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The map label for this gene is moaE2 [H]

Identifier: 169627965

GI number: 169627965

Start: 864503

End: 864931

Strand: Direct

Name: moaE2 [H]

Synonym: MAB_0866

Alternate gene names: 169627965

Gene position: 864503-864931 (Clockwise)

Preceding gene: 169627964

Following gene: 169627971

Centisome position: 17.06

GC content: 66.9

Gene sequence:

>429_bases
ATGAGCACCGCCGTCACTCGTGCCCTGTTGACCGCGGAGTCCATCTCGCTGATCGAACACGAGAGGCTGGTCGATCATGA
ATCGGCCGGCGCCACTGTTGGATTCGTCGGCAATGTGCGCGACCACGACGGCGGCAAGACGGTGCTGCGGCTGGAGTATT
CGGCGCATCCGTCGGCGCAGCAGGTGCTCACCGATGTGGTGCGGCGCATCGCCGAGGAAGCAGACGGCGTACGGGCCGTC
GCGGTGAGCCATCGCATCGGTGCGCTGATGGTGGGGGAAGCAGCCTTCGTGGTGGCCGTGAGCGCAGACCACCGCCGTCA
GGCCTTCGCCACCTGTCAGCGCCTCGTCGACGACGTGAAGGCCGCGCTGCCGGTGTGGAAACACCAGTTCTTCGCCAACG
GCACCGACGAGTGGGTGGGCTCGGCCTGA

Upstream 100 bases:

>100_bases
TCAACCTGCCCGGCTCCGCCGGCGGCGTCCGCGACGGGCTCGCGGTGCTCGGCGGCGTGCTCGGCCACGCCTTGGACCAG
CTAGCCGGGGGTGATCACGT

Downstream 100 bases:

>100_bases
AAACTCCGGTCGCCCAACATGGCCCGGCTACATCCGTTCGGCGATCACCGTGTACACCGGCACGTGCAGCAGCGGATCGG
TGACATCCTGGTCCAGCCGG

Product: molybdopterin-converting factor subunit 2 (MoaE)

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E 2; Molybdopterin-converting factor large subunit 2; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 142; Mature: 141

Protein sequence:

>142_residues
MSTAVTRALLTAESISLIEHERLVDHESAGATVGFVGNVRDHDGGKTVLRLEYSAHPSAQQVLTDVVRRIAEEADGVRAV
AVSHRIGALMVGEAAFVVAVSADHRRQAFATCQRLVDDVKAALPVWKHQFFANGTDEWVGSA

Sequences:

>Translated_142_residues
MSTAVTRALLTAESISLIEHERLVDHESAGATVGFVGNVRDHDGGKTVLRLEYSAHPSAQQVLTDVVRRIAEEADGVRAV
AVSHRIGALMVGEAAFVVAVSADHRRQAFATCQRLVDDVKAALPVWKHQFFANGTDEWVGSA
>Mature_141_residues
STAVTRALLTAESISLIEHERLVDHESAGATVGFVGNVRDHDGGKTVLRLEYSAHPSAQQVLTDVVRRIAEEADGVRAVA
VSHRIGALMVGEAAFVVAVSADHRRQAFATCQRLVDDVKAALPVWKHQFFANGTDEWVGSA

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=133, Percent_Identity=33.8345864661654, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1787003, Length=122, Percent_Identity=33.6065573770492, Blast_Score=62, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17509279, Length=126, Percent_Identity=32.5396825396825, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21356259, Length=121, Percent_Identity=33.0578512396694, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 15272; Mature: 15141

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAVTRALLTAESISLIEHERLVDHESAGATVGFVGNVRDHDGGKTVLRLEYSAHPSAQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEEEECCCCCHH
QVLTDVVRRIAEEADGVRAVAVSHRIGALMVGEAAFVVAVSADHRRQAFATCQRLVDDVK
HHHHHHHHHHHHHCCCCEEEHHHHHHCEEEECCEEEEEEECCCHHHHHHHHHHHHHHHHH
AALPVWKHQFFANGTDEWVGSA
HHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
STAVTRALLTAESISLIEHERLVDHESAGATVGFVGNVRDHDGGKTVLRLEYSAHPSAQ
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEEEECCCCCHH
QVLTDVVRRIAEEADGVRAVAVSHRIGALMVGEAAFVVAVSADHRRQAFATCQRLVDDVK
HHHHHHHHHHHHHCCCCEEEHHHHHHCEEEECCEEEEEEECCCHHHHHHHHHHHHHHHHH
AALPVWKHQFFANGTDEWVGSA
HHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]