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The map label for this gene is sucD [H]

Identifier: 169628152

GI number: 169628152

Start: 1066920

End: 1067822

Strand: Direct

Name: sucD [H]

Synonym: MAB_1057

Alternate gene names: 169628152

Gene position: 1066920-1067822 (Clockwise)

Preceding gene: 169628151

Following gene: 169628153

Centisome position: 21.06

GC content: 64.01

Gene sequence:

>903_bases
ATGTCTATCTTTCTGAACAAGGATTCGAAGGTCATCGTCCAGGGCATCACCGGTGGTGAGGGCACCAAGCACACCGCGCT
GATGCTCAAGGCCGGTACTCAGGTTGTCGGCGGCGTCAACGCCCGCAAGGCCGGAACCACCGTGTCGCATGTGGATAAGA
GCGGTCAAAGTGTCGACTTACCCGTGTTCGGCAGTGTCGCCGAGGCCATCAAGGAGACCGGGGCCGACGTGTCGATCGCC
TTCGTGCCGCCGGCCTTCTCCAAGGACGCCATCATCGAGGCAATCGACGCCGAGATCCCGCTGCTCGTTGTCATCACTGA
GGGAATCCCGGTGCAGGACAGCGCGTATGCGTGGGCCTACAACGTCGAGAAGGGCAACAAGACCCGCATCATCGGGCCCA
ACTGCCCCGGCATCATCACCCCCGGCGAGGCGCTGGTGGGTATCACTCCTAACAACATCACCGGCACCGGTCCGGTCGGT
CTGGTGTCCAAGTCCGGCACCCTGACCTACCAGATGATGTACGAGCTGCGCGATTTCGGCTTCTCCACCGCCATCGGTAT
CGGCGGCGACCCCGTCATCGGCACCACCCACATCGACGCCATCGAGGCGTTCGAGAAGGACCCGGAGACCAAGATCATCG
TCATGATCGGTGAGATCGGTGGCGACGCCGAGGAGCGTGCGGCCGACTACATCAAGGCCAACGTGTCCAAGCCCGTCGTC
GGCTACGTTGCGGGCTTCACCGCCCCCGAGGGCAAGACCATGGGCCACGCCGGTGCCATCGTGTCCGGCAGCTCGGGTAC
CGCCCAGGCCAAGAAGGAGGCCCTCGAGGCCGCCGGTGTGAAGGTCGGCAAGACGCCGTCCGAGACGGCCAAGCTGGCGC
GAGAGATCCTGCAGAGCCTGTAG

Upstream 100 bases:

>100_bases
TCCAGGCCGAGACCATGGACGCCGGTGCCGACAAGGCGGCCGCCCTGGCGGCCGCATCCAACTAGAGCGCCGAGTCCGCA
GATTAAGGGAGCTTGAACCA

Downstream 100 bases:

>100_bases
GAGGTTTCCTGCGCAAGGGCCCCACCGGTTTTCCGGTTGGGGCCCTTGTTCTTTCGGCCCCGTCCGGTGTGAAGTTGCTG
CGGAAATCAGGCCGAATTGC

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MSIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQVVGGVNARKAGTTVSHVDKSGQSVDLPVFGSVAEAIKETGADVSIA
FVPPAFSKDAIIEAIDAEIPLLVVITEGIPVQDSAYAWAYNVEKGNKTRIIGPNCPGIITPGEALVGITPNNITGTGPVG
LVSKSGTLTYQMMYELRDFGFSTAIGIGGDPVIGTTHIDAIEAFEKDPETKIIVMIGEIGGDAEERAADYIKANVSKPVV
GYVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAAGVKVGKTPSETAKLAREILQSL

Sequences:

>Translated_300_residues
MSIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQVVGGVNARKAGTTVSHVDKSGQSVDLPVFGSVAEAIKETGADVSIA
FVPPAFSKDAIIEAIDAEIPLLVVITEGIPVQDSAYAWAYNVEKGNKTRIIGPNCPGIITPGEALVGITPNNITGTGPVG
LVSKSGTLTYQMMYELRDFGFSTAIGIGGDPVIGTTHIDAIEAFEKDPETKIIVMIGEIGGDAEERAADYIKANVSKPVV
GYVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAAGVKVGKTPSETAKLAREILQSL
>Mature_299_residues
SIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQVVGGVNARKAGTTVSHVDKSGQSVDLPVFGSVAEAIKETGADVSIAF
VPPAFSKDAIIEAIDAEIPLLVVITEGIPVQDSAYAWAYNVEKGNKTRIIGPNCPGIITPGEALVGITPNNITGTGPVGL
VSKSGTLTYQMMYELRDFGFSTAIGIGGDPVIGTTHIDAIEAFEKDPETKIIVMIGEIGGDAEERAADYIKANVSKPVVG
YVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAAGVKVGKTPSETAKLAREILQSL

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=292, Percent_Identity=47.6027397260274, Blast_Score=211, Evalue=5e-55,
Organism=Homo sapiens, GI38569423, Length=261, Percent_Identity=30.6513409961686, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI38569421, Length=261, Percent_Identity=30.6513409961686, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1786949, Length=300, Percent_Identity=52.6666666666667, Blast_Score=293, Evalue=7e-81,
Organism=Caenorhabditis elegans, GI17550194, Length=293, Percent_Identity=51.1945392491468, Blast_Score=257, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI17553126, Length=293, Percent_Identity=49.8293515358362, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17557344, Length=261, Percent_Identity=27.9693486590038, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17551266, Length=261, Percent_Identity=27.2030651340996, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324716, Length=295, Percent_Identity=48.135593220339, Blast_Score=231, Evalue=1e-61,
Organism=Drosophila melanogaster, GI21356559, Length=294, Percent_Identity=47.2789115646259, Blast_Score=250, Evalue=6e-67,
Organism=Drosophila melanogaster, GI28574296, Length=305, Percent_Identity=47.5409836065574, Blast_Score=228, Evalue=3e-60,
Organism=Drosophila melanogaster, GI281363477, Length=244, Percent_Identity=29.9180327868852, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI281363475, Length=244, Percent_Identity=29.9180327868852, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281363473, Length=244, Percent_Identity=29.9180327868852, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30838; Mature: 30706

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQVVGGVNARKAGTTVSHVDKSGQSVDL
CEEEEECCCEEEEEEECCCCCCCEEEEEEECCCCEECCCCCCCCCCCHHHHCCCCCEECC
PVFGSVAEAIKETGADVSIAFVPPAFSKDAIIEAIDAEIPLLVVITEGIPVQDSAYAWAY
CCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCEEEEE
NVEKGNKTRIIGPNCPGIITPGEALVGITPNNITGTGPVGLVSKSGTLTYQMMYELRDFG
EECCCCEEEEECCCCCCEECCCCEEEEECCCCCCCCCCEEEEECCCCEEHHHHHHHHHCC
FSTAIGIGGDPVIGTTHIDAIEAFEKDPETKIIVMIGEIGGDAEERAADYIKANVSKPVV
CEEEECCCCCCEEECCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEE
GYVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAAGVKVGKTPSETAKLAREILQSL
EEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
>Mature Secondary Structure 
SIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQVVGGVNARKAGTTVSHVDKSGQSVDL
EEEEECCCEEEEEEECCCCCCCEEEEEEECCCCEECCCCCCCCCCCHHHHCCCCCEECC
PVFGSVAEAIKETGADVSIAFVPPAFSKDAIIEAIDAEIPLLVVITEGIPVQDSAYAWAY
CCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCEEEEE
NVEKGNKTRIIGPNCPGIITPGEALVGITPNNITGTGPVGLVSKSGTLTYQMMYELRDFG
EECCCCEEEEECCCCCCEECCCCEEEEECCCCCCCCCCEEEEECCCCEEHHHHHHHHHCC
FSTAIGIGGDPVIGTTHIDAIEAFEKDPETKIIVMIGEIGGDAEERAADYIKANVSKPVV
CEEEECCCCCCEEECCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEE
GYVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAAGVKVGKTPSETAKLAREILQSL
EEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]