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The map label for this gene is fadH [C]

Identifier: 169629824

GI number: 169629824

Start: 2788327

End: 2789454

Strand: Reverse

Name: fadH [C]

Synonym: MAB_2740c

Alternate gene names: 169629824

Gene position: 2789454-2788327 (Counterclockwise)

Preceding gene: 169629828

Following gene: 169629823

Centisome position: 55.05

GC content: 67.73

Gene sequence:

>1128_bases
GTGACCGACGTGAGACCAGACGTAGCGCCCCTTTTCGAGCCCTTCGCTGTCAAATCGATGACATCGCCCAACCGATTCGC
GATGGCGCCGATGACGCGGTCGGCCTCGCCCGGTGGTGTGCCGGGAGAGAATGTGGCCGCCTACTATCGGCGTCGCGCGG
CTGGTGGTGTCGGCCTCATCATCACCGAGGGCGTCTTCATCCCGCATGATGCCGCCGGTGGGCAGTCGAATGTGCCGCGG
CTGGCCGGTGCTGATTCGCTGGCGGGGTGGTCGGCCGTCACCGATGCGGTGCATGGGGAGGGATCGGTGATCGCCGCACA
GCTCTGGCATCAGGGTGTGGAGCGCGGTGTCGATCCGGAGTTCAACCCCGGGGTGGAGTCGGTGAGCCCGTCGGGTTTGG
CCGGTGACGCGTCGCCCCGCGGGCGCGCGTTGCAGACCGGTGAGCTCGCCCCGCTTGCGGGGCAGTACGCGGAGGCCGCC
CGCAACGCCAAGGCCGCCGGGTTCGACGCGGTCGAACTGCACGGTGCCCACGGCTACCTGCTCGACCAGTTCCTGTGGGA
GCGGACCAACGTTCGCGCCGACGGCTACGGTGGCTCGGCAGCGCAGCGGTTGCGGTTCCCGGTGGAGGTGGTGCGTGCGG
TACGTGCCGCTGTGGGGCCGGATTTCCCTATCCTGTACCGGTTTTCGCAGTGGAAGCAGGCCGATTACACCGCGACGCTG
GCCGACAGCCCCGCGGAACTGGAAGGCCTGCTGGCGCCCCTCGTGGATGCGGGTGTGGACGTCTTTCATCCGTCCACCCG
TCGGCACTATGTGCCCGCGTTCCCGGAGCTGGCGGGCGCCGACGGAGAGTTGAGCCTGGCGGGCTGGACCAAACGACTCA
CCGGCCTGCCGGCCGTCGCCGTTGGCTCGGTCGGGTTGCAGACGGAGTTCAAACCTTCGGAGGTGCGCGATATCGAACCT
GCACCTGTCGAGGCGGTGCTGCGTCAATTCGCCGATAACGAGTTCGACGTCATCGCGGTCGGACGGGCGCTGTTGTCGGA
CCCGGAGTGGGTGAACAAGCTGCGGTCCGGCAGGCAGGGCGAATTCGTCGGATTCAATATCGGCAAGGCACTGTCGGCGC
TCTACTGA

Upstream 100 bases:

>100_bases
GCTGGCGATCACCAGGAACGCGGGCCGGGGCCTGAGGTTTGGTGACATGGTTGACCACGTTATCTGGAATGGATGCGGTG
ACGGCGTAGTTTGACACCTC

Downstream 100 bases:

>100_bases
CCGCCGGCGGAACATCGCGCACTCCGGCAACGTTGAGGACTACATGGCAACACGTGACATCACCGCTGACGCGTTCAATG
ACCTGATCCACGACAACGAC

Product: oxidoreductase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MTDVRPDVAPLFEPFAVKSMTSPNRFAMAPMTRSASPGGVPGENVAAYYRRRAAGGVGLIITEGVFIPHDAAGGQSNVPR
LAGADSLAGWSAVTDAVHGEGSVIAAQLWHQGVERGVDPEFNPGVESVSPSGLAGDASPRGRALQTGELAPLAGQYAEAA
RNAKAAGFDAVELHGAHGYLLDQFLWERTNVRADGYGGSAAQRLRFPVEVVRAVRAAVGPDFPILYRFSQWKQADYTATL
ADSPAELEGLLAPLVDAGVDVFHPSTRRHYVPAFPELAGADGELSLAGWTKRLTGLPAVAVGSVGLQTEFKPSEVRDIEP
APVEAVLRQFADNEFDVIAVGRALLSDPEWVNKLRSGRQGEFVGFNIGKALSALY

Sequences:

>Translated_375_residues
MTDVRPDVAPLFEPFAVKSMTSPNRFAMAPMTRSASPGGVPGENVAAYYRRRAAGGVGLIITEGVFIPHDAAGGQSNVPR
LAGADSLAGWSAVTDAVHGEGSVIAAQLWHQGVERGVDPEFNPGVESVSPSGLAGDASPRGRALQTGELAPLAGQYAEAA
RNAKAAGFDAVELHGAHGYLLDQFLWERTNVRADGYGGSAAQRLRFPVEVVRAVRAAVGPDFPILYRFSQWKQADYTATL
ADSPAELEGLLAPLVDAGVDVFHPSTRRHYVPAFPELAGADGELSLAGWTKRLTGLPAVAVGSVGLQTEFKPSEVRDIEP
APVEAVLRQFADNEFDVIAVGRALLSDPEWVNKLRSGRQGEFVGFNIGKALSALY
>Mature_374_residues
TDVRPDVAPLFEPFAVKSMTSPNRFAMAPMTRSASPGGVPGENVAAYYRRRAAGGVGLIITEGVFIPHDAAGGQSNVPRL
AGADSLAGWSAVTDAVHGEGSVIAAQLWHQGVERGVDPEFNPGVESVSPSGLAGDASPRGRALQTGELAPLAGQYAEAAR
NAKAAGFDAVELHGAHGYLLDQFLWERTNVRADGYGGSAAQRLRFPVEVVRAVRAAVGPDFPILYRFSQWKQADYTATLA
DSPAELEGLLAPLVDAGVDVFHPSTRRHYVPAFPELAGADGELSLAGWTKRLTGLPAVAVGSVGLQTEFKPSEVRDIEPA
PVEAVLRQFADNEFDVIAVGRALLSDPEWVNKLRSGRQGEFVGFNIGKALSALY

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=385, Percent_Identity=30.3896103896104, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1787939, Length=221, Percent_Identity=38.9140271493213, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17540738, Length=215, Percent_Identity=32.5581395348837, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17559802, Length=218, Percent_Identity=31.1926605504587, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17559804, Length=215, Percent_Identity=28.8372093023256, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI72001454, Length=216, Percent_Identity=29.6296296296296, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17564188, Length=212, Percent_Identity=28.3018867924528, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17565138, Length=218, Percent_Identity=31.1926605504587, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17566914, Length=226, Percent_Identity=28.7610619469027, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321973, Length=370, Percent_Identity=28.9189189189189, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6325086, Length=224, Percent_Identity=35.7142857142857, Blast_Score=118, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 39652; Mature: 39521

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVRPDVAPLFEPFAVKSMTSPNRFAMAPMTRSASPGGVPGENVAAYYRRRAAGGVGLI
CCCCCCCHHHHHCHHHHHCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEE
ITEGVFIPHDAAGGQSNVPRLAGADSLAGWSAVTDAVHGEGSVIAAQLWHQGVERGVDPE
EECCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
FNPGVESVSPSGLAGDASPRGRALQTGELAPLAGQYAEAARNAKAAGFDAVELHGAHGYL
CCCCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCHHH
LDQFLWERTNVRADGYGGSAAQRLRFPVEVVRAVRAAVGPDFPILYRFSQWKQADYTATL
HHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCEEEE
ADSPAELEGLLAPLVDAGVDVFHPSTRRHYVPAFPELAGADGELSLAGWTKRLTGLPAVA
CCCHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHCCCCCCEEHHHHHHHHCCCCCHH
VGSVGLQTEFKPSEVRDIEPAPVEAVLRQFADNEFDVIAVGRALLSDPEWVNKLRSGRQG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEHHHHHHCCHHHHHHHHCCCCC
EFVGFNIGKALSALY
CEEEEEHHHHHHHCC
>Mature Secondary Structure 
TDVRPDVAPLFEPFAVKSMTSPNRFAMAPMTRSASPGGVPGENVAAYYRRRAAGGVGLI
CCCCCCHHHHHCHHHHHCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEE
ITEGVFIPHDAAGGQSNVPRLAGADSLAGWSAVTDAVHGEGSVIAAQLWHQGVERGVDPE
EECCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
FNPGVESVSPSGLAGDASPRGRALQTGELAPLAGQYAEAARNAKAAGFDAVELHGAHGYL
CCCCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCHHH
LDQFLWERTNVRADGYGGSAAQRLRFPVEVVRAVRAAVGPDFPILYRFSQWKQADYTATL
HHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCEEEE
ADSPAELEGLLAPLVDAGVDVFHPSTRRHYVPAFPELAGADGELSLAGWTKRLTGLPAVA
CCCHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHCCCCCCEEHHHHHHHHCCCCCHH
VGSVGLQTEFKPSEVRDIEPAPVEAVLRQFADNEFDVIAVGRALLSDPEWVNKLRSGRQG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEHHHHHHCCHHHHHHHHCCCCC
EFVGFNIGKALSALY
CEEEEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]