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The map label for this gene is ethA [H]

Identifier: 169629739

GI number: 169629739

Start: 2696699

End: 2698270

Strand: Direct

Name: ethA [H]

Synonym: MAB_2654

Alternate gene names: 169629739

Gene position: 2696699-2698270 (Clockwise)

Preceding gene: 169629735

Following gene: 169629740

Centisome position: 53.22

GC content: 61.32

Gene sequence:

>1572_bases
ATGACCACCTCAGCACCTCGCCCCGACTACTACGACGTGGTGATCATCGGCGCCGGTATCTCGGGAATCGGCGCCGCCGC
CTACCTCACTCGCGAATTCCCGAAGAAGAAGGTGGTGCTGTTGGAGGGGCGCGGCGCCCTAGGTGGCACCTGGGATCTAT
TCCGGTACCCCGGCATTCGGTCGGACTCAGATCTGCACACGTTCGCGTACGAGTTCAAGAGTTGGCGCCACAAGAACGCG
ATCGCCGACGCGCCGCTCATCCTGGACTATCTCAAGGAGACCGTCGATGAGTACGGCCTGGCCGACATCATCAAATACCG
GCACAACGTCATTGCCGCCGCATGGTCGAGCGATGACGCGGAATGGGTTCTGACGGTCGATGTCACCGATCCCGACGGAT
CGGTGCGCAGCGAGGTGATCAAGGCGGGGTGGGTCTATGCGGGTACTGGCTATTACCGCTACGACAAGGCCTATACCCCG
GAGTTCGAGGGCAGGGAAGAATTCGAGGGCGACATCATCCACCCCCAGTTCTGGCCCGAGGGCTACGACCATTCCGGCAA
GAACATAGTCGTGATCGGAAGCGGCGCAACGGCAATCACGCTCATCCCGTCGATGCTCAAGGGTGACGACGCTGCTGAAC
ATGTCACCATGCTGCAGCGGACACCTACGTACATCATGTCGATGCCACGCACTGACGCCCTCAGCCTCAAGCTCACCCGA
CTCCTCGGAGAGCGGCGCGGCTATTTAGCGACCCGGTGGAAGAACGTGTTGCTCGATTGGGTGGTCGTCGAGCTGATGAC
CAGATTCCCGAAGGCCGCGCGGCGCCTTATCCGCCACCTCAACACGAAGGAACTGCCGGCAGGATTCGATGTAGACCGCC
ACTTCAATCCTCCCTACGACCCCTGGGACCAGCGTCTTTGCCTGGCACCCGATGGCGATTTCTTCACCTCGATCCGTGAG
GGCCGGGCATCGGTCGTCACCGACCGCATCCGCCGGTTCACCAAGAACGGAATCGAGCTCGAATCCGGCGAGGAGCTGCC
TGCCGATGTCATCGTCACGGCAACCGGGCTGAACATGCGTCTCTTCGGCGGCGTCGACCTCACTGTCGACGGGCGCCCGA
TCGACCTGTCCAGCAGTGTGGTGTATCGAGGGCTGCTGCTGTCCGGCCTGCCGAACTGGATGATGGCCATTGGTTACACC
AAATCGTCGTGGACTCTGAAGATATCGCTGCTCGGTAAGAGCCTCATCGAGCTCCTGCACCACATGGACACCCATGGTTA
CGACACTGTTGCTCCGTACGCGGCCGAGGGCGTCGGCACTCGGTCGATTCTCGACCTCGACGCCGGATACATGCAGCGCT
CCAAGCACTCCCTACCGCGCCAGGGCGACGCCATGCCATGGCAGATGCGGAACGTGTTCCTGGAGGATCGAAAGATGTAC
CGGGGATCGATCATCGACGACAATCTCCACTTCAGTTCGCGGTTGGAGCGCGAACTGAAGGACAGCGGCAGCAACAGTCC
TGATCGTCGCACCCAGATCAGCCGAGCATCTTCCGGAGGCGCGACGTCATGA

Upstream 100 bases:

>100_bases
ACGCAGAACGTTGCATTTCGCCGTGGTGCGCGTCACATCCTTCCTGGCATTCTTGGGCTCATCGCGACACGCCGATGTCG
GCGCAGGAAGGAAACGAAAG

Downstream 100 bases:

>100_bases
CGAGCATCACTGCGGAGGCACCGCCACGCCTGACCGTCTCCGAACTGATCCAGCGCGCCGCGTTCACAACACTGGACCGA
ATTCCGAAAGTTGTTCTTCG

Product: putative monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MTTSAPRPDYYDVVIIGAGISGIGAAAYLTREFPKKKVVLLEGRGALGGTWDLFRYPGIRSDSDLHTFAYEFKSWRHKNA
IADAPLILDYLKETVDEYGLADIIKYRHNVIAAAWSSDDAEWVLTVDVTDPDGSVRSEVIKAGWVYAGTGYYRYDKAYTP
EFEGREEFEGDIIHPQFWPEGYDHSGKNIVVIGSGATAITLIPSMLKGDDAAEHVTMLQRTPTYIMSMPRTDALSLKLTR
LLGERRGYLATRWKNVLLDWVVVELMTRFPKAARRLIRHLNTKELPAGFDVDRHFNPPYDPWDQRLCLAPDGDFFTSIRE
GRASVVTDRIRRFTKNGIELESGEELPADVIVTATGLNMRLFGGVDLTVDGRPIDLSSSVVYRGLLLSGLPNWMMAIGYT
KSSWTLKISLLGKSLIELLHHMDTHGYDTVAPYAAEGVGTRSILDLDAGYMQRSKHSLPRQGDAMPWQMRNVFLEDRKMY
RGSIIDDNLHFSSRLERELKDSGSNSPDRRTQISRASSGGATS

Sequences:

>Translated_523_residues
MTTSAPRPDYYDVVIIGAGISGIGAAAYLTREFPKKKVVLLEGRGALGGTWDLFRYPGIRSDSDLHTFAYEFKSWRHKNA
IADAPLILDYLKETVDEYGLADIIKYRHNVIAAAWSSDDAEWVLTVDVTDPDGSVRSEVIKAGWVYAGTGYYRYDKAYTP
EFEGREEFEGDIIHPQFWPEGYDHSGKNIVVIGSGATAITLIPSMLKGDDAAEHVTMLQRTPTYIMSMPRTDALSLKLTR
LLGERRGYLATRWKNVLLDWVVVELMTRFPKAARRLIRHLNTKELPAGFDVDRHFNPPYDPWDQRLCLAPDGDFFTSIRE
GRASVVTDRIRRFTKNGIELESGEELPADVIVTATGLNMRLFGGVDLTVDGRPIDLSSSVVYRGLLLSGLPNWMMAIGYT
KSSWTLKISLLGKSLIELLHHMDTHGYDTVAPYAAEGVGTRSILDLDAGYMQRSKHSLPRQGDAMPWQMRNVFLEDRKMY
RGSIIDDNLHFSSRLERELKDSGSNSPDRRTQISRASSGGATS
>Mature_522_residues
TTSAPRPDYYDVVIIGAGISGIGAAAYLTREFPKKKVVLLEGRGALGGTWDLFRYPGIRSDSDLHTFAYEFKSWRHKNAI
ADAPLILDYLKETVDEYGLADIIKYRHNVIAAAWSSDDAEWVLTVDVTDPDGSVRSEVIKAGWVYAGTGYYRYDKAYTPE
FEGREEFEGDIIHPQFWPEGYDHSGKNIVVIGSGATAITLIPSMLKGDDAAEHVTMLQRTPTYIMSMPRTDALSLKLTRL
LGERRGYLATRWKNVLLDWVVVELMTRFPKAARRLIRHLNTKELPAGFDVDRHFNPPYDPWDQRLCLAPDGDFFTSIREG
RASVVTDRIRRFTKNGIELESGEELPADVIVTATGLNMRLFGGVDLTVDGRPIDLSSSVVYRGLLLSGLPNWMMAIGYTK
SSWTLKISLLGKSLIELLHHMDTHGYDTVAPYAAEGVGTRSILDLDAGYMQRSKHSLPRQGDAMPWQMRNVFLEDRKMYR
GSIIDDNLHFSSRLERELKDSGSNSPDRRTQISRASSGGATS

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 58658; Mature: 58527

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSAPRPDYYDVVIIGAGISGIGAAAYLTREFPKKKVVLLEGRGALGGTWDLFRYPGIR
CCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHCCCCCC
SDSDLHTFAYEFKSWRHKNAIADAPLILDYLKETVDEYGLADIIKYRHNVIAAAWSSDDA
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEECCCCC
EWVLTVDVTDPDGSVRSEVIKAGWVYAGTGYYRYDKAYTPEFEGREEFEGDIIHPQFWPE
CEEEEEEEECCCCHHHHHHHHHCEEEECCCEEEECCCCCCCCCCCHHCCCCCCCCCCCCC
GYDHSGKNIVVIGSGATAITLIPSMLKGDDAAEHVTMLQRTPTYIMSMPRTDALSLKLTR
CCCCCCCEEEEEECCCCEEHHHHHHHCCCCHHHHHHHHHCCCHHHEECCCCCHHHHHHHH
LLGERRGYLATRWKNVLLDWVVVELMTRFPKAARRLIRHLNTKELPAGFDVDRHFNPPYD
HHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PWDQRLCLAPDGDFFTSIREGRASVVTDRIRRFTKNGIELESGEELPADVIVTATGLNMR
HHHCEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEEECCCCEE
LFGGVDLTVDGRPIDLSSSVVYRGLLLSGLPNWMMAIGYTKSSWTLKISLLGKSLIELLH
EECCEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHEEEEECCCEEEEEEHHHHHHHHHHH
HMDTHGYDTVAPYAAEGVGTRSILDLDAGYMQRSKHSLPRQGDAMPWQMRNVFLEDRKMY
HHCCCCCCCCCCHHHCCCCCCEEEECCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
RGSIIDDNLHFSSRLERELKDSGSNSPDRRTQISRASSGGATS
CCCEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TTSAPRPDYYDVVIIGAGISGIGAAAYLTREFPKKKVVLLEGRGALGGTWDLFRYPGIR
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHCCCCCC
SDSDLHTFAYEFKSWRHKNAIADAPLILDYLKETVDEYGLADIIKYRHNVIAAAWSSDDA
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEECCCCC
EWVLTVDVTDPDGSVRSEVIKAGWVYAGTGYYRYDKAYTPEFEGREEFEGDIIHPQFWPE
CEEEEEEEECCCCHHHHHHHHHCEEEECCCEEEECCCCCCCCCCCHHCCCCCCCCCCCCC
GYDHSGKNIVVIGSGATAITLIPSMLKGDDAAEHVTMLQRTPTYIMSMPRTDALSLKLTR
CCCCCCCEEEEEECCCCEEHHHHHHHCCCCHHHHHHHHHCCCHHHEECCCCCHHHHHHHH
LLGERRGYLATRWKNVLLDWVVVELMTRFPKAARRLIRHLNTKELPAGFDVDRHFNPPYD
HHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PWDQRLCLAPDGDFFTSIREGRASVVTDRIRRFTKNGIELESGEELPADVIVTATGLNMR
HHHCEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEEECCCCEE
LFGGVDLTVDGRPIDLSSSVVYRGLLLSGLPNWMMAIGYTKSSWTLKISLLGKSLIELLH
EECCEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHEEEEECCCEEEEEEHHHHHHHHHHH
HMDTHGYDTVAPYAAEGVGTRSILDLDAGYMQRSKHSLPRQGDAMPWQMRNVFLEDRKMY
HHCCCCCCCCCCHHHCCCCCCEEEECCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
RGSIIDDNLHFSSRLERELKDSGSNSPDRRTQISRASSGGATS
CCCEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]