Click here to switch to the map view.

The map label for this gene is ubiB [C]

Identifier: 169629477

GI number: 169629477

Start: 2446476

End: 2447852

Strand: Direct

Name: ubiB [C]

Synonym: MAB_2391

Alternate gene names: 169629477

Gene position: 2446476-2447852 (Clockwise)

Preceding gene: 169629476

Following gene: 169629478

Centisome position: 48.28

GC content: 62.09

Gene sequence:

>1377_bases
GTGAGCGATACGTCCGATGAGTCTCGACGGCCCCGGAAACTGGATCCGGTCTCCGCCGAGGTTCAGTTCGATCGATTGGC
GGCGACGGCCGGTCAGCTCCTCAAGGCGGGATCGCGAATACTGAGTCAGCGACCGACGGAGCGCGACCTGCGCCAGGTGG
TGGCCAAGGAGATGCGCAGGTCATTTGCCGAACTTGGGCCCGCCTACGTCAAATTCGGCCAGCTCATCGCCTCGTCACCG
GGGATGTTCCCCGAGGACCTCTCGGCGGAGTTCCGATCGCTGCTCGATCAAGTGCCACCCGCCGACCCTCAGACGATTCG
CTCCATGTTGAGTAACGAGCTCGGCGCGTCGCCGGAGAATGTATTCGGCTCATTCGACGAGGTCCCGTTCGCGTCGGCGT
CGATTGCCCAGGTGCACAGGGCGACATTGAAGGACGGCACCGCGGTTGTCGTGAAGATACAACGCCCCGCGATCCGCACC
CGCCTCGCGGCCGACCTGCAGATTCTCAAACAGATCGCCCGGGGTCTCGAACTGACCGAGATGGGCCGGATGTCGAACAT
CTATGAGGTGATGCGGGACTTTGAGTCGAACCTCGCCGAGGAACTGGATTTCAGCCTGGAAGCTCGGGCCATGCGAGATT
GGACCGCTGGGCTTGCGGGCTCCAGGTATGCGTCGAAGGTGCGTGTCCCCGAAATCTATTCGGATCTCTGCACCGACAAG
GTGCTCACCATGGAGTATGTCGAGGGCATCAGGATTGATGATGCGGACGCGATTCGGGCGGCGGGGTTCGACGGACCCGA
AGTGGTGAAGACCCTGATGCTCACACTGTTCGATTCCGCGTTCACCGCCGGAACCTTCCATGGTGATCTGCATGCCGGGA
ACCTCATGGTGGATCCGCACGGACGAATCGTGTTCTTGGACTTCGGGATTGTTGGCCGCCTTGATCAGCGGACGCGCAAG
ACACTGCGTGAGCTGATCGGCGCACTCATCCTCGAACCCGATGACGAGGCGGCGGCGCGCACGCTGATCAAACTCGGGGC
GATCGATGCCCATGCGGACCCGGCCAGGGTCGCTGAGTCACTTCGGAAGGTCACCCGCCCCATGGGTACCTCGTTGGGCA
AGATCTCCTACGGGACCATCGGCCGCCAGCTCACCGCCCTGGGGCGCGAACATGACGCCATCCTTCCCAAGGAGTTCATC
CTGGTCGGCAAGCAGCTGCTCTATGTCGAGCGCTACACCAAACTGCTTGCGCCCGACTGGCAGCCGGTGGGCGATCCGGA
GATCCTCACCTACTTCGGCACCTTGATAGCGGAGTATCAACAGGCCCGCGAAGAAATCAAGCACAGCAAGAACGACACGG
ACGGGCTCGGAGAATGA

Upstream 100 bases:

>100_bases
GATCATTCCCGGCCGCTCCCGGGCATTCGATTAACATACATACCAGTTTGTCGGTAATGTCTCACCGACGTACGACCGGT
GAGGACGGGAGGGAGTGGCG

Downstream 100 bases:

>100_bases
CACGTACCGCCGGTAGCCCAGCACGCTCAAGCACGCGTCCCCAGCGTGCCGAGCGGCGGACCCAGGAGGAACGCAGCGCG
GCCATGCGTGGCCGGCTGCT

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSDTSDESRRPRKLDPVSAEVQFDRLAATAGQLLKAGSRILSQRPTERDLRQVVAKEMRRSFAELGPAYVKFGQLIASSP
GMFPEDLSAEFRSLLDQVPPADPQTIRSMLSNELGASPENVFGSFDEVPFASASIAQVHRATLKDGTAVVVKIQRPAIRT
RLAADLQILKQIARGLELTEMGRMSNIYEVMRDFESNLAEELDFSLEARAMRDWTAGLAGSRYASKVRVPEIYSDLCTDK
VLTMEYVEGIRIDDADAIRAAGFDGPEVVKTLMLTLFDSAFTAGTFHGDLHAGNLMVDPHGRIVFLDFGIVGRLDQRTRK
TLRELIGALILEPDDEAAARTLIKLGAIDAHADPARVAESLRKVTRPMGTSLGKISYGTIGRQLTALGREHDAILPKEFI
LVGKQLLYVERYTKLLAPDWQPVGDPEILTYFGTLIAEYQQAREEIKHSKNDTDGLGE

Sequences:

>Translated_458_residues
MSDTSDESRRPRKLDPVSAEVQFDRLAATAGQLLKAGSRILSQRPTERDLRQVVAKEMRRSFAELGPAYVKFGQLIASSP
GMFPEDLSAEFRSLLDQVPPADPQTIRSMLSNELGASPENVFGSFDEVPFASASIAQVHRATLKDGTAVVVKIQRPAIRT
RLAADLQILKQIARGLELTEMGRMSNIYEVMRDFESNLAEELDFSLEARAMRDWTAGLAGSRYASKVRVPEIYSDLCTDK
VLTMEYVEGIRIDDADAIRAAGFDGPEVVKTLMLTLFDSAFTAGTFHGDLHAGNLMVDPHGRIVFLDFGIVGRLDQRTRK
TLRELIGALILEPDDEAAARTLIKLGAIDAHADPARVAESLRKVTRPMGTSLGKISYGTIGRQLTALGREHDAILPKEFI
LVGKQLLYVERYTKLLAPDWQPVGDPEILTYFGTLIAEYQQAREEIKHSKNDTDGLGE
>Mature_457_residues
SDTSDESRRPRKLDPVSAEVQFDRLAATAGQLLKAGSRILSQRPTERDLRQVVAKEMRRSFAELGPAYVKFGQLIASSPG
MFPEDLSAEFRSLLDQVPPADPQTIRSMLSNELGASPENVFGSFDEVPFASASIAQVHRATLKDGTAVVVKIQRPAIRTR
LAADLQILKQIARGLELTEMGRMSNIYEVMRDFESNLAEELDFSLEARAMRDWTAGLAGSRYASKVRVPEIYSDLCTDKV
LTMEYVEGIRIDDADAIRAAGFDGPEVVKTLMLTLFDSAFTAGTFHGDLHAGNLMVDPHGRIVFLDFGIVGRLDQRTRKT
LRELIGALILEPDDEAAARTLIKLGAIDAHADPARVAESLRKVTRPMGTSLGKISYGTIGRQLTALGREHDAILPKEFIL
VGKQLLYVERYTKLLAPDWQPVGDPEILTYFGTLIAEYQQAREEIKHSKNDTDGLGE

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=290, Percent_Identity=30.6896551724138, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI41393593, Length=288, Percent_Identity=32.6388888888889, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI217035081, Length=266, Percent_Identity=28.9473684210526, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI34147522, Length=273, Percent_Identity=27.1062271062271, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI27363457, Length=286, Percent_Identity=27.2727272727273, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI217416386, Length=202, Percent_Identity=29.7029702970297, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI2367309, Length=375, Percent_Identity=29.0666666666667, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17559152, Length=372, Percent_Identity=28.494623655914, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI32565180, Length=216, Percent_Identity=29.1666666666667, Blast_Score=79, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323282, Length=291, Percent_Identity=26.8041237113402, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321319, Length=303, Percent_Identity=25.0825082508251, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI22024280, Length=286, Percent_Identity=29.7202797202797, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24662575, Length=356, Percent_Identity=26.9662921348315, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI18859849, Length=252, Percent_Identity=28.968253968254, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 50604; Mature: 50473

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTSDESRRPRKLDPVSAEVQFDRLAATAGQLLKAGSRILSQRPTERDLRQVVAKEMRR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SFAELGPAYVKFGQLIASSPGMFPEDLSAEFRSLLDQVPPADPQTIRSMLSNELGASPEN
HHHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHH
VFGSFDEVPFASASIAQVHRATLKDGTAVVVKIQRPAIRTRLAADLQILKQIARGLELTE
HCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHH
MGRMSNIYEVMRDFESNLAEELDFSLEARAMRDWTAGLAGSRYASKVRVPEIYSDLCTDK
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHH
VLTMEYVEGIRIDDADAIRAAGFDGPEVVKTLMLTLFDSAFTAGTFHGDLHAGNLMVDPH
HHHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCC
GRIVFLDFGIVGRLDQRTRKTLRELIGALILEPDDEAAARTLIKLGAIDAHADPARVAES
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
LRKVTRPMGTSLGKISYGTIGRQLTALGREHDAILPKEFILVGKQLLYVERYTKLLAPDW
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
QPVGDPEILTYFGTLIAEYQQAREEIKHSKNDTDGLGE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SDTSDESRRPRKLDPVSAEVQFDRLAATAGQLLKAGSRILSQRPTERDLRQVVAKEMRR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SFAELGPAYVKFGQLIASSPGMFPEDLSAEFRSLLDQVPPADPQTIRSMLSNELGASPEN
HHHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHH
VFGSFDEVPFASASIAQVHRATLKDGTAVVVKIQRPAIRTRLAADLQILKQIARGLELTE
HCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHH
MGRMSNIYEVMRDFESNLAEELDFSLEARAMRDWTAGLAGSRYASKVRVPEIYSDLCTDK
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHH
VLTMEYVEGIRIDDADAIRAAGFDGPEVVKTLMLTLFDSAFTAGTFHGDLHAGNLMVDPH
HHHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCC
GRIVFLDFGIVGRLDQRTRKTLRELIGALILEPDDEAAARTLIKLGAIDAHADPARVAES
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
LRKVTRPMGTSLGKISYGTIGRQLTALGREHDAILPKEFILVGKQLLYVERYTKLLAPDW
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
QPVGDPEILTYFGTLIAEYQQAREEIKHSKNDTDGLGE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]