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The map label for this gene is accD6 [H]

Identifier: 169628964

GI number: 169628964

Start: 1873957

End: 1875378

Strand: Reverse

Name: accD6 [H]

Synonym: MAB_1876c

Alternate gene names: 169628964

Gene position: 1875378-1873957 (Counterclockwise)

Preceding gene: 169628965

Following gene: 169628963

Centisome position: 37.01

GC content: 69.48

Gene sequence:

>1422_bases
ATGACGATCCTGGCTCCCGAGGCCATCGACGAATCACTCGATCCGCGTGACCCCCTGCTACGGCTTAACACCTTCTTCGA
TGACGGCAGCGTCGAGTTGCTGCATGAGCGTGACCGCTCGGGTGTGCTGGCCGCCGCGGGCACGGTCAACGGAGTCAGGA
CCATCGCCTTCTGCACCGACGGCACCGTCATGGGCGGCGCCATGGGTGTCGAGGGTTGCCGCCACATCGTCAACGCCTAC
GACACCGCCATCGAGGAGCAGAGCCCCATCGTGGGTATCTGGCACTCCGGCGGTGCGCGGTTGGCCGAGGGTGTGAAGGC
TCTGCACGCCGTCGGGCTGGTCTTCGAGGCCATGATCCGGGCCTCGGGCTACATCCCCCAGATCTCGGTGGTCGTGGGCT
TCGCCGCCGGCGGCGCGGCATACGGCCCGGCCCTGACCGACGTCATCATCATGGCGCCGGAGAGCCGCGTGTTCGTCACC
GGGCCCGACGTGGTCCGCAGCGTCACCGGTGAGGACGTCGACATGGCGACCCTGGGTGGCCCCGATGCCCACCACAAGAA
GTCGGGTGTGTGCCACATCGTCGCCGACGATGAACTGGACGCCTACGCCCGCGGCCGCAAGCTGGTCGGCTTCTTCTGCC
AGCAAGGCGTTTTCGACCGGGGCCGCGCCGAGGCCGACCACACCGATCTGCGCGCCCTGCTCCCCGAGTCGGCCAAGCGC
GCCTACGACGTGCACCCGATCGTCAACGCGCTGCTCGACGGGGACGACCCGTTCGAAGAGTTCCAGGGCAAGTGGGCCCC
CTCGATGGTCATCGGCCTGGGCCGGCTGGCCGGACGTACCGTCGGCGTGCTGGCCAACAATCCGCTGCGTCTGGGCGGCT
GCCTGAACTCCGAAAGCGCCGAGAAGGCAGCACGTTTCGTGCGCCTGTGCAACGCCTTCGGCATCCCGCTGATCGTGCTC
GTGGACGTGCCGGGTTACCTGCCCGGTGTGGGCCAGGAGTGGGGCGGCGTGGTGCGCCGCGGCGCCAAGCTGCTGCACGC
GTTCGGTGAGGCCACCGTTCCGCGCGTCACGCTGGTGACCCGCAAGATCTACGGCGGCGCCTACATCGCCATGAACTCCC
GCTCGCTGGGCGCCACCAAGGTGTTCGCCTGGCCGGACGCCGAGGTCGCCGTGATGGGCGCCAAGGCCGCCGTCGGCATT
CTGCACAAGAAGCAACTCGCCGCCGCCGCACCCGAGGAGCGCGAGGCGCTGCACGAGGAGCTGGCGCTCGAGCACGAGCG
GATCGCCGGTGGCGTGGATCGCGCCATCGAGATCGGCGTGGTCGACGAGGAGATCGAGCCGTCGCAGACCCGCGCGGTAC
TGACCCGCGCGCTGGCCGAGGCGCCCTCGCGCCGCGGCCGTCACAAGAACATCCCGCTGTAG

Upstream 100 bases:

>100_bases
TCACGGGGATTTTAAGTATGCGATCAACAACTCGTTTGGATTCGGCGGGCACAACGTCGCGCTTGCCTTTGGCAAGTATT
AAGAACCAGAGAGGCTGAAG

Downstream 100 bases:

>100_bases
ACCCTGCATGTCGGAGCACCGGCGCACGTCCATCTCCGTCGACGGACACCGGCTGGCATATCGCCAGTTCGGTTCCGGGG
ACCGCGTCGTGGTGCTGTCT

Product: propionyl-CoA carboxylase beta chain 6

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTILAPEAIDESLDPRDPLLRLNTFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCRHIVNAY
DTAIEEQSPIVGIWHSGGARLAEGVKALHAVGLVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVIIMAPESRVFVT
GPDVVRSVTGEDVDMATLGGPDAHHKKSGVCHIVADDELDAYARGRKLVGFFCQQGVFDRGRAEADHTDLRALLPESAKR
AYDVHPIVNALLDGDDPFEEFQGKWAPSMVIGLGRLAGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCNAFGIPLIVL
VDVPGYLPGVGQEWGGVVRRGAKLLHAFGEATVPRVTLVTRKIYGGAYIAMNSRSLGATKVFAWPDAEVAVMGAKAAVGI
LHKKQLAAAAPEEREALHEELALEHERIAGGVDRAIEIGVVDEEIEPSQTRAVLTRALAEAPSRRGRHKNIPL

Sequences:

>Translated_473_residues
MTILAPEAIDESLDPRDPLLRLNTFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCRHIVNAY
DTAIEEQSPIVGIWHSGGARLAEGVKALHAVGLVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVIIMAPESRVFVT
GPDVVRSVTGEDVDMATLGGPDAHHKKSGVCHIVADDELDAYARGRKLVGFFCQQGVFDRGRAEADHTDLRALLPESAKR
AYDVHPIVNALLDGDDPFEEFQGKWAPSMVIGLGRLAGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCNAFGIPLIVL
VDVPGYLPGVGQEWGGVVRRGAKLLHAFGEATVPRVTLVTRKIYGGAYIAMNSRSLGATKVFAWPDAEVAVMGAKAAVGI
LHKKQLAAAAPEEREALHEELALEHERIAGGVDRAIEIGVVDEEIEPSQTRAVLTRALAEAPSRRGRHKNIPL
>Mature_472_residues
TILAPEAIDESLDPRDPLLRLNTFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCRHIVNAYD
TAIEEQSPIVGIWHSGGARLAEGVKALHAVGLVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVIIMAPESRVFVTG
PDVVRSVTGEDVDMATLGGPDAHHKKSGVCHIVADDELDAYARGRKLVGFFCQQGVFDRGRAEADHTDLRALLPESAKRA
YDVHPIVNALLDGDDPFEEFQGKWAPSMVIGLGRLAGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCNAFGIPLIVLV
DVPGYLPGVGQEWGGVVRRGAKLLHAFGEATVPRVTLVTRKIYGGAYIAMNSRSLGATKVFAWPDAEVAVMGAKAAVGIL
HKKQLAAAAPEEREALHEELALEHERIAGGVDRAIEIGVVDEEIEPSQTRAVLTRALAEAPSRRGRHKNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=447, Percent_Identity=41.6107382550336, Blast_Score=319, Evalue=5e-87,
Organism=Homo sapiens, GI295821216, Length=429, Percent_Identity=42.1911421911422, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI11545863, Length=487, Percent_Identity=30.1848049281314, Blast_Score=188, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI25147362, Length=487, Percent_Identity=40.2464065708419, Blast_Score=325, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI25147359, Length=487, Percent_Identity=40.2464065708419, Blast_Score=325, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI17552936, Length=480, Percent_Identity=29.375, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71997163, Length=429, Percent_Identity=22.6107226107226, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24586065, Length=506, Percent_Identity=29.2490118577075, Blast_Score=181, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 50199; Mature: 50068

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILAPEAIDESLDPRDPLLRLNTFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTD
CCEECCHHHCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCEEEECCCCCCEEEEEEEEC
GTVMGGAMGVEGCRHIVNAYDTAIEEQSPIVGIWHSGGARLAEGVKALHAVGLVFEAMIR
CCEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ASGYIPQISVVVGFAAGGAAYGPALTDVIIMAPESRVFVTGPDVVRSVTGEDVDMATLGG
HCCCCCEEEEEEEEECCCCCCCHHHHEEEEECCCCEEEEECHHHHHHCCCCCCEEEECCC
PDAHHKKSGVCHIVADDELDAYARGRKLVGFFCQQGVFDRGRAEADHTDLRALLPESAKR
CCCCCCCCCEEEEEECCCHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHH
AYDVHPIVNALLDGDDPFEEFQGKWAPSMVIGLGRLAGRTVGVLANNPLRLGGCLNSESA
HCCHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHH
EKAARFVRLCNAFGIPLIVLVDVPGYLPGVGQEWGGVVRRGAKLLHAFGEATVPRVTLVT
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
RKIYGGAYIAMNSRSLGATKVFAWPDAEVAVMGAKAAVGILHKKQLAAAAPEEREALHEE
HHHCCCEEEEECCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHH
LALEHERIAGGVDRAIEIGVVDEEIEPSQTRAVLTRALAEAPSRRGRHKNIPL
HHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCHHHCCCCCCCCC
>Mature Secondary Structure 
TILAPEAIDESLDPRDPLLRLNTFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTD
CEECCHHHCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCEEEECCCCCCEEEEEEEEC
GTVMGGAMGVEGCRHIVNAYDTAIEEQSPIVGIWHSGGARLAEGVKALHAVGLVFEAMIR
CCEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ASGYIPQISVVVGFAAGGAAYGPALTDVIIMAPESRVFVTGPDVVRSVTGEDVDMATLGG
HCCCCCEEEEEEEEECCCCCCCHHHHEEEEECCCCEEEEECHHHHHHCCCCCCEEEECCC
PDAHHKKSGVCHIVADDELDAYARGRKLVGFFCQQGVFDRGRAEADHTDLRALLPESAKR
CCCCCCCCCEEEEEECCCHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHH
AYDVHPIVNALLDGDDPFEEFQGKWAPSMVIGLGRLAGRTVGVLANNPLRLGGCLNSESA
HCCHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHH
EKAARFVRLCNAFGIPLIVLVDVPGYLPGVGQEWGGVVRRGAKLLHAFGEATVPRVTLVT
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
RKIYGGAYIAMNSRSLGATKVFAWPDAEVAVMGAKAAVGILHKKQLAAAAPEEREALHEE
HHHCCCEEEEECCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHH
LALEHERIAGGVDRAIEIGVVDEEIEPSQTRAVLTRALAEAPSRRGRHKNIPL
HHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]