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The map label for this gene is ethR [H]

Identifier: 169628081

GI number: 169628081

Start: 991363

End: 992001

Strand: Reverse

Name: ethR [H]

Synonym: MAB_0984c

Alternate gene names: 169628081

Gene position: 992001-991363 (Counterclockwise)

Preceding gene: 169628084

Following gene: 169628080

Centisome position: 19.58

GC content: 64.16

Gene sequence:

>639_bases
GTGACAAAACCGGCTACGAGAGGCCGCAAAACGACGCGCCCGTCCGGGGACGAGCGGATACAAGCGATCCTGGCCACCGC
CGAAGAACTGCTCGGCAAGCGCCCGCTTGCCGATGTCTCGGTCGATGATCTGGCGCGCGGAGCCGGGATTTCCCGGCCGA
CCTTCTACTTCTACTTCTCCTCCAAAGAGTCCGTACTCCTCACACTCGCCGAGCGAATCATCGAGGAGGCCGACGCCAAT
GTCGCGAGCATCGATCCCGCGGCCATGACAAGTCCCGCGCAGTACTGGCGGGCCGTGATCAAGGCCTACTTTGACGCCTT
CGGCTCCCACCGGGCCCTCACTGTCGCGCTGTCCAGCATGCAAGGAACAAGCCCCGAGCTGGACCAGCGCTGGTCCGAGG
TGACCGAGAACTGGGTCGCCAATACGACGGTGGGCATTGAGGCCGAACGCGCTCGTGGCGCGGCGCCCAGCGTGGTACCC
GCCCGTGATATCGCGATCGCGCTCAACCTCATCAACCAGGCGATGATGCGCGCCACTTTCACCGGGCAGCAACCCGCCGT
CGACGACGGCAAGGTGGTCGATACGCTGCTCCACGTCTGGCTCAACGCGATTTACGGAGGGGTTTGTGCGAATTCGTAG

Upstream 100 bases:

>100_bases
ATGACAATGTCGACATGTTCGGTCATGACAGCTAGGCTATCGACGCAGTGTTGAGAAAGTCAACAGTGTGTCGATAACTT
TAAAGAATGCGCAGGTAGAC

Downstream 100 bases:

>100_bases
TGCGGTGCTGCACGCGGCACCGATCGAAAGGCCGTACCGCGACACCCACCCGCTGAAAGTCATTGAGCTAGAACTCGACC
CGCCGGGCCCCGGCGAGGTG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MTKPATRGRKTTRPSGDERIQAILATAEELLGKRPLADVSVDDLARGAGISRPTFYFYFSSKESVLLTLAERIIEEADAN
VASIDPAAMTSPAQYWRAVIKAYFDAFGSHRALTVALSSMQGTSPELDQRWSEVTENWVANTTVGIEAERARGAAPSVVP
ARDIAIALNLINQAMMRATFTGQQPAVDDGKVVDTLLHVWLNAIYGGVCANS

Sequences:

>Translated_212_residues
MTKPATRGRKTTRPSGDERIQAILATAEELLGKRPLADVSVDDLARGAGISRPTFYFYFSSKESVLLTLAERIIEEADAN
VASIDPAAMTSPAQYWRAVIKAYFDAFGSHRALTVALSSMQGTSPELDQRWSEVTENWVANTTVGIEAERARGAAPSVVP
ARDIAIALNLINQAMMRATFTGQQPAVDDGKVVDTLLHVWLNAIYGGVCANS
>Mature_211_residues
TKPATRGRKTTRPSGDERIQAILATAEELLGKRPLADVSVDDLARGAGISRPTFYFYFSSKESVLLTLAERIIEEADANV
ASIDPAAMTSPAQYWRAVIKAYFDAFGSHRALTVALSSMQGTSPELDQRWSEVTENWVANTTVGIEAERARGAAPSVVPA
RDIAIALNLINQAMMRATFTGQQPAVDDGKVVDTLLHVWLNAIYGGVCANS

Specific function: Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 22899; Mature: 22768

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPATRGRKTTRPSGDERIQAILATAEELLGKRPLADVSVDDLARGAGISRPTFYFYFS
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCEEEEEEC
SKESVLLTLAERIIEEADANVASIDPAAMTSPAQYWRAVIKAYFDAFGSHRALTVALSSM
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCHHHEEEHHHC
QGTSPELDQRWSEVTENWVANTTVGIEAERARGAAPSVVPARDIAIALNLINQAMMRATF
CCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
TGQQPAVDDGKVVDTLLHVWLNAIYGGVCANS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKPATRGRKTTRPSGDERIQAILATAEELLGKRPLADVSVDDLARGAGISRPTFYFYFS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCEEEEEEC
SKESVLLTLAERIIEEADANVASIDPAAMTSPAQYWRAVIKAYFDAFGSHRALTVALSSM
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCHHHEEEHHHC
QGTSPELDQRWSEVTENWVANTTVGIEAERARGAAPSVVPARDIAIALNLINQAMMRATF
CCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
TGQQPAVDDGKVVDTLLHVWLNAIYGGVCANS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]