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The map label for this gene is prrB [H]

Identifier: 169629015

GI number: 169629015

Start: 1927619

End: 1928908

Strand: Direct

Name: prrB [H]

Synonym: MAB_1927

Alternate gene names: 169629015

Gene position: 1927619-1928908 (Clockwise)

Preceding gene: 169629014

Following gene: 169629017

Centisome position: 38.04

GC content: 67.6

Gene sequence:

>1290_bases
GTGAAACGCTCGCTGTCCCTGCGTACCCGGGTCGCGGTGGCGGCCTTCCTCGCCGCCGGCCTGGTGGTCGCCCTGATCGG
CATTGTCGCCGGTATTGCCCTGGTGCGCAACGACACCCGGCAGCTCGATCGGCGTCTCGACATGCTGACCGATGCGGTGC
AAGCCACCACTCGGCACGGTGAAACCACATTCGTGCTGACGGTCCGTGACACCAAGAGTGGAGGACTGGTGATCTTCCGG
GGCGTCGAGCTGCCACGGCTGCCGTTGGGCACTCGGAATGTGACCGTCGGCGACGTGAACTACCGGGTGCGCACCATCGA
GAACCCGGAAGAACAGACGGTGATTTCGCTCGGGACCCGGTCGGACACGGTACTGGTCAATCACCGCGGGATCCCGGTAT
TCATTGCCCTGGGTGTGCTTTCGATGCTGCTGGCCGGTGGTTTCGCCTGGCTGTTCGCCGGGCGCGCGGTGCGGCCGCTG
CATCAGCTCACCGACCAGACCCGCCAGCTCGATACCGACGGCCTGCAGGTGGCTGCGGTGCGCGGTGCCCGAGAGTCCGA
GGAGCTTGCCGAGGCCATGGCCGCCATGCTGAGCCGAGTCTCGGCGGCACAGTCCGAAACCACCAAATCTCTTCTGGCGG
CCCGTGATTTTGCCGCGAGTGCGGCACACGAATTACGCACGCCGCTCACCGCGATGCGCGCCGACCTGGATACTCTGCGC
GCACACGACTTGTCGGGCGATGAACGTGTCGAGGTGATCGGCGACCTGCAGCGCGCCCAGCGACGTGTCGAGGCCACCAT
CACGGCGCTCGGCCAGTTGGCCTCGGGCGACCTCGCCAGGACCGAGGACCGCGAACTGGTGGACATCGCAGACCTGTTGG
ACCGGGTGGCGGGGGATGCGTTGATGCACCGGGCCGACGCGCCGGAGATCACCGTCCATGCGGACGACTGTGGTGTGGTG
CTGGGTTGGCCCGACGGGCTGCGGCTGGCCGTGGACAACCTGGTGCGCAACGCGATCAACCATGGCGAAGCCAGACATAT
TGTGCTGTCGGCAAATCGGATCGACAACCGGCTGGTTATCGAGGTCGATGACGACGGTCCCGGCCTACCCGAGGCCGACC
GGGAGCGGGTGCTCGGACGATTCGAACGCGGCCCCGGCGCTAAGCCGGGCGGGCTGGGCCTGGGGTTGGCACTCGTGGCG
CAGCAGGCCGCGTTGCACGGCGGAGACGTGGTGCTGTCGTCAAGCCCGCTGGGCGGGCTGCGGGCGACGCTGACGATCGC
CGCGGAATAG

Upstream 100 bases:

>100_bases
ATGTCTTCGTCAGCTATCTGCGCCGCAAGCTGGAAGCTGGGGGAGCCGCGCGAGTCATCCATACCGTCAGGGGAGTCGGC
TACGTGATGCGGGAAGAGCC

Downstream 100 bases:

>100_bases
ACGCGACTATCAGTTCTGGCGCGGCCCGTATTTGGCGAGCCACTCCCTGGCCTCGTCGGGCAGATTGCCGGCAGCCTCGG
CCGCCCTACACCAGCGCCGC

Product: putative sensor-type histidine kinase PrrB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MKRSLSLRTRVAVAAFLAAGLVVALIGIVAGIALVRNDTRQLDRRLDMLTDAVQATTRHGETTFVLTVRDTKSGGLVIFR
GVELPRLPLGTRNVTVGDVNYRVRTIENPEEQTVISLGTRSDTVLVNHRGIPVFIALGVLSMLLAGGFAWLFAGRAVRPL
HQLTDQTRQLDTDGLQVAAVRGARESEELAEAMAAMLSRVSAAQSETTKSLLAARDFAASAAHELRTPLTAMRADLDTLR
AHDLSGDERVEVIGDLQRAQRRVEATITALGQLASGDLARTEDRELVDIADLLDRVAGDALMHRADAPEITVHADDCGVV
LGWPDGLRLAVDNLVRNAINHGEARHIVLSANRIDNRLVIEVDDDGPGLPEADRERVLGRFERGPGAKPGGLGLGLALVA
QQAALHGGDVVLSSSPLGGLRATLTIAAE

Sequences:

>Translated_429_residues
MKRSLSLRTRVAVAAFLAAGLVVALIGIVAGIALVRNDTRQLDRRLDMLTDAVQATTRHGETTFVLTVRDTKSGGLVIFR
GVELPRLPLGTRNVTVGDVNYRVRTIENPEEQTVISLGTRSDTVLVNHRGIPVFIALGVLSMLLAGGFAWLFAGRAVRPL
HQLTDQTRQLDTDGLQVAAVRGARESEELAEAMAAMLSRVSAAQSETTKSLLAARDFAASAAHELRTPLTAMRADLDTLR
AHDLSGDERVEVIGDLQRAQRRVEATITALGQLASGDLARTEDRELVDIADLLDRVAGDALMHRADAPEITVHADDCGVV
LGWPDGLRLAVDNLVRNAINHGEARHIVLSANRIDNRLVIEVDDDGPGLPEADRERVLGRFERGPGAKPGGLGLGLALVA
QQAALHGGDVVLSSSPLGGLRATLTIAAE
>Mature_429_residues
MKRSLSLRTRVAVAAFLAAGLVVALIGIVAGIALVRNDTRQLDRRLDMLTDAVQATTRHGETTFVLTVRDTKSGGLVIFR
GVELPRLPLGTRNVTVGDVNYRVRTIENPEEQTVISLGTRSDTVLVNHRGIPVFIALGVLSMLLAGGFAWLFAGRAVRPL
HQLTDQTRQLDTDGLQVAAVRGARESEELAEAMAAMLSRVSAAQSETTKSLLAARDFAASAAHELRTPLTAMRADLDTLR
AHDLSGDERVEVIGDLQRAQRRVEATITALGQLASGDLARTEDRELVDIADLLDRVAGDALMHRADAPEITVHADDCGVV
LGWPDGLRLAVDNLVRNAINHGEARHIVLSANRIDNRLVIEVDDDGPGLPEADRERVLGRFERGPGAKPGGLGLGLALVA
QQAALHGGDVVLSSSPLGGLRATLTIAAE

Specific function: Member of the two-component regulatory system prrB/prrA. Involved specifically in early intracellular multiplication of Mycobacterium. Probably phosphorylates prrA [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=31.9634703196347, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789403, Length=343, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789808, Length=293, Percent_Identity=30.3754266211604, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787374, Length=300, Percent_Identity=26, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788393, Length=232, Percent_Identity=28.448275862069, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790346, Length=213, Percent_Identity=31.924882629108, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790551, Length=295, Percent_Identity=27.4576271186441, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790861, Length=301, Percent_Identity=29.5681063122924, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=336, Percent_Identity=26.4880952380952, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45787; Mature: 45787

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRSLSLRTRVAVAAFLAAGLVVALIGIVAGIALVRNDTRQLDRRLDMLTDAVQATTRHG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCC
ETTFVLTVRDTKSGGLVIFRGVELPRLPLGTRNVTVGDVNYRVRTIENPEEQTVISLGTR
CEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCEEEECCCEEEEECCCCCCCEEEEECCC
SDTVLVNHRGIPVFIALGVLSMLLAGGFAWLFAGRAVRPLHQLTDQTRQLDTDGLQVAAV
CCEEEEECCCCHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEE
RGARESEELAEAMAAMLSRVSAAQSETTKSLLAARDFAASAAHELRTPLTAMRADLDTLR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
AHDLSGDERVEVIGDLQRAQRRVEATITALGQLASGDLARTEDRELVDIADLLDRVAGDA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
LMHRADAPEITVHADDCGVVLGWPDGLRLAVDNLVRNAINHGEARHIVLSANRIDNRLVI
HHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEE
EVDDDGPGLPEADRERVLGRFERGPGAKPGGLGLGLALVAQQAALHGGDVVLSSSPLGGL
EECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCC
RATLTIAAE
EEEEEEEEC
>Mature Secondary Structure
MKRSLSLRTRVAVAAFLAAGLVVALIGIVAGIALVRNDTRQLDRRLDMLTDAVQATTRHG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCC
ETTFVLTVRDTKSGGLVIFRGVELPRLPLGTRNVTVGDVNYRVRTIENPEEQTVISLGTR
CEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCEEEECCCEEEEECCCCCCCEEEEECCC
SDTVLVNHRGIPVFIALGVLSMLLAGGFAWLFAGRAVRPLHQLTDQTRQLDTDGLQVAAV
CCEEEEECCCCHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEE
RGARESEELAEAMAAMLSRVSAAQSETTKSLLAARDFAASAAHELRTPLTAMRADLDTLR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
AHDLSGDERVEVIGDLQRAQRRVEATITALGQLASGDLARTEDRELVDIADLLDRVAGDA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
LMHRADAPEITVHADDCGVVLGWPDGLRLAVDNLVRNAINHGEARHIVLSANRIDNRLVI
HHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEE
EVDDDGPGLPEADRERVLGRFERGPGAKPGGLGLGLALVAQQAALHGGDVVLSSSPLGGL
EECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCC
RATLTIAAE
EEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]