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The map label for this gene is hisC [C]

Identifier: 169628990

GI number: 169628990

Start: 1899145

End: 1900164

Strand: Direct

Name: hisC [C]

Synonym: MAB_1902

Alternate gene names: 169628990

Gene position: 1899145-1900164 (Clockwise)

Preceding gene: 169628986

Following gene: 169628991

Centisome position: 37.48

GC content: 68.43

Gene sequence:

>1020_bases
ATGACTGGGCCGCGAAAGGGAGCGCGCTACCACGGCGACCAGGCGCTGATACCAGGCGTCCTGGACTTCGCTGTGAACGT
GCGCGCCGCGGCGCCACCGCCGTGGCTACGGGATCGGCTCGCGTCGCGGCTGGACGAGCTGGGCAGTTATCCGCGCCGCG
AGGACGAGCAACGCGCTGTCGACGCCGTCGCCGAACGGCATGGTCGCCCGCCCGACGAGGTGCTGCTGCTGGCGGGGGCC
GCTGAGGGTTTCGCGATGCTGCCGCGGCTGAATCCGCGACGGGCGGCCGTCGTCGCCCCGGGGTTCACCGAGCCCGAGGC
AGTCCTGGCCGATGCCGGTATCCCTCTCGAGCATGTGGTGTTGCCGCCACCGTTCACCCTCGGCGACACCGTGCGAGTTC
CAGATGAGGCCGATCTGGTGGTTGTCGGGAACCCCACCAACCCGACCGGTGTGCTGCATACCCGAGAACAATTGCTTGCG
CTGCGTCGGCCCGGACGCATCCTGGTTGTCGATGAGGCCTTCATCGACGCGGTGCCGGGCGAGCCGGAGTCGGTGGCCTC
GCTGAGCCTGCCCGGCCTCGTGGTGCTGCGCAGCCTCACCAAGACCTGGGCGCTCGCCGGACTACGCGCGGGCTATGCCG
TCGGCGATCCCGAGCTGCTTCGCAGGCTTGCGCGGGGGCGTGCGCATTGGCCTTTGGGCACATTGCAACTGGAAGCGTTG
GCTGCCTGCAATACCGCGCAAGCGGTGGGAAGCGCGGTGCTGGATGCGCAGCGGCTCGTCGAGACGCGACACCGGCAGGC
CGAGGGGCTGCGTGGGCTGGGTTTGGCCGTGACGGAAGGTGTCGCGCCCTTCCTGCTGGTGGCCGTGCCCCATGCGGATT
TGATGCGAAAACACCTGAAGGTCAAAAATATCGCGGTCCGGCGTTGCGACACCTTTGTCGGGCTGGACGGCGACTACCTA
CGGGTGGCGGTGCGACCGGAATGGCCGGAGCTGGTGCAAGCGATGAAGGAGATCTTGTAG

Upstream 100 bases:

>100_bases
GAAACTCGAGACAATCCCTGGTGCGGAGTCGGTCAGGGTGCCGTCGAGATCGAAGATCACCAGCATCGGAGGGGCCACCC
CCTTACATTAGTGTCGAGAC

Downstream 100 bases:

>100_bases
TGGGTGTGCGGCTCGCGGACATCATCGGCGTGCTCGACGCGGCCTATCCGCCGGCGCTGGCCGAATCGTGGGATTCGGTG
GGCTTGGTCTGCGGCGACCC

Product: hypothetical protein

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTGPRKGARYHGDQALIPGVLDFAVNVRAAAPPPWLRDRLASRLDELGSYPRREDEQRAVDAVAERHGRPPDEVLLLAGA
AEGFAMLPRLNPRRAAVVAPGFTEPEAVLADAGIPLEHVVLPPPFTLGDTVRVPDEADLVVVGNPTNPTGVLHTREQLLA
LRRPGRILVVDEAFIDAVPGEPESVASLSLPGLVVLRSLTKTWALAGLRAGYAVGDPELLRRLARGRAHWPLGTLQLEAL
AACNTAQAVGSAVLDAQRLVETRHRQAEGLRGLGLAVTEGVAPFLLVAVPHADLMRKHLKVKNIAVRRCDTFVGLDGDYL
RVAVRPEWPELVQAMKEIL

Sequences:

>Translated_339_residues
MTGPRKGARYHGDQALIPGVLDFAVNVRAAAPPPWLRDRLASRLDELGSYPRREDEQRAVDAVAERHGRPPDEVLLLAGA
AEGFAMLPRLNPRRAAVVAPGFTEPEAVLADAGIPLEHVVLPPPFTLGDTVRVPDEADLVVVGNPTNPTGVLHTREQLLA
LRRPGRILVVDEAFIDAVPGEPESVASLSLPGLVVLRSLTKTWALAGLRAGYAVGDPELLRRLARGRAHWPLGTLQLEAL
AACNTAQAVGSAVLDAQRLVETRHRQAEGLRGLGLAVTEGVAPFLLVAVPHADLMRKHLKVKNIAVRRCDTFVGLDGDYL
RVAVRPEWPELVQAMKEIL
>Mature_338_residues
TGPRKGARYHGDQALIPGVLDFAVNVRAAAPPPWLRDRLASRLDELGSYPRREDEQRAVDAVAERHGRPPDEVLLLAGAA
EGFAMLPRLNPRRAAVVAPGFTEPEAVLADAGIPLEHVVLPPPFTLGDTVRVPDEADLVVVGNPTNPTGVLHTREQLLAL
RRPGRILVVDEAFIDAVPGEPESVASLSLPGLVVLRSLTKTWALAGLRAGYAVGDPELLRRLARGRAHWPLGTLQLEALA
ACNTAQAVGSAVLDAQRLVETRHRQAEGLRGLGLAVTEGVAPFLLVAVPHADLMRKHLKVKNIAVRRCDTFVGLDGDYLR
VAVRPEWPELVQAMKEIL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=199, Percent_Identity=32.1608040201005, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9

Molecular weight: Translated: 36578; Mature: 36447

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPRKGARYHGDQALIPGVLDFAVNVRAAAPPPWLRDRLASRLDELGSYPRREDEQRAV
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHH
DAVAERHGRPPDEVLLLAGAAEGFAMLPRLNPRRAAVVAPGFTEPEAVLADAGIPLEHVV
HHHHHHCCCCHHHEEEEEECCCCEEECCCCCCCCEEEECCCCCCCHHHHCCCCCCCEEEE
LPPPFTLGDTVRVPDEADLVVVGNPTNPTGVLHTREQLLALRRPGRILVVDEAFIDAVPG
ECCCCCCCCEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHCCCC
EPESVASLSLPGLVVLRSLTKTWALAGLRAGYAVGDPELLRRLARGRAHWPLGTLQLEAL
CCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
AACNTAQAVGSAVLDAQRLVETRHRQAEGLRGLGLAVTEGVAPFLLVAVPHADLMRKHLK
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEECCCHHHHHHHHH
VKNIAVRRCDTFVGLDGDYLRVAVRPEWPELVQAMKEIL
HHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHC
>Mature Secondary Structure 
TGPRKGARYHGDQALIPGVLDFAVNVRAAAPPPWLRDRLASRLDELGSYPRREDEQRAV
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHH
DAVAERHGRPPDEVLLLAGAAEGFAMLPRLNPRRAAVVAPGFTEPEAVLADAGIPLEHVV
HHHHHHCCCCHHHEEEEEECCCCEEECCCCCCCCEEEECCCCCCCHHHHCCCCCCCEEEE
LPPPFTLGDTVRVPDEADLVVVGNPTNPTGVLHTREQLLALRRPGRILVVDEAFIDAVPG
ECCCCCCCCEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHCCCC
EPESVASLSLPGLVVLRSLTKTWALAGLRAGYAVGDPELLRRLARGRAHWPLGTLQLEAL
CCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
AACNTAQAVGSAVLDAQRLVETRHRQAEGLRGLGLAVTEGVAPFLLVAVPHADLMRKHLK
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEECCCHHHHHHHHH
VKNIAVRRCDTFVGLDGDYLRVAVRPEWPELVQAMKEIL
HHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]