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The map label for this gene is purL

Identifier: 169627808

GI number: 169627808

Start: 708070

End: 710355

Strand: Direct

Name: purL

Synonym: MAB_0707

Alternate gene names: 169627808

Gene position: 708070-710355 (Clockwise)

Preceding gene: 169627806

Following gene: 169627809

Centisome position: 13.97

GC content: 65.7

Gene sequence:

>2286_bases
GTGACTTCACGGGTTGACACGGTCGACAACGCAGCATCCACCCCCGATCACCCGCAGCCATTCGCTGAGCTAGGGCTCAA
GGACGACGAGTACGCGCGCATCCGCGAGATCCTCGGTCGTCGCCCCACCGACGCCGAGCTGGCCATGTATTCGGTGATGT
GGAGCGAGCACTGCTCCTACAAGTCCTCGAAGGTGCACCTGCGCTACTTCGGGCAGACCACCACCGAGGAGATGCGCTCG
GCGATGCTCGCCGGCATCGGGGAGAACGCCGGGGTGGTGGATATCGGCGACGGGTGGGCAGTCACGTTCAAGGTCGAATC
GCACAACCATCCCTCGTACGTGGAGCCTTATCAGGGCGCGGCGACCGGCGTGGGCGGCATCGTGCGCGACATCATGGCCA
TGGGTGCCCGGCCGATCGCTGTCATGGATCAGCTGCGCTTCGGCGCCGCCGATGCGCCCGACACCCGTCGTGTTTTCGAT
GGCGTAGTACGTGGTATCGGTGGCTACGGAAACTCACTGGGTCTGCCGAACATCGGCGGCGAGACGGTGTTCGACGCATC
GTATGCCGGCAACCCCTTGGTGAACGCCCTGTGCGCCGGCGTGCTGCGTAAGGAAGATCTGCACTTGGCGTTCGCCTCCG
GCGCCGGCAACAAGATCATTCTGTTCGGTGCGCGCACCGGGCTCGACGGTATTGGCGGAGTCTCGGTCCTGGCGTCAGAG
ACATTCGGCGGTGACGAGGCCGACGGCGCCTCGCGCAAGAAGCTTCCCAGTGTGCAGGTGGGTGATCCGTTCACCGAGAA
GGTGCTCATCGAGTGCTGTCTGGAGCTGTATGCCGCTCACCTGGTGGTTGGTATCCAGGACCTCGGCGGCGCCGGACTGT
CCTGTGCGACATCGGAACTGGCATCCGCGGGGGATGGCGGTATGCACATCGACCTGGACAAGGTGCCGCTGCGTGCCACC
GGTATGACCCCGGCCGAGGTGCTCTCCAGCGAGTCCCAGGAGCGTATGTGCGCTGTGGTGACTCCGGAAAACGTGGATGC
CTTCATGGCCGTGTGCCGCAAATGGGACGTGCTGGCCACGGTCATCGGCGAGGTCACCGACGGTGACCGGCTCCGGATCA
CCTGGCACGGCGAGACCGTTGTCGATGTGCCGCCGCGGACCGTCGCGCACGAGGGCCCTGTCTATCAGCGCCCGGTGGCT
CGCCCAGATACCCAGGATGCGTTGATCGCCGATACCGCGGGCGGATTGGCGCGCCCGGCCAGCGCCGCCGAGCTACGCCA
AACGCTGCTGGACATGATCGGCAGCCCGCACCTGTGCAGCCGCGCCTTCATCACCGAGCAGTATGACCGGTACGTGCGTG
GAAACACCGTGCTTGCCGAGCATGCCGACTCGGGCGTGATCCGGGTGGATGAGCAGACCGGGCGTGGAATCGCCTTGGCC
ACCGATGCTTCCGGACGCTACACGCTTCTGGATCCATACCGCGGCGCCCAGCTGGCACTTGCGGAGGCATACCGCAATGT
GGCCGCGTCGGGGGCCACTCCGGTCGCGGTGACCAACTGCCTGAACTTCGGCTCGCCGGAGGATCCGGGTGTCATGTGGC
AGTTCTCCGAAGCGGTCCGTGGCCTTGCCGATGGCTGTGTGACGCTGGGTATCCCGGTCACGGGAGGCAATGTCAGCTTC
TACAACCAGACCGGTACGACCCCCATTCTGCCCACCCCGGTGGTTGGCGTGCTGGGCGTGATCGACGATGTGAATCGGCG
CATTCCCACGGGATTCGGAACCGAGCCCGGGGAAACACTGATCCTGCTGGGCGACACCGCCGATGAGTTCGACGGATCGA
TCTGGGCGCAGGTGGCACATGACCACCTCGGTGGCACACCACCCAAGGTCGACCTGGCCCGCGAACAGCTGCTGGCACAG
GTTCTTACCGCCGCGTCACGGGACGGGCTGGTGTCCGCCGCCCACGACCTATCCGAGGGCGGGCTCATCCAGGCCGTCGT
CGAATCGGCGCTGGCAGGTGAAACCGGCTGCCGCCTCCTGCTTCCCGAAGGCGCCGATCCCTTCGTGGCGTTGTTCTCCG
AGTCTGCGGGGCGCGTGCTGGTCGCGGTACCGCGCACCGAGGAGAGCAGATTCATGTCGATGTGCGAAGCGCGGCAGCTT
CCCGCCGTCCGTATCGGTGTGGTCGATCAGGGCTCGGATTCCGTTGAGGTGCAGGGACAGTTCTCGGTCACCCTGGCCGA
GCTACGCGAGATTCACGAAGGCGTGCTGCCCGGACTGTTCGGATGA

Upstream 100 bases:

>100_bases
TGTGCCCGGCCCGCACCATCCCTCCGGCTGGTAGGCCCGCTCCGTACGGTCAGCACGGTGCGTAGCGAGGGCAAGGCGGG
TTCGACGGTAGAATCTGTTC

Downstream 100 bases:

>100_bases
GCGAGACTCCTGGAGTCCCGGTAACAACGAGCACCGTCGATCCCGATGACTGGATCGGCCGCAGTTGGCTGGCATTTCAG
GAACTGGAAGAGCACATCGA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 761; Mature: 760

Protein sequence:

>761_residues
MTSRVDTVDNAASTPDHPQPFAELGLKDDEYARIREILGRRPTDAELAMYSVMWSEHCSYKSSKVHLRYFGQTTTEEMRS
AMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPIAVMDQLRFGAADAPDTRRVFD
GVVRGIGGYGNSLGLPNIGGETVFDASYAGNPLVNALCAGVLRKEDLHLAFASGAGNKIILFGARTGLDGIGGVSVLASE
TFGGDEADGASRKKLPSVQVGDPFTEKVLIECCLELYAAHLVVGIQDLGGAGLSCATSELASAGDGGMHIDLDKVPLRAT
GMTPAEVLSSESQERMCAVVTPENVDAFMAVCRKWDVLATVIGEVTDGDRLRITWHGETVVDVPPRTVAHEGPVYQRPVA
RPDTQDALIADTAGGLARPASAAELRQTLLDMIGSPHLCSRAFITEQYDRYVRGNTVLAEHADSGVIRVDEQTGRGIALA
TDASGRYTLLDPYRGAQLALAEAYRNVAASGATPVAVTNCLNFGSPEDPGVMWQFSEAVRGLADGCVTLGIPVTGGNVSF
YNQTGTTPILPTPVVGVLGVIDDVNRRIPTGFGTEPGETLILLGDTADEFDGSIWAQVAHDHLGGTPPKVDLAREQLLAQ
VLTAASRDGLVSAAHDLSEGGLIQAVVESALAGETGCRLLLPEGADPFVALFSESAGRVLVAVPRTEESRFMSMCEARQL
PAVRIGVVDQGSDSVEVQGQFSVTLAELREIHEGVLPGLFG

Sequences:

>Translated_761_residues
MTSRVDTVDNAASTPDHPQPFAELGLKDDEYARIREILGRRPTDAELAMYSVMWSEHCSYKSSKVHLRYFGQTTTEEMRS
AMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPIAVMDQLRFGAADAPDTRRVFD
GVVRGIGGYGNSLGLPNIGGETVFDASYAGNPLVNALCAGVLRKEDLHLAFASGAGNKIILFGARTGLDGIGGVSVLASE
TFGGDEADGASRKKLPSVQVGDPFTEKVLIECCLELYAAHLVVGIQDLGGAGLSCATSELASAGDGGMHIDLDKVPLRAT
GMTPAEVLSSESQERMCAVVTPENVDAFMAVCRKWDVLATVIGEVTDGDRLRITWHGETVVDVPPRTVAHEGPVYQRPVA
RPDTQDALIADTAGGLARPASAAELRQTLLDMIGSPHLCSRAFITEQYDRYVRGNTVLAEHADSGVIRVDEQTGRGIALA
TDASGRYTLLDPYRGAQLALAEAYRNVAASGATPVAVTNCLNFGSPEDPGVMWQFSEAVRGLADGCVTLGIPVTGGNVSF
YNQTGTTPILPTPVVGVLGVIDDVNRRIPTGFGTEPGETLILLGDTADEFDGSIWAQVAHDHLGGTPPKVDLAREQLLAQ
VLTAASRDGLVSAAHDLSEGGLIQAVVESALAGETGCRLLLPEGADPFVALFSESAGRVLVAVPRTEESRFMSMCEARQL
PAVRIGVVDQGSDSVEVQGQFSVTLAELREIHEGVLPGLFG
>Mature_760_residues
TSRVDTVDNAASTPDHPQPFAELGLKDDEYARIREILGRRPTDAELAMYSVMWSEHCSYKSSKVHLRYFGQTTTEEMRSA
MLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPIAVMDQLRFGAADAPDTRRVFDG
VVRGIGGYGNSLGLPNIGGETVFDASYAGNPLVNALCAGVLRKEDLHLAFASGAGNKIILFGARTGLDGIGGVSVLASET
FGGDEADGASRKKLPSVQVGDPFTEKVLIECCLELYAAHLVVGIQDLGGAGLSCATSELASAGDGGMHIDLDKVPLRATG
MTPAEVLSSESQERMCAVVTPENVDAFMAVCRKWDVLATVIGEVTDGDRLRITWHGETVVDVPPRTVAHEGPVYQRPVAR
PDTQDALIADTAGGLARPASAAELRQTLLDMIGSPHLCSRAFITEQYDRYVRGNTVLAEHADSGVIRVDEQTGRGIALAT
DASGRYTLLDPYRGAQLALAEAYRNVAASGATPVAVTNCLNFGSPEDPGVMWQFSEAVRGLADGCVTLGIPVTGGNVSFY
NQTGTTPILPTPVVGVLGVIDDVNRRIPTGFGTEPGETLILLGDTADEFDGSIWAQVAHDHLGGTPPKVDLAREQLLAQV
LTAASRDGLVSAAHDLSEGGLIQAVVESALAGETGCRLLLPEGADPFVALFSESAGRVLVAVPRTEESRFMSMCEARQLP
AVRIGVVDQGSDSVEVQGQFSVTLAELREIHEGVLPGLFG

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=677, Percent_Identity=24.3722304283604, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI48994899, Length=781, Percent_Identity=26.7605633802817, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17553022, Length=692, Percent_Identity=22.8323699421965, Blast_Score=101, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321498, Length=792, Percent_Identity=24.3686868686869, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24582111, Length=722, Percent_Identity=24.0997229916898, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24582109, Length=722, Percent_Identity=24.0997229916898, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17137292, Length=722, Percent_Identity=24.0997229916898, Blast_Score=105, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_MYCA9 (B1MHY1)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001701457.1
- ProteinModelPortal:   B1MHY1
- SMR:   B1MHY1
- EnsemblBacteria:   EBMYCT00000006829
- GeneID:   5963241
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_0707
- GeneTree:   EBGT00070000032341
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   MABS561007:MAB_0707-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 80207; Mature: 80076

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRVDTVDNAASTPDHPQPFAELGLKDDEYARIREILGRRPTDAELAMYSVMWSEHCSY
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
KSSKVHLRYFGQTTTEEMRSAMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGA
CCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEECCCCEEEEEEEECCCCCCCCCCCCCC
ATGVGGIVRDIMAMGARPIAVMDQLRFGAADAPDTRRVFDGVVRGIGGYGNSLGLPNIGG
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
ETVFDASYAGNPLVNALCAGVLRKEDLHLAFASGAGNKIILFGARTGLDGIGGVSVLASE
CCEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCHHEEEEC
TFGGDEADGASRKKLPSVQVGDPFTEKVLIECCLELYAAHLVVGIQDLGGAGLSCATSEL
CCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ASAGDGGMHIDLDKVPLRATGMTPAEVLSSESQERMCAVVTPENVDAFMAVCRKWDVLAT
HCCCCCCEEEEECCCCEEECCCCHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
VIGEVTDGDRLRITWHGETVVDVPPRTVAHEGPVYQRPVARPDTQDALIADTAGGLARPA
HHHCCCCCCEEEEEECCCEEEECCCCHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCC
SAAELRQTLLDMIGSPHLCSRAFITEQYDRYVRGNTVLAEHADSGVIRVDEQTGRGIALA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCEEEEE
TDASGRYTLLDPYRGAQLALAEAYRNVAASGATPVAVTNCLNFGSPEDPGVMWQFSEAVR
ECCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEEHHHHHH
GLADGCVTLGIPVTGGNVSFYNQTGTTPILPTPVVGVLGVIDDVNRRIPTGFGTEPGETL
HHHCCCEEEEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEE
ILLGDTADEFDGSIWAQVAHDHLGGTPPKVDLAREQLLAQVLTAASRDGLVSAAHDLSEG
EEECCCCHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCC
GLIQAVVESALAGETGCRLLLPEGADPFVALFSESAGRVLVAVPRTEESRFMSMCEARQL
CHHHHHHHHHHCCCCCCEEEECCCCCHHHHEECCCCCEEEEEECCCCHHHHHHHHHHHCC
PAVRIGVVDQGSDSVEVQGQFSVTLAELREIHEGVLPGLFG
CEEEEEEEECCCCCEEEEEEEEEEHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TSRVDTVDNAASTPDHPQPFAELGLKDDEYARIREILGRRPTDAELAMYSVMWSEHCSY
CCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
KSSKVHLRYFGQTTTEEMRSAMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGA
CCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEECCCCEEEEEEEECCCCCCCCCCCCCC
ATGVGGIVRDIMAMGARPIAVMDQLRFGAADAPDTRRVFDGVVRGIGGYGNSLGLPNIGG
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
ETVFDASYAGNPLVNALCAGVLRKEDLHLAFASGAGNKIILFGARTGLDGIGGVSVLASE
CCEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCHHEEEEC
TFGGDEADGASRKKLPSVQVGDPFTEKVLIECCLELYAAHLVVGIQDLGGAGLSCATSEL
CCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ASAGDGGMHIDLDKVPLRATGMTPAEVLSSESQERMCAVVTPENVDAFMAVCRKWDVLAT
HCCCCCCEEEEECCCCEEECCCCHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
VIGEVTDGDRLRITWHGETVVDVPPRTVAHEGPVYQRPVARPDTQDALIADTAGGLARPA
HHHCCCCCCEEEEEECCCEEEECCCCHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCC
SAAELRQTLLDMIGSPHLCSRAFITEQYDRYVRGNTVLAEHADSGVIRVDEQTGRGIALA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCEEEEE
TDASGRYTLLDPYRGAQLALAEAYRNVAASGATPVAVTNCLNFGSPEDPGVMWQFSEAVR
ECCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEEHHHHHH
GLADGCVTLGIPVTGGNVSFYNQTGTTPILPTPVVGVLGVIDDVNRRIPTGFGTEPGETL
HHHCCCEEEEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEE
ILLGDTADEFDGSIWAQVAHDHLGGTPPKVDLAREQLLAQVLTAASRDGLVSAAHDLSEG
EEECCCCHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCC
GLIQAVVESALAGETGCRLLLPEGADPFVALFSESAGRVLVAVPRTEESRFMSMCEARQL
CHHHHHHHHHHCCCCCCEEEECCCCCHHHHEECCCCCEEEEEECCCCHHHHHHHHHHHCC
PAVRIGVVDQGSDSVEVQGQFSVTLAELREIHEGVLPGLFG
CEEEEEEEECCCCCEEEEEEEEEEHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA