| Definition | Mycobacterium abscessus ATCC 19977 chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_010397 |
| Length | 5,067,172 |
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The map label for this gene is murE [H]
Identifier: 169629088
GI number: 169629088
Start: 1998726
End: 2000273
Strand: Direct
Name: murE [H]
Synonym: MAB_2001
Alternate gene names: 169629088
Gene position: 1998726-2000273 (Clockwise)
Preceding gene: 169629087
Following gene: 169629089
Centisome position: 39.44
GC content: 66.8
Gene sequence:
>1548_bases GTGGCGGCATCCGGAACCCATCGGTTCCTTCCCCGGACGCACCAGCACCTGGTCTCCGACCTCGCGTCATTGGTTTCGGC CGAGCTACACGGGCCAAGCGCCACCACGGTGGGGGGAGTCACGCTCAGGGCGCAGGACGCCCGTACGGGTGACCTCTTTG CCGCGCTGCCGGGCACCAGCACCCATGGCGCGCAGTTCGCCTCTGAGGCGGTCTCCGCGGGCGCGGCGGCCGTGCTGACG GACGCCGCCGGCGCCGAACTGGTGGCAGGACAGGGTCTTGATATCGCGGTACTGGTTCATCCCGTCCCGCGCTCGGTGCT CGGTGAGCTGGCCGCGACCGTGTACGGGGAGCCCTCCCGTCATCTACAGGTAGTGGGAGTCACCGGTACCTCCGGCAAGA CCACGACCACCTACCTGGTCGAGGCCGGGCTGCGGGCGGCGGGTAAGAGGGTGGGTCTCATCGGGACCGTCGGGGTGCGG ATCGACGGCGAGGATGTGCCGAGTGCCCTGACCACGCCCGAGGCGCCGGCGTTGCAGGAACTGCTCGCCGAGATGGTCCA GCGCGGGGTGGACACGGTGGTCATGGAGGTGTCCAGCCATGCGTTGGCCCTCAATCGTGTGGACGGCACCCGTTTTGCGG TAGGCGCATTCACGAACCTGTCACGCGATCACCTGGATTTCCATCCCGACATGCAGGATTACTTCGCCACCAAGGCTCGC TTGTTCCGGCGCGATTCGCCGCAGCGCGCGCACCGCAGTGTCGTCTGCATCGACGATGATGCCGGCCGCGCCATGGCCGA GCTGGCCCGTGAGGCGGGACCTGATGTCACCACCGTGAGCTCGCTCGACGGCGGCGTCGCGGACTGGAGATGTTCGAATG TGGCGGTCGGTCATGATGGTGGCCAGCGGTTCGTCGCGAATGGTCCAGACCGCGATACCGAGCTCACAATCGCGTTGCCT GGGCATTACAACGTGGCCAATTGTCTTGTGGCCATTGCGATCTTGGATGTTCTCGGAGTTTCGGCCGCGACCGCCGCGCC TGGAATCGCGACCGCGGGTGTGCCGGGGCGTATGGAAGCCGTGGCGGCGGGGCAGCCATTCCTGGCTGTCGTGGACTATG CCCACAAGCCCGGCGCGCTGCGGGCAGTCCTGGAAAGTCTGCGCAGTCACCGCGATGGCCGCCTGGCCGTGGTGTTCGGT GCCGGAGGCAACCGTGATCGCGGCAAACGGGCCGACATGGGCAAGGTCGCCGCGGAGCTGGCCGATCTGGTGGTGGTCAC CGATGACAATCCGCGCAACGAGGAGCCGGCGGCGATCCGTACCGAGATCATTTCCGGGACTACCGGTTCGGAGGCTCAGA TCATCGAAATCGGCGACCGTAGAGCTGCTATCGACTTCGCCACGTTGTGGGCGCGGCCGGGCGATACCGTCCTTGTCGCC GGCAAGGGGCATGAGAGCGGTCAGAAGACCGGCGATGTCACGGTGCCTTTCGATGATCGTGTGGAGTTGCGCGCAGCCCT CGAAGCGCTTGGGAGCCTGGATGATTGA
Upstream 100 bases:
>100_bases CCGCCCGGTAATGTCGTTTGACGCCCGAGGACGAGCAGCCGGCGCGAATACCGTCGAGCCAGGGCATGGTCGGCAGAAAT ACGGCAGGAGGTGACCGCAG
Downstream 100 bases:
>100_bases GATGACTGTGGCCGAGATCGCCGAAATCGTCGGTGGGCGCCTTGACGGAATCAGCGCGCAGGAAGCTCGGCAGGCGCGCG TCACCGGCACCGTGGAATTC
Product: UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase
Products: NA
Alternate protein names: Meso-A2pm-adding enzyme; Meso-diaminopimelate-adding enzyme; UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase; UDP-MurNAc-tripeptide synthetase; UDP-N-acetylmuramyl-tripeptide synthetase [H]
Number of amino acids: Translated: 515; Mature: 514
Protein sequence:
>515_residues MAASGTHRFLPRTHQHLVSDLASLVSAELHGPSATTVGGVTLRAQDARTGDLFAALPGTSTHGAQFASEAVSAGAAAVLT DAAGAELVAGQGLDIAVLVHPVPRSVLGELAATVYGEPSRHLQVVGVTGTSGKTTTTYLVEAGLRAAGKRVGLIGTVGVR IDGEDVPSALTTPEAPALQELLAEMVQRGVDTVVMEVSSHALALNRVDGTRFAVGAFTNLSRDHLDFHPDMQDYFATKAR LFRRDSPQRAHRSVVCIDDDAGRAMAELAREAGPDVTTVSSLDGGVADWRCSNVAVGHDGGQRFVANGPDRDTELTIALP GHYNVANCLVAIAILDVLGVSAATAAPGIATAGVPGRMEAVAAGQPFLAVVDYAHKPGALRAVLESLRSHRDGRLAVVFG AGGNRDRGKRADMGKVAAELADLVVVTDDNPRNEEPAAIRTEIISGTTGSEAQIIEIGDRRAAIDFATLWARPGDTVLVA GKGHESGQKTGDVTVPFDDRVELRAALEALGSLDD
Sequences:
>Translated_515_residues MAASGTHRFLPRTHQHLVSDLASLVSAELHGPSATTVGGVTLRAQDARTGDLFAALPGTSTHGAQFASEAVSAGAAAVLT DAAGAELVAGQGLDIAVLVHPVPRSVLGELAATVYGEPSRHLQVVGVTGTSGKTTTTYLVEAGLRAAGKRVGLIGTVGVR IDGEDVPSALTTPEAPALQELLAEMVQRGVDTVVMEVSSHALALNRVDGTRFAVGAFTNLSRDHLDFHPDMQDYFATKAR LFRRDSPQRAHRSVVCIDDDAGRAMAELAREAGPDVTTVSSLDGGVADWRCSNVAVGHDGGQRFVANGPDRDTELTIALP GHYNVANCLVAIAILDVLGVSAATAAPGIATAGVPGRMEAVAAGQPFLAVVDYAHKPGALRAVLESLRSHRDGRLAVVFG AGGNRDRGKRADMGKVAAELADLVVVTDDNPRNEEPAAIRTEIISGTTGSEAQIIEIGDRRAAIDFATLWARPGDTVLVA GKGHESGQKTGDVTVPFDDRVELRAALEALGSLDD >Mature_514_residues AASGTHRFLPRTHQHLVSDLASLVSAELHGPSATTVGGVTLRAQDARTGDLFAALPGTSTHGAQFASEAVSAGAAAVLTD AAGAELVAGQGLDIAVLVHPVPRSVLGELAATVYGEPSRHLQVVGVTGTSGKTTTTYLVEAGLRAAGKRVGLIGTVGVRI DGEDVPSALTTPEAPALQELLAEMVQRGVDTVVMEVSSHALALNRVDGTRFAVGAFTNLSRDHLDFHPDMQDYFATKARL FRRDSPQRAHRSVVCIDDDAGRAMAELAREAGPDVTTVSSLDGGVADWRCSNVAVGHDGGQRFVANGPDRDTELTIALPG HYNVANCLVAIAILDVLGVSAATAAPGIATAGVPGRMEAVAAGQPFLAVVDYAHKPGALRAVLESLRSHRDGRLAVVFGA GGNRDRGKRADMGKVAAELADLVVVTDDNPRNEEPAAIRTEIISGTTGSEAQIIEIGDRRAAIDFATLWARPGDTVLVAG KGHESGQKTGDVTVPFDDRVELRAALEALGSLDD
Specific function: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan [H]
COG id: COG0769
COG function: function code M; UDP-N-acetylmuramyl tripeptide synthase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the MurCDEF family. MurE subfamily [H]
Homologues:
Organism=Escherichia coli, GI1786273, Length=474, Percent_Identity=39.662447257384, Blast_Score=235, Evalue=5e-63,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004101 - InterPro: IPR013221 - InterPro: IPR000713 - InterPro: IPR005761 [H]
Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]
EC number: =6.3.2.13 [H]
Molecular weight: Translated: 53361; Mature: 53230
Theoretical pI: Translated: 5.31; Mature: 5.31
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 1.9 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 1.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAASGTHRFLPRTHQHLVSDLASLVSAELHGPSATTVGGVTLRAQDARTGDLFAALPGTS CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCEEEEECCCCCCCEEEECCCCC THGAQFASEAVSAGAAAVLTDAAGAELVAGQGLDIAVLVHPVPRSVLGELAATVYGEPSR CCHHHHHHHHHHCCCCEEEECCCCCEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCCCC HLQVVGVTGTSGKTTTTYLVEAGLRAAGKRVGLIGTVGVRIDGEDVPSALTTPEAPALQE CEEEEEEECCCCCCEEEHEEHHHHHHCCCEEEEEEEEEEEECCCCCCCCCCCCCCHHHHH LLAEMVQRGVDTVVMEVSSHALALNRVDGTRFAVGAFTNLSRDHLDFHPDMQDYFATKAR HHHHHHHCCHHHEEHHHCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHH LFRRDSPQRAHRSVVCIDDDAGRAMAELAREAGPDVTTVSSLDGGVADWRCSNVAVGHDG HHHCCCHHHHHCEEEEEECCCCHHHHHHHHHCCCCCEEECCCCCCCCCCEECCEEEECCC GQRFVANGPDRDTELTIALPGHYNVANCLVAIAILDVLGVSAATAAPGIATAGVPGRMEA CCEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHCCCCCEECCCCCCCHH VAAGQPFLAVVDYAHKPGALRAVLESLRSHRDGRLAVVFGAGGNRDRGKRADMGKVAAEL HHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHH ADLVVVTDDNPRNEEPAAIRTEIISGTTGSEAQIIEIGDRRAAIDFATLWARPGDTVLVA HCEEEEECCCCCCCCCCHHHHHEECCCCCCCEEEEEECCCCEEEEEEHHHCCCCCEEEEE GKGHESGQKTGDVTVPFDDRVELRAALEALGSLDD ECCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCC >Mature Secondary Structure AASGTHRFLPRTHQHLVSDLASLVSAELHGPSATTVGGVTLRAQDARTGDLFAALPGTS CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCEEEEECCCCCCCEEEECCCCC THGAQFASEAVSAGAAAVLTDAAGAELVAGQGLDIAVLVHPVPRSVLGELAATVYGEPSR CCHHHHHHHHHHCCCCEEEECCCCCEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCCCC HLQVVGVTGTSGKTTTTYLVEAGLRAAGKRVGLIGTVGVRIDGEDVPSALTTPEAPALQE CEEEEEEECCCCCCEEEHEEHHHHHHCCCEEEEEEEEEEEECCCCCCCCCCCCCCHHHHH LLAEMVQRGVDTVVMEVSSHALALNRVDGTRFAVGAFTNLSRDHLDFHPDMQDYFATKAR HHHHHHHCCHHHEEHHHCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHH LFRRDSPQRAHRSVVCIDDDAGRAMAELAREAGPDVTTVSSLDGGVADWRCSNVAVGHDG HHHCCCHHHHHCEEEEEECCCCHHHHHHHHHCCCCCEEECCCCCCCCCCEECCEEEECCC GQRFVANGPDRDTELTIALPGHYNVANCLVAIAILDVLGVSAATAAPGIATAGVPGRMEA CCEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHCCCCCEECCCCCCCHH VAAGQPFLAVVDYAHKPGALRAVLESLRSHRDGRLAVVFGAGGNRDRGKRADMGKVAAEL HHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHH ADLVVVTDDNPRNEEPAAIRTEIISGTTGSEAQIIEIGDRRAAIDFATLWARPGDTVLVA HCEEEEECCCCCCCCCCHHHHHEECCCCCCCEEEEEECCCCEEEEEEHHHCCCCCEEEEE GKGHESGQKTGDVTVPFDDRVELRAALEALGSLDD ECCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA