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The map label for this gene is fabG [C]

Identifier: 169629411

GI number: 169629411

Start: 2379186

End: 2380142

Strand: Direct

Name: fabG [C]

Synonym: MAB_2325

Alternate gene names: 169629411

Gene position: 2379186-2380142 (Clockwise)

Preceding gene: 169629410

Following gene: 169629416

Centisome position: 46.95

GC content: 66.04

Gene sequence:

>957_bases
ATGCCCGCACCTCTGCAGATCAGGCACTTTCGTGAATCGGATGTTCCCGACCAGACTGGCAAGACACACGTCATCACCGG
TGCGAATAACGGTCTGGGTCTGGTTGCCGCGGAGGCGCTCGCACGTGCCGGCGCCCGCGTCGTGCTTGCCTGCCGCAACC
AGCAGACCGGGCGCGCGGCCCTGGACAAGGTGCGTGCCCTGGGTCCGAATGCTGACCACGCGCTCGTTGAATTGGACCTC
ACCAGTCTGGCATCGGTGCGATCGGCCGCGGACGCCATCCGCACCCAGGCGCCGACCATCGACGTGCTGCTGAACAACGC
GGGTGTCATGGCGATCCCGTTGCAGCGCACCGCCGAAGGATTCGAGATGCAGATCGGCGTGAACCATCTCGGCCACTTCG
TGCTGACCGACGCGCTGCTGCCGTCGCTACTGGCCGCCGACGCGCCCCGGGTGATTTCTCTGGGCAGCGTCGCGCACGCG
CAGGGACGCAATAACCTGAAGGTCGACGACCTGAACTTCACTCAGCGTCGGTACAACCGGATGACCGCCTATCGCGCCTC
GAAGCTCGCGTGCATGCTGTTCGGCTCGGAGTTGGCTCGAAAGGCCGCGGCCGCCGGATCCTCGCTGGTGTCGGTGAATG
TGCACCCCGGAGTGGCGGCCACCAACCTGTTCGACTCCATGATTCCGAAACTCCCGGGGCTGCATAAGGCCTTCTACTTC
GGCATGGGCCTGGTGCTGCAGGACGAGCGCCAAGGTGCGGAGTCCGAGCTGTACGCCGCGTCGATGCCGGATGTCCAGCC
CGACGACTATCTGGGCCCCACCCAGTTGACCGGCGCCAGGGGACCGGTAGCGCGCGCACCCCGGAGCAAGGAAGCACGTG
ACCCCAAGCTGGCGGCGCAGTTGTGGCAGAAGTCGGTGGAACTCACCGGGGCCGACTACTCGCGACTCAGCGGTTAG

Upstream 100 bases:

>100_bases
GTACGCCACGGCGCGGATGCATCGCCGTCAATAGCCTCCAGTACTATCCGACAAAGCCGTAACGGCGAGTACTAGTAACT
TCGATGGATCGAGGAACCTC

Downstream 100 bases:

>100_bases
CGCCGCTGGGATCACTCTGAGTCCAACACTCGTGTCGCGCATCGTGGTTCGGCATTATCGGTGCTCGACGCGGGTGTGGC
TGAGAGGCTAGGCACCGGCC

Product: putative short-chain dehydrogenase/reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MPAPLQIRHFRESDVPDQTGKTHVITGANNGLGLVAAEALARAGARVVLACRNQQTGRAALDKVRALGPNADHALVELDL
TSLASVRSAADAIRTQAPTIDVLLNNAGVMAIPLQRTAEGFEMQIGVNHLGHFVLTDALLPSLLAADAPRVISLGSVAHA
QGRNNLKVDDLNFTQRRYNRMTAYRASKLACMLFGSELARKAAAAGSSLVSVNVHPGVAATNLFDSMIPKLPGLHKAFYF
GMGLVLQDERQGAESELYAASMPDVQPDDYLGPTQLTGARGPVARAPRSKEARDPKLAAQLWQKSVELTGADYSRLSG

Sequences:

>Translated_318_residues
MPAPLQIRHFRESDVPDQTGKTHVITGANNGLGLVAAEALARAGARVVLACRNQQTGRAALDKVRALGPNADHALVELDL
TSLASVRSAADAIRTQAPTIDVLLNNAGVMAIPLQRTAEGFEMQIGVNHLGHFVLTDALLPSLLAADAPRVISLGSVAHA
QGRNNLKVDDLNFTQRRYNRMTAYRASKLACMLFGSELARKAAAAGSSLVSVNVHPGVAATNLFDSMIPKLPGLHKAFYF
GMGLVLQDERQGAESELYAASMPDVQPDDYLGPTQLTGARGPVARAPRSKEARDPKLAAQLWQKSVELTGADYSRLSG
>Mature_317_residues
PAPLQIRHFRESDVPDQTGKTHVITGANNGLGLVAAEALARAGARVVLACRNQQTGRAALDKVRALGPNADHALVELDLT
SLASVRSAADAIRTQAPTIDVLLNNAGVMAIPLQRTAEGFEMQIGVNHLGHFVLTDALLPSLLAADAPRVISLGSVAHAQ
GRNNLKVDDLNFTQRRYNRMTAYRASKLACMLFGSELARKAAAAGSSLVSVNVHPGVAATNLFDSMIPKLPGLHKAFYFG
MGLVLQDERQGAESELYAASMPDVQPDDYLGPTQLTGARGPVARAPRSKEARDPKLAAQLWQKSVELTGADYSRLSG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI225579078, Length=303, Percent_Identity=38.6138613861386, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI186928839, Length=321, Percent_Identity=36.4485981308411, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI166795268, Length=316, Percent_Identity=34.4936708860759, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI10190746, Length=308, Percent_Identity=36.038961038961, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI146231950, Length=295, Percent_Identity=38.6440677966102, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI19923931, Length=253, Percent_Identity=38.7351778656126, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI193804850, Length=315, Percent_Identity=31.1111111111111, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI7706523, Length=298, Percent_Identity=33.5570469798658, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI7705421, Length=241, Percent_Identity=27.3858921161826, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787335, Length=207, Percent_Identity=28.5024154589372, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17558006, Length=313, Percent_Identity=29.073482428115, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193207620, Length=307, Percent_Identity=31.2703583061889, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17532805, Length=306, Percent_Identity=30.718954248366, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71992402, Length=299, Percent_Identity=31.1036789297659, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17532791, Length=303, Percent_Identity=28.7128712871287, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17535059, Length=327, Percent_Identity=28.1345565749235, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17505416, Length=191, Percent_Identity=32.4607329842932, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI32565532, Length=213, Percent_Identity=29.1079812206573, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI72001364, Length=274, Percent_Identity=29.9270072992701, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI193203117, Length=228, Percent_Identity=28.0701754385965, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI193203115, Length=220, Percent_Identity=29.0909090909091, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324820, Length=323, Percent_Identity=27.8637770897833, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI22024069, Length=299, Percent_Identity=37.123745819398, Blast_Score=160, Evalue=9e-40,
Organism=Drosophila melanogaster, GI28573296, Length=258, Percent_Identity=38.7596899224806, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI19921754, Length=305, Percent_Identity=34.0983606557377, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI161076371, Length=252, Percent_Identity=38.8888888888889, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24586328, Length=301, Percent_Identity=32.5581395348837, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI20129347, Length=301, Percent_Identity=31.8936877076412, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI45554248, Length=301, Percent_Identity=35.2159468438538, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24640117, Length=301, Percent_Identity=35.2159468438538, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24656154, Length=299, Percent_Identity=34.4481605351171, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI19922628, Length=299, Percent_Identity=34.4481605351171, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24647946, Length=311, Percent_Identity=30.5466237942122, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI45553409, Length=298, Percent_Identity=30.8724832214765, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24647948, Length=298, Percent_Identity=30.8724832214765, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24647931, Length=307, Percent_Identity=30.6188925081433, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21358495, Length=223, Percent_Identity=30.9417040358744, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24640492, Length=254, Percent_Identity=24.4094488188976, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 33815; Mature: 33684

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPLQIRHFRESDVPDQTGKTHVITGANNGLGLVAAEALARAGARVVLACRNQQTGRAA
CCCCCCEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHH
LDKVRALGPNADHALVELDLTSLASVRSAADAIRTQAPTIDVLLNNAGVMAIPLQRTAEG
HHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEHHHCCCC
FEMQIGVNHLGHFVLTDALLPSLLAADAPRVISLGSVAHAQGRNNLKVDDLNFTQRRYNR
EEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHCCCCCCEEECCCHHHHHHHH
MTAYRASKLACMLFGSELARKAAAAGSSLVSVNVHPGVAATNLFDSMIPKLPGLHKAFYF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHH
GMGLVLQDERQGAESELYAASMPDVQPDDYLGPTQLTGARGPVARAPRSKEARDPKLAAQ
CCCEEEECCCCCCCHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
LWQKSVELTGADYSRLSG
HHHHHHHCCCCCHHHCCC
>Mature Secondary Structure 
PAPLQIRHFRESDVPDQTGKTHVITGANNGLGLVAAEALARAGARVVLACRNQQTGRAA
CCCCCEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHH
LDKVRALGPNADHALVELDLTSLASVRSAADAIRTQAPTIDVLLNNAGVMAIPLQRTAEG
HHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEHHHCCCC
FEMQIGVNHLGHFVLTDALLPSLLAADAPRVISLGSVAHAQGRNNLKVDDLNFTQRRYNR
EEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHCCCCCCEEECCCHHHHHHHH
MTAYRASKLACMLFGSELARKAAAAGSSLVSVNVHPGVAATNLFDSMIPKLPGLHKAFYF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHH
GMGLVLQDERQGAESELYAASMPDVQPDDYLGPTQLTGARGPVARAPRSKEARDPKLAAQ
CCCEEEECCCCCCCHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
LWQKSVELTGADYSRLSG
HHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]