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The map label for this gene is prrA [H]

Identifier: 169629014

GI number: 169629014

Start: 1926912

End: 1927622

Strand: Direct

Name: prrA [H]

Synonym: MAB_1926

Alternate gene names: 169629014

Gene position: 1926912-1927622 (Clockwise)

Preceding gene: 169629013

Following gene: 169629015

Centisome position: 38.03

GC content: 64.98

Gene sequence:

>711_bases
ATGACACAGGAAACTACCGCCCGTCACAAGGTGTTGATGGTCGATGACGACCCGGACGTTCGGAACTCGGTAGCCCGCGG
GCTACGCCACTCGGGTTTCGACGTCCGGGTCGCCGTTGATGGCCGCGACGCGCTCACCCAGCTCGCGGCCGATGAGCCCG
ATGCCCTGGTACTCGACGTGCAGATGCCCGAGCTGGACGGGGTTGCGGTGGTCACCGCTCTGCGGGCCCTGGGTAACGAC
ATTCCGATCTGCGTGCTCAGTGCACGCGACACCGTCAACGACCGAATCGCCGGCTTGGAGGCCGGTGCCGACGACTACTT
GACCAAACCCTTTGACCTCGGCGAGCTGGTGGCTCGCCTGCGTGCGCTGCTGCGCCGTCGCGGCGCCGGTTCGGGCGGCC
TCGCCGATTCCGCCATCACCGTCGGACAGATCACCGTGGACGTGTCGCGCCGCTTGGTCTTTGTCAACGGAGAACGTGTC
GAGCTGAGTAAGCGGGAGTTCGATCTGCTGGTGGTGCTGGCCGAGAACACCGGTGTGGTGCTGAGCCGCACCCGGCTGCT
GGAATTGGTGTGGGGGTACGACTTTGACGTCGAGACCAATGTTGCCGATGTCTTCGTCAGCTATCTGCGCCGCAAGCTGG
AAGCTGGGGGAGCCGCGCGAGTCATCCATACCGTCAGGGGAGTCGGCTACGTGATGCGGGAAGAGCCGTGA

Upstream 100 bases:

>100_bases
ACCGCCAATACCCCGCAGGCGGCCCCGAACGTCGCCGCGGTGGTTGATCAGCAGGACGTCTAACAACACCTCCGGGCGGG
CGGCTTAGCCTTATGTGGCG

Downstream 100 bases:

>100_bases
AACGCTCGCTGTCCCTGCGTACCCGGGTCGCGGTGGCGGCCTTCCTCGCCGCCGGCCTGGTGGTCGCCCTGATCGGCATT
GTCGCCGGTATTGCCCTGGT

Product: putative transcriptional regulatory protein PrrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTQETTARHKVLMVDDDPDVRNSVARGLRHSGFDVRVAVDGRDALTQLAADEPDALVLDVQMPELDGVAVVTALRALGND
IPICVLSARDTVNDRIAGLEAGADDYLTKPFDLGELVARLRALLRRRGAGSGGLADSAITVGQITVDVSRRLVFVNGERV
ELSKREFDLLVVLAENTGVVLSRTRLLELVWGYDFDVETNVADVFVSYLRRKLEAGGAARVIHTVRGVGYVMREEP

Sequences:

>Translated_236_residues
MTQETTARHKVLMVDDDPDVRNSVARGLRHSGFDVRVAVDGRDALTQLAADEPDALVLDVQMPELDGVAVVTALRALGND
IPICVLSARDTVNDRIAGLEAGADDYLTKPFDLGELVARLRALLRRRGAGSGGLADSAITVGQITVDVSRRLVFVNGERV
ELSKREFDLLVVLAENTGVVLSRTRLLELVWGYDFDVETNVADVFVSYLRRKLEAGGAARVIHTVRGVGYVMREEP
>Mature_235_residues
TQETTARHKVLMVDDDPDVRNSVARGLRHSGFDVRVAVDGRDALTQLAADEPDALVLDVQMPELDGVAVVTALRALGNDI
PICVLSARDTVNDRIAGLEAGADDYLTKPFDLGELVARLRALLRRRGAGSGGLADSAITVGQITVDVSRRLVFVNGERVE
LSKREFDLLVVLAENTGVVLSRTRLLELVWGYDFDVETNVADVFVSYLRRKLEAGGAARVIHTVRGVGYVMREEP

Specific function: Member of the two-component regulatory system prrB/prrA. Involved specifically in early intracellular multiplication of Mycobacterium [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=35.7466063348416, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=37.6681614349776, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=36.7256637168142, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=37.219730941704, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=38.2882882882883, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=34.5291479820628, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=35.9649122807018, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=36.7713004484305, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=37.9912663755458, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790860, Length=227, Percent_Identity=33.4801762114537, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=30.3964757709251, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=33.1877729257642, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=30.2631578947368, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=30.0429184549356, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788550, Length=111, Percent_Identity=36.036036036036, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=36.8421052631579, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788713, Length=113, Percent_Identity=36.283185840708, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI145693157, Length=103, Percent_Identity=34.9514563106796, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788191, Length=122, Percent_Identity=33.6065573770492, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787487, Length=110, Percent_Identity=30.9090909090909, Blast_Score=61, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=117, Percent_Identity=32.4786324786325, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25708; Mature: 25576

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQETTARHKVLMVDDDPDVRNSVARGLRHSGFDVRVAVDGRDALTQLAADEPDALVLDV
CCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCCEEEEEE
QMPELDGVAVVTALRALGNDIPICVLSARDTVNDRIAGLEAGADDYLTKPFDLGELVARL
ECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCCHHCCCCCCHHHHHHHH
RALLRRRGAGSGGLADSAITVGQITVDVSRRLVFVNGERVELSKREFDLLVVLAENTGVV
HHHHHHCCCCCCCCCCCEEEEEEEEEEECCEEEEEECCEEEECCCCEEEEEEEECCCCEE
LSRTRLLELVWGYDFDVETNVADVFVSYLRRKLEAGGAARVIHTVRGVGYVMREEP
EEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEECCC
>Mature Secondary Structure 
TQETTARHKVLMVDDDPDVRNSVARGLRHSGFDVRVAVDGRDALTQLAADEPDALVLDV
CCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCCEEEEEE
QMPELDGVAVVTALRALGNDIPICVLSARDTVNDRIAGLEAGADDYLTKPFDLGELVARL
ECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCCHHCCCCCCHHHHHHHH
RALLRRRGAGSGGLADSAITVGQITVDVSRRLVFVNGERVELSKREFDLLVVLAENTGVV
HHHHHHCCCCCCCCCCCEEEEEEEEEEECCEEEEEECCEEEECCCCEEEEEEEECCCCEE
LSRTRLLELVWGYDFDVETNVADVFVSYLRRKLEAGGAARVIHTVRGVGYVMREEP
EEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]