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The map label for this gene is dctA [H]

Identifier: 169628630

GI number: 169628630

Start: 1560375

End: 1561742

Strand: Direct

Name: dctA [H]

Synonym: MAB_1540

Alternate gene names: 169628630

Gene position: 1560375-1561742 (Clockwise)

Preceding gene: 169628628

Following gene: 169628631

Centisome position: 30.79

GC content: 62.5

Gene sequence:

>1368_bases
ATGACAGCGACCGAACCAGCCACTTCCGAGAGCACACCACCGAAGAAACACAAGGACCGCACCCATTGGCTGTATATCGC
GGTTGTCGTCGCGGTGGCGCTCGGTGTGGCCGTCGGCATGCTGTGGCCGGGATTCGGCAGGTCGGTGGGTGTGCTCGGCG
AGATATTCGTCAGTCTCATCAAGATGATGATCAGCCCGGTGATCTTCTGCACCATCGTGCTGGGCATCGGATCGGTACGC
AAGGCCGCAAGTGTGGGACGAGTGGGCGGATTGGCGTTCGTGTACTTCCTGGCGATGTCGACGGTCGCACTGGCGATCGG
ACTCGTTGTCGGCAATCTATTGGCGCCCGGCACCGGTTTGCACCTTTCGGGCTCCAACCAGGGTGCGGGAGCCAAGTACG
TGGACCAGGCTCACGCCGCCGGCGGCACCTGGCACTTCATCAAATCGATTGTGCCGGAGACCATGTTCTCGGCGCTGACC
TCCGGCAGCGTGCTGCAGACGCTGTTCATCGCGCTGTTGGTCGGCTTCGCGGTACAGGCTCTCGGTGGTACCGGCGAATC
GATCGTCCGGGGTGTGGGGATGCTGCAGAAGCTGGTCTTCAAGGTCCTCATCATGGTGCTGTGGCTGGCTCCCATCGGTG
CCTTCGGGGCCATTGCGAATGTGGTGGGGCAGACCGGCTGGGACGCGGTCAAGGAGCTGGGCACGCTGATGCTTGGCTTC
TATGTGACCTGCGCGATCTTCATTTTCGGTGTGCTGGGCACGCTGCTGTGGGCGGTATCGCGAGTGTCGATATTCAGGCT
GGTGCGCTACCTGGCGCGCGAGTACTTGTTGATCGTGTCGACGTCGTCCTCCGAATCGGCACTGCCCCGGCTGATCGCGA
AGATGGCCCATCTGGGTGTGGATAAGTCCACGGTGGGAATTGTTGTCCCAACCGGGTATTCGTTCAACCTGGACGGGACT
GCGATCTACCTCACGATGGCCTCGTTGTTCGTAGCCGACGCCATGGGTGCGCCCCTATCGGTGGGCGAGCAGATCTCCCT
GCTGGCATTCATGATGATCGCGTCCAAGGGCGCGGCCGGTGTGACCGGCGCCGGAATGGCCACGCTGGCAGCCGGGTTGC
AAAGCCACCGGCCCGATCTGGTCGACGGTGTCGGCATGATCGTCGGCATCGATCGGTTCATGTCCGAGGCGCGGGCGTTG
ACCAACTTCTCTGGAAACGCGGTGGCCACGCTGCTCATCGCGACCTGGACCAAGACGATGGATCGCGATCGGGTCAAGAC
GGTGCTCTCGGGGGCCGATCCCTTCGACGAAACAACCATGCTCGACGACCATGCCGGCGAGGCGGTTGTGGACAAGGTGG
TCAGCTGA

Upstream 100 bases:

>100_bases
TGAAGGCCGGTCGGCCGTGTTTTCGGTGGTACGTCGCCGGACATGGGCGAATGGCGAGGTTGTGCTGTGATCCCGGTCAC
GGTGCGGCACGATAGGGGCC

Downstream 100 bases:

>100_bases
CCGCTGGTAGCGTGCGCATGTCGCCGATCGGTGGCATCCTGGAATGAGGTAGCCGATACGAGTTCGCCGAGCGCAGATTC
GTTACACCACTTGAGCATTG

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MTATEPATSESTPPKKHKDRTHWLYIAVVVAVALGVAVGMLWPGFGRSVGVLGEIFVSLIKMMISPVIFCTIVLGIGSVR
KAASVGRVGGLAFVYFLAMSTVALAIGLVVGNLLAPGTGLHLSGSNQGAGAKYVDQAHAAGGTWHFIKSIVPETMFSALT
SGSVLQTLFIALLVGFAVQALGGTGESIVRGVGMLQKLVFKVLIMVLWLAPIGAFGAIANVVGQTGWDAVKELGTLMLGF
YVTCAIFIFGVLGTLLWAVSRVSIFRLVRYLAREYLLIVSTSSSESALPRLIAKMAHLGVDKSTVGIVVPTGYSFNLDGT
AIYLTMASLFVADAMGAPLSVGEQISLLAFMMIASKGAAGVTGAGMATLAAGLQSHRPDLVDGVGMIVGIDRFMSEARAL
TNFSGNAVATLLIATWTKTMDRDRVKTVLSGADPFDETTMLDDHAGEAVVDKVVS

Sequences:

>Translated_455_residues
MTATEPATSESTPPKKHKDRTHWLYIAVVVAVALGVAVGMLWPGFGRSVGVLGEIFVSLIKMMISPVIFCTIVLGIGSVR
KAASVGRVGGLAFVYFLAMSTVALAIGLVVGNLLAPGTGLHLSGSNQGAGAKYVDQAHAAGGTWHFIKSIVPETMFSALT
SGSVLQTLFIALLVGFAVQALGGTGESIVRGVGMLQKLVFKVLIMVLWLAPIGAFGAIANVVGQTGWDAVKELGTLMLGF
YVTCAIFIFGVLGTLLWAVSRVSIFRLVRYLAREYLLIVSTSSSESALPRLIAKMAHLGVDKSTVGIVVPTGYSFNLDGT
AIYLTMASLFVADAMGAPLSVGEQISLLAFMMIASKGAAGVTGAGMATLAAGLQSHRPDLVDGVGMIVGIDRFMSEARAL
TNFSGNAVATLLIATWTKTMDRDRVKTVLSGADPFDETTMLDDHAGEAVVDKVVS
>Mature_454_residues
TATEPATSESTPPKKHKDRTHWLYIAVVVAVALGVAVGMLWPGFGRSVGVLGEIFVSLIKMMISPVIFCTIVLGIGSVRK
AASVGRVGGLAFVYFLAMSTVALAIGLVVGNLLAPGTGLHLSGSNQGAGAKYVDQAHAAGGTWHFIKSIVPETMFSALTS
GSVLQTLFIALLVGFAVQALGGTGESIVRGVGMLQKLVFKVLIMVLWLAPIGAFGAIANVVGQTGWDAVKELGTLMLGFY
VTCAIFIFGVLGTLLWAVSRVSIFRLVRYLAREYLLIVSTSSSESALPRLIAKMAHLGVDKSTVGIVVPTGYSFNLDGTA
IYLTMASLFVADAMGAPLSVGEQISLLAFMMIASKGAAGVTGAGMATLAAGLQSHRPDLVDGVGMIVGIDRFMSEARALT
NFSGNAVATLLIATWTKTMDRDRVKTVLSGADPFDETTMLDDHAGEAVVDKVVS

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI66773030, Length=493, Percent_Identity=22.920892494929, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI21314632, Length=408, Percent_Identity=24.5098039215686, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI40254478, Length=417, Percent_Identity=23.7410071942446, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI169790839, Length=466, Percent_Identity=22.3175965665236, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI194239697, Length=271, Percent_Identity=27.6752767527675, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI5032093, Length=412, Percent_Identity=23.0582524271845, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI223468564, Length=274, Percent_Identity=24.8175182481752, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI223468566, Length=274, Percent_Identity=24.8175182481752, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4827012, Length=231, Percent_Identity=26.8398268398268, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI262359914, Length=373, Percent_Identity=21.1796246648794, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1789947, Length=422, Percent_Identity=45.7345971563981, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1790514, Length=413, Percent_Identity=34.8668280871671, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1789473, Length=355, Percent_Identity=26.1971830985915, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788024, Length=397, Percent_Identity=23.1738035264484, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17537407, Length=407, Percent_Identity=25.5528255528256, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI193206654, Length=443, Percent_Identity=24.3792325056433, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71983099, Length=458, Percent_Identity=24.6724890829694, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI71983106, Length=458, Percent_Identity=24.6724890829694, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71996953, Length=459, Percent_Identity=23.7472766884532, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI193206505, Length=479, Percent_Identity=22.3382045929019, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24583025, Length=406, Percent_Identity=23.3990147783251, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17137668, Length=406, Percent_Identity=23.3990147783251, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24583023, Length=406, Percent_Identity=23.3990147783251, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281360481, Length=418, Percent_Identity=26.3157894736842, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI281360483, Length=418, Percent_Identity=26.3157894736842, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17137666, Length=418, Percent_Identity=26.3157894736842, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47478; Mature: 47346

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
TATEPATSESTPPKKHKDRTHWLYIAVVVAVALGVAVGMLWPGFGRSVGVLGEIFVSLI
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH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HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]