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The map label for this gene is uvrB [H]

Identifier: 169629394

GI number: 169629394

Start: 2359024

End: 2361183

Strand: Direct

Name: uvrB [H]

Synonym: MAB_2308

Alternate gene names: 169629394

Gene position: 2359024-2361183 (Clockwise)

Preceding gene: 169629389

Following gene: 169629396

Centisome position: 46.56

GC content: 61.3

Gene sequence:

>2160_bases
ATGGCTTTCGCAACAGAACACCCCATCGTTGCGCATTCCGAGTATCGCCCGGTCACCGATATCTTGCGTACCGAGGGGCG
GTTCGAGGTCGTCAGTCAGTATGAACCCGCTGGCGACCAGCCCGGTGCTATCGCCGAGCTCGAACGCAGGGTCCGCGCGG
GGGAGAAGGACGTGGTACTCCTCGGTGCCACCGGTACCGGTAAGTCGGCCACGACGGCCTGGCTCATCGAACGCTTGCAG
CGACCGACGCTCGTCATGGCACCCAACAAGACCCTCGCGGCACAGTTGGCCAACGAGCTCCGGGAAATGTTGCCGCACAA
TGCCGTCGAGTATTTCGTTTCGTATTACGACTACTACCAGCCGGAAGCGTATATCGCGCAAACCGATACCTACATCGAAA
AAGACAGCTCCATCAACGATGACGTGGAGCGTCTGCGGCACTCGGCGACATCCAACTTGCTGTCCCGCCGGGATGTCGTG
GTAGTGGCCTCGGTCTCATGCATCTACGGATTGGGTACTCCGCAGTCGTACCTGGATCGTTCGGTGCAGTTGGACGTGGG
GCTGGAGGTGCCTCGCGATGCGCTGCTGCGGCTGCTGGTCGACATGCAGTACAACCGCAATGACATGGCCTTCACCCGGG
GCACCTTCCGGGTACGCGGCGACACCGTCGAGATCATCCCGTCCTACGAAGAGCTGGCCGTTCGCATCGAATTCTTCGGT
GACGAGGTAGAGGCACTCTATTATCTGCATCCGCTCACGGGAGATGTTGTGCGGCAGACTAATTCGCTGAGAATTTTTCC
CGCCACGCATTACGTGGCCGGGCCGGAGCGAATGGGGAAGGCGCTGGAGGGTATCGAGCAGGAGCTCGAGGAGCGTCTGT
CCGAATTGGAAGGGCAAGGCAAGCTGTTGGAGGCGCAGCGCCTGCGGATGCGCACCAACTACGACATCGAGATGATGCGC
AATGTCGGCTTCTGCTCGGGTATCGAAAACTATTCGCGGCATATCGACGGACGCGGTGCCGGTACGCCGCCGGCCACCTT
GCTGGACTACTTCCCGGATGACTTCCTGCTGGTCATCGACGAATCTCACGTGACTGTTCCGCAGATCGGTGCCATGTATG
AGGGCGACATGTCGCGTAAACGGAACCTGGTGGACTTCGGTTTCCGGCTCCCGTCCGCCGTCGACAATCGTCCACTCACC
TGGGAAGAGTTCGCCGACCGTATCGGCCAGACGGTGTATCTGTCCGCAACCCCCGGAAACTATGAGCGCAGTGCGGCGGG
TGGCGAGTTCGTGGAACAGGTCATCCGGCCGACCGGGCTGGTGGATCCCAAGGTGGTGGTCAAACCCACCAAGGGGCAGA
TCGACGATCTCATCGCATCGATCCGGCAGCGCACCGAGGCCGACGAACGTGTGCTGGTGACCACGTTGACGAAAAAGATG
GCGGAGGACCTCACCGACTACCTTCTGGAAATGGGTATTCGGGTGCGTTATCTGCACTCCGAGGTGGACACGCTGCGGCG
AGTCGAGCTGTTGCGCCAGCTCAGGCTTGGCGAGTACGACGTCCTGGTGGGTATCAACCTGCTACGGGAAGGCCTTGACC
TGCCCGAAGTGTCGTTGGTTGCGATTCTGGACGCCGACAAGGAAGGGTTCCTGCGGTCCAGTCGAAGCCTGATCCAGACC
ATCGGTCGTGCCGCGCGCAACGTCTCCGGCGAGGTGCACATGTATGCCGACACCATGACCGACTCCATGAAGGAGGCGAT
CGACGAGACGGATCGTCGACGTGCCAAGCAGATCGCCTATAACCAGGCCAATGGAATCGACCCACAACCTTTGCGCAAGA
AGATCGCCGACATCCTGGACCAGGTGTACCGGGAGGCCGAGGACACCGAGGAAGTGGCGGTCGGTGGATCCGGCCGAAAC
TCCAGCCGGGGTCGGCGGGCTCAAGGCGAGCCCGGTCGCGCGGTCAGCGCCGGGGTCTTCGAAGGTCGTGACACCAAGAC
TATGCCGCGCGCGGAGCTGGCCGATCTGATCAAGGACATGACCGAGCAGATGATGACGGCGGCACGCGATCTGCAGTTTG
AGTTGGCGGCCCGGTTCCGCGACGAGATCGCCGATCTCAAAAAGGAATTGCGCGGCATGGATGCCGCGGGCCTGAAGTAG

Upstream 100 bases:

>100_bases
CAGGTCGAAGATCTCGTGTTTCGGCGGGTGCACGGTGGTTTTCTGCCGCCTTCCTCGCTGGTATTGGAGGGATGTCAGAC
CCTCGGCTTACCCTGGGGCC

Downstream 100 bases:

>100_bases
TCAGCCGAGATCGGCAAGCAACAGTGCGCCGGTCGAGCCGTCGTCGGCCAGGATGTCCGCAGGGTTGAACAGGGCGCATT
TCGTCATCGACAGGCAGCCG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 719; Mature: 718

Protein sequence:

>719_residues
MAFATEHPIVAHSEYRPVTDILRTEGRFEVVSQYEPAGDQPGAIAELERRVRAGEKDVVLLGATGTGKSATTAWLIERLQ
RPTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSNLLSRRDVV
VVASVSCIYGLGTPQSYLDRSVQLDVGLEVPRDALLRLLVDMQYNRNDMAFTRGTFRVRGDTVEIIPSYEELAVRIEFFG
DEVEALYYLHPLTGDVVRQTNSLRIFPATHYVAGPERMGKALEGIEQELEERLSELEGQGKLLEAQRLRMRTNYDIEMMR
NVGFCSGIENYSRHIDGRGAGTPPATLLDYFPDDFLLVIDESHVTVPQIGAMYEGDMSRKRNLVDFGFRLPSAVDNRPLT
WEEFADRIGQTVYLSATPGNYERSAAGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIASIRQRTEADERVLVTTLTKKM
AEDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSSRSLIQT
IGRAARNVSGEVHMYADTMTDSMKEAIDETDRRRAKQIAYNQANGIDPQPLRKKIADILDQVYREAEDTEEVAVGGSGRN
SSRGRRAQGEPGRAVSAGVFEGRDTKTMPRAELADLIKDMTEQMMTAARDLQFELAARFRDEIADLKKELRGMDAAGLK

Sequences:

>Translated_719_residues
MAFATEHPIVAHSEYRPVTDILRTEGRFEVVSQYEPAGDQPGAIAELERRVRAGEKDVVLLGATGTGKSATTAWLIERLQ
RPTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSNLLSRRDVV
VVASVSCIYGLGTPQSYLDRSVQLDVGLEVPRDALLRLLVDMQYNRNDMAFTRGTFRVRGDTVEIIPSYEELAVRIEFFG
DEVEALYYLHPLTGDVVRQTNSLRIFPATHYVAGPERMGKALEGIEQELEERLSELEGQGKLLEAQRLRMRTNYDIEMMR
NVGFCSGIENYSRHIDGRGAGTPPATLLDYFPDDFLLVIDESHVTVPQIGAMYEGDMSRKRNLVDFGFRLPSAVDNRPLT
WEEFADRIGQTVYLSATPGNYERSAAGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIASIRQRTEADERVLVTTLTKKM
AEDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSSRSLIQT
IGRAARNVSGEVHMYADTMTDSMKEAIDETDRRRAKQIAYNQANGIDPQPLRKKIADILDQVYREAEDTEEVAVGGSGRN
SSRGRRAQGEPGRAVSAGVFEGRDTKTMPRAELADLIKDMTEQMMTAARDLQFELAARFRDEIADLKKELRGMDAAGLK
>Mature_718_residues
AFATEHPIVAHSEYRPVTDILRTEGRFEVVSQYEPAGDQPGAIAELERRVRAGEKDVVLLGATGTGKSATTAWLIERLQR
PTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSNLLSRRDVVV
VASVSCIYGLGTPQSYLDRSVQLDVGLEVPRDALLRLLVDMQYNRNDMAFTRGTFRVRGDTVEIIPSYEELAVRIEFFGD
EVEALYYLHPLTGDVVRQTNSLRIFPATHYVAGPERMGKALEGIEQELEERLSELEGQGKLLEAQRLRMRTNYDIEMMRN
VGFCSGIENYSRHIDGRGAGTPPATLLDYFPDDFLLVIDESHVTVPQIGAMYEGDMSRKRNLVDFGFRLPSAVDNRPLTW
EEFADRIGQTVYLSATPGNYERSAAGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIASIRQRTEADERVLVTTLTKKMA
EDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSSRSLIQTI
GRAARNVSGEVHMYADTMTDSMKEAIDETDRRRAKQIAYNQANGIDPQPLRKKIADILDQVYREAEDTEEVAVGGSGRNS
SRGRRAQGEPGRAVSAGVFEGRDTKTMPRAELADLIKDMTEQMMTAARDLQFELAARFRDEIADLKKELRGMDAAGLK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=683, Percent_Identity=55.4904831625183, Blast_Score=727, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 80822; Mature: 80690

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFATEHPIVAHSEYRPVTDILRTEGRFEVVSQYEPAGDQPGAIAELERRVRAGEKDVVL
CCCCCCCCEEECCCCCCHHHHHHCCCCEEEHHCCCCCCCCCCHHHHHHHHHHCCCCCEEE
LGATGTGKSATTAWLIERLQRPTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQ
EECCCCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
PEAYIAQTDTYIEKDSSINDDVERLRHSATSNLLSRRDVVVVASVSCIYGLGTPQSYLDR
CCEEEECCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHCC
SVQLDVGLEVPRDALLRLLVDMQYNRNDMAFTRGTFRVRGDTVEIIPSYEELAVRIEFFG
CEEEEECCCCCHHHHHHHHHHHCCCCCCCEEECCEEEECCCEEEECCCHHHHEEEEEECC
DEVEALYYLHPLTGDVVRQTNSLRIFPATHYVAGPERMGKALEGIEQELEERLSELEGQG
CCEEEEEEECCCCHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
KLLEAQRLRMRTNYDIEMMRNVGFCSGIENYSRHIDGRGAGTPPATLLDYFPDDFLLVID
CCHHHHHHHHHCCCCHHHHHCCCHHCCHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEE
ESHVTVPQIGAMYEGDMSRKRNLVDFGFRLPSAVDNRPLTWEEFADRIGQTVYLSATPGN
CCCCCCCCCCCHHCCCHHHHCCHHHHCCCCCCCCCCCCCCHHHHHHHCCCEEEEEECCCC
YERSAAGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIASIRQRTEADERVLVTTLTKKM
CCCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
AEDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLV
HHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEE
AILDADKEGFLRSSRSLIQTIGRAARNVSGEVHMYADTMTDSMKEAIDETDRRRAKQIAY
EEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
NQANGIDPQPLRKKIADILDQVYREAEDTEEVAVGGSGRNSSRGRRAQGEPGRAVSAGVF
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCCCCCCCCCCCCCCCEEECCCC
EGRDTKTMPRAELADLIKDMTEQMMTAARDLQFELAARFRDEIADLKKELRGMDAAGLK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AFATEHPIVAHSEYRPVTDILRTEGRFEVVSQYEPAGDQPGAIAELERRVRAGEKDVVL
CCCCCCCEEECCCCCCHHHHHHCCCCEEEHHCCCCCCCCCCHHHHHHHHHHCCCCCEEE
LGATGTGKSATTAWLIERLQRPTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQ
EECCCCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
PEAYIAQTDTYIEKDSSINDDVERLRHSATSNLLSRRDVVVVASVSCIYGLGTPQSYLDR
CCEEEECCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHCC
SVQLDVGLEVPRDALLRLLVDMQYNRNDMAFTRGTFRVRGDTVEIIPSYEELAVRIEFFG
CEEEEECCCCCHHHHHHHHHHHCCCCCCCEEECCEEEECCCEEEECCCHHHHEEEEEECC
DEVEALYYLHPLTGDVVRQTNSLRIFPATHYVAGPERMGKALEGIEQELEERLSELEGQG
CCEEEEEEECCCCHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
KLLEAQRLRMRTNYDIEMMRNVGFCSGIENYSRHIDGRGAGTPPATLLDYFPDDFLLVID
CCHHHHHHHHHCCCCHHHHHCCCHHCCHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEE
ESHVTVPQIGAMYEGDMSRKRNLVDFGFRLPSAVDNRPLTWEEFADRIGQTVYLSATPGN
CCCCCCCCCCCHHCCCHHHHCCHHHHCCCCCCCCCCCCCCHHHHHHHCCCEEEEEECCCC
YERSAAGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIASIRQRTEADERVLVTTLTKKM
CCCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
AEDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLV
HHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEE
AILDADKEGFLRSSRSLIQTIGRAARNVSGEVHMYADTMTDSMKEAIDETDRRRAKQIAY
EEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
NQANGIDPQPLRKKIADILDQVYREAEDTEEVAVGGSGRNSSRGRRAQGEPGRAVSAGVF
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCCCCCCCCCCCCCCCEEECCCC
EGRDTKTMPRAELADLIKDMTEQMMTAARDLQFELAARFRDEIADLKKELRGMDAAGLK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA