Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 169629117

GI number: 169629117

Start: 2029312

End: 2030652

Strand: Direct

Name: fabF [H]

Synonym: MAB_2030

Alternate gene names: 169629117

Gene position: 2029312-2030652 (Clockwise)

Preceding gene: 169629116

Following gene: 169629118

Centisome position: 40.05

GC content: 62.49

Gene sequence:

>1341_bases
TTGCGGTGTCCAAGGACAGGTTTGCGCTGTCGTAGTGGAAAAGGTGGCGCGATGAGCGATGTGAACCAGCCCAGACACGG
CAATCGTGTACTGGTGACGGGCCTTGGCGTGGTCTGTGGCCTTGGCATGAACTGGCAGTCCATGTGGGACGGATTGGTCA
ACGGACGCTCGGCAATACAGGCATGGTCGCCGCCCGATGTTCCGAACTTTCCCGTCGGCTACGCGGCACCGGTAGACGAT
CAAGCGTTTACCGCGTTGTTTCCCGATTTCGGTGCGCCGATGGAGAAGCGCACCCGGTTCGGCCTCGCCGCCGCGCAGCA
AGCACTGGAGGACGGCGGTGTGACGAATGCCGCGGCACTGGCCCGCGTTGGTGTTTCGATCGCGTCGGAAATGCCAGAAC
GTGAATCGGGAGAGTTGTTGAGTGCGTATGTCGATGGCGTCGTGGACTGGAAACGCGTACACGAACAGCAGATCGGCCTT
GACCGGTCCCACGCGCCGTTGGCCACTGGCGATGCCTTGGCGACCGAAATCGCTACGCGCTCCGGCCTAGCTGGTCCCAC
GCTCAACCTCAATACGGCGTGCGCCGGAGCAACACATGCACTCGGGCACGGCTTCCGGATGATCCGGCGTGGGGAAACAG
ACGCCGTGATCGCCGGGGGAGCGGTTAGCCCCCTGAATCTGCCGATAATGACGAGTCTGTACCTGCTCGGCGCCCCATCA
ACATCAAAACTTTACGGCGACCGGCTATGTCGAGCGTTTGACCGCGATCGCAGTGGGATGGTCACCGCCGAGGGGGCGGC
AATGGTGCTGTTGGAGAGCGAGTCGTCGGCACTGGCGCGCGGTGCGCACGTGTACGGCGAGGTGGCGGGATTTGGCAGCT
CGCTGGACGCATATCAGGTGACCGCACCGCACCCGCAAGGAGGCGGGTCGGTTTTGGCGATGCAGCGTGCCCTCGCCGAT
GCTGGAGTCGCCCCGTCCGAAGTGGGTTATGTCAGTGCGCACGGTACATCCACCCCGCTGAGCGACGCGGCCGAGACAGC
TGCGATCAAAGAAGTGTTCCGCACCGGTGAGCATTACCGCTCACTCATGGTCAGCTCTATCAAGACGATGCTGGGTCACA
TGCTCGCCGCGGCAGGTGCCCAACAGCTGATATCTACGGTGCTGTCGTTACGCGACGGGATCATTCCGCCGACGCTCAAC
CTGGAGAACCCCGACCCGGCCTGTGACCTTGACTATGTGCCGGGTCAGGCCCGCAAGGCTGATATCGAGGTGGCAATCAA
CAACTCGCTCGGGTTCGGTGGGCTCAACGCTGCTTTGGTGGTACGCCGTTATGACAACTGA

Upstream 100 bases:

>100_bases
GACTGCTGCGCGGGCTACGGCTGCTCCCGGTGAACGGCAACGGCGACGATGCCGTGGCCGAAGAATCACTGTCAAACAAT
CAGGCGGTTGTGGTGCTCAG

Downstream 100 bases:

>100_bases
ACATTCAGGTCAATCAATAGTCGTGACAGGAACCGGCGTGGTGCTGCCGACGGGTCGTCACATCACACCCCTGTGGGACG
CCTGGACTGACGGGAAACCG

Product: 3-oxoacyl-(Acyl-carrier-protein) synthase II KasA

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MRCPRTGLRCRSGKGGAMSDVNQPRHGNRVLVTGLGVVCGLGMNWQSMWDGLVNGRSAIQAWSPPDVPNFPVGYAAPVDD
QAFTALFPDFGAPMEKRTRFGLAAAQQALEDGGVTNAAALARVGVSIASEMPERESGELLSAYVDGVVDWKRVHEQQIGL
DRSHAPLATGDALATEIATRSGLAGPTLNLNTACAGATHALGHGFRMIRRGETDAVIAGGAVSPLNLPIMTSLYLLGAPS
TSKLYGDRLCRAFDRDRSGMVTAEGAAMVLLESESSALARGAHVYGEVAGFGSSLDAYQVTAPHPQGGGSVLAMQRALAD
AGVAPSEVGYVSAHGTSTPLSDAAETAAIKEVFRTGEHYRSLMVSSIKTMLGHMLAAAGAQQLISTVLSLRDGIIPPTLN
LENPDPACDLDYVPGQARKADIEVAINNSLGFGGLNAALVVRRYDN

Sequences:

>Translated_446_residues
MRCPRTGLRCRSGKGGAMSDVNQPRHGNRVLVTGLGVVCGLGMNWQSMWDGLVNGRSAIQAWSPPDVPNFPVGYAAPVDD
QAFTALFPDFGAPMEKRTRFGLAAAQQALEDGGVTNAAALARVGVSIASEMPERESGELLSAYVDGVVDWKRVHEQQIGL
DRSHAPLATGDALATEIATRSGLAGPTLNLNTACAGATHALGHGFRMIRRGETDAVIAGGAVSPLNLPIMTSLYLLGAPS
TSKLYGDRLCRAFDRDRSGMVTAEGAAMVLLESESSALARGAHVYGEVAGFGSSLDAYQVTAPHPQGGGSVLAMQRALAD
AGVAPSEVGYVSAHGTSTPLSDAAETAAIKEVFRTGEHYRSLMVSSIKTMLGHMLAAAGAQQLISTVLSLRDGIIPPTLN
LENPDPACDLDYVPGQARKADIEVAINNSLGFGGLNAALVVRRYDN
>Mature_446_residues
MRCPRTGLRCRSGKGGAMSDVNQPRHGNRVLVTGLGVVCGLGMNWQSMWDGLVNGRSAIQAWSPPDVPNFPVGYAAPVDD
QAFTALFPDFGAPMEKRTRFGLAAAQQALEDGGVTNAAALARVGVSIASEMPERESGELLSAYVDGVVDWKRVHEQQIGL
DRSHAPLATGDALATEIATRSGLAGPTLNLNTACAGATHALGHGFRMIRRGETDAVIAGGAVSPLNLPIMTSLYLLGAPS
TSKLYGDRLCRAFDRDRSGMVTAEGAAMVLLESESSALARGAHVYGEVAGFGSSLDAYQVTAPHPQGGGSVLAMQRALAD
AGVAPSEVGYVSAHGTSTPLSDAAETAAIKEVFRTGEHYRSLMVSSIKTMLGHMLAAAGAQQLISTVLSLRDGIIPPTLN
LENPDPACDLDYVPGQARKADIEVAINNSLGFGGLNAALVVRRYDN

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=461, Percent_Identity=35.7917570498915, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI223972627, Length=170, Percent_Identity=45.8823529411765, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI41872631, Length=430, Percent_Identity=25.5813953488372, Blast_Score=108, Evalue=9e-24,
Organism=Escherichia coli, GI1787337, Length=428, Percent_Identity=36.214953271028, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1788663, Length=442, Percent_Identity=31.2217194570136, Blast_Score=158, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71983541, Length=429, Percent_Identity=31.9347319347319, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71983535, Length=261, Percent_Identity=37.1647509578544, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI212642053, Length=381, Percent_Identity=27.2965879265092, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=363, Percent_Identity=25.6198347107438, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=451, Percent_Identity=28.3813747228381, Blast_Score=166, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24644341, Length=445, Percent_Identity=34.8314606741573, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI221330659, Length=376, Percent_Identity=26.8617021276596, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI19920632, Length=376, Percent_Identity=26.8617021276596, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24581345, Length=280, Percent_Identity=28.2142857142857, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 46534; Mature: 46534

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCPRTGLRCRSGKGGAMSDVNQPRHGNRVLVTGLGVVCGLGMNWQSMWDGLVNGRSAIQ
CCCCCCCCEECCCCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHCCHHHEE
AWSPPDVPNFPVGYAAPVDDQAFTALFPDFGAPMEKRTRFGLAAAQQALEDGGVTNAAAL
CCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
ARVGVSIASEMPERESGELLSAYVDGVVDWKRVHEQQIGLDRSHAPLATGDALATEIATR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
SGLAGPTLNLNTACAGATHALGHGFRMIRRGETDAVIAGGAVSPLNLPIMTSLYLLGAPS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHEECCCC
TSKLYGDRLCRAFDRDRSGMVTAEGAAMVLLESESSALARGAHVYGEVAGFGSSLDAYQV
HHHHHHHHHHHHHCCCCCCEEEECCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCEEE
TAPHPQGGGSVLAMQRALADAGVAPSEVGYVSAHGTSTPLSDAAETAAIKEVFRTGEHYR
ECCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
SLMVSSIKTMLGHMLAAAGAQQLISTVLSLRDGIIPPTLNLENPDPACDLDYVPGQARKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DIEVAINNSLGFGGLNAALVVRRYDN
EEEEEEECCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MRCPRTGLRCRSGKGGAMSDVNQPRHGNRVLVTGLGVVCGLGMNWQSMWDGLVNGRSAIQ
CCCCCCCCEECCCCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHCCHHHEE
AWSPPDVPNFPVGYAAPVDDQAFTALFPDFGAPMEKRTRFGLAAAQQALEDGGVTNAAAL
CCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
ARVGVSIASEMPERESGELLSAYVDGVVDWKRVHEQQIGLDRSHAPLATGDALATEIATR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
SGLAGPTLNLNTACAGATHALGHGFRMIRRGETDAVIAGGAVSPLNLPIMTSLYLLGAPS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHEECCCC
TSKLYGDRLCRAFDRDRSGMVTAEGAAMVLLESESSALARGAHVYGEVAGFGSSLDAYQV
HHHHHHHHHHHHHCCCCCCEEEECCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCEEE
TAPHPQGGGSVLAMQRALADAGVAPSEVGYVSAHGTSTPLSDAAETAAIKEVFRTGEHYR
ECCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
SLMVSSIKTMLGHMLAAAGAQQLISTVLSLRDGIIPPTLNLENPDPACDLDYVPGQARKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DIEVAINNSLGFGGLNAALVVRRYDN
EEEEEEECCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]