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The map label for this gene is eryA [H]

Identifier: 169629206

GI number: 169629206

Start: 2119646

End: 2120971

Strand: Reverse

Name: eryA [H]

Synonym: MAB_2120c

Alternate gene names: 169629206

Gene position: 2120971-2119646 (Counterclockwise)

Preceding gene: 169629207

Following gene: 169629205

Centisome position: 41.86

GC content: 66.52

Gene sequence:

>1326_bases
ATGACCGCCGTTCACGTTGACCCCGTCGTCATCTCCGGAATGGCGATCGAGGCGCCGGGTGGGATCGACACCCCGGCGGC
ATTCTGGAATGCGCTGGCCGACGGTCGCGAACTCATCTCGGCGTTCCCCCGTGACCGTGGCTGGCCAGTGGACGAGCTGC
TATCGCTGTCGAACCTGGACGGCTGGGGCCGCATTTCCGATGCCGGCGGATTCATCACCGACGCAAGCGCTTTCGACCCC
ACTTTCTACGGCATCACGCAGCGTGAGGCCGTGGCGATGGATCCGCAGCAGCGGGTAGCCATGCGGGTCGCGTGGAAGGC
GCTGGAAAACACCGGGCTCAATCCGGGAGCAGTCGACGGATCGGAAGCCGGTTGTTTCATCGGCATCTCCCCTAACGAAT
ACGGGCCGCCAGTCGGTGAAGTCAACGCGCACAGCGGAATGCGTGTCGTCGGCCGCGGACAGCTGGGTGCCGCGGGCCGA
ATCTCGCACGGCCTGGGCCTCATCGGCCCATCCGTCTGTGTCGACTCCGCGTGTGCTTCGTCGTTGGCGGCGCTGCATCT
CGCGGCGTCCGCCGTTCGTGCGGACGAATGCGAGTGGGCCATCGCCGGCGGAGTCTGTGTCATGGGCTCGCCCGGAGGGT
TTTACGAATTTTCTCGCATGCACGCGCTCGACCCCGACGGGCACTGCCGCTCCTATTCGGACGAGGCCAACGGCACACTC
TGGGGCGAGGCCGTGGGAATGGTCGTACTGGAGCGCGAGTCACGGGCGCGCGCCCTGGGACACCGGGTGTACGGACGCAT
CATGGCCGTACGCACCAACCACAACGGCGGCGGCAAACCCATTCTCGTGCCACGGGGACGGGCACAGGCCAAGCTGGTCG
CCGCCACCATCGCCGCTTCCGGTGTGGATCCGGCCGATGTCGGGATGCTCGAGGGGCACGGCACGGGAACGCGTGCCGGC
GACCCGCTGGAGATCCTGGCGCTGCAAAGCACATACGGCGCGGGCGGCTCGAATGCCCTGCTAGGGTCCGCGAAATCCAA
TGCCGGACACGCACAATCCGCCGCCGGCATGGTGGGTCTGATAAAGCTCCTGCTGTCCGGACAACACGGGCATATCCCGC
CGACGCTCTTCGCGGACAACCCCACCACCAAGATTGACTGGTCGATGACCGGGATTCGCCTGGCCACGAAGCTGCACCCG
TGGGAACCCAAAGACGGCATCCGCTACGGCTCGGTCTCGTCCTTCGGAGCGGGGGGCGCCAACGCTCATGCCATCATCGC
GATGCCCGCCATGGACGCACAGGGAGAGGACGGGGACGATTTCTAG

Upstream 100 bases:

>100_bases
TGACGTTGTTCGACGGCGGCCACTTCTTCCTGAACTCGCAAACCGAGGCACTGGCCGAGCTGCTGGTCGCGAACTCTGCC
TCCGCGTCCTCGCCACAACG

Downstream 100 bases:

>100_bases
CCACCGCTTACCCAATGGAACCATCCCGGTCCTGCTCTCCGCAGATACACCAGAGGTGCTTCGCCGCGAGGCTTCGGCGC
TTCTCGCATACGTCGCTGAT

Product: putative polyketide synthase MbtC

Products: NA

Alternate protein names: 6-deoxyerythronolide B synthase I; DEBS 1; ORF 1 [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTAVHVDPVVISGMAIEAPGGIDTPAAFWNALADGRELISAFPRDRGWPVDELLSLSNLDGWGRISDAGGFITDASAFDP
TFYGITQREAVAMDPQQRVAMRVAWKALENTGLNPGAVDGSEAGCFIGISPNEYGPPVGEVNAHSGMRVVGRGQLGAAGR
ISHGLGLIGPSVCVDSACASSLAALHLAASAVRADECEWAIAGGVCVMGSPGGFYEFSRMHALDPDGHCRSYSDEANGTL
WGEAVGMVVLERESRARALGHRVYGRIMAVRTNHNGGGKPILVPRGRAQAKLVAATIAASGVDPADVGMLEGHGTGTRAG
DPLEILALQSTYGAGGSNALLGSAKSNAGHAQSAAGMVGLIKLLLSGQHGHIPPTLFADNPTTKIDWSMTGIRLATKLHP
WEPKDGIRYGSVSSFGAGGANAHAIIAMPAMDAQGEDGDDF

Sequences:

>Translated_441_residues
MTAVHVDPVVISGMAIEAPGGIDTPAAFWNALADGRELISAFPRDRGWPVDELLSLSNLDGWGRISDAGGFITDASAFDP
TFYGITQREAVAMDPQQRVAMRVAWKALENTGLNPGAVDGSEAGCFIGISPNEYGPPVGEVNAHSGMRVVGRGQLGAAGR
ISHGLGLIGPSVCVDSACASSLAALHLAASAVRADECEWAIAGGVCVMGSPGGFYEFSRMHALDPDGHCRSYSDEANGTL
WGEAVGMVVLERESRARALGHRVYGRIMAVRTNHNGGGKPILVPRGRAQAKLVAATIAASGVDPADVGMLEGHGTGTRAG
DPLEILALQSTYGAGGSNALLGSAKSNAGHAQSAAGMVGLIKLLLSGQHGHIPPTLFADNPTTKIDWSMTGIRLATKLHP
WEPKDGIRYGSVSSFGAGGANAHAIIAMPAMDAQGEDGDDF
>Mature_440_residues
TAVHVDPVVISGMAIEAPGGIDTPAAFWNALADGRELISAFPRDRGWPVDELLSLSNLDGWGRISDAGGFITDASAFDPT
FYGITQREAVAMDPQQRVAMRVAWKALENTGLNPGAVDGSEAGCFIGISPNEYGPPVGEVNAHSGMRVVGRGQLGAAGRI
SHGLGLIGPSVCVDSACASSLAALHLAASAVRADECEWAIAGGVCVMGSPGGFYEFSRMHALDPDGHCRSYSDEANGTLW
GEAVGMVVLERESRARALGHRVYGRIMAVRTNHNGGGKPILVPRGRAQAKLVAATIAASGVDPADVGMLEGHGTGTRAGD
PLEILALQSTYGAGGSNALLGSAKSNAGHAQSAAGMVGLIKLLLSGQHGHIPPTLFADNPTTKIDWSMTGIRLATKLHPW
EPKDGIRYGSVSSFGAGGANAHAIIAMPAMDAQGEDGDDF

Specific function: Catalyzes The Condensation Reaction Of Fatty Acid Synthesis By The Addition To An Acyl Acceptor Of Two Carbons From Malonyl-Acp. Has A Preference For Short Chain Acid Substrates And May Function To Supply The Octanoic Substrates For Lipoic Acid Biosynthe

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI41872631, Length=424, Percent_Identity=33.7264150943396, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI8923559, Length=275, Percent_Identity=27.6363636363636, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1787337, Length=274, Percent_Identity=28.4671532846715, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788663, Length=268, Percent_Identity=27.2388059701493, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212642053, Length=423, Percent_Identity=32.387706855792, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17550940, Length=421, Percent_Identity=32.541567695962, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71983541, Length=274, Percent_Identity=24.4525547445255, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71983535, Length=256, Percent_Identity=25, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=23.0941704035874, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI221330659, Length=426, Percent_Identity=33.0985915492958, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI19920632, Length=426, Percent_Identity=33.0985915492958, Blast_Score=207, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24581345, Length=429, Percent_Identity=31.002331002331, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24644341, Length=279, Percent_Identity=26.8817204301075, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR009081
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016036
- InterPro:   IPR016040
- InterPro:   IPR006163
- InterPro:   IPR020842
- InterPro:   IPR020801
- InterPro:   IPR020841
- InterPro:   IPR013968
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF08659 KR; PF00550 PP-binding [H]

EC number: =2.3.1.94 [H]

Molecular weight: Translated: 45463; Mature: 45332

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVHVDPVVISGMAIEAPGGIDTPAAFWNALADGRELISAFPRDRGWPVDELLSLSNLD
CCEEEECCEEEECEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC
GWGRISDAGGFITDASAFDPTFYGITQREAVAMDPQQRVAMRVAWKALENTGLNPGAVDG
CCCEECCCCCEEECCCCCCCEEECCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCCCC
SEAGCFIGISPNEYGPPVGEVNAHSGMRVVGRGQLGAAGRISHGLGLIGPSVCVDSACAS
CCCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHH
SLAALHLAASAVRADECEWAIAGGVCVMGSPGGFYEFSRMHALDPDGHCRSYSDEANGTL
HHHHHHHHHHHHHCCCCCEEEECCEEEECCCCCCHHHHHEECCCCCCCCCCCCCCCCCEE
WGEAVGMVVLERESRARALGHRVYGRIMAVRTNHNGGGKPILVPRGRAQAKLVAATIAAS
EHHEEEEEEEECCHHHHHHHHHHHEEEEEEEECCCCCCCEEEEECCCCCCEEEEEEHHHC
GVDPADVGMLEGHGTGTRAGDPLEILALQSTYGAGGSNALLGSAKSNAGHAQSAAGMVGL
CCCHHHCCEEECCCCCCCCCCCEEEEEEECCCCCCCCCCEEECCCCCCCCHHHHHHHHHH
IKLLLSGQHGHIPPTLFADNPTTKIDWSMTGIRLATKLHPWEPKDGIRYGSVSSFGAGGA
HHHHHCCCCCCCCCEEECCCCCCEEEEEECCEEEEEECCCCCCCCCCEECCCCCCCCCCC
NAHAIIAMPAMDAQGEDGDDF
CCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TAVHVDPVVISGMAIEAPGGIDTPAAFWNALADGRELISAFPRDRGWPVDELLSLSNLD
CEEEECCEEEECEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC
GWGRISDAGGFITDASAFDPTFYGITQREAVAMDPQQRVAMRVAWKALENTGLNPGAVDG
CCCEECCCCCEEECCCCCCCEEECCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCCCC
SEAGCFIGISPNEYGPPVGEVNAHSGMRVVGRGQLGAAGRISHGLGLIGPSVCVDSACAS
CCCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHH
SLAALHLAASAVRADECEWAIAGGVCVMGSPGGFYEFSRMHALDPDGHCRSYSDEANGTL
HHHHHHHHHHHHHCCCCCEEEECCEEEECCCCCCHHHHHEECCCCCCCCCCCCCCCCCEE
WGEAVGMVVLERESRARALGHRVYGRIMAVRTNHNGGGKPILVPRGRAQAKLVAATIAAS
EHHEEEEEEEECCHHHHHHHHHHHEEEEEEEECCCCCCCEEEEECCCCCCEEEEEEHHHC
GVDPADVGMLEGHGTGTRAGDPLEILALQSTYGAGGSNALLGSAKSNAGHAQSAAGMVGL
CCCHHHCCEEECCCCCCCCCCCEEEEEEECCCCCCCCCCEEECCCCCCCCHHHHHHHHHH
IKLLLSGQHGHIPPTLFADNPTTKIDWSMTGIRLATKLHPWEPKDGIRYGSVSSFGAGGA
HHHHHCCCCCCCCCEEECCCCCCEEEEEECCEEEEEECCCCCCCCCCEECCCCCCCCCCC
NAHAIIAMPAMDAQGEDGDDF
CCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2024119; 8386127 [H]