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The map label for this gene is wecA [H]

Identifier: 169628536

GI number: 169628536

Start: 1449855

End: 1451072

Strand: Direct

Name: wecA [H]

Synonym: MAB_1445

Alternate gene names: 169628536

Gene position: 1449855-1451072 (Clockwise)

Preceding gene: 169628535

Following gene: 169628537

Centisome position: 28.61

GC content: 63.96

Gene sequence:

>1218_bases
GTGAGTGAGCTGCTGGCCCTTGCCGATCGCGGCGCGGGCGTCCCGTTGCGGGAACTTGCGCTGGTCGGCTTGACGGCAGC
CATCACAACTTTTTTCTGCACCGGTGGTGTGCGGATGTTCGCGACCCGGGTGGGCGCGGTGGCCTACCCCCGTGAGCGTG
ATGTGCATCTGCAGCCGACGCCGCGGATGGGTGGGCTCGGCATGTACTTCGGGGTCTGCGCCGCAATATTTCTGGCTTCG
CAGCTACCCGCGCTGACAAGGGGTTTCGTCTACTCCTCGGGCATGCCTGCCGTCGTCGTCGCGGGGGGCATCATCATGAT
CGTCGGTCTCATCGACGACAAATGGGGCCTGGATGCGCTCACCAAATTCGCGGGTCAGGTCACCGCCGCGAGCGTGCTGG
TCACTATGGGGGTGGCCTGGAGCATGATCTACATCCCATTCGGTGGGGTGGGGACGATTGTGCTGGATCAGATGTCGTCG
ATCCTGGTCACGCTGGCGTTGACGGTATCCATCGTCAACGCGATGAACTTCGTGGACGGCCTCGACGGTCTGGCCGCCGG
CCTGGGATTGATCACCGCGGCGGCCATCTGCATCTTTTCGATCGGGCTGCTGCGCAGTCACGGTGGCGACGTCCTGTACT
ACCCGCCCGCGGTGATCTCGGTCGTGTTGGCAGGGGCCTGCCTGGGCTTCCTTCCGCACAACTTCCATCGGGCGCGGATC
TTCATGGGTGACTCGGGCTCGATGCTGATCGGCCTGATGCTGGCCGCAGCCTCGACCACGGCGGCGGGCCCTATTTCGCA
GAGCTCCTACGGCGCCAAGGACATGTTCGTCCTGCTTTCACCCTTCCTGCTGGTGATCGCGGTCATGCTGGTGCCGGCAC
TGGATGCGTTGTTGGCGATCATCCGGCGCACGCGTGCGGGTCGCAGCCCGTTCAGCCCGGACAAGATGCATCTGCATCAC
CGTCTCCTGCAGATCGGTCATTCGCACCGCAAGGCGGTGTTGATCATCTATCTATGGGTGGCGATCATCGCCTTCGGGGC
CGCCAGCACCATATTCTTCGAGCCCCGCTACGCCGGGGCGGTGGTGGTCGGTGCCATCGGCATCGCGATTGTCGCGACGG
TCATTCCATTGCTGCGCCGTGAAGACACCGATCCGGCTTTGGCTACCGCGCCGGACTCAAGTCCGGGGACGGAACCGGTC
GTGTACGACGAAAAGTAG

Upstream 100 bases:

>100_bases
CAGTCGGGAGCAGATCGTGGAGGTGATCGGCGGCCAAGTCGGACCTGTTGAGTCGGGCGAGTCGGGGGAGCCCACAGAAT
CGTGAAGTACGGTCGGACGC

Downstream 100 bases:

>100_bases
TAGGGGTGCATTAACCGCCTCTACCATGTGATACGGTTCTGCCATACCCGAAAACTCACGGGTGCCGGCCACACCGGATC
GGCAGGGATTTTGGAAGGTC

Product: putative undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MSELLALADRGAGVPLRELALVGLTAAITTFFCTGGVRMFATRVGAVAYPRERDVHLQPTPRMGGLGMYFGVCAAIFLAS
QLPALTRGFVYSSGMPAVVVAGGIIMIVGLIDDKWGLDALTKFAGQVTAASVLVTMGVAWSMIYIPFGGVGTIVLDQMSS
ILVTLALTVSIVNAMNFVDGLDGLAAGLGLITAAAICIFSIGLLRSHGGDVLYYPPAVISVVLAGACLGFLPHNFHRARI
FMGDSGSMLIGLMLAAASTTAAGPISQSSYGAKDMFVLLSPFLLVIAVMLVPALDALLAIIRRTRAGRSPFSPDKMHLHH
RLLQIGHSHRKAVLIIYLWVAIIAFGAASTIFFEPRYAGAVVVGAIGIAIVATVIPLLRREDTDPALATAPDSSPGTEPV
VYDEK

Sequences:

>Translated_405_residues
MSELLALADRGAGVPLRELALVGLTAAITTFFCTGGVRMFATRVGAVAYPRERDVHLQPTPRMGGLGMYFGVCAAIFLAS
QLPALTRGFVYSSGMPAVVVAGGIIMIVGLIDDKWGLDALTKFAGQVTAASVLVTMGVAWSMIYIPFGGVGTIVLDQMSS
ILVTLALTVSIVNAMNFVDGLDGLAAGLGLITAAAICIFSIGLLRSHGGDVLYYPPAVISVVLAGACLGFLPHNFHRARI
FMGDSGSMLIGLMLAAASTTAAGPISQSSYGAKDMFVLLSPFLLVIAVMLVPALDALLAIIRRTRAGRSPFSPDKMHLHH
RLLQIGHSHRKAVLIIYLWVAIIAFGAASTIFFEPRYAGAVVVGAIGIAIVATVIPLLRREDTDPALATAPDSSPGTEPV
VYDEK
>Mature_404_residues
SELLALADRGAGVPLRELALVGLTAAITTFFCTGGVRMFATRVGAVAYPRERDVHLQPTPRMGGLGMYFGVCAAIFLASQ
LPALTRGFVYSSGMPAVVVAGGIIMIVGLIDDKWGLDALTKFAGQVTAASVLVTMGVAWSMIYIPFGGVGTIVLDQMSSI
LVTLALTVSIVNAMNFVDGLDGLAAGLGLITAAAICIFSIGLLRSHGGDVLYYPPAVISVVLAGACLGFLPHNFHRARIF
MGDSGSMLIGLMLAAASTTAAGPISQSSYGAKDMFVLLSPFLLVIAVMLVPALDALLAIIRRTRAGRSPFSPDKMHLHHR
LLQIGHSHRKAVLIIYLWVAIIAFGAASTIFFEPRYAGAVVVGAIGIAIVATVIPLLRREDTDPALATAPDSSPGTEPVV
YDEK

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55), the lipid intermediate involved in the synthesis of various bacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=320, Percent_Identity=26.5625, Blast_Score=102, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 42394; Mature: 42263

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELLALADRGAGVPLRELALVGLTAAITTFFCTGGVRMFATRVGAVAYPRERDVHLQPT
CCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCC
PRMGGLGMYFGVCAAIFLASQLPALTRGFVYSSGMPAVVVAGGIIMIVGLIDDKWGLDAL
CCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHCCCCEEEEECCCCCCHHHH
TKFAGQVTAASVLVTMGVAWSMIYIPFGGVGTIVLDQMSSILVTLALTVSIVNAMNFVDG
HHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDGLAAGLGLITAAAICIFSIGLLRSHGGDVLYYPPAVISVVLAGACLGFLPHNFHRARI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCCEEEEE
FMGDSGSMLIGLMLAAASTTAAGPISQSSYGAKDMFVLLSPFLLVIAVMLVPALDALLAI
EECCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRRTRAGRSPFSPDKMHLHHRLLQIGHSHRKAVLIIYLWVAIIAFGAASTIFFEPRYAGA
HHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHEEECCCCCCH
VVVGAIGIAIVATVIPLLRREDTDPALATAPDSSPGTEPVVYDEK
HHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEECCC
>Mature Secondary Structure 
SELLALADRGAGVPLRELALVGLTAAITTFFCTGGVRMFATRVGAVAYPRERDVHLQPT
CHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCC
PRMGGLGMYFGVCAAIFLASQLPALTRGFVYSSGMPAVVVAGGIIMIVGLIDDKWGLDAL
CCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHCCCCEEEEECCCCCCHHHH
TKFAGQVTAASVLVTMGVAWSMIYIPFGGVGTIVLDQMSSILVTLALTVSIVNAMNFVDG
HHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDGLAAGLGLITAAAICIFSIGLLRSHGGDVLYYPPAVISVVLAGACLGFLPHNFHRARI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCCEEEEE
FMGDSGSMLIGLMLAAASTTAAGPISQSSYGAKDMFVLLSPFLLVIAVMLVPALDALLAI
EECCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRRTRAGRSPFSPDKMHLHHRLLQIGHSHRKAVLIIYLWVAIIAFGAASTIFFEPRYAGA
HHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHEEECCCCCCH
VVVGAIGIAIVATVIPLLRREDTDPALATAPDSSPGTEPVVYDEK
HHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]