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The map label for this gene is panB [H]

Identifier: 169629004

GI number: 169629004

Start: 1915040

End: 1915918

Strand: Reverse

Name: panB [H]

Synonym: MAB_1916c

Alternate gene names: 169629004

Gene position: 1915918-1915040 (Counterclockwise)

Preceding gene: 169629011

Following gene: 169629002

Centisome position: 37.81

GC content: 64.96

Gene sequence:

>879_bases
ATGTCCGAATCTGCCTTGTATGGCGCTGCTTCCGAAAAATCGACTGAGCCGCGTACGCAGCCTGATGCTCTTCGCGCAAA
ACGCTCATCGCAGACCCGTGTGCACCACTTGCAAAAGTGGAAGGCCGAGGGCCACAAGTGGTCGATGCTCACCGCGTACG
ACTACTCCACCGCGCGGGTATTCAACGATGCCGGGATTCCCGTTCTGCTGGTCGGAGATTCGGCCGCGAACGTGGTCTAC
GGATATGACACCACCGTGCCGATCACCATCGACGAGCTGATTCCGTTGGTGCGTGGCGTGGTTCGTGGCGCGCCCGAGGC
GCTGGTGGTCGCCGACCTACCCTTCGGTTCCTATGAGGGCGGCGCCGCTCAGGCGCTCGCGAGCGCCACTCGGTTCATGA
AGGAAGCCGGCGCCCACGCCGTGAAACTCGAAGGCGGAGAACGGGTTGCCGAGCAGATCGCCACACTGACCGCCGCCGGC
ATCCCGGTGGTGGCGCACATCGGGTTCACGCCACAGAGCGTGAACGGCCTTGGCGGATACCGAGTCCAGGGTCGCGACGA
CGCTGCCGCACAGCTCATTCACGACGCCATCGCGGTTCAGGAGGCGGGGGCCATCGCCGTGGTGATGGAGATGGTGCCGG
CGGAGCTGGCCACACAGATCACCGGCAAGCTCACCATCCCCACCGTCGGCATCGGCGCGGGCCGGGAGTGCGACGCCCAG
GTGTTGGTGTGGCAGGACATGGCCGGAATGACCAGCGGTAAGACCGCCAAGTTCGTCAAGCAATTCGGCCAGGTCGGTGC
CGAGCTACGCAAGGCCGCCGAGCAGTACGCCGATGAGGTGGCTCGCGGAGTGTTCCCCGCTCCCGAGCACTCGTACTAA

Upstream 100 bases:

>100_bases
TATTCATCTCCTCGCTATGCGGTGGCACACTGAACATCGTTAGAAACCCAGGGACCCGGATGGGCCTTGAGGAATTTCAA
AACGATGAGGTGACTTCTTC

Downstream 100 bases:

>100_bases
ATCGAGATCGTCAGGCGCGCACGCCGAGTTTGTTGTCCAGGTACTCCTGGCGGCAGGCTCGGCGTGCGAGCTTTCCGCTG
GTAGTGCGGGGAATCGCACC

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MSESALYGAASEKSTEPRTQPDALRAKRSSQTRVHHLQKWKAEGHKWSMLTAYDYSTARVFNDAGIPVLLVGDSAANVVY
GYDTTVPITIDELIPLVRGVVRGAPEALVVADLPFGSYEGGAAQALASATRFMKEAGAHAVKLEGGERVAEQIATLTAAG
IPVVAHIGFTPQSVNGLGGYRVQGRDDAAAQLIHDAIAVQEAGAIAVVMEMVPAELATQITGKLTIPTVGIGAGRECDAQ
VLVWQDMAGMTSGKTAKFVKQFGQVGAELRKAAEQYADEVARGVFPAPEHSY

Sequences:

>Translated_292_residues
MSESALYGAASEKSTEPRTQPDALRAKRSSQTRVHHLQKWKAEGHKWSMLTAYDYSTARVFNDAGIPVLLVGDSAANVVY
GYDTTVPITIDELIPLVRGVVRGAPEALVVADLPFGSYEGGAAQALASATRFMKEAGAHAVKLEGGERVAEQIATLTAAG
IPVVAHIGFTPQSVNGLGGYRVQGRDDAAAQLIHDAIAVQEAGAIAVVMEMVPAELATQITGKLTIPTVGIGAGRECDAQ
VLVWQDMAGMTSGKTAKFVKQFGQVGAELRKAAEQYADEVARGVFPAPEHSY
>Mature_291_residues
SESALYGAASEKSTEPRTQPDALRAKRSSQTRVHHLQKWKAEGHKWSMLTAYDYSTARVFNDAGIPVLLVGDSAANVVYG
YDTTVPITIDELIPLVRGVVRGAPEALVVADLPFGSYEGGAAQALASATRFMKEAGAHAVKLEGGERVAEQIATLTAAGI
PVVAHIGFTPQSVNGLGGYRVQGRDDAAAQLIHDAIAVQEAGAIAVVMEMVPAELATQITGKLTIPTVGIGAGRECDAQV
LVWQDMAGMTSGKTAKFVKQFGQVGAELRKAAEQYADEVARGVFPAPEHSY

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=262, Percent_Identity=47.3282442748092, Blast_Score=235, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6319653, Length=251, Percent_Identity=39.0438247011952, Blast_Score=173, Evalue=2e-44,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 30788; Mature: 30657

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESALYGAASEKSTEPRTQPDALRAKRSSQTRVHHLQKWKAEGHKWSMLTAYDYSTARV
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEEECCCHHEE
FNDAGIPVLLVGDSAANVVYGYDTTVPITIDELIPLVRGVVRGAPEALVVADLPFGSYEG
ECCCCCEEEEECCCCCCEEEECCCEECEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
GAAQALASATRFMKEAGAHAVKLEGGERVAEQIATLTAAGIPVVAHIGFTPQSVNGLGGY
HHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCE
RVQGRDDAAAQLIHDAIAVQEAGAIAVVMEMVPAELATQITGKLTIPTVGIGAGRECDAQ
EECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEECEECCCCCCCCCCE
VLVWQDMAGMTSGKTAKFVKQFGQVGAELRKAAEQYADEVARGVFPAPEHSY
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SESALYGAASEKSTEPRTQPDALRAKRSSQTRVHHLQKWKAEGHKWSMLTAYDYSTARV
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEEECCCHHEE
FNDAGIPVLLVGDSAANVVYGYDTTVPITIDELIPLVRGVVRGAPEALVVADLPFGSYEG
ECCCCCEEEEECCCCCCEEEECCCEECEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
GAAQALASATRFMKEAGAHAVKLEGGERVAEQIATLTAAGIPVVAHIGFTPQSVNGLGGY
HHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCE
RVQGRDDAAAQLIHDAIAVQEAGAIAVVMEMVPAELATQITGKLTIPTVGIGAGRECDAQ
EECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEECEECCCCCCCCCCE
VLVWQDMAGMTSGKTAKFVKQFGQVGAELRKAAEQYADEVARGVFPAPEHSY
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA