Click here to switch to the map view.

The map label for this gene is frmA [H]

Identifier: 169628080

GI number: 169628080

Start: 990267

End: 991376

Strand: Reverse

Name: frmA [H]

Synonym: MAB_0983c

Alternate gene names: 169628080

Gene position: 991376-990267 (Counterclockwise)

Preceding gene: 169628081

Following gene: 169628079

Centisome position: 19.56

GC content: 68.65

Gene sequence:

>1110_bases
GTGCGAATTCGTAGTGCGGTGCTGCACGCGGCACCGATCGAAAGGCCGTACCGCGACACCCACCCGCTGAAAGTCATTGA
GCTAGAACTCGACCCGCCGGGCCCCGGCGAGGTGCTGGTACGCATCGAAGCCGCGGGCCTGTGCCACTCGGATCTGTCGG
TGGTCGACGGGAACCGGATACGTCCGGTACCCATGGCACTCGGACACGAGGCGGCCGGTGTCATCGCCGCGGTGGGCCCC
GGCGTACGCGACGTCTCCCCCGGTGATCATGTGGTGCTGGTGTATGTACCGAGCTGCGGCGCGTGCAGGTACTGCTCATC
CGGTCGCCCGGCGCTATGCCCGGACGCCGCCGCGGCGAACGGCCGCGGTGACCTGATCCGCGGCGGCACCCGGCTGCACG
ATCTGGACGGCACCGAGGTACGTCACCATCTTGGTGTCTCCGGGTTCGCCGATCATGCTGTGGTGGATCGCAATTCGGTG
GTCGTCATCGATGAGAACGTTCCTCTCGACACCGCTGCCCTCTTTGGCTGCGCCATGCTCACCGGCTTTGGCGCGGTTAC
CCACACCGCGTCCGTGCGCCCCGGAGACTCCGTGGCGGTCCTCGGATTGGGTGGCGTCGGTCTGGCCGTGGTGATGTCGG
CGGCCGCCGCCGGCGCGGGTGAGGTACTGGCTATCGACCCCGTGCCCGCCAAACGCGAACTCGCCCTTGAGCTCGGCGCC
ACCAGCGCCTGCGCGCCGGATGAAGCCCCCGGCGGACATGACTGGGTGTTCGAGGTGGTCGGTTCGGCCGCCGTGCTGGA
GCAGGCCTACGCGCTCACCGGGCGCGGCGGCGGCACCGTGTCGGTGGGCCTACCGCATCCCGATGCACGAATCAGCCTGC
CCGCGTTGAATATCGTCGCGGAGGGCCGCAGCATCCTGGGCTCATACATGGGTTCGGCGCAACCGCAACAGGACATCCCG
GCCATGCTGGCGCTGTGGCGGGCGGGGCGCCTGCCAGTGGAGAAGCTCAAGTCCGATGACCTGCCGTTGTCCGATATCAA
TATCGCGCTCGACGCCCTTGCCGAGGGCCAGGCGGTGCGTCAGATCCTGCGCCCGGGAGTGAGCGCGTGA

Upstream 100 bases:

>100_bases
ATGCGCGCCACTTTCACCGGGCAGCAACCCGCCGTCGACGACGGCAAGGTGGTCGATACGCTGCTCCACGTCTGGCTCAA
CGCGATTTACGGAGGGGTTT

Downstream 100 bases:

>100_bases
CCAAACCCGAGCTGCCCACCAAGGCTGACTTCCCGGTGCACCGGAGGCACCAAACTCGTTGGGCCGACAACGATGTCTAC
GGGCATGTCAACAACGTGGT

Product: zinc-containing alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MRIRSAVLHAAPIERPYRDTHPLKVIELELDPPGPGEVLVRIEAAGLCHSDLSVVDGNRIRPVPMALGHEAAGVIAAVGP
GVRDVSPGDHVVLVYVPSCGACRYCSSGRPALCPDAAAANGRGDLIRGGTRLHDLDGTEVRHHLGVSGFADHAVVDRNSV
VVIDENVPLDTAALFGCAMLTGFGAVTHTASVRPGDSVAVLGLGGVGLAVVMSAAAAGAGEVLAIDPVPAKRELALELGA
TSACAPDEAPGGHDWVFEVVGSAAVLEQAYALTGRGGGTVSVGLPHPDARISLPALNIVAEGRSILGSYMGSAQPQQDIP
AMLALWRAGRLPVEKLKSDDLPLSDINIALDALAEGQAVRQILRPGVSA

Sequences:

>Translated_369_residues
MRIRSAVLHAAPIERPYRDTHPLKVIELELDPPGPGEVLVRIEAAGLCHSDLSVVDGNRIRPVPMALGHEAAGVIAAVGP
GVRDVSPGDHVVLVYVPSCGACRYCSSGRPALCPDAAAANGRGDLIRGGTRLHDLDGTEVRHHLGVSGFADHAVVDRNSV
VVIDENVPLDTAALFGCAMLTGFGAVTHTASVRPGDSVAVLGLGGVGLAVVMSAAAAGAGEVLAIDPVPAKRELALELGA
TSACAPDEAPGGHDWVFEVVGSAAVLEQAYALTGRGGGTVSVGLPHPDARISLPALNIVAEGRSILGSYMGSAQPQQDIP
AMLALWRAGRLPVEKLKSDDLPLSDINIALDALAEGQAVRQILRPGVSA
>Mature_369_residues
MRIRSAVLHAAPIERPYRDTHPLKVIELELDPPGPGEVLVRIEAAGLCHSDLSVVDGNRIRPVPMALGHEAAGVIAAVGP
GVRDVSPGDHVVLVYVPSCGACRYCSSGRPALCPDAAAANGRGDLIRGGTRLHDLDGTEVRHHLGVSGFADHAVVDRNSV
VVIDENVPLDTAALFGCAMLTGFGAVTHTASVRPGDSVAVLGLGGVGLAVVMSAAAAGAGEVLAIDPVPAKRELALELGA
TSACAPDEAPGGHDWVFEVVGSAAVLEQAYALTGRGGGTVSVGLPHPDARISLPALNIVAEGRSILGSYMGSAQPQQDIP
AMLALWRAGRLPVEKLKSDDLPLSDINIALDALAEGQAVRQILRPGVSA

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=360, Percent_Identity=36.3888888888889, Blast_Score=234, Evalue=8e-62,
Organism=Homo sapiens, GI34577061, Length=376, Percent_Identity=35.1063829787234, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI4501929, Length=376, Percent_Identity=33.7765957446808, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI262073058, Length=360, Percent_Identity=32.7777777777778, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI71743840, Length=360, Percent_Identity=32.7777777777778, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI156523966, Length=377, Percent_Identity=32.6259946949602, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI71565154, Length=358, Percent_Identity=31.8435754189944, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI4501939, Length=371, Percent_Identity=32.3450134770889, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI71565152, Length=360, Percent_Identity=31.9444444444444, Blast_Score=192, Evalue=3e-49,
Organism=Escherichia coli, GI1786552, Length=357, Percent_Identity=36.4145658263305, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI87081918, Length=348, Percent_Identity=29.5977011494253, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1788073, Length=363, Percent_Identity=26.9972451790634, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1788407, Length=343, Percent_Identity=30.6122448979592, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082125, Length=322, Percent_Identity=24.5341614906832, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1787863, Length=360, Percent_Identity=25.5555555555556, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790045, Length=352, Percent_Identity=25, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788075, Length=362, Percent_Identity=24.8618784530387, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786518, Length=312, Percent_Identity=28.525641025641, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082401, Length=356, Percent_Identity=27.247191011236, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI226510992, Length=339, Percent_Identity=23.3038348082596, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1786825, Length=213, Percent_Identity=29.1079812206573, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=360, Percent_Identity=32.5, Blast_Score=210, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI71997431, Length=362, Percent_Identity=32.0441988950276, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=32.0699708454811, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17562584, Length=336, Percent_Identity=26.1904761904762, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=325, Percent_Identity=27.3846153846154, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=367, Percent_Identity=24.7956403269755, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=337, Percent_Identity=26.1127596439169, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=227, Percent_Identity=27.3127753303965, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=365, Percent_Identity=34.5205479452055, Blast_Score=229, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6323961, Length=312, Percent_Identity=30.4487179487179, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323729, Length=311, Percent_Identity=29.5819935691318, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=311, Percent_Identity=29.2604501607717, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=311, Percent_Identity=29.2604501607717, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=340, Percent_Identity=25.8823529411765, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=358, Percent_Identity=28.7709497206704, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=314, Percent_Identity=25.4777070063694, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=358, Percent_Identity=28.4916201117318, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319949, Length=342, Percent_Identity=28.3625730994152, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737895, Length=364, Percent_Identity=35.1648351648352, Blast_Score=227, Evalue=9e-60,
Organism=Drosophila melanogaster, GI17737897, Length=359, Percent_Identity=27.2980501392758, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 37779; Mature: 37779

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIRSAVLHAAPIERPYRDTHPLKVIELELDPPGPGEVLVRIEAAGLCHSDLSVVDGNRI
CCHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEEEECCCCCCCCEEECCCCC
RPVPMALGHEAAGVIAAVGPGVRDVSPGDHVVLVYVPSCGACRYCSSGRPALCPDAAAAN
CCCCHHCCCCCCCEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
GRGDLIRGGTRLHDLDGTEVRHHLGVSGFADHAVVDRNSVVVIDENVPLDTAALFGCAML
CCCCEEECCCEEECCCCHHHHHHCCCCCCCCCEEECCCCEEEEECCCCCHHHHHHHHHHH
TGFGAVTHTASVRPGDSVAVLGLGGVGLAVVMSAAAAGAGEVLAIDPVPAKRELALELGA
HHCCHHHEECCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCEEEECCCCCCHHEEEEECC
TSACAPDEAPGGHDWVFEVVGSAAVLEQAYALTGRGGGTVSVGLPHPDARISLPALNIVA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCCCCCEEECCHHEEEC
EGRSILGSYMGSAQPQQDIPAMLALWRAGRLPVEKLKSDDLPLSDINIALDALAEGQAVR
CCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHCCHHHH
QILRPGVSA
HHHCCCCCC
>Mature Secondary Structure
MRIRSAVLHAAPIERPYRDTHPLKVIELELDPPGPGEVLVRIEAAGLCHSDLSVVDGNRI
CCHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEEEECCCCCCCCEEECCCCC
RPVPMALGHEAAGVIAAVGPGVRDVSPGDHVVLVYVPSCGACRYCSSGRPALCPDAAAAN
CCCCHHCCCCCCCEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
GRGDLIRGGTRLHDLDGTEVRHHLGVSGFADHAVVDRNSVVVIDENVPLDTAALFGCAML
CCCCEEECCCEEECCCCHHHHHHCCCCCCCCCEEECCCCEEEEECCCCCHHHHHHHHHHH
TGFGAVTHTASVRPGDSVAVLGLGGVGLAVVMSAAAAGAGEVLAIDPVPAKRELALELGA
HHCCHHHEECCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCEEEECCCCCCHHEEEEECC
TSACAPDEAPGGHDWVFEVVGSAAVLEQAYALTGRGGGTVSVGLPHPDARISLPALNIVA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCCCCCEEECCHHEEEC
EGRSILGSYMGSAQPQQDIPAMLALWRAGRLPVEKLKSDDLPLSDINIALDALAEGQAVR
CCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHCCHHHH
QILRPGVSA
HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]