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The map label for this gene is mutT2 [H]

Identifier: 169628401

GI number: 169628401

Start: 1308955

End: 1309347

Strand: Direct

Name: mutT2 [H]

Synonym: MAB_1308

Alternate gene names: 169628401

Gene position: 1308955-1309347 (Clockwise)

Preceding gene: 169628399

Following gene: 169628403

Centisome position: 25.83

GC content: 70.23

Gene sequence:

>393_bases
GTGGTCGCGGGCGCGGTCATCGACGGAGACAAGCTGCTGATCGCTCAGCGCGCCAAACCCGCCGAACTCGCCGGGCAGTG
GGAGCTGCCGGGTGGAAAGGTCGCCGACGGCGAGTCGGAGCCGCAGGCGCTGGTGCGGGAGCTTCGTGAAGAACTCGGCA
TCGAGGTCGAAGTCGGTGCCCGCCTCGGCGAGGACGTCGTCGTCGGGAATCTGGTGCTGCGTGCCTATAGCGCGCGGTTA
CATCCGCAGCACCCGGGTAGCCCGCACCCGCATGAGCATCTCGCGCTGCGCTGGGTCACCGCCGGCGAACTCGACGCCGT
CGAATGGGTGGCGGCCGACGGCGGATGGATCCCGGCGCTCAAGCAGGCGCTAGTGGGCACGCGCCCGGTGTAG

Upstream 100 bases:

>100_bases
TCGCGTGTCCAGCCGGGAAGCCCGGCGAGCGCCGCGTTGATCTGGTCATCGGTGAGCAGGGCCATAGTGTCAACGTATAG
CGTCGAGCACCATGGCGATA

Downstream 100 bases:

>100_bases
CACCTTCTTCAGCTCTTTTTCCGAGAGTCCGTGATGCTCGGCCTTCTGCATTTTGTGCACCACAACGGGGCACTTGGTGC
AGCGTGGCTTGCTTTTGCAG

Product: mutator protein MutT2/NUDIX hydrolase

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 130; Mature: 130

Protein sequence:

>130_residues
MVAGAVIDGDKLLIAQRAKPAELAGQWELPGGKVADGESEPQALVRELREELGIEVEVGARLGEDVVVGNLVLRAYSARL
HPQHPGSPHPHEHLALRWVTAGELDAVEWVAADGGWIPALKQALVGTRPV

Sequences:

>Translated_130_residues
MVAGAVIDGDKLLIAQRAKPAELAGQWELPGGKVADGESEPQALVRELREELGIEVEVGARLGEDVVVGNLVLRAYSARL
HPQHPGSPHPHEHLALRWVTAGELDAVEWVAADGGWIPALKQALVGTRPV
>Mature_130_residues
MVAGAVIDGDKLLIAQRAKPAELAGQWELPGGKVADGESEPQALVRELREELGIEVEVGARLGEDVVVGNLVLRAYSARL
HPQHPGSPHPHEHLALRWVTAGELDAVEWVAADGGWIPALKQALVGTRPV

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=134, Percent_Identity=42.5373134328358, Blast_Score=70, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 13852; Mature: 13852

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00893 NUDIX ; PS01039 SBP_BACTERIAL_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAGAVIDGDKLLIAQRAKPAELAGQWELPGGKVADGESEPQALVRELREELGIEVEVGA
CCCCEEECCCEEEEECCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEECC
RLGEDVVVGNLVLRAYSARLHPQHPGSPHPHEHLALRWVTAGELDAVEWVAADGGWIPAL
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCHHHH
KQALVGTRPV
HHHHCCCCCC
>Mature Secondary Structure
MVAGAVIDGDKLLIAQRAKPAELAGQWELPGGKVADGESEPQALVRELREELGIEVEVGA
CCCCEEECCCEEEEECCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEECC
RLGEDVVVGNLVLRAYSARLHPQHPGSPHPHEHLALRWVTAGELDAVEWVAADGGWIPAL
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCHHHH
KQALVGTRPV
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]