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The map label for this gene is glcD [H]

Identifier: 169628498

GI number: 169628498

Start: 1410223

End: 1411590

Strand: Reverse

Name: glcD [H]

Synonym: MAB_1407c

Alternate gene names: 169628498

Gene position: 1411590-1410223 (Counterclockwise)

Preceding gene: 169628499

Following gene: 169628497

Centisome position: 27.86

GC content: 64.69

Gene sequence:

>1368_bases
ATGAGCCGGGACGCCCTCCACGCCCTCACCGCCGTCCTCGGTGAGGGCGCCGTCATCACCGATCCCGATATCACCGCCTC
GTACCGGCAGGACCGCGCCTTCGATCCCGATGCCGGAATGCCGCTGGCAGTGGTGCGCCCGCGTAGCACCGAAGAGGTTT
CTGCCACCCTCAAATGGGCCAGTGCACACCATATCTCCGTGGTCCCCCGTGGCGCGGGTACCGGATTGTCGGGTGGCTCC
ACGGCTCAGGATGGCGCGGTGGTGCTGTCTACCGAACGGATGCGCACCATCACGATCGATACCGCCACCCGGGTTGCGAT
TACCCAACCGGGTGCGCTCAACGCCGAGGTGAAGGCCGCTGCCGCCGCACAGGGCCTCTGGTACCCGCCCGACCCGTCAT
CCTTCGAGATCTGCAGCATCGGCGGCAATATCGCCACCAACGCCGGCGGACTGTGCTGCGTCAAGTACGGCGTAACCACC
GACTACGTGCTCGGCATGCAGGTGGTACTGGCCGACGGCACCGTCCTCAAACTGGGCGGACCGCGTCTGAAAGATGTTGC
CGGCCTGAGCCTTACCAAATTATTCGTCGGCAGTGAGGGAACGCTGGGGGTGATCACCGAGGTCACTCTGCGCCTGCTCC
CCTGCCAGCCGACGCCGTGCACGGTGGTGGCGACCTTCTCGTCGGTGCATGACGCGACCGACGCAGTCTTGGCGATCACC
GCACAGATCCGGCCATCGATGCTGGAGTTCATGGACTCGGTGGCGATCAACGCCGTCGAAGACAAACTGAAGATGGGTCT
GGACCGTGCGGCAGGCGCCATGCTGGTAGCACGCTCGGATGAACGCGGCCATACTTCCACCGAGGACGCCGAACTCATCG
CCCGCATCTTCACCGATCACCATGCCGCCGAGGTCTTTTCCACCGATGACGAGGAGGAAGGCGAGGCCTTTGTCGCGGCG
CGCCGGTTCGCGATTCCCGCGGTGGAAGCCAAGGGGTCGCTACTCCTTGAAGACGTGGGCGTCCCCCTACCGAAACTCGC
GCAGCTGGTAGAGGGCGTGGAAGCCATTGCCGCACAGCACCGGCTACTGATCTCGGTAATCGCGCACGCCGGCGACGGCA
ACACACATCCACTCATCGTGCACGACCCCACCGACCCCGACGAATCGCGACGTGCCCAAACCGCCTTCGGACAGATCATG
GATCTGGCCATCTCACTGGGCGGCACCATCACCGGTGAGCACGGTGTCGGACGACTCAAGAAGCCGTGGCTGGGCGATCA
GGTGGGTCCCGAGGTACTCGAGGTCAATCGCCGGATCAAGCAGGCGCTCGACCCGGACGGAATCCTCAATCCCGGCACGC
TGATCTAA

Upstream 100 bases:

>100_bases
AAGAGGTCACCCGCGCCGTGCTGTTCCTGGTCGACGAGGCGAGCTCACATATCACCGGTACCGTGTTGCCGATCGACGCC
GGCGCCACGGCGCGAATGAT

Downstream 100 bases:

>100_bases
CCGGCGCGATATTGACACATCGACTGACATGCCTTACACATAAGACATGTCAGTCGATGTGTCTCATACCGTTGCGCCGC
GCTACGTTCCCGGAACGGCC

Product: oxidoreductase

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSRDALHALTAVLGEGAVITDPDITASYRQDRAFDPDAGMPLAVVRPRSTEEVSATLKWASAHHISVVPRGAGTGLSGGS
TAQDGAVVLSTERMRTITIDTATRVAITQPGALNAEVKAAAAAQGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTT
DYVLGMQVVLADGTVLKLGGPRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLLPCQPTPCTVVATFSSVHDATDAVLAIT
AQIRPSMLEFMDSVAINAVEDKLKMGLDRAAGAMLVARSDERGHTSTEDAELIARIFTDHHAAEVFSTDDEEEGEAFVAA
RRFAIPAVEAKGSLLLEDVGVPLPKLAQLVEGVEAIAAQHRLLISVIAHAGDGNTHPLIVHDPTDPDESRRAQTAFGQIM
DLAISLGGTITGEHGVGRLKKPWLGDQVGPEVLEVNRRIKQALDPDGILNPGTLI

Sequences:

>Translated_455_residues
MSRDALHALTAVLGEGAVITDPDITASYRQDRAFDPDAGMPLAVVRPRSTEEVSATLKWASAHHISVVPRGAGTGLSGGS
TAQDGAVVLSTERMRTITIDTATRVAITQPGALNAEVKAAAAAQGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTT
DYVLGMQVVLADGTVLKLGGPRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLLPCQPTPCTVVATFSSVHDATDAVLAIT
AQIRPSMLEFMDSVAINAVEDKLKMGLDRAAGAMLVARSDERGHTSTEDAELIARIFTDHHAAEVFSTDDEEEGEAFVAA
RRFAIPAVEAKGSLLLEDVGVPLPKLAQLVEGVEAIAAQHRLLISVIAHAGDGNTHPLIVHDPTDPDESRRAQTAFGQIM
DLAISLGGTITGEHGVGRLKKPWLGDQVGPEVLEVNRRIKQALDPDGILNPGTLI
>Mature_454_residues
SRDALHALTAVLGEGAVITDPDITASYRQDRAFDPDAGMPLAVVRPRSTEEVSATLKWASAHHISVVPRGAGTGLSGGST
AQDGAVVLSTERMRTITIDTATRVAITQPGALNAEVKAAAAAQGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTTD
YVLGMQVVLADGTVLKLGGPRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLLPCQPTPCTVVATFSSVHDATDAVLAITA
QIRPSMLEFMDSVAINAVEDKLKMGLDRAAGAMLVARSDERGHTSTEDAELIARIFTDHHAAEVFSTDDEEEGEAFVAAR
RFAIPAVEAKGSLLLEDVGVPLPKLAQLVEGVEAIAAQHRLLISVIAHAGDGNTHPLIVHDPTDPDESRRAQTAFGQIMD
LAISLGGTITGEHGVGRLKKPWLGDQVGPEVLEVNRRIKQALDPDGILNPGTLI

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=463, Percent_Identity=31.9654427645788, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI37595754, Length=486, Percent_Identity=30.6584362139918, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI119964728, Length=448, Percent_Identity=31.0267857142857, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI4501993, Length=221, Percent_Identity=26.2443438914027, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789351, Length=418, Percent_Identity=41.1483253588517, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI48994907, Length=489, Percent_Identity=26.9938650306748, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1787977, Length=501, Percent_Identity=25.1497005988024, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI48994914, Length=340, Percent_Identity=25.5882352941176, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71992373, Length=463, Percent_Identity=30.8855291576674, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71992381, Length=459, Percent_Identity=29.8474945533769, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71992392, Length=359, Percent_Identity=30.6406685236769, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17534361, Length=461, Percent_Identity=31.0195227765727, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17556096, Length=221, Percent_Identity=24.8868778280543, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320023, Length=480, Percent_Identity=27.0833333333333, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320027, Length=438, Percent_Identity=28.7671232876712, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320764, Length=458, Percent_Identity=26.8558951965066, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI18921117, Length=418, Percent_Identity=29.1866028708134, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24639277, Length=418, Percent_Identity=29.1866028708134, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24639275, Length=418, Percent_Identity=29.1866028708134, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24653753, Length=181, Percent_Identity=31.4917127071823, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 47670; Mature: 47539

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRDALHALTAVLGEGAVITDPDITASYRQDRAFDPDAGMPLAVVRPRSTEEVSATLKWA
CCHHHHHHHHHHHCCCCEEECCCCCCCHHHCCCCCCCCCCCEEEECCCCCHHHHHEEEEC
SAHHISVVPRGAGTGLSGGSTAQDGAVVLSTERMRTITIDTATRVAITQPGALNAEVKAA
CCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCEEEEEEECCEEEEEECCCCCCCHHHHH
AAAQGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTTDYVLGMQVVLADGTVLKLGG
HHHCCCCCCCCCCCEEEEECCCCEECCCCCEEEEEECCCCCHHHCEEEEEECCEEEEECC
PRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLLPCQPTPCTVVATFSSVHDATDAVLAIT
CCHHHHCCCEEEEEEECCCCCEEHHEEEEEEEECCCCCCCEEEEEHHHHHHHCCEEEEEE
AQIRPSMLEFMDSVAINAVEDKLKMGLDRAAGAMLVARSDERGHTSTEDAELIARIFTDH
HHCCHHHHHHHHHHHHHHHHHHHHHCHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCH
HAAEVFSTDDEEEGEAFVAARRFAIPAVEAKGSLLLEDVGVPLPKLAQLVEGVEAIAAQH
HHHHHHCCCCCCCCCCEEHHHHHCCCEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
RLLISVIAHAGDGNTHPLIVHDPTDPDESRRAQTAFGQIMDLAISLGGTITGEHGVGRLK
HHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCC
KPWLGDQVGPEVLEVNRRIKQALDPDGILNPGTLI
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SRDALHALTAVLGEGAVITDPDITASYRQDRAFDPDAGMPLAVVRPRSTEEVSATLKWA
CHHHHHHHHHHHCCCCEEECCCCCCCHHHCCCCCCCCCCCEEEECCCCCHHHHHEEEEC
SAHHISVVPRGAGTGLSGGSTAQDGAVVLSTERMRTITIDTATRVAITQPGALNAEVKAA
CCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCEEEEEEECCEEEEEECCCCCCCHHHHH
AAAQGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTTDYVLGMQVVLADGTVLKLGG
HHHCCCCCCCCCCCEEEEECCCCEECCCCCEEEEEECCCCCHHHCEEEEEECCEEEEECC
PRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLLPCQPTPCTVVATFSSVHDATDAVLAIT
CCHHHHCCCEEEEEEECCCCCEEHHEEEEEEEECCCCCCCEEEEEHHHHHHHCCEEEEEE
AQIRPSMLEFMDSVAINAVEDKLKMGLDRAAGAMLVARSDERGHTSTEDAELIARIFTDH
HHCCHHHHHHHHHHHHHHHHHHHHHCHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCH
HAAEVFSTDDEEEGEAFVAARRFAIPAVEAKGSLLLEDVGVPLPKLAQLVEGVEAIAAQH
HHHHHHCCCCCCCCCCEEHHHHHCCCEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
RLLISVIAHAGDGNTHPLIVHDPTDPDESRRAQTAFGQIMDLAISLGGTITGEHGVGRLK
HHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCC
KPWLGDQVGPEVLEVNRRIKQALDPDGILNPGTLI
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]