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The map label for this gene is trxC [H]

Identifier: 169629823

GI number: 169629823

Start: 2787930

End: 2788283

Strand: Reverse

Name: trxC [H]

Synonym: MAB_2739c

Alternate gene names: 169629823

Gene position: 2788283-2787930 (Counterclockwise)

Preceding gene: 169629824

Following gene: 169629822

Centisome position: 55.03

GC content: 62.99

Gene sequence:

>354_bases
ATGGCAACACGTGACATCACCGCTGACGCGTTCAATGACCTGATCCACGACAACGACATCGTGCTGGTCGACTTCTGGGC
GTCCTGGTGTGGACCGTGCCGTCAGTTCGGCCCGGTCTTCGAAGCGTCGTCGGAAGCCAACCCCGATGTGGTGCACGCCA
AGGTGGACACCGAGGCCGAACAGGCTCTGGCGTCGGCGGCGAATATCCGCTCGATTCCCACGCTGATGGCGTTCAAGCAG
GGGCAGTTGGTCTTCAACCAGGCGGGCGCGTTGCCTCCGGCGTCGTTGGCCGATTTGGTACAGCAGGTGAGGGACCTGGA
CGTCGAGGCGGCGCTACGCGAGCAAGAGGCTTAA

Upstream 100 bases:

>100_bases
AGGCAGGGCGAATTCGTCGGATTCAATATCGGCAAGGCACTGTCGGCGCTCTACTGACCGCCGGCGGAACATCGCGCACT
CCGGCAACGTTGAGGACTAC

Downstream 100 bases:

>100_bases
CCAAGCGCGGAGCCACCCACGGTAAGTAAGTGTAGGCTACGCTTACTTACCGTGGGTAGTCATGTTCCAGTCGACGGCGA
AACACCTCTCTCGGAAGGTG

Product: thioredoxin TrxB

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 117; Mature: 116

Protein sequence:

>117_residues
MATRDITADAFNDLIHDNDIVLVDFWASWCGPCRQFGPVFEASSEANPDVVHAKVDTEAEQALASAANIRSIPTLMAFKQ
GQLVFNQAGALPPASLADLVQQVRDLDVEAALREQEA

Sequences:

>Translated_117_residues
MATRDITADAFNDLIHDNDIVLVDFWASWCGPCRQFGPVFEASSEANPDVVHAKVDTEAEQALASAANIRSIPTLMAFKQ
GQLVFNQAGALPPASLADLVQQVRDLDVEAALREQEA
>Mature_116_residues
ATRDITADAFNDLIHDNDIVLVDFWASWCGPCRQFGPVFEASSEANPDVVHAKVDTEAEQALASAANIRSIPTLMAFKQG
QLVFNQAGALPPASLADLVQQVRDLDVEAALREQEA

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758304, Length=81, Percent_Identity=37.037037037037, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI50592994, Length=73, Percent_Identity=39.7260273972603, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788936, Length=91, Percent_Identity=48.3516483516484, Blast_Score=92, Evalue=1e-20,
Organism=Escherichia coli, GI87082331, Length=97, Percent_Identity=35.0515463917526, Blast_Score=73, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=94, Percent_Identity=37.2340425531915, Blast_Score=72, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=96, Percent_Identity=35.4166666666667, Blast_Score=70, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=95, Percent_Identity=34.7368421052632, Blast_Score=67, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 12667; Mature: 12536

Theoretical pI: Translated: 4.01; Mature: 4.01

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRDITADAFNDLIHDNDIVLVDFWASWCGPCRQFGPVFEASSEANPDVVHAKVDTEAE
CCCCCCCHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHH
QALASAANIRSIPTLMAFKQGQLVFNQAGALPPASLADLVQQVRDLDVEAALREQEA
HHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCC
>Mature Secondary Structure 
ATRDITADAFNDLIHDNDIVLVDFWASWCGPCRQFGPVFEASSEANPDVVHAKVDTEAE
CCCCCCHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHH
QALASAANIRSIPTLMAFKQGQLVFNQAGALPPASLADLVQQVRDLDVEAALREQEA
HHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]