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The map label for this gene is yngE [H]

Identifier: 169628167

GI number: 169628167

Start: 1084653

End: 1086248

Strand: Reverse

Name: yngE [H]

Synonym: MAB_1072c

Alternate gene names: 169628167

Gene position: 1086248-1084653 (Counterclockwise)

Preceding gene: 169628168

Following gene: 169628166

Centisome position: 21.44

GC content: 64.1

Gene sequence:

>1596_bases
ATGACCGTCCTGCGCACCGCCGTCAACACCAACTCGCCCGAGTACATGGCCGCCGCCGAGGCCATGCTGATCAAGCTGGC
CGAGGTCAATGCCGAGACCGCCAAGGCCCTTGCCGGCGGCGGGCCGAAATACGTTGCCCGTCACCATGAACGCGGCAAGC
TACTGGCGCGGGAGCGCATCGAGCTGCTGATCGATCCCGACTCGCCATTCCTGGAACTGTGCCCGCTCGCCGCATGGGGC
AGCGATTTCACCGTGGGCGCCTCCCTGGTCACCGGTATCGGTGTGATCGAGGGTGTCGAGTGCATGATCGTGGCCAATGA
CCCCACCGTCAAGGGTGGCACCAGCAACCCCTGGACCCTGCGTAAGGTCCTGCGGGCCAACGATATCGCCTTCAAGAATC
GCTTGCCGGTGATCTCACTGGTGGAGTCCGGCGGCGCGGATCTGCCCACCCAAAAGGAAGTGTTCGTGCCGGGCGGGCAG
ATGTTCCGCGACCTCACCCGGCTTTCCGCCGCCGGTATCCCGACGATCGCGCTGGTGTTCGGCAACTCGACAGCAGGCGG
CGCCTATATCCCGGGCATGTCCGACCACGTCGTGATGATCAAGGAACGCTCCAAGGTCTTCCTGGCAGGTCCCCCACTGG
TCAAGATGGCGACCGGCGAAGAGTCCGACGACGAATCTCTCGGTGGCGCCGAGATGCACTCCCGCGTCTCCGGTTTGGGC
GACTATCTGGCCGTGGACGAACAGGATGCCGTGCGCCTGGGTCGCCAGATCGTGTCGCGCCTGAACTGGGTGAAGAAGGG
GCCGAAGCCCGCCGCGGTCATCGAGCCGATCGCCGATCAGGAAGAGCTGATCGGCATTGTCCCGGGTGATCTGCGCATCC
CGTTCGATCCACGTGAAGTCATCGCGCGCATCGTCGACGGCTCCGAGTTCGACGAATTCAAGGAACAGTACGGTTCCTCG
CTGGTCACCGGATGGGCACGCCTGCACGGCTACCCGATCGGCATCCTCGCCAACGCACGTGGCGTGCTGTTCAGCGAAGA
GGCGCAAAAGGCCACGCAGTTCATTCAGCTAGCCAACCAGACCAACACGCCACTGTTGTTCGTGCATAACACCACCGGGT
ACATGGTGGGCAAGGAGTACGAGGAGGGCGGCATGATCAAACACGGATCGATGATGATCAACGCCGTGTCGAACTCGACG
GTGCCGCACCTGTCGCTCATCGTCGGCGCCTCCTATGGGGCGGGGCACTACGGCATGTGCGGACGCGCGTACGACCCCCG
GTTCCTGTTCGCCTGGCCCAGTGCCAAGTCCGCTGTTATGGGTGGCGCCCAGCTTGCGGGCGTCATCTCCATAGTCAGCC
GTGCCGCCGCGGCAGCACGCGGCCAACAGGTCGACGACGCCGCTGATGCTGCTTTGAAGGCGGCCATCGAGGCGCAGATC
GAGGCCGAGTCGCTGCCCATGTTCATGTCCGGACGTCTCTACGACGACGGGGTTATCGATCCCCGTGATACCCGGGCCGT
ACTCGGTATGTGCCTGTCCGCCATCGCCAATGGACCCATCGAGGGGACGTCGAACTTCGGCGTCTTCCGGATGTGA

Upstream 100 bases:

>100_bases
AAATCGAACGGCAGTATCGCGATATGCGCATCATCGGGATCGGTGGTGGCACCACCGAAATCCTCACCTCCCTGGCCGCC
AAGCTCCTGGGATTCCAGTC

Downstream 100 bases:

>100_bases
CACGTAAGGAATCGATGACAGTGCCTTCAATCACCTCCGTTCTGGTTGCCAACCGCGGCGAGATCGCCCGTCGCGTCTTC
GCCACCTGTCGCAAGCTCGG

Product: pobable propionyl-CoA carboxylase beta subunit AccD2

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MTVLRTAVNTNSPEYMAAAEAMLIKLAEVNAETAKALAGGGPKYVARHHERGKLLARERIELLIDPDSPFLELCPLAAWG
SDFTVGASLVTGIGVIEGVECMIVANDPTVKGGTSNPWTLRKVLRANDIAFKNRLPVISLVESGGADLPTQKEVFVPGGQ
MFRDLTRLSAAGIPTIALVFGNSTAGGAYIPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHSRVSGLG
DYLAVDEQDAVRLGRQIVSRLNWVKKGPKPAAVIEPIADQEELIGIVPGDLRIPFDPREVIARIVDGSEFDEFKEQYGSS
LVTGWARLHGYPIGILANARGVLFSEEAQKATQFIQLANQTNTPLLFVHNTTGYMVGKEYEEGGMIKHGSMMINAVSNST
VPHLSLIVGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLAGVISIVSRAAAAARGQQVDDAADAALKAAIEAQI
EAESLPMFMSGRLYDDGVIDPRDTRAVLGMCLSAIANGPIEGTSNFGVFRM

Sequences:

>Translated_531_residues
MTVLRTAVNTNSPEYMAAAEAMLIKLAEVNAETAKALAGGGPKYVARHHERGKLLARERIELLIDPDSPFLELCPLAAWG
SDFTVGASLVTGIGVIEGVECMIVANDPTVKGGTSNPWTLRKVLRANDIAFKNRLPVISLVESGGADLPTQKEVFVPGGQ
MFRDLTRLSAAGIPTIALVFGNSTAGGAYIPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHSRVSGLG
DYLAVDEQDAVRLGRQIVSRLNWVKKGPKPAAVIEPIADQEELIGIVPGDLRIPFDPREVIARIVDGSEFDEFKEQYGSS
LVTGWARLHGYPIGILANARGVLFSEEAQKATQFIQLANQTNTPLLFVHNTTGYMVGKEYEEGGMIKHGSMMINAVSNST
VPHLSLIVGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLAGVISIVSRAAAAARGQQVDDAADAALKAAIEAQI
EAESLPMFMSGRLYDDGVIDPRDTRAVLGMCLSAIANGPIEGTSNFGVFRM
>Mature_530_residues
TVLRTAVNTNSPEYMAAAEAMLIKLAEVNAETAKALAGGGPKYVARHHERGKLLARERIELLIDPDSPFLELCPLAAWGS
DFTVGASLVTGIGVIEGVECMIVANDPTVKGGTSNPWTLRKVLRANDIAFKNRLPVISLVESGGADLPTQKEVFVPGGQM
FRDLTRLSAAGIPTIALVFGNSTAGGAYIPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHSRVSGLGD
YLAVDEQDAVRLGRQIVSRLNWVKKGPKPAAVIEPIADQEELIGIVPGDLRIPFDPREVIARIVDGSEFDEFKEQYGSSL
VTGWARLHGYPIGILANARGVLFSEEAQKATQFIQLANQTNTPLLFVHNTTGYMVGKEYEEGGMIKHGSMMINAVSNSTV
PHLSLIVGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLAGVISIVSRAAAAARGQQVDDAADAALKAAIEAQIE
AESLPMFMSGRLYDDGVIDPRDTRAVLGMCLSAIANGPIEGTSNFGVFRM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=537, Percent_Identity=49.9068901303538, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI119943100, Length=503, Percent_Identity=31.4115308151093, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI295821216, Length=523, Percent_Identity=30.4015296367113, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI310133460, Length=108, Percent_Identity=55.5555555555556, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17552936, Length=536, Percent_Identity=46.455223880597, Blast_Score=485, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI25147362, Length=512, Percent_Identity=30.078125, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=30.3747534516765, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24586065, Length=553, Percent_Identity=47.7396021699819, Blast_Score=508, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 56500; Mature: 56369

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLRTAVNTNSPEYMAAAEAMLIKLAEVNAETAKALAGGGPKYVARHHERGKLLARERI
CCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCCHHHHCCCE
ELLIDPDSPFLELCPLAAWGSDFTVGASLVTGIGVIEGVECMIVANDPTVKGGTSNPWTL
EEEECCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHH
RKVLRANDIAFKNRLPVISLVESGGADLPTQKEVFVPGGQMFRDLTRLSAAGIPTIALVF
HHHHHHCCCHHHCCCCEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEE
GNSTAGGAYIPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHSRVSGLG
CCCCCCCEECCCCCCCEEEEEECCEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHCCC
DYLAVDEQDAVRLGRQIVSRLNWVKKGPKPAAVIEPIADQEELIGIVPGDLRIPFDPREV
CEEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCEEEECCCCCCCCCCHHHH
IARIVDGSEFDEFKEQYGSSLVTGWARLHGYPIGILANARGVLFSEEAQKATQFIQLANQ
HHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCCEECHHHHHHHHHHHHHCC
TNTPLLFVHNTTGYMVGKEYEEGGMIKHGSMMINAVSNSTVPHLSLIVGASYGAGHYGMC
CCCCEEEEECCCCEEECCEECCCCCEEECCEEEEECCCCCCCEEEEEEECCCCCCCCCCC
GRAYDPRFLFAWPSAKSAVMGGAQLAGVISIVSRAAAAARGQQVDDAADAALKAAIEAQI
CCCCCCEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
EAESLPMFMSGRLYDDGVIDPRDTRAVLGMCLSAIANGPIEGTSNFGVFRM
CHHCCCEEECCEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEC
>Mature Secondary Structure 
TVLRTAVNTNSPEYMAAAEAMLIKLAEVNAETAKALAGGGPKYVARHHERGKLLARERI
CEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCCHHHHCCCE
ELLIDPDSPFLELCPLAAWGSDFTVGASLVTGIGVIEGVECMIVANDPTVKGGTSNPWTL
EEEECCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHH
RKVLRANDIAFKNRLPVISLVESGGADLPTQKEVFVPGGQMFRDLTRLSAAGIPTIALVF
HHHHHHCCCHHHCCCCEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEE
GNSTAGGAYIPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHSRVSGLG
CCCCCCCEECCCCCCCEEEEEECCEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHCCC
DYLAVDEQDAVRLGRQIVSRLNWVKKGPKPAAVIEPIADQEELIGIVPGDLRIPFDPREV
CEEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCEEEECCCCCCCCCCHHHH
IARIVDGSEFDEFKEQYGSSLVTGWARLHGYPIGILANARGVLFSEEAQKATQFIQLANQ
HHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCCEECHHHHHHHHHHHHHCC
TNTPLLFVHNTTGYMVGKEYEEGGMIKHGSMMINAVSNSTVPHLSLIVGASYGAGHYGMC
CCCCEEEEECCCCEEECCEECCCCCEEECCEEEEECCCCCCCEEEEEEECCCCCCCCCCC
GRAYDPRFLFAWPSAKSAVMGGAQLAGVISIVSRAAAAARGQQVDDAADAALKAAIEAQI
CCCCCCEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
EAESLPMFMSGRLYDDGVIDPRDTRAVLGMCLSAIANGPIEGTSNFGVFRM
CHHCCCEEECCEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]