDCRMQ
- ProtClustDB:   PRK09311
- BioCyc:   MABS561007:MAB_2796C-MONOMER
- HAMAP:   MF_01283
- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299
- Gene3D:   G3DSA:3.90.870.10
- PIRSF:   PIRSF001259
- TIGRFAMs:   TIGR00505
- TIGRFAMs:   TIGR00506

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2; SSF55821 DHBP_synth_RibB-like_a/b_dom

EC number: =4.1.99.12; =3.5.4.25

Molecular weight: Translated: 45141; Mature: 45009

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: ACT_SITE 337-337 ACT_SITE 339-339 BINDING 33-33 BINDING 165-165 BINDING 280-280 BINDING 325-325 BINDING 360-360 BINDING 365-365

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLDSIERAVADIAAGKAVVVVDDEDRENEGDLIFAAEKATPELVAFMVRYTSGYLCVP
CCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEE
LAGEDCDRLGLLPQYAVNQDKHGTAYTVTVDAKNGIGTGISASDRAATMRLLADAASTAD
ECCCCHHHHCCCCHHHCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCHH
DFTKPGHVVPLRAKDGGVLRRPGHTEASVDLAKLAGLRPAAVICEIVSQKDEGAMAQTEE
HCCCCCCEEEEEECCCCEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCC
LRVFADEHNLALVSIADLIEWRRKHEKHVQRIAEARIPTQHGEFRAVGYTSIYDDVEHVA
EEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHH
LVLGDISGPDGDGNDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMEMVAKEGRGIVLYMR
HEEECCCCCCCCCCEEEEEEECHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEE
GHEGRGIGLMHKLQAYQLQDAGEDTVDANLKLGLPADARDYGLGAQILVDLGVKSMRLLT
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCHHCCCCHHHHHHCCCHHHHHHC
NNPAKRVGLDGYGLHIIERVPLPVRANSENIRYLRTKRDRMGHDLADLDDHPEADGA
CCCHHHCCCCCCCEEEEEECCCCEECCCCCCEEEEHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TRLDSIERAVADIAAGKAVVVVDDEDRENEGDLIFAAEKATPELVAFMVRYTSGYLCVP
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEE
LAGEDCDRLGLLPQYAVNQDKHGTAYTVTVDAKNGIGTGISASDRAATMRLLADAASTAD
ECCCCHHHHCCCCHHHCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCHH
DFTKPGHVVPLRAKDGGVLRRPGHTEASVDLAKLAGLRPAAVICEIVSQKDEGAMAQTEE
HCCCCCCEEEEEECCCCEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCC
LRVFADEHNLALVSIADLIEWRRKHEKHVQRIAEARIPTQHGEFRAVGYTSIYDDVEHVA
EEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHH
LVLGDISGPDGDGNDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMEMVAKEGRGIVLYMR
HEEECCCCCCCCCCEEEEEEECHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEE
GHEGRGIGLMHKLQAYQLQDAGEDTVDANLKLGLPADARDYGLGAQILVDLGVKSMRLLT
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCHHCCCCHHHHHHCCCHHHHHHC
NNPAKRVGLDGYGLHIIERVPLPVRANSENIRYLRTKRDRMGHDLADLDDHPEADGA
CCCHHHCCCCCCCEEEEEECCCCEECCCCCCEEEEHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA