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The map label for this gene is degP1 [H]

Identifier: 169628455

GI number: 169628455

Start: 1361078

End: 1362556

Strand: Direct

Name: degP1 [H]

Synonym: MAB_1364

Alternate gene names: 169628455

Gene position: 1361078-1362556 (Clockwise)

Preceding gene: 169628454

Following gene: 169628456

Centisome position: 26.86

GC content: 65.99

Gene sequence:

>1479_bases
GTGACCGCAAATCAGGACACCGCCCCCCGGTTGGCGCCGCGCCCGGTTGACCGGCCGCCTGTCGATCCGGCTTCGCAGCG
GGCTTTCGGCCGTCCGTCGGGGGTATCCGGTTCGTTCCAGGGCGCGGACAAGTACCGAGACCAAGGGGAGTACACACCGC
GAGTAGGTCCGCCGGACCCGGTGTTGGCACAGGCCTTCGGGCGGCCCGACAACGTGACCACGTCGCTTCAACGCCACCCT
GCCGACGCCGGCAAGCTCGACGCCGCCGACGAAGGACCGGATGCCGCGGAGGACCCGTGGCGCGACCCCACGGCGCAGGT
CCAGCTGGGCAGGCCCGCCGTCAACAAGGCGCCCGTATCGTTGTCCGGTGCACCGGCCCCGAAGCTGGGTGTGCGCGATG
TTCTCTTCGGTGGCCGGGTGTCCATCCCCGCGCTCGCCATTCTTGCCGCGGTCGCACTACTGATCGGTCTGGTCGGCGGC
ATCATCGGGCGCAAGACGGCCGAGGTAGTCGAGGCATTCACCACGTCGAAGGTCACCTTGACCACCGATGACAGCACCCA
GCCCGACGAGTCCCGATTCACCGCGGTGGCCAATGCCGTCAAGAGCTCGGTGGTGACTATCGAGGCCAGTTCGGATGACG
AGGTGGCCCAGGGCTCGGGAGTCGTGATCGACCCCAAGGGCTACATCATTACCAACAACCATGTGATCTCCGACGCCGCC
AAGAACCCCGGCAAGTTCAAGATCGAGGTCATCTTCAACGACAGCAAGAAGGTGCCCGCCAATCTGGTCGGGCGCGATCC
GAAGACGGACATCGCGGTGCTGAAGGTCGACAACGTCGACAACCTGACCGTGGCGCGCCTGGGAGACTCCGACAAGGTCG
CCGTCGGCGCCGAGGTCATCGCGTTCGGTTCCCCGCTGGGTTTGCGTAGCACCGTGACCGGCGGCATCATCAGCGCCCTG
CACCGACCGGTGCCGCTCTCGGGAGAGGGTAGCGACACCGACACCGTGATCGATGCGCTCCAGACCGACGCCGCCATCAA
CCACGGCAACTCCGGTGGTCCGCTCATCGATATGAAGTCTCAGGTGATCGGGATCAACACCGCCGGAAAATCGTTGAGCG
ACAGCTCAAGTGGCCTCGGATTCGCCATCCCCATCAATGAGGCTGCCGACGTCGCGCAGACGTTGATCCGCGACGGAAAG
ATCGTGCACGCGACCCTGGGCATCAGCAGCCGTACGGTCAGTAACGCGACCGCCACCGGGGCCGAGGTGGCCAACGTCAA
GGCCGGCAGCCCCGCGGAAAAGGGCGGCATGCTGGAGAACGATGTCGTGGTCAAGGTCGGTAACCGGACAGTGGCCGACG
CCGACGAGTTCGTGGTCGCGGTGCGGCAGTTGAAGATCGGGCAGGAAGCCACCATCACTGTGCTCCGTCAGGGTCGGCCC
GTCGAGCTCAAAGTCACGCCCGGTCCAGACGGCTCCTGA

Upstream 100 bases:

>100_bases
GCAGCCCTCGGCACACGAGGGTGAGCTGCCGCCCGCGTTGGGTGGTGACGCGGTGCGGCCGGATAGCCGCGCACGTCGTA
AACGCCGGTAGGGTGGGCCG

Downstream 100 bases:

>100_bases
TGTTCGGCAGTGTCGGCTGGGGAGAGCTGCTGGTCCTGCTGATCGTGGGGCTCGTGGTGCTCGGCCCGGAGCGGCTGCCC
GGGGCGATTCGGTGGACCAC

Product: serine protease HtrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MTANQDTAPRLAPRPVDRPPVDPASQRAFGRPSGVSGSFQGADKYRDQGEYTPRVGPPDPVLAQAFGRPDNVTTSLQRHP
ADAGKLDAADEGPDAAEDPWRDPTAQVQLGRPAVNKAPVSLSGAPAPKLGVRDVLFGGRVSIPALAILAAVALLIGLVGG
IIGRKTAEVVEAFTTSKVTLTTDDSTQPDESRFTAVANAVKSSVVTIEASSDDEVAQGSGVVIDPKGYIITNNHVISDAA
KNPGKFKIEVIFNDSKKVPANLVGRDPKTDIAVLKVDNVDNLTVARLGDSDKVAVGAEVIAFGSPLGLRSTVTGGIISAL
HRPVPLSGEGSDTDTVIDALQTDAAINHGNSGGPLIDMKSQVIGINTAGKSLSDSSSGLGFAIPINEAADVAQTLIRDGK
IVHATLGISSRTVSNATATGAEVANVKAGSPAEKGGMLENDVVVKVGNRTVADADEFVVAVRQLKIGQEATITVLRQGRP
VELKVTPGPDGS

Sequences:

>Translated_492_residues
MTANQDTAPRLAPRPVDRPPVDPASQRAFGRPSGVSGSFQGADKYRDQGEYTPRVGPPDPVLAQAFGRPDNVTTSLQRHP
ADAGKLDAADEGPDAAEDPWRDPTAQVQLGRPAVNKAPVSLSGAPAPKLGVRDVLFGGRVSIPALAILAAVALLIGLVGG
IIGRKTAEVVEAFTTSKVTLTTDDSTQPDESRFTAVANAVKSSVVTIEASSDDEVAQGSGVVIDPKGYIITNNHVISDAA
KNPGKFKIEVIFNDSKKVPANLVGRDPKTDIAVLKVDNVDNLTVARLGDSDKVAVGAEVIAFGSPLGLRSTVTGGIISAL
HRPVPLSGEGSDTDTVIDALQTDAAINHGNSGGPLIDMKSQVIGINTAGKSLSDSSSGLGFAIPINEAADVAQTLIRDGK
IVHATLGISSRTVSNATATGAEVANVKAGSPAEKGGMLENDVVVKVGNRTVADADEFVVAVRQLKIGQEATITVLRQGRP
VELKVTPGPDGS
>Mature_491_residues
TANQDTAPRLAPRPVDRPPVDPASQRAFGRPSGVSGSFQGADKYRDQGEYTPRVGPPDPVLAQAFGRPDNVTTSLQRHPA
DAGKLDAADEGPDAAEDPWRDPTAQVQLGRPAVNKAPVSLSGAPAPKLGVRDVLFGGRVSIPALAILAAVALLIGLVGGI
IGRKTAEVVEAFTTSKVTLTTDDSTQPDESRFTAVANAVKSSVVTIEASSDDEVAQGSGVVIDPKGYIITNNHVISDAAK
NPGKFKIEVIFNDSKKVPANLVGRDPKTDIAVLKVDNVDNLTVARLGDSDKVAVGAEVIAFGSPLGLRSTVTGGIISALH
RPVPLSGEGSDTDTVIDALQTDAAINHGNSGGPLIDMKSQVIGINTAGKSLSDSSSGLGFAIPINEAADVAQTLIRDGKI
VHATLGISSRTVSNATATGAEVANVKAGSPAEKGGMLENDVVVKVGNRTVADADEFVVAVRQLKIGQEATITVLRQGRPV
ELKVTPGPDGS

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=268, Percent_Identity=33.955223880597, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI4506141, Length=285, Percent_Identity=32.6315789473684, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI7019477, Length=298, Percent_Identity=31.2080536912752, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI24308541, Length=267, Percent_Identity=30.3370786516854, Blast_Score=105, Evalue=8e-23,
Organism=Escherichia coli, GI1786356, Length=280, Percent_Identity=35.7142857142857, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1789629, Length=278, Percent_Identity=38.1294964028777, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1789630, Length=303, Percent_Identity=34.6534653465347, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24646839, Length=297, Percent_Identity=31.986531986532, Blast_Score=123, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 50620; Mature: 50489

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANQDTAPRLAPRPVDRPPVDPASQRAFGRPSGVSGSFQGADKYRDQGEYTPRVGPPDP
CCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCH
VLAQAFGRPDNVTTSLQRHPADAGKLDAADEGPDAAEDPWRDPTAQVQLGRPAVNKAPVS
HHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEE
LSGAPAPKLGVRDVLFGGRVSIPALAILAAVALLIGLVGGIIGRKTAEVVEAFTTSKVTL
CCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEE
TTDDSTQPDESRFTAVANAVKSSVVTIEASSDDEVAQGSGVVIDPKGYIITNNHVISDAA
EECCCCCCCHHHHHHHHHHHHCEEEEEECCCCCCHHCCCCEEECCCCEEEECCEEEECCC
KNPGKFKIEVIFNDSKKVPANLVGRDPKTDIAVLKVDNVDNLTVARLGDSDKVAVGAEVI
CCCCCEEEEEEECCCCCCCHHHCCCCCCCCEEEEEECCCCCEEEEEECCCCCEEECEEEE
AFGSPLGLRSTVTGGIISALHRPVPLSGEGSDTDTVIDALQTDAAINHGNSGGPLIDMKS
EECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECC
QVIGINTAGKSLSDSSSGLGFAIPINEAADVAQTLIRDGKIVHATLGISSRTVSNATATG
EEEEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCC
AEVANVKAGSPAEKGGMLENDVVVKVGNRTVADADEFVVAVRQLKIGQEATITVLRQGRP
CEEEEECCCCCHHHCCCCCCCEEEEECCCEECCHHHHHHHHHHHHCCCCEEEEEEECCCC
VELKVTPGPDGS
EEEEECCCCCCC
>Mature Secondary Structure 
TANQDTAPRLAPRPVDRPPVDPASQRAFGRPSGVSGSFQGADKYRDQGEYTPRVGPPDP
CCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCH
VLAQAFGRPDNVTTSLQRHPADAGKLDAADEGPDAAEDPWRDPTAQVQLGRPAVNKAPVS
HHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEE
LSGAPAPKLGVRDVLFGGRVSIPALAILAAVALLIGLVGGIIGRKTAEVVEAFTTSKVTL
CCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEE
TTDDSTQPDESRFTAVANAVKSSVVTIEASSDDEVAQGSGVVIDPKGYIITNNHVISDAA
EECCCCCCCHHHHHHHHHHHHCEEEEEECCCCCCHHCCCCEEECCCCEEEECCEEEECCC
KNPGKFKIEVIFNDSKKVPANLVGRDPKTDIAVLKVDNVDNLTVARLGDSDKVAVGAEVI
CCCCCEEEEEEECCCCCCCHHHCCCCCCCCEEEEEECCCCCEEEEEECCCCCEEECEEEE
AFGSPLGLRSTVTGGIISALHRPVPLSGEGSDTDTVIDALQTDAAINHGNSGGPLIDMKS
EECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECC
QVIGINTAGKSLSDSSSGLGFAIPINEAADVAQTLIRDGKIVHATLGISSRTVSNATATG
EEEEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCC
AEVANVKAGSPAEKGGMLENDVVVKVGNRTVADADEFVVAVRQLKIGQEATITVLRQGRP
CEEEEECCCCCHHHCCCCCCCEEEEECCCEECCHHHHHHHHHHHHCCCCEEEEEEECCCC
VELKVTPGPDGS
EEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550509; 11481430 [H]