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The map label for this gene is tesB [H]

Identifier: 169629723

GI number: 169629723

Start: 2679722

End: 2680525

Strand: Reverse

Name: tesB [H]

Synonym: MAB_2638c

Alternate gene names: 169629723

Gene position: 2680525-2679722 (Counterclockwise)

Preceding gene: 169629724

Following gene: 169629722

Centisome position: 52.9

GC content: 60.95

Gene sequence:

>804_bases
GTGTTCGTCGGTGGGCATCCGACTGTCAATCCGCCGCGCACCTTTGGCGGGCAGTTGATGGCGCAGTCGCTCGTGGCTTC
CGGGCGTACCGTGTCGGAGAAGCTCTCGCTGGCGGCCATCTCGACCCACTTCGTCAACGGCGGCGATCCCGAACTGGACA
TCGAGTTCCGGGTGCAGCGGTTGCGGGACGAACGCAATTTCGCCAATCGGCGTGTTGATGCGGTCCAGGGTGATCTGTTG
CTGTCCTCGGCCTTGGTGTCGTATCTCAAGGATTCACCGGGCCTGGAGCACGCCGTGAATCCACCGGTGGTGGCAGATCC
GGAGACATTGCCGTCCATCGATGAGCATCTGGTCGGCTATGAAGAGACCGTGCCGATGTTCGTGGCTGCGCTCAAACCGA
TCGAGTGGCGGTACGACAACGACCCCGCTTGGGTATTGAAGGCCAAATCGCAACGGCTGGAACATAATCGGGTTTGGATG
AAGACCCATGCCGCTCTGCCCGATGACCCGGTGCTGCACAGTGCGGCGCTGGTCTACTCCTCGGACACGACGATATTGGA
CTCGATCATCACCACTCATGGGCTGTCCTGGGGCTACGACCGGATATTCGCCGCGACAATCAACCACAGTGTGTGGTTTC
ACCGCCCACTGCGGTTTGATGACTGGGTGCTGTATGCCACCGAGTCGCCGGTCGCCTCGGCGGGCCGGGGAATGGGTGCA
GGACGGTACTTCGATCGCGACGGAGCGTTGCTGGCCAGTACTATCCAGGAAGGCATTGTCAAATACTTTCCGGGGCGGTC
ATGA

Upstream 100 bases:

>100_bases
CCGGATCGGCGAGGACGACCACTAGGAGCTCAGCATCAGCAACGCACCGGACTTCGAACAGCTTCTCGCGCTGCTGGAAC
TGAAGAATCCCGAGACAGAT

Downstream 100 bases:

>100_bases
TTCGAATTCTTTCTCTGCTGGTGCTGGTTCTCACCGTTATCACCATCATTTCCATCATCAAGGATCCCGTGAAGCCCAAT
GGCGAGAAGCTCCCGTGGGC

Product: acyl-CoA thioesterase

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MFVGGHPTVNPPRTFGGQLMAQSLVASGRTVSEKLSLAAISTHFVNGGDPELDIEFRVQRLRDERNFANRRVDAVQGDLL
LSSALVSYLKDSPGLEHAVNPPVVADPETLPSIDEHLVGYEETVPMFVAALKPIEWRYDNDPAWVLKAKSQRLEHNRVWM
KTHAALPDDPVLHSAALVYSSDTTILDSIITTHGLSWGYDRIFAATINHSVWFHRPLRFDDWVLYATESPVASAGRGMGA
GRYFDRDGALLASTIQEGIVKYFPGRS

Sequences:

>Translated_267_residues
MFVGGHPTVNPPRTFGGQLMAQSLVASGRTVSEKLSLAAISTHFVNGGDPELDIEFRVQRLRDERNFANRRVDAVQGDLL
LSSALVSYLKDSPGLEHAVNPPVVADPETLPSIDEHLVGYEETVPMFVAALKPIEWRYDNDPAWVLKAKSQRLEHNRVWM
KTHAALPDDPVLHSAALVYSSDTTILDSIITTHGLSWGYDRIFAATINHSVWFHRPLRFDDWVLYATESPVASAGRGMGA
GRYFDRDGALLASTIQEGIVKYFPGRS
>Mature_267_residues
MFVGGHPTVNPPRTFGGQLMAQSLVASGRTVSEKLSLAAISTHFVNGGDPELDIEFRVQRLRDERNFANRRVDAVQGDLL
LSSALVSYLKDSPGLEHAVNPPVVADPETLPSIDEHLVGYEETVPMFVAALKPIEWRYDNDPAWVLKAKSQRLEHNRVWM
KTHAALPDDPVLHSAALVYSSDTTILDSIITTHGLSWGYDRIFAATINHSVWFHRPLRFDDWVLYATESPVASAGRGMGA
GRYFDRDGALLASTIQEGIVKYFPGRS

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=277, Percent_Identity=31.4079422382672, Blast_Score=136, Evalue=2e-32,
Organism=Escherichia coli, GI1786657, Length=270, Percent_Identity=31.8518518518519, Blast_Score=145, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17558508, Length=281, Percent_Identity=28.4697508896797, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17531889, Length=268, Percent_Identity=26.865671641791, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI115532456, Length=268, Percent_Identity=26.865671641791, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17531885, Length=268, Percent_Identity=26.865671641791, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71988741, Length=268, Percent_Identity=27.6119402985075, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71982224, Length=287, Percent_Identity=29.616724738676, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322480, Length=301, Percent_Identity=24.9169435215947, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 29566; Mature: 29566

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVGGHPTVNPPRTFGGQLMAQSLVASGRTVSEKLSLAAISTHFVNGGDPELDIEFRVQR
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEHHHHHHH
LRDERNFANRRVDAVQGDLLLSSALVSYLKDSPGLEHAVNPPVVADPETLPSIDEHLVGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCHHHHHCCC
EETVPMFVAALKPIEWRYDNDPAWVLKAKSQRLEHNRVWMKTHAALPDDPVLHSAALVYS
HHHHHHHHHHHCCEEEEECCCCEEEEECCHHHHHHCEEEEEECCCCCCCCHHHHEEEEEE
SDTTILDSIITTHGLSWGYDRIFAATINHSVWFHRPLRFDDWVLYATESPVASAGRGMGA
CCHHHHHHHHHHCCCCCCHHHEEEEEECCCEEEECCCCCCCEEEEEECCCHHHCCCCCCC
GRYFDRDGALLASTIQEGIVKYFPGRS
CCEECCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFVGGHPTVNPPRTFGGQLMAQSLVASGRTVSEKLSLAAISTHFVNGGDPELDIEFRVQR
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEHHHHHHH
LRDERNFANRRVDAVQGDLLLSSALVSYLKDSPGLEHAVNPPVVADPETLPSIDEHLVGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCHHHHHCCC
EETVPMFVAALKPIEWRYDNDPAWVLKAKSQRLEHNRVWMKTHAALPDDPVLHSAALVYS
HHHHHHHHHHHCCEEEEECCCCEEEEECCHHHHHHCEEEEEECCCCCCCCHHHHEEEEEE
SDTTILDSIITTHGLSWGYDRIFAATINHSVWFHRPLRFDDWVLYATESPVASAGRGMGA
CCHHHHHHHHHHCCCCCCHHHEEEEEECCCEEEECCCCCCCEEEEEECCCHHHCCCCCCC
GRYFDRDGALLASTIQEGIVKYFPGRS
CCEECCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]