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The map label for this gene is mutM [C]

Identifier: 169628665

GI number: 169628665

Start: 1605050

End: 1605847

Strand: Direct

Name: mutM [C]

Synonym: MAB_1575

Alternate gene names: 169628665

Gene position: 1605050-1605847 (Clockwise)

Preceding gene: 169628664

Following gene: 169628666

Centisome position: 31.68

GC content: 66.42

Gene sequence:

>798_bases
GTGCCGGAGGGTCATACCCTGCACCGGCTGGCCCGGTTGCACCAGCGCCGGTTCGCCGGTGCGCCGGTGTCGGTGAGCAG
CCCGCAGGGACGGTTCACCGAAGGCGCGGCCGCGGTCAATGGACGTACCTTTGTCCAGGCGCACGCCTGGGGTAAGCATC
TGTTTCACGACTACGGCCCTGTCGGCGTGGTGCATGTGCACCTTGGGCTGTATGGCGCGTTCACGGAATTACCCGTGCCG
ATGGGCCTGCCGGTTGGTCAGGTGCGGATGCGTATCGAAGGGGCCGAGTTCGGCACCGACCTGCGTGGCGCGACGGCATG
TGAGCTCATCGACGCCCCGCAAGTCGACGCCATCCTGGCCCGCCTGGGCCCTGACCCACTGCGTCCCCGATCGGATCCGG
CGTCCGCGTTCGAGCGGATCGCTAAGTCGCACAGGCCAATCGGCGCATTGCTGATGGATCAGAAGATCATCGCCGGTGTG
GGGAATGTGTATCGCAGCGAGGTGCTGTTCCGTAGGCGGATCGATCCGTACCGCGAGGGGAGCCGCCTCGATCCGGAACA
GCTCACCGCGCTCTGGAGCGATCTGGTGGATCGGATGCGCGTCGGACTGCGGGTCGGCAAGATCGTCACCGTCGATCCTG
AGCACGACTGCGGCGACCCGTCCTATGCTCCGGACCGCCCGCGCACCTACGTGTACCGGCGTGCAGGTGCGCCGTGCCGG
GTGTGCGGAACGCCGATCCTCACCGCGGAAATGGACGCGCGAAACCTCTTCTGGTGTCCCTCATGTCAAATTGGCTGA

Upstream 100 bases:

>100_bases
GTCGGAGGAGCCGCGGCACCAGCGCCGCATCGACATCCTGGCCGAGTACGAGACCACGCGCGTGGCGCCGCCGGTACCTG
GCGCCAGCTCGTAAACGCCT

Downstream 100 bases:

>100_bases
TGACCGCCGTGATGACGCCTGCGGTTGTAAGCTGCGCTGAATGGGACGCCGAGTACCAATAACCCGAGAGGTGGGTTCAT
GACGCGACCGGGTGCGCCAC

Product: formamidopyrimidine-DNA glycolase

Products: NA

Alternate protein names: Putative DNA-(apurinic or apyrimidinic site) lyase Rv2464c/MT2539; Putative AP lyase Rv2464c/MT2539 [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MPEGHTLHRLARLHQRRFAGAPVSVSSPQGRFTEGAAAVNGRTFVQAHAWGKHLFHDYGPVGVVHVHLGLYGAFTELPVP
MGLPVGQVRMRIEGAEFGTDLRGATACELIDAPQVDAILARLGPDPLRPRSDPASAFERIAKSHRPIGALLMDQKIIAGV
GNVYRSEVLFRRRIDPYREGSRLDPEQLTALWSDLVDRMRVGLRVGKIVTVDPEHDCGDPSYAPDRPRTYVYRRAGAPCR
VCGTPILTAEMDARNLFWCPSCQIG

Sequences:

>Translated_265_residues
MPEGHTLHRLARLHQRRFAGAPVSVSSPQGRFTEGAAAVNGRTFVQAHAWGKHLFHDYGPVGVVHVHLGLYGAFTELPVP
MGLPVGQVRMRIEGAEFGTDLRGATACELIDAPQVDAILARLGPDPLRPRSDPASAFERIAKSHRPIGALLMDQKIIAGV
GNVYRSEVLFRRRIDPYREGSRLDPEQLTALWSDLVDRMRVGLRVGKIVTVDPEHDCGDPSYAPDRPRTYVYRRAGAPCR
VCGTPILTAEMDARNLFWCPSCQIG
>Mature_264_residues
PEGHTLHRLARLHQRRFAGAPVSVSSPQGRFTEGAAAVNGRTFVQAHAWGKHLFHDYGPVGVVHVHLGLYGAFTELPVPM
GLPVGQVRMRIEGAEFGTDLRGATACELIDAPQVDAILARLGPDPLRPRSDPASAFERIAKSHRPIGALLMDQKIIAGVG
NVYRSEVLFRRRIDPYREGSRLDPEQLTALWSDLVDRMRVGLRVGKIVTVDPEHDCGDPSYAPDRPRTYVYRRAGAPCRV
CGTPILTAEMDARNLFWCPSCQIG

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA b

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=214, Percent_Identity=30.3738317757009, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1786932, Length=272, Percent_Identity=26.1029411764706, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR012319
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 29188; Mature: 29057

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEGHTLHRLARLHQRRFAGAPVSVSSPQGRFTEGAAAVNGRTFVQAHAWGKHLFHDYGP
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCEEEEEHHHHHHHHHCCCC
VGVVHVHLGLYGAFTELPVPMGLPVGQVRMRIEGAEFGTDLRGATACELIDAPQVDAILA
EEEEEEEEHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCCCHHHHHH
RLGPDPLRPRSDPASAFERIAKSHRPIGALLMDQKIIAGVGNVYRSEVLFRRRIDPYREG
HCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SRLDPEQLTALWSDLVDRMRVGLRVGKIVTVDPEHDCGDPSYAPDRPRTYVYRRAGAPCR
CCCCHHHHHHHHHHHHHHHHHHHEECEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEE
VCGTPILTAEMDARNLFWCPSCQIG
ECCCEEEEEECCCCCEEECCCCCCC
>Mature Secondary Structure 
PEGHTLHRLARLHQRRFAGAPVSVSSPQGRFTEGAAAVNGRTFVQAHAWGKHLFHDYGP
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCEEEEEHHHHHHHHHCCCC
VGVVHVHLGLYGAFTELPVPMGLPVGQVRMRIEGAEFGTDLRGATACELIDAPQVDAILA
EEEEEEEEHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCCCHHHHHH
RLGPDPLRPRSDPASAFERIAKSHRPIGALLMDQKIIAGVGNVYRSEVLFRRRIDPYREG
HCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SRLDPEQLTALWSDLVDRMRVGLRVGKIVTVDPEHDCGDPSYAPDRPRTYVYRRAGAPCR
CCCCHHHHHHHHHHHHHHHHHHHEECEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEE
VCGTPILTAEMDARNLFWCPSCQIG
ECCCEEEEEECCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]