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The map label for this gene is kasA [H]

Identifier: 169628965

GI number: 169628965

Start: 1875397

End: 1876650

Strand: Reverse

Name: kasA [H]

Synonym: MAB_1877c

Alternate gene names: 169628965

Gene position: 1876650-1875397 (Counterclockwise)

Preceding gene: 169628966

Following gene: 169628964

Centisome position: 37.04

GC content: 64.27

Gene sequence:

>1254_bases
GTGACACTCCCTTCCACTGCCAACGGTGGCTTCCCCAACGTCGTTGTGACGGCTCTCGCCGCAACGACATCTATCGCGCC
TGACATCGAGGGCACGTGGAAGGGACTGATCGCCGGGGAGAGCGGTATCGAGGTTCTCGAGGACGAATTCGTCGAGAAGT
TCGGACTGCCGGTGTGGATCGGTGGGCACCTCAAGGAGCCCATCGATAACCACATGACCCGGTTGGAACTTCGCCGGATG
GCCTACGTGCAGCGGATGGCGCTGCACGTAGGCCGTCAGGTGTGGCAGAACGCCGGCTCGCCCGATGACATCGACAAGGA
CCGCCTTGGTGTCGTCATCGGTACCGGGCTCGGCGGCGGCGAGCGCATCGTCGAAACCTACGACACCATGAACGAGCATG
GCATTCGCAAGGTTTCGCCCCTCGCCGTGCAGATGTGCATGCCCAACGGTGCCGCCGCGGTGGTGGGCCTGGAGATCGGC
GCCCGCGCGGGTGTCATCACGCCGGTGTCGGCGTGTTCCTCCGGCTCCGAGGCCATCGCGCACGCGTGGCGCCAGATCGT
GATGGGCGATGCAGACATGATCGTCTGCGGTGGTGTCGAGGGCATGATCGAAGCCCTGCCCATCGCCGCGTTCTCCATGA
TGCGCGCCATGTCGACGCGGAATGACGAGCCGGAGAAGGCTTCTCGCCCGTTCGACAAGGACCGCGACGGATTCGTGTTC
GGCGAGGCCGGTGCTCTCATGGTCATCGAGACCGAGGAGCACGCCAAGGCTCGCGGCGCACAGATCATCGGCCGCGTGAT
GGGTGCCGGTATCACCTCCGACGCGTACCACATGGTGGCTCCCGGCCCCGACGGCATTCGCGCCGGCGCGGCCATGACCC
GCGCAATTCAGACAGCAGGCTTGTCCCCCAAGGACATTGACCACATCAACGCTCACGGCACGGCCACCCCGATCGGCGAT
GTCGCCGAGGCCAACGCCATTCACGTCGCCGGCGTACAGCACGCCGCGGTCTACGCGCCAAAGTCGGCGCTCGGCCACTC
GATCGGCGCCGTCGGCGCGTTGGAGTCCGTGCTTACTGTGCTGGCTCTGCGTGACGGTGTTATCCCCCCGACGCTCAATC
TTGACAACCTTGATCCCGAAATCGACCTGGATGTCGTTGCGGGCGAGCCTCGTCACGGGGATTTTAAGTATGCGATCAAC
AACTCGTTTGGATTCGGCGGGCACAACGTCGCGCTTGCCTTTGGCAAGTATTAA

Upstream 100 bases:

>100_bases
TGCGCACCGTCGGTGACGTCGTGAACTACATCGAGAAGCTCGAGCAGGAGAACCCCGAGGCCGCGGCCAACATCCGCGCG
CAGCTGGAGGGCTCCGACAA

Downstream 100 bases:

>100_bases
GAACCAGAGAGGCTGAAGATGACGATCCTGGCTCCCGAGGCCATCGACGAATCACTCGATCCGCGTGACCCCCTGCTACG
GCTTAACACCTTCTTCGATG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: Beta-ketoacyl-ACP synthase 1; KAS 1 [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTLPSTANGGFPNVVVTALAATTSIAPDIEGTWKGLIAGESGIEVLEDEFVEKFGLPVWIGGHLKEPIDNHMTRLELRRM
AYVQRMALHVGRQVWQNAGSPDDIDKDRLGVVIGTGLGGGERIVETYDTMNEHGIRKVSPLAVQMCMPNGAAAVVGLEIG
ARAGVITPVSACSSGSEAIAHAWRQIVMGDADMIVCGGVEGMIEALPIAAFSMMRAMSTRNDEPEKASRPFDKDRDGFVF
GEAGALMVIETEEHAKARGAQIIGRVMGAGITSDAYHMVAPGPDGIRAGAAMTRAIQTAGLSPKDIDHINAHGTATPIGD
VAEANAIHVAGVQHAAVYAPKSALGHSIGAVGALESVLTVLALRDGVIPPTLNLDNLDPEIDLDVVAGEPRHGDFKYAIN
NSFGFGGHNVALAFGKY

Sequences:

>Translated_417_residues
MTLPSTANGGFPNVVVTALAATTSIAPDIEGTWKGLIAGESGIEVLEDEFVEKFGLPVWIGGHLKEPIDNHMTRLELRRM
AYVQRMALHVGRQVWQNAGSPDDIDKDRLGVVIGTGLGGGERIVETYDTMNEHGIRKVSPLAVQMCMPNGAAAVVGLEIG
ARAGVITPVSACSSGSEAIAHAWRQIVMGDADMIVCGGVEGMIEALPIAAFSMMRAMSTRNDEPEKASRPFDKDRDGFVF
GEAGALMVIETEEHAKARGAQIIGRVMGAGITSDAYHMVAPGPDGIRAGAAMTRAIQTAGLSPKDIDHINAHGTATPIGD
VAEANAIHVAGVQHAAVYAPKSALGHSIGAVGALESVLTVLALRDGVIPPTLNLDNLDPEIDLDVVAGEPRHGDFKYAIN
NSFGFGGHNVALAFGKY
>Mature_416_residues
TLPSTANGGFPNVVVTALAATTSIAPDIEGTWKGLIAGESGIEVLEDEFVEKFGLPVWIGGHLKEPIDNHMTRLELRRMA
YVQRMALHVGRQVWQNAGSPDDIDKDRLGVVIGTGLGGGERIVETYDTMNEHGIRKVSPLAVQMCMPNGAAAVVGLEIGA
RAGVITPVSACSSGSEAIAHAWRQIVMGDADMIVCGGVEGMIEALPIAAFSMMRAMSTRNDEPEKASRPFDKDRDGFVFG
EAGALMVIETEEHAKARGAQIIGRVMGAGITSDAYHMVAPGPDGIRAGAAMTRAIQTAGLSPKDIDHINAHGTATPIGDV
AEANAIHVAGVQHAAVYAPKSALGHSIGAVGALESVLTVLALRDGVIPPTLNLDNLDPEIDLDVVAGEPRHGDFKYAINN
SFGFGGHNVALAFGKY

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=415, Percent_Identity=37.1084337349398, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=45.2054794520548, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI41872631, Length=254, Percent_Identity=28.3464566929134, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1787337, Length=409, Percent_Identity=41.320293398533, Blast_Score=260, Evalue=9e-71,
Organism=Escherichia coli, GI1788663, Length=408, Percent_Identity=33.3333333333333, Blast_Score=189, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI71983541, Length=410, Percent_Identity=34.8780487804878, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI71983535, Length=262, Percent_Identity=40.4580152671756, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17550940, Length=277, Percent_Identity=25.9927797833935, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212642053, Length=254, Percent_Identity=28.3464566929134, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320904, Length=441, Percent_Identity=32.6530612244898, Blast_Score=216, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24644341, Length=426, Percent_Identity=36.3849765258216, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24581345, Length=434, Percent_Identity=23.963133640553, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221330659, Length=377, Percent_Identity=23.0769230769231, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19920632, Length=377, Percent_Identity=23.0769230769231, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43677; Mature: 43546

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPSTANGGFPNVVVTALAATTSIAPDIEGTWKGLIAGESGIEVLEDEFVEKFGLPVWI
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEE
GGHLKEPIDNHMTRLELRRMAYVQRMALHVGRQVWQNAGSPDDIDKDRLGVVIGTGLGGG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCC
ERIVETYDTMNEHGIRKVSPLAVQMCMPNGAAAVVGLEIGARAGVITPVSACSSGSEAIA
HHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCHHHCCCCHHHHH
HAWRQIVMGDADMIVCGGVEGMIEALPIAAFSMMRAMSTRNDEPEKASRPFDKDRDGFVF
HHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEE
GEAGALMVIETEEHAKARGAQIIGRVMGAGITSDAYHMVAPGPDGIRAGAAMTRAIQTAG
ECCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCC
LSPKDIDHINAHGTATPIGDVAEANAIHVAGVQHAAVYAPKSALGHSIGAVGALESVLTV
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHEECCHHHHHHHHHHHHHHHHHHHH
LALRDGVIPPTLNLDNLDPEIDLDVVAGEPRHGDFKYAINNSFGFGGHNVALAFGKY
HHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
TLPSTANGGFPNVVVTALAATTSIAPDIEGTWKGLIAGESGIEVLEDEFVEKFGLPVWI
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEE
GGHLKEPIDNHMTRLELRRMAYVQRMALHVGRQVWQNAGSPDDIDKDRLGVVIGTGLGGG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCC
ERIVETYDTMNEHGIRKVSPLAVQMCMPNGAAAVVGLEIGARAGVITPVSACSSGSEAIA
HHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCHHHCCCCHHHHH
HAWRQIVMGDADMIVCGGVEGMIEALPIAAFSMMRAMSTRNDEPEKASRPFDKDRDGFVF
HHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEE
GEAGALMVIETEEHAKARGAQIIGRVMGAGITSDAYHMVAPGPDGIRAGAAMTRAIQTAG
ECCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCC
LSPKDIDHINAHGTATPIGDVAEANAIHVAGVQHAAVYAPKSALGHSIGAVGALESVLTV
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHEECCHHHHHHHHHHHHHHHHHHHH
LALRDGVIPPTLNLDNLDPEIDLDVVAGEPRHGDFKYAINNSFGFGGHNVALAFGKY
HHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]