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The map label for this gene is mprA [H]

Identifier: 169627776

GI number: 169627776

Start: 676212

End: 676955

Strand: Direct

Name: mprA [H]

Synonym: MAB_0673

Alternate gene names: 169627776

Gene position: 676212-676955 (Clockwise)

Preceding gene: 169627774

Following gene: 169627777

Centisome position: 13.34

GC content: 62.23

Gene sequence:

>744_bases
ATGGTGAGCATCACGACAGAGACACACCAAGGAACCTTCTCCGCCAACGGCACCACCCCCGCCAAGGTGCTGGTGGTCGA
CGATGAATCGAACATCGTCGAGTTGCTCTCGGTCAGTCTCAAATTCCAGGGCTTTGATGTCTATACCGCAGACAGCGGAG
CCGCCGCCCTGGACCTGGCGCGCACGGTCCGCCCCGACGCGGTGATCCTCGACGTGATGATGCCCGGAATGGATGGATTC
GGAGTTCTGCGCAGGCTGCGCGCCGACGGCATCGACGCACCGACACTGTTCCTCACGGCACGGGACGGCCTGCAGGACAA
GATCGCCGGCCTGACGCTGGGCGCAGACGACTACGTGACCAAGCCATTCAGTCTGGAAGAGGTGGTTGCCCGGCTGCGGG
TGATCCTGCGCCGGTCCGGCATGGGCTCCGAGCCGGCTCGCAAGTCGCGACTGAGCTTCGCCGATATCGAACTCGATGAG
GACACCCATGAGGTGTGGAAGGCGGGGGAGCCGGTGGCGCTGTCTCCCACGGAGTTCACACTGCTGCGCTATTTCATGAT
CAACGCGGGCACCGTGCTCAGTAAGCCCAAGATCCTCGATCATGTGTGGCGCTACGACTTCGGTGGCGACGTGAACGTGG
TGGAGTCCTACGTCTCGTATCTGCGCCGCAAGATCGACAACGGTGAGAAGCGGCTATTGCATACTCTTCGTGGCGTGGGA
TACGTATTGCGCGAGCCGCGATGA

Upstream 100 bases:

>100_bases
GGCGACCTCGCGCGGTTGGCTGACAATCTCCTGTGAGTAACTCACAGGAAGCTCACAGTGAAGATCCAGCGCATCGTAAA
TTTTGGGGGGAAGATTACCT

Downstream 100 bases:

>100_bases
GCGTCTGCGCGAAGAGCAGTTGGCGCTGCTAGTGGCAGTCCCCGGCGTTCGTCGGGGTGTACCGCTGCGGGTGAGCCTTG
TGGTCGGAACCCTGGTTTTG

Product: putative DNA-binding response regulator PhoP

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MVSITTETHQGTFSANGTTPAKVLVVDDESNIVELLSVSLKFQGFDVYTADSGAAALDLARTVRPDAVILDVMMPGMDGF
GVLRRLRADGIDAPTLFLTARDGLQDKIAGLTLGADDYVTKPFSLEEVVARLRVILRRSGMGSEPARKSRLSFADIELDE
DTHEVWKAGEPVALSPTEFTLLRYFMINAGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDNGEKRLLHTLRGVG
YVLREPR

Sequences:

>Translated_247_residues
MVSITTETHQGTFSANGTTPAKVLVVDDESNIVELLSVSLKFQGFDVYTADSGAAALDLARTVRPDAVILDVMMPGMDGF
GVLRRLRADGIDAPTLFLTARDGLQDKIAGLTLGADDYVTKPFSLEEVVARLRVILRRSGMGSEPARKSRLSFADIELDE
DTHEVWKAGEPVALSPTEFTLLRYFMINAGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDNGEKRLLHTLRGVG
YVLREPR
>Mature_247_residues
MVSITTETHQGTFSANGTTPAKVLVVDDESNIVELLSVSLKFQGFDVYTADSGAAALDLARTVRPDAVILDVMMPGMDGF
GVLRRLRADGIDAPTLFLTARDGLQDKIAGLTLGADDYVTKPFSLEEVVARLRVILRRSGMGSEPARKSRLSFADIELDE
DTHEVWKAGEPVALSPTEFTLLRYFMINAGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDNGEKRLLHTLRGVG
YVLREPR

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=39.8230088495575, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=35.2678571428571, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=39.1111111111111, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=38.3928571428571, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=34.6846846846847, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=36.4864864864865, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=33.4841628959276, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=31.7180616740088, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788394, Length=231, Percent_Identity=33.3333333333333, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=32.1428571428571, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.5263157894737, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=29.8245614035088, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=30.4347826086957, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788550, Length=127, Percent_Identity=35.4330708661417, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=35.1851851851852, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=26.4069264069264, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1790437, Length=110, Percent_Identity=34.5454545454545, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788191, Length=123, Percent_Identity=37.3983739837398, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI145693157, Length=128, Percent_Identity=33.59375, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27305; Mature: 27305

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSITTETHQGTFSANGTTPAKVLVVDDESNIVELLSVSLKFQGFDVYTADSGAAALDLA
CEEEEECCCCCEEECCCCCCEEEEEEECCCCHHHHHHHHEEECCEEEEECCCCCHHHHHH
RTVRPDAVILDVMMPGMDGFGVLRRLRADGIDAPTLFLTARDGLQDKIAGLTLGADDYVT
HHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHEEEECCCCCCC
KPFSLEEVVARLRVILRRSGMGSEPARKSRLSFADIELDEDTHEVWKAGEPVALSPTEFT
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCEEEEEEECCCHHHHHHCCCCEEECCHHHH
LLRYFMINAGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDNGEKRLLHTLRGVG
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
YVLREPR
HHHCCCC
>Mature Secondary Structure
MVSITTETHQGTFSANGTTPAKVLVVDDESNIVELLSVSLKFQGFDVYTADSGAAALDLA
CEEEEECCCCCEEECCCCCCEEEEEEECCCCHHHHHHHHEEECCEEEEECCCCCHHHHHH
RTVRPDAVILDVMMPGMDGFGVLRRLRADGIDAPTLFLTARDGLQDKIAGLTLGADDYVT
HHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHEEEECCCCCCC
KPFSLEEVVARLRVILRRSGMGSEPARKSRLSFADIELDEDTHEVWKAGEPVALSPTEFT
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCEEEEEEECCCHHHHHHCCCCEEECCHHHH
LLRYFMINAGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDNGEKRLLHTLRGVG
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
YVLREPR
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA