Click here to switch to the map view.

The map label for this gene is mbtB [H]

Identifier: 169629207

GI number: 169629207

Start: 2120968

End: 2121732

Strand: Reverse

Name: mbtB [H]

Synonym: MAB_2121c

Alternate gene names: 169629207

Gene position: 2121732-2120968 (Counterclockwise)

Preceding gene: 169629211

Following gene: 169629206

Centisome position: 41.87

GC content: 61.44

Gene sequence:

>765_bases
GTGGATCGCAAACTCGGATGGATCAGGCAGTTTCATAAGCCGGAGTCACCCGATGCACCATTGCTGCTGATTTTTCCGCA
TGCAGGGGCCGGAGCCTCGGCCTATCGCACGCTCTCCAAGGCTTCTTCAGCAAATTTCAATGTGCTCGTCTTCCAATACC
CGGGCAGGCAGGATCGGGCAGGTGAGCCGGCCCTCCCGACCCTGTCCGATATTGCCGCGGGTGCCTTCGCCGAGTTCCAG
TCGTCGGAACACAATCGACGCGTACCCATCCATACTTTCGGCCACAGCATGGGGGCCGTGGTCTCCTTCGAGTTCGCCCG
GCTGGCCGAGGCCGCCGGCCTGGATGTACATCAGCTGACCGTTTCCTCGGCAGTGGCACCCTGCAATATCGCGGATAAGC
CCGCGCTGCCCACCGATGATGACGCGGTGTTGGCCCACATGGGTGCCCTTGAGGGCACGAACTCCACGGTCATGGGCAAT
CTCGATGTGATGCGGATGGCGTTACCCGTCATGAAGGGTGACTACCAGGCCTTCAACGCGTACCAGTGTGCCGACGGCGC
CAAGGTTGCGGCACGCATCCATTCGATCGGCGGAGACCAGGACCCGATGATCACGATGCGCGATTTATACGGTTGGGCTC
AGCACACCGACGCACTTGAGGTGACGTTGTTCGACGGCGGCCACTTCTTCCTGAACTCGCAAACCGAGGCACTGGCCGAG
CTGCTGGTCGCGAACTCTGCCTCCGCGTCCTCGCCACAACGATGA

Upstream 100 bases:

>100_bases
CATGGGTGCCGTGCATCACCCGCACATGGATGAGCCACATACCTCCGAACGGGTTACGTTAGGCTAATCTAACTATCTGC
AAGTTGGAAGGAAGCTCGAC

Downstream 100 bases:

>100_bases
CCGCCGTTCACGTTGACCCCGTCGTCATCTCCGGAATGGCGATCGAGGCGCCGGGTGGGATCGACACCCCGGCGGCATTC
TGGAATGCGCTGGCCGACGG

Product: putative phenyloxazoline synthase MbtB/ thioesterase

Products: NA

Alternate protein names: Mycobactin synthetase protein B [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MDRKLGWIRQFHKPESPDAPLLLIFPHAGAGASAYRTLSKASSANFNVLVFQYPGRQDRAGEPALPTLSDIAAGAFAEFQ
SSEHNRRVPIHTFGHSMGAVVSFEFARLAEAAGLDVHQLTVSSAVAPCNIADKPALPTDDDAVLAHMGALEGTNSTVMGN
LDVMRMALPVMKGDYQAFNAYQCADGAKVAARIHSIGGDQDPMITMRDLYGWAQHTDALEVTLFDGGHFFLNSQTEALAE
LLVANSASASSPQR

Sequences:

>Translated_254_residues
MDRKLGWIRQFHKPESPDAPLLLIFPHAGAGASAYRTLSKASSANFNVLVFQYPGRQDRAGEPALPTLSDIAAGAFAEFQ
SSEHNRRVPIHTFGHSMGAVVSFEFARLAEAAGLDVHQLTVSSAVAPCNIADKPALPTDDDAVLAHMGALEGTNSTVMGN
LDVMRMALPVMKGDYQAFNAYQCADGAKVAARIHSIGGDQDPMITMRDLYGWAQHTDALEVTLFDGGHFFLNSQTEALAE
LLVANSASASSPQR
>Mature_254_residues
MDRKLGWIRQFHKPESPDAPLLLIFPHAGAGASAYRTLSKASSANFNVLVFQYPGRQDRAGEPALPTLSDIAAGAFAEFQ
SSEHNRRVPIHTFGHSMGAVVSFEFARLAEAAGLDVHQLTVSSAVAPCNIADKPALPTDDDAVLAHMGALEGTNSTVMGN
LDVMRMALPVMKGDYQAFNAYQCADGAKVAARIHSIGGDQDPMITMRDLYGWAQHTDALEVTLFDGGHFFLNSQTEALAE
LLVANSASASSPQR

Specific function: Involved in the initial steps of the mycobactin biosynthetic pathway. Putatively couples activated salicylic acid with serine or threonine and cyclizes this precursor to the hydroxyphenyloxazoline ring system present in this class of siderophores [H]

COG id: COG3208

COG function: function code Q; Predicted thioesterase involved in non-ribosomal peptide biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 acyl carrier domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR013624
- InterPro:   IPR006163
- InterPro:   IPR006162
- InterPro:   IPR001031 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF08415 NRPS; PF00550 PP-binding; PF00975 Thioesterase [H]

EC number: NA

Molecular weight: Translated: 27183; Mature: 27183

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRKLGWIRQFHKPESPDAPLLLIFPHAGAGASAYRTLSKASSANFNVLVFQYPGRQDRA
CCCCHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCC
GEPALPTLSDIAAGAFAEFQSSEHNRRVPIHTFGHSMGAVVSFEFARLAEAAGLDVHQLT
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEH
VSSAVAPCNIADKPALPTDDDAVLAHMGALEGTNSTVMGNLDVMRMALPVMKGDYQAFNA
HHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHCCCCHHCCC
YQCADGAKVAARIHSIGGDQDPMITMRDLYGWAQHTDALEVTLFDGGHFFLNSQTEALAE
EECCCCHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCEEEEEEEECCEEEECCHHHHHHH
LLVANSASASSPQR
HHHHCCCCCCCCCC
>Mature Secondary Structure
MDRKLGWIRQFHKPESPDAPLLLIFPHAGAGASAYRTLSKASSANFNVLVFQYPGRQDRA
CCCCHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCC
GEPALPTLSDIAAGAFAEFQSSEHNRRVPIHTFGHSMGAVVSFEFARLAEAAGLDVHQLT
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEH
VSSAVAPCNIADKPALPTDDDAVLAHMGALEGTNSTVMGNLDVMRMALPVMKGDYQAFNA
HHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHCCCCHHCCC
YQCADGAKVAARIHSIGGDQDPMITMRDLYGWAQHTDALEVTLFDGGHFFLNSQTEALAE
EECCCCHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCEEEEEEEECCEEEECCHHHHHHH
LLVANSASASSPQR
HHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]