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The map label for this gene is trpE [H]

Identifier: 169629732

GI number: 169629732

Start: 2687514

End: 2689049

Strand: Reverse

Name: trpE [H]

Synonym: MAB_2647c

Alternate gene names: 169629732

Gene position: 2689049-2687514 (Counterclockwise)

Preceding gene: 169629733

Following gene: 169629731

Centisome position: 53.07

GC content: 65.69

Gene sequence:

>1536_bases
ATGCATAGCACCGTCAGCGGGGCCGCCACCACCACCCGGGAAGAGTTCAACGCCCTGGCGGCCGTGCATCGCGTGGTGCC
GGTGACCCGAAAAGTACTGGCAGACAGTGAAACTCCACTCTCGGCGTATAGGAAACTGGGTGCCAACCGTCCGGGTACCT
TCTTGCTTGAGTCGGCCGAAAACGGCCGGTCGTGGTCCCGCTGGTCGTTCATCGGCGCCGGATCGCCCTCGGCGCTGACG
GTGCGAGACGGCCAATCCGCGTGGCTGGGTGCGACCCCCGAAGGAGCCCCGGTGGGGGGTGACCCGCTGGACGCGCTGCG
CGCCACGATGGATCTGTTGGCAGGCGAGTCCCTCGCGGGCCTCCCGCCGCTGTCCGGTGGCATGGTCGGCTTTCTGGCAT
ACGACATCGTCCGGCGGCTCGAGAAGCTACCGGAGCTTGCCGCCGACGACCTTGGGCTCCCGGATCTGCTGCTCTTGCTT
GCCACCGATATGGCAGCGGTCGATCACCATGAGGGCACCATCACCCTGATCGCCAACGCGGTCAACTGGGATGACACCCC
CGAACGCGTGGCCGAGGCGTACGACGGCGCGGTGGCGCGGCTGGATGTGATGACGGCCGCCCTCGGGCAGCCGCTGCCGT
CTACCGTCGCGCATTTCGACCGCCCGGCACCTACCTATCGCAGCCAGCGCACCGTCCAGGAGTACAGCGCCATCGTGGAC
AAGCTGGTGGGCGACATCGAAGCCGGCGAAGCATTCCAGGTGGTACCGAGTATGCGCTTCGAAATGGAAACCGATGTCGA
CCCACTCGAGGTGTACCGGATCCTGCGCGTCACCAATCCCAGTCCCTATATGTACCTGCTTCACGCGCCGGACTCCGAAG
GCGGAACGGCGTTTTCGATTGTCGGATCCAGCCCGGAGGCCCTGGTCACCGTGCAGGATGGGGTGGCGACCACCCACCCG
ATCGCGGGGACTCGCTGGCGCGGGGCGACCGATGAGGAAGACGTCCTGCTCGCCAAGGATCTGCTGGCCGACGAGAAAGA
ACTCTCCGAACATCTGATGCTGGTCGATCTGGGCCGCAACGACCTCGGCCGGGTGTGCACGCCGGGTTCGGTCAAGGTCA
GTGACTACAGCCATATCGAGCGCTACAGCCACGTCATGCACCTGGTATCGACGGTGTCCGGATCATTGGCCGACGGCAAG
ACGGCGCTGGACGCCATCACGGCATGCTTTCCGGCGGGTACGTTGTCGGGCGCGCCGAAGGTGCGGGCCATGGAATTGAT
CGAGGAGGTCGAGCTGACCCGCCGTGGACTATACGGGGGCGTCCTGGGATACCTGGATTTCGCCGGCAATGCCGATTTCG
CCATCGCGATCCGTACCGCACTGTTCAAAGATGGTCGCGCCTATGTGCAGGCCGGCGGGGGTGTGGTCGCCGATTCCACC
GGCGAGTACGAGTACAACGAGGCCCGCAACAAGGCCACCGCCGTGCTCAATGCCATCGCCGCGGCGGAAACGCTCACGGG
CGCCGCGGATGTCTGA

Upstream 100 bases:

>100_bases
CGGTTGGTGGCGACGCTGAAGGCGTACGAGGGCTAGGCCAACAGCACCGCGACTGGCGACATGGCCAAATCGGTTGGCGA
CGGTCTGGGAGAATGGCGTC

Downstream 100 bases:

>100_bases
CCCCGCCCCGCGGAATCCGGGCCGCCGGCGCCTGCTCATGGGCGCCGGGCTCCTCGTGATCGCGGCGGGAGCGCTGTGGG
TTGCCTCGAAATTCAGCTGG

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MHSTVSGAATTTREEFNALAAVHRVVPVTRKVLADSETPLSAYRKLGANRPGTFLLESAENGRSWSRWSFIGAGSPSALT
VRDGQSAWLGATPEGAPVGGDPLDALRATMDLLAGESLAGLPPLSGGMVGFLAYDIVRRLEKLPELAADDLGLPDLLLLL
ATDMAAVDHHEGTITLIANAVNWDDTPERVAEAYDGAVARLDVMTAALGQPLPSTVAHFDRPAPTYRSQRTVQEYSAIVD
KLVGDIEAGEAFQVVPSMRFEMETDVDPLEVYRILRVTNPSPYMYLLHAPDSEGGTAFSIVGSSPEALVTVQDGVATTHP
IAGTRWRGATDEEDVLLAKDLLADEKELSEHLMLVDLGRNDLGRVCTPGSVKVSDYSHIERYSHVMHLVSTVSGSLADGK
TALDAITACFPAGTLSGAPKVRAMELIEEVELTRRGLYGGVLGYLDFAGNADFAIAIRTALFKDGRAYVQAGGGVVADST
GEYEYNEARNKATAVLNAIAAAETLTGAADV

Sequences:

>Translated_511_residues
MHSTVSGAATTTREEFNALAAVHRVVPVTRKVLADSETPLSAYRKLGANRPGTFLLESAENGRSWSRWSFIGAGSPSALT
VRDGQSAWLGATPEGAPVGGDPLDALRATMDLLAGESLAGLPPLSGGMVGFLAYDIVRRLEKLPELAADDLGLPDLLLLL
ATDMAAVDHHEGTITLIANAVNWDDTPERVAEAYDGAVARLDVMTAALGQPLPSTVAHFDRPAPTYRSQRTVQEYSAIVD
KLVGDIEAGEAFQVVPSMRFEMETDVDPLEVYRILRVTNPSPYMYLLHAPDSEGGTAFSIVGSSPEALVTVQDGVATTHP
IAGTRWRGATDEEDVLLAKDLLADEKELSEHLMLVDLGRNDLGRVCTPGSVKVSDYSHIERYSHVMHLVSTVSGSLADGK
TALDAITACFPAGTLSGAPKVRAMELIEEVELTRRGLYGGVLGYLDFAGNADFAIAIRTALFKDGRAYVQAGGGVVADST
GEYEYNEARNKATAVLNAIAAAETLTGAADV
>Mature_511_residues
MHSTVSGAATTTREEFNALAAVHRVVPVTRKVLADSETPLSAYRKLGANRPGTFLLESAENGRSWSRWSFIGAGSPSALT
VRDGQSAWLGATPEGAPVGGDPLDALRATMDLLAGESLAGLPPLSGGMVGFLAYDIVRRLEKLPELAADDLGLPDLLLLL
ATDMAAVDHHEGTITLIANAVNWDDTPERVAEAYDGAVARLDVMTAALGQPLPSTVAHFDRPAPTYRSQRTVQEYSAIVD
KLVGDIEAGEAFQVVPSMRFEMETDVDPLEVYRILRVTNPSPYMYLLHAPDSEGGTAFSIVGSSPEALVTVQDGVATTHP
IAGTRWRGATDEEDVLLAKDLLADEKELSEHLMLVDLGRNDLGRVCTPGSVKVSDYSHIERYSHVMHLVSTVSGSLADGK
TALDAITACFPAGTLSGAPKVRAMELIEEVELTRRGLYGGVLGYLDFAGNADFAIAIRTALFKDGRAYVQAGGGVVADST
GEYEYNEARNKATAVLNAIAAAETLTGAADV

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=385, Percent_Identity=42.5974025974026, Blast_Score=266, Evalue=3e-72,
Organism=Escherichia coli, GI1788114, Length=460, Percent_Identity=33.0434782608696, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI1786809, Length=224, Percent_Identity=27.2321428571429, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082077, Length=209, Percent_Identity=27.7511961722488, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320935, Length=479, Percent_Identity=40.7098121085595, Blast_Score=298, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6324361, Length=402, Percent_Identity=24.3781094527363, Blast_Score=106, Evalue=9e-24,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54193; Mature: 54193

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSTVSGAATTTREEFNALAAVHRVVPVTRKVLADSETPLSAYRKLGANRPGTFLLESAE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEECCC
NGRSWSRWSFIGAGSPSALTVRDGQSAWLGATPEGAPVGGDPLDALRATMDLLAGESLAG
CCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
LPPLSGGMVGFLAYDIVRRLEKLPELAADDLGLPDLLLLLATDMAAVDHHEGTITLIANA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEC
VNWDDTPERVAEAYDGAVARLDVMTAALGQPLPSTVAHFDRPAPTYRSQRTVQEYSAIVD
CCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHH
KLVGDIEAGEAFQVVPSMRFEMETDVDPLEVYRILRVTNPSPYMYLLHAPDSEGGTAFSI
HHHCCCCCCCEEEECCCCCEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEE
VGSSPEALVTVQDGVATTHPIAGTRWRGATDEEDVLLAKDLLADEKELSEHLMLVDLGRN
ECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHCCEEEEECCCC
DLGRVCTPGSVKVSDYSHIERYSHVMHLVSTVSGSLADGKTALDAITACFPAGTLSGAPK
CCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCC
VRAMELIEEVELTRRGLYGGVLGYLDFAGNADFAIAIRTALFKDGRAYVQAGGGVVADST
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCCEEEEECCCEEECCC
GEYEYNEARNKATAVLNAIAAAETLTGAADV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MHSTVSGAATTTREEFNALAAVHRVVPVTRKVLADSETPLSAYRKLGANRPGTFLLESAE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEECCC
NGRSWSRWSFIGAGSPSALTVRDGQSAWLGATPEGAPVGGDPLDALRATMDLLAGESLAG
CCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
LPPLSGGMVGFLAYDIVRRLEKLPELAADDLGLPDLLLLLATDMAAVDHHEGTITLIANA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEC
VNWDDTPERVAEAYDGAVARLDVMTAALGQPLPSTVAHFDRPAPTYRSQRTVQEYSAIVD
CCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHH
KLVGDIEAGEAFQVVPSMRFEMETDVDPLEVYRILRVTNPSPYMYLLHAPDSEGGTAFSI
HHHCCCCCCCEEEECCCCCEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEE
VGSSPEALVTVQDGVATTHPIAGTRWRGATDEEDVLLAKDLLADEKELSEHLMLVDLGRN
ECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHCCEEEEECCCC
DLGRVCTPGSVKVSDYSHIERYSHVMHLVSTVSGSLADGKTALDAITACFPAGTLSGAPK
CCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCC
VRAMELIEEVELTRRGLYGGVLGYLDFAGNADFAIAIRTALFKDGRAYVQAGGGVVADST
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCCEEEEECCCEEECCC
GEYEYNEARNKATAVLNAIAAAETLTGAADV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA